{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:24:19Z","timestamp":1778556259970,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16POST29900003"],"award-info":[{"award-number":["16POST29900003"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14SDG17990000"],"award-info":[{"award-number":["14SDG17990000"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5R01HL130106-04"],"award-info":[{"award-number":["5R01HL130106-04"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["HORM CANC"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s12672-019-00375-0","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T16:02:40Z","timestamp":1580400160000},"page":"52-62","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular and Electrophysiological Analyses of ATP2B4 Gene Variants in Bilateral Adrenal Hyperaldosteronism"],"prefix":"10.1007","volume":"11","author":[{"given":"Namita Ganesh","family":"Hattangady","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Marcondes","family":"Lerario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ponce-Balbuena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juilee","family":"Rege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Monticone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Rainey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Mulatero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-0011","authenticated-orcid":false,"given":"Tobias","family":"Else","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"issue":"7","key":"375_CR1","doi-asserted-by":"publisher","first-page":"e41926","DOI":"10.1371\/journal.pone.0041926","volume":"7","author":"T Akerstrom","year":"2012","unstructured":"Akerstrom T, Crona J, Verdugo AD, Starker LF, Cupisti K, Willenberg HS, Knoefel WT, Saeger W, Feller A, Ip J, Soon P, Anlauf M, Alesina PF, Schmid KW, Decaussin M, Levillain P, Wangberg B, Peix JL, Robinson B, Zedenius J, Backdahl M, Caramuta S, Iwen KA, Botling J, Stalberg P, Kraimps JL, Dralle H, Hellman P, Sidhu S, Westin G, Lehnert H, Walz MK, Akerstrom G, Carling T, Choi M, Lifton RP, Bjorklund P (2012) Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS One 7(7):e41926","journal-title":"PLoS One"},{"issue":"3","key":"375_CR2","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1161\/HYPERTENSIONAHA.111.186239","volume":"59","author":"EA Azizan","year":"2012","unstructured":"Azizan EA, Murthy M, Stowasser M, Gordon R, Kowalski B, Xu S, Brown MJ, O'Shaughnessy KM (2012) Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas. Hypertension 59(3):587\u2013591","journal-title":"Hypertension"},{"issue":"9","key":"375_CR3","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/ng.2716","volume":"45","author":"EA Azizan","year":"2013","unstructured":"Azizan EA, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Teo AE, Davenport AP, Dekkers T, Tops B, Kusters B, Ceral J, Yeo GS, Neogi SG, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ (2013) Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet 45(9):1055\u20131060","journal-title":"Nat Genet"},{"issue":"4","key":"375_CR4","doi-asserted-by":"publisher","first-page":"440\u20134","DOI":"10.1038\/ng.2550","volume":"45","author":"F Beuschlein","year":"2013","unstructured":"Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M (2013) Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet 45(4):440\u20134\u2013444e1\u20132","journal-title":"Nat Genet"},{"issue":"8","key":"375_CR5","doi-asserted-by":"publisher","first-page":"E1532","DOI":"10.1210\/jc.2012-1334","volume":"97","author":"E Charmandari","year":"2012","unstructured":"Charmandari E, Sertedaki A, Kino T, Merakou C, Hoffman DA, Hatch MM, Hurt DE, Lin L, Xekouki P, Stratakis CA, Chrousos GP (2012) A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension. J Clin Endocrinol Metab 97(8):E1532\u2013E1539","journal-title":"J Clin Endocrinol Metab"},{"issue":"6018","key":"375_CR6","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1126\/science.1198785","volume":"331","author":"M Choi","year":"2011","unstructured":"Choi M, Scholl UI, Yue P, Bjorklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Akerstrom G, Wang W, Carling T, Lifton RP (2011) K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science 331(6018):768\u2013772","journal-title":"Science"},{"issue":"9","key":"375_CR7","doi-asserted-by":"publisher","first-page":"E1765","DOI":"10.1210\/jc.2014-1927","volume":"99","author":"M Kuppusamy","year":"2014","unstructured":"Kuppusamy M, Caroccia B, Stindl J, Bandulik S, Lenzini L, Gioco F, Fishman V, Zanotti G, Gomez-Sanchez C, Bader M, Warth R, Rossi GP (2014) A novel KCNJ5-insT149 somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium. J Clin Endocrinol Metab 99(9):E1765\u2013E1773","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"375_CR8","doi-asserted-by":"publisher","first-page":"E1861","DOI":"10.1210\/jc.2013-2428","volume":"98","author":"S Monticone","year":"2013","unstructured":"Monticone S, Hattangady NG, Penton D, Isales CM, Edwards MA, Williams TA, Sterner C, Warth R, Mulatero P, Rainey WE (2013) A novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III. J Clin Endocrinol Metab 98(11):E1861\u2013E1865","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"375_CR9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1161\/HYPERTENSIONAHA.111.183996","volume":"59","author":"P Mulatero","year":"2012","unstructured":"Mulatero P, Tauber P, Zennaro MC, Monticone S, Lang K, Beuschlein F, Fischer E, Tizzani D, Pallauf A, Viola A, Amar L, Williams TA, Strom TM, Graf E, Bandulik S, Penton D, Plouin PF, Warth R, Allolio B, Jeunemaitre X, Veglio F, Reincke M (2012) KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism. Hypertension 59(2):235\u2013240","journal-title":"Hypertension"},{"issue":"9","key":"375_CR10","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1097\/HJH.0b013e328356139f","volume":"30","author":"M Murthy","year":"2012","unstructured":"Murthy M, Azizan EA, Brown MJ, O'Shaughnessy KM (2012) Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma. J Hypertens 30(9):1827\u20131833","journal-title":"J Hypertens"},{"issue":"9","key":"375_CR11","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/ng.2695","volume":"45","author":"UI Scholl","year":"2013","unstructured":"Scholl UI, Goh G, Stolting G, de Oliveira RC, Choi M, Overton JD, Fonseca AL, Korah R, Starker LF, Kunstman JW, Prasad ML, Hartung EA, Mauras N, Benson MR, Brady T, Shapiro JR, Loring E, Nelson-Williams C, Libutti SK, Mane S, Hellman P, Westin G, Akerstrom G, Bjorklund P, Carling T, Fahlke C, Hidalgo P, Lifton RP (2013) Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet 45(9):1050\u20131054","journal-title":"Nat Genet"},{"key":"375_CR12","doi-asserted-by":"publisher","first-page":"e06315","DOI":"10.7554\/eLife.06315","volume":"4","author":"UI Scholl","year":"2015","unstructured":"Scholl UI, Stolting G, Nelson-Williams C, Vichot AA, Choi M, Loring E, Prasad ML, Goh G, Carling T, Juhlin CC, Quack I, Rump LC, Thiel A, Lande M, Frazier BG, Rasoulpour M, Bowlin DL, Sethna CB, Trachtman H, Fahlke C, Lifton RP (2015) Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism. Elife 4:e06315","journal-title":"Elife"},{"key":"375_CR13","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ebiom.2016.10.002","volume":"13","author":"G Daniil","year":"2016","unstructured":"Daniil G, Fernandes-Rosa FL, Chemin J, Blesneac I, Beltrand J, Polak M, Jeunemaitre X, Boulkroun S, Amar L, Strom TM, Lory P, Zennaro MC (2016) CACNA1H mutations are associated with different forms of primary Aldosteronism. EBioMedicine 13:225\u2013236","journal-title":"EBioMedicine"},{"issue":"7","key":"375_CR14","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1073\/pnas.1121407109","volume":"109","author":"UI Scholl","year":"2012","unstructured":"Scholl UI, Nelson-Williams C, Yue P, Grekin R, Wyatt RJ, Dillon MJ, Couch R, Hammer LK, Harley FL, Farhi A, Wang WH, Lifton RP (2012) Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5. Proc Natl Acad Sci U S A 109(7):2533\u20132538","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"375_CR15","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1210\/jc.2018-01004","volume":"103","author":"K Nanba","year":"2018","unstructured":"Nanba K, Omata K, Else T, Beck PCC, Nanba AT, Turcu AF, Miller BS, Giordano TJ, Tomlins SA, Rainey WE (2018) Targeted Molecular characterization of aldosterone-producing adenomas in white Americans. J Clin Endocrinol Metab 103(10):3869\u20133876","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"375_CR16","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1161\/HYPERTENSIONAHA.118.12070","volume":"73","author":"K Nanba","year":"2019","unstructured":"Nanba K, Omata K, Gomez-Sanchez CE, Stratakis CA, Demidowich AP, Suzuki M, Thompson LDR, Cohen DL, Luther JM, Gellert L, Vaidya A, Barletta JA, Else T, Giordano TJ, Tomlins SA, Rainey WE (2019) Genetic characteristics of aldosterone-producing adenomas in blacks. Hypertension 73(4):885\u2013892","journal-title":"Hypertension"},{"issue":"2","key":"375_CR17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","volume":"64","author":"FL Fernandes-Rosa","year":"2014","unstructured":"Fernandes-Rosa FL, Williams TA, Riester A, Steichen O, Beuschlein F, Boulkroun S, Strom TM, Monticone S, Amar L, Meatchi T, Mantero F, Cicala MV, Quinkler M, Fallo F, Allolio B, Bernini G, Maccario M, Giacchetti G, Jeunemaitre X, Mulatero P, Reincke M, Zennaro MC (2014) Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma. Hypertension 64(2):354\u2013361","journal-title":"Hypertension"},{"issue":"8","key":"375_CR18","doi-asserted-by":"publisher","first-page":"E1567","DOI":"10.1210\/jc.2011-3132","volume":"97","author":"S Monticone","year":"2012","unstructured":"Monticone S, Hattangady NG, Nishimoto K, Mantero F, Rubin B, Cicala MV, Pezzani R, Auchus RJ, Ghayee HK, Shibata H, Kurihara I, Williams TA, Giri JG, Bollag RJ, Edwards MA, Isales CM, Rainey WE (2012) Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. J Clin Endocrinol Metab 97(8):E1567\u2013E1572","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"375_CR19","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41588-018-0053-8","volume":"50","author":"FL Fernandes-Rosa","year":"2018","unstructured":"Fernandes-Rosa FL, Daniil G, Orozco IJ, Goppner C, El Zein R, Jain V, Boulkroun S, Jeunemaitre X, Amar L, Lefebvre H, Schwarzmayr T, Strom TM, Jentsch TJ, Zennaro MC (2018) A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism. Nat Genet 50(3):355\u2013361","journal-title":"Nat Genet"},{"issue":"3","key":"375_CR20","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41588-018-0048-5","volume":"50","author":"UI Scholl","year":"2018","unstructured":"Scholl UI, Stolting G, Schewe J, Thiel A, Tan H, Nelson-Williams C, Vichot AA, Jin SC, Loring E, Untiet V, Yoo T, Choi J, Xu S, Wu A, Kirchner M, Mertins P, Rump LC, Onder AM, Gamble C, McKenney D, Lash RW, Jones DP, Chune G, Gagliardi P, Choi M, Gordon R, Stowasser M, Fahlke C, Lifton RP (2018) CLCN2 chloride channel mutations in familial hyperaldosteronism type II. Nat Genet 50(3):349\u2013354","journal-title":"Nat Genet"},{"issue":"C","key":"375_CR21","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/0968-0004(87)90090-9","volume":"12","author":"PLCE Pedersen","year":"1987","unstructured":"Pedersen PLCE (1987b) Ion motive ATPases. II. Energy coupling and work output. Trends Biochem Sci 12(C):186\u2013189","journal-title":"Trends Biochem Sci"},{"key":"375_CR22","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/0968-0004(87)90071-5","volume":"12","author":"PLCE Pedersen","year":"1987","unstructured":"Pedersen PLCE (1987a) Ion motive ATPases. I. Ubiquity, properties, and significance to cell function. Trends Biochem Sci 12:146\u2013150","journal-title":"Trends Biochem Sci"},{"issue":"4","key":"375_CR23","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1152\/physrev.00032.2008","volume":"89","author":"M Brini","year":"2009","unstructured":"Brini M, Carafoli E (2009) Calcium pumps in health and disease. Physiol Rev 89(4):1341\u20131378","journal-title":"Physiol Rev"},{"issue":"5","key":"375_CR24","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.bbamcr.2010.12.007","volume":"1813","author":"D Oceandy","year":"2011","unstructured":"Oceandy D, Mohamed TM, Cartwright EJ, Neyses L (2011) Local signals with global impacts and clinical implications: lessons from the plasma membrane calcium pump (PMCA4). Biochim Biophys Acta 1813(5):974\u2013978","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"375_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1152\/physrev.2001.81.1.21","volume":"81","author":"EE Strehler","year":"2001","unstructured":"Strehler EE, Zacharias DA (2001) Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. Physiol Rev 81(1):21\u201350","journal-title":"Physiol Rev"},{"issue":"7","key":"375_CR26","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1016\/S0021-9258(18)42846-3","volume":"267","author":"P Brandt","year":"1992","unstructured":"Brandt P, Neve RL, Kammesheidt A, Rhoads RE, Vanaman TC (1992) Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. J Biol Chem 267(7):4376\u20134385","journal-title":"J Biol Chem"},{"issue":"34","key":"375_CR27","doi-asserted-by":"publisher","first-page":"25993","DOI":"10.1016\/S0021-9258(19)74484-6","volume":"268","author":"TP Stauffer","year":"1993","unstructured":"Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1993) Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. J Biol Chem 268(34):25993\u201326003","journal-title":"J Biol Chem"},{"issue":"51","key":"375_CR28","doi-asserted-by":"publisher","first-page":"21047","DOI":"10.1074\/jbc.M117.789776","volume":"292","author":"TR Kolodecik","year":"2017","unstructured":"Kolodecik TR, Reed AM, Date K, Shugrue CA, Patel V, Chung SL, Desir GV, Gorelick FS (2017) The serum protein renalase reduces injury in experimental pancreatitis. J Biol Chem 292(51):21047\u201321059","journal-title":"J Biol Chem"},{"issue":"6","key":"375_CR29","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1210\/en.2015-2029","volume":"157","author":"P Tauber","year":"2016","unstructured":"Tauber P, Aichinger B, Christ C, Stindl J, Rhayem Y, Beuschlein F, Warth R, Bandulik S (2016) Cellular pathophysiology of an adrenal adenoma-associated mutant of the plasma membrane Ca(2+)-ATPase ATP2B3. Endocrinology 157(6):2489\u20132499","journal-title":"Endocrinology"},{"issue":"Pt 1","key":"375_CR30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1042\/bj3030275","volume":"303","author":"A Howard","year":"1994","unstructured":"Howard A, Barley NF, Legon S, Walters JR (1994) Plasma-membrane calcium-pump isoforms in human and rat liver. Biochem J 303(Pt 1):275\u2013279","journal-title":"Biochem J"},{"issue":"1","key":"375_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0021-9258(17)42307-6","volume":"269","author":"A Enyedi","year":"1994","unstructured":"Enyedi A, Verma AK, Heim R, Adamo HP, Filoteo AG, Strehler EE, Penniston JT (1994) The Ca2+ affinity of the plasma membrane Ca2+ pump is controlled by alternative splicing. J Biol Chem 269(1):41\u201343","journal-title":"J Biol Chem"},{"issue":"5","key":"375_CR32","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1016\/S0021-9258(18)49937-1","volume":"266","author":"R Falchetto","year":"1991","unstructured":"Falchetto R, Vorherr T, Brunner J, Carafoli E (1991) The plasma membrane Ca2+ pump contains a site that interacts with its calmodulin-binding domain. J Biol Chem 266(5):2930\u20132936","journal-title":"J Biol Chem"},{"issue":"12","key":"375_CR33","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/pro.5560011209","volume":"1","author":"R Falchetto","year":"1992","unstructured":"Falchetto R, Vorherr T, Carafoli E (1992) The calmodulin-binding site of the plasma membrane Ca2+ pump interacts with the transduction domain of the enzyme. Protein Sci 1(12):1613\u20131621","journal-title":"Protein Sci"},{"issue":"4","key":"375_CR34","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/0888-7543(91)90356-J","volume":"9","author":"S Olson","year":"1991","unstructured":"Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW (1991) Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23. Genomics 9(4):629\u2013641","journal-title":"Genomics"},{"issue":"Pt 3","key":"375_CR35","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1042\/bj3060779","volume":"306","author":"TP Keeton","year":"1995","unstructured":"Keeton TP, Shull GE (1995) Primary structure of rat plasma membrane Ca(2+)-ATPase isoform 4 and analysis of alternative splicing patterns at splice site a. Biochem J 306(Pt 3):779\u2013785","journal-title":"Biochem J"},{"issue":"37","key":"375_CR36","doi-asserted-by":"publisher","first-page":"35798","DOI":"10.1074\/jbc.M305794200","volume":"278","author":"R Padanyi","year":"2003","unstructured":"Padanyi R, Paszty K, Penheiter AR, Filoteo AG, Penniston JT, Enyedi A (2003) Intramolecular interactions of the regulatory region with the catalytic core in the plasma membrane calcium pump. J Biol Chem 278(37):35798\u201335804","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"375_CR37","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.mce.2005.12.028","volume":"250","author":"S Withers","year":"2006","unstructured":"Withers S, Cartwright EJ, Neyses L (2006) Sperm phenotype of mice carrying a gene deletion for the plasma membrane calcium\/calmodulin dependent ATPase 4. Mol Cell Endocrinol 250(1\u20132):93\u201397","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"375_CR38","doi-asserted-by":"publisher","first-page":"e00321","DOI":"10.1002\/brb3.321","volume":"5","author":"PW Ho","year":"2015","unstructured":"Ho PW, Pang SY, Li M, Tse ZH, Kung MH, Sham PC, Ho SL (2015) PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion. Brain Behav 5(4):e00321","journal-title":"Brain Behav"},{"issue":"8","key":"375_CR39","doi-asserted-by":"publisher","first-page":"e104790","DOI":"10.1371\/journal.pone.0104790","volume":"9","author":"M Li","year":"2014","unstructured":"Li M, Ho PW, Pang SY, Tse ZH, Kung MH, Sham PC, Ho SL (2014) PMCA4 (ATP2B4) mutation in familial spastic paraplegia. PLoS One 9(8):e104790","journal-title":"PLoS One"},{"issue":"8","key":"375_CR40","doi-asserted-by":"publisher","first-page":"e6529","DOI":"10.1371\/journal.pone.0006529","volume":"4","author":"E Campeau","year":"2009","unstructured":"Campeau E, Ruhl VE, Rodier F, Smith CL, Rahmberg BL, Fuss JO, Campisi J, Yaswen P, Cooper PK, Kaufman PD (2009) A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One 4(8):e6529","journal-title":"PLoS One"},{"issue":"10","key":"375_CR41","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1089\/hum.2010.179","volume":"22","author":"M Giry-Laterriere","year":"2011","unstructured":"Giry-Laterriere M, Cherpin O, Kim YS, Jensen J, Salmon P (2011) Polyswitch lentivectors: \"all-in-one\" lentiviral vectors for drug-inducible gene expression, live selection, and recombination cloning. Hum Gene Ther 22(10):1255\u20131267","journal-title":"Hum Gene Ther"},{"issue":"1","key":"375_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/JME-15-0324","volume":"57","author":"NG Hattangady","year":"2016","unstructured":"Hattangady NG, Karashima S, Yuan L, Ponce-Balbuena D, Jalife J, Gomez-Sanchez CE, Auchus RJ, Rainey WE, Else T (2016) Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production. J Mol Endocrinol 57(1):1\u201311","journal-title":"J Mol Endocrinol"},{"issue":"4","key":"375_CR43","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1210\/en.2011-1733","volume":"153","author":"K Oki","year":"2012","unstructured":"Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE (2012) Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Endocrinology 153(4):1774\u20131782","journal-title":"Endocrinology"},{"issue":"7","key":"375_CR44","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1210\/en.2014-1942","volume":"156","author":"J Rege","year":"2015","unstructured":"Rege J, Nishimoto HK, Nishimoto K, Rodgers RJ, Auchus RJ, Rainey WE (2015) Bone morphogenetic Protein-4 (BMP4): a paracrine regulator of human adrenal C19 steroid synthesis. Endocrinology 156(7):2530\u20132540","journal-title":"Endocrinology"},{"issue":"4","key":"375_CR45","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1161\/HYPERTENSIONAHA.118.11086","volume":"72","author":"K Omata","year":"2018","unstructured":"Omata K, Satoh F, Morimoto R, Ito S, Yamazaki Y, Nakamura Y, Anand SK, Guo Z, Stowasser M, Sasano H, Tomlins SA, Rainey WE (2018) Cellular and genetic causes of idiopathic Hyperaldosteronism. Hypertension 72(4):874\u2013880","journal-title":"Hypertension"}],"container-title":["Hormones and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-019-00375-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-019-00375-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-019-00375-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T15:45:11Z","timestamp":1650123911000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-019-00375-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,30]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["375"],"URL":"https:\/\/doi.org\/10.1007\/s12672-019-00375-0","relation":{},"ISSN":["1868-8497","1868-8500"],"issn-type":[{"value":"1868-8497","type":"print"},{"value":"1868-8500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,30]]},"assertion":[{"value":"18 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}