{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:14:06Z","timestamp":1765728846883},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"High-level Hospital Construction Research Project of Maoming People`s Hospital and Maoming Municipal Science and Technology Bureau Special Plan","award":["No. 2020KJZX018"],"award-info":[{"award-number":["No. 2020KJZX018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ganglioneuromas (GNs) arise from the Schwann cells, ganglion cells, and neuronal tissues, and are extremely rare, slow-growing, benign tumors. GN has usually grown very large when it is diagnosed since no specific clinical symptoms or laboratory findings indicating GN are available, especially when it occurs in the retroperitoneal space. Total resection of the tumor is the recommended treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case summary<\/jats:title>\n                <jats:p>We present the imaging and pathological findings of a giant adrenal GN in a child. A 7-year-old boy suffered from nausea and postprandial vomiting for 1\u2009week with no precipitating factors. There was no family history of any disease, and the boy did not suffer from any disease in the past. Biochemical examination showed normal results. Physical examination showed an immobilized palpable mass in the left abdominal area. Abdominal computed tomography revealed a 13\u2009cm \u00d7 10\u2009cm solid mass in the retroperitoneal space. The mass showed slight and heterogeneous enhancement after injection of a contrasting agent. The mass was surgically resected locally to address the embedded abdominal vessels, and the histopathological and immunohistochemical diagnosis of the mass was GN. After the surgery, the symptoms of nausea and vomiting were relieved, and no complications occurred.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>GN should be considered when a child presents with a giant retroperitoneal hypodense mass and the mass presents uneven and delayed enhancement. Histopathology is the golden standard for the diagnosis of GN. Currently, surgical excision is the optimal treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12672-022-00573-3","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T08:03:15Z","timestamp":1665734595000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Giant adrenal ganglioneuroma in children: a case report"],"prefix":"10.1007","volume":"13","author":[{"given":"Mingqiu","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"573_CR1","first-page":"10326","volume-title":"Campell-Walsh-Wein urology","author":"TA Masterson","year":"2021","unstructured":"Masterson TA, Cary KC, Foster RS. Retroperitoneal tumors. In: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, editors. Campell-Walsh-Wein urology. 12th ed. Philadelphia: Saunders Elsevier; 2021. p. 10326\u2013416.","edition":"12"},{"issue":"8","key":"573_CR2","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1007\/s00268-018-4499-8","volume":"42","author":"J Xie","year":"2018","unstructured":"Xie J, Dai J, Zhou WL, Sun FK. Adrenal ganglioneuroma: features and outcomes of 42 cases in a Chinese population. World J Surg\u00a0 2018;42(8):2469\u201375.","journal-title":"World J Surg\u00a0"},{"key":"573_CR3","first-page":"196","volume-title":"World Health Organization classification of tumours of endocrine organs","author":"RV Lloyd","year":"2017","unstructured":"Lloyd RV, Osamura RY, Kl\u00f6ppel G. World Health Organization classification of tumours of endocrine organs. IARC: Lyon; 2017. p. 196\u2013203."},{"issue":"8","key":"573_CR4","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1097\/PAS.0b013e318289c765","volume":"37","author":"D Nonaka","year":"2013","unstructured":"Nonaka D, Wang BY, Edmondson D, et al. A study of gata3 and phox2b expression in tumors of the autonomic nervous system. Am J Surg Pathol. 2013;37(8):1236\u201341.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"573_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1476-4598-12-70","volume":"12","author":"A Wilz\u00e9n","year":"2013","unstructured":"Wilz\u00e9n A, Krona C, Sveinbj\u00f6rnsson B, et al. ERBB3 is a marker of a ganglioneuroblastoma\/ganglioneuroma-like expression profile in neuroblastic tumours. Mol Cancer. 2013;12(1):70.","journal-title":"Mol Cancer"},{"issue":"10","key":"573_CR6","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1002\/1097-0142(20010515)91:10<1905::AID-CNCR1213>3.0.CO;2-4","volume":"91","author":"B Geoerger","year":"2001","unstructured":"Geoerger B, Hero B, Harms D, et al. Metabolic activity and clinical features of primary ganglioneuromas. Cancer. 2001;91(10):1905\u201313.","journal-title":"Cancer"},{"issue":"990","key":"573_CR7","doi-asserted-by":"publisher","first-page":"e108-10","DOI":"10.1259\/bjr\/17325482","volume":"83","author":"S Eljack","year":"2010","unstructured":"Eljack S, Rosenkrantz AB, Das K. CT and MRI appearance of solitary parapelvic neurofibroma of the kidney. Br J Radiol. 2010 Jun;83(990):e108-10.","journal-title":"Br J Radiol"},{"issue":"3","key":"573_CR8","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/cen.12320","volume":"80","author":"H Shawa","year":"2014","unstructured":"Shawa H, Elsayes KM, Javadi S, et al. Adrenal ganglioneuroma: features and outcomes of 27 cases at a referral cancer centre. Clin Endocrinol (Oxf). 2014;80(3):342\u20137.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"573_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.eucr.2017.03.024","volume":"13","author":"P Chen","year":"2017","unstructured":"Chen P, Lin C, Jin L, et al. A case report of giant adrenal ganglioneuroma. Urol Case Rep. 2017;13:37\u20138.","journal-title":"Urol Case Rep"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-022-00573-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-022-00573-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-022-00573-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T08:37:28Z","timestamp":1665736648000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-022-00573-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,14]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["573"],"URL":"https:\/\/doi.org\/10.1007\/s12672-022-00573-3","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,14]]},"assertion":[{"value":"31 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study was granted an exemption from requiring ethics approval from the Ethics Committee of Maoming People`s Hospital, as it was observation report. All the experiment protocol for involving human data was in accordance with the guidelines of our institutional or Declaration of Helsinki in the manuscript, and the written informed consent from study participant`s legal guardian was obtained.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There is no conflict of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"104"}}