{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:00:54Z","timestamp":1790074854900,"version":"4.0.1"},"reference-count":132,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-024-01593-x","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T11:40:39Z","timestamp":1732621239000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["TLN1: an oncogene associated with tumorigenesis and progression"],"prefix":"10.1007","volume":"15","author":[{"given":"Sixin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangsheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"issue":"6","key":"1593_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA-A Cancer J Clin. 2018;68(6):394\u2013424.","journal-title":"CA-A Cancer J Clin"},{"issue":"12","key":"1593_CR2","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.1096\/fj.15-273409","volume":"29","author":"Q Wu","year":"2015","unstructured":"Wu Q, et al. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB J. 2015;29(12):4989\u20135005.","journal-title":"FASEB J"},{"issue":"16","key":"1593_CR3","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1128\/MCB.01403-10","volume":"31","author":"J Liu","year":"2011","unstructured":"Liu J, et al. Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis. Mol Cell Biol. 2011;31(16):3366\u201377.","journal-title":"Mol Cell Biol"},{"issue":"8","key":"1593_CR4","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/ncb0803-694","volume":"5","author":"DA Calderwood","year":"2003","unstructured":"Calderwood DA, Ginsberg MH. Talin forges the links between integrins and actin. Nat Cell Biol. 2003;5(8):694\u20137.","journal-title":"Nat Cell Biol"},{"issue":"5430","key":"1593_CR5","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1126\/science.285.5430.1028","volume":"285","author":"FG Giancotti","year":"1999","unstructured":"Giancotti FG, Ruoslahti E. Transduction\u2014Integrin signaling. Science. 1999;285(5430):1028\u201332.","journal-title":"Science"},{"key":"1593_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1351-5","author":"Y-F Xu","year":"2015","unstructured":"Xu Y-F, et al. High expression of Talin-1 is associated with poor prognosis in patients with nasopharyngeal carcinoma. BMC Cancer. 2015. https:\/\/doi.org\/10.1186\/s12885-015-1351-5.","journal-title":"BMC Cancer."},{"issue":"14","key":"1593_CR7","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1038\/onc.2014.116","volume":"34","author":"JK Jin","year":"2015","unstructured":"Jin JK, et al. Talin1 phosphorylation activates beta 1 integrins: a novel mechanism to promote prostate cancer bone metastasis. Oncogene. 2015;34(14):1811\u201321.","journal-title":"Oncogene"},{"issue":"29","key":"1593_CR8","doi-asserted-by":"publisher","first-page":"27239","DOI":"10.18632\/oncotarget.4835","volume":"6","author":"W Kang","year":"2015","unstructured":"Kang W, et al. Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme. Oncotarget. 2015;6(29):27239\u201351.","journal-title":"Oncotarget"},{"issue":"12","key":"1593_CR9","first-page":"3265","volume":"12","author":"J-L Zhang","year":"2011","unstructured":"Zhang J-L, et al. Talin1, a valuable marker for diagnosis and prognostic assessment of human hepatocelluar carcinomas. Asian Pac J Cancer Prev. 2011;12(12):3265\u20139.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"5","key":"1593_CR10","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1158\/0008-5472.CAN-09-2833","volume":"70","author":"S Sakamoto","year":"2010","unstructured":"Sakamoto S, et al. Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance. Can Res. 2010;70(5):1885\u201395.","journal-title":"Can Res"},{"issue":"10","key":"1593_CR11","doi-asserted-by":"publisher","first-page":"4715","DOI":"10.21873\/anticanres.15976","volume":"42","author":"J Huang","year":"2022","unstructured":"Huang J, et al. Micro RNA miR-1303 promotion of proliferation, migration and invasion of human liver cancer cells is enhanced by low talin 1 (TLN1) expression. Anticancer Res. 2022;42(10):4715\u201325.","journal-title":"Anticancer Res"},{"key":"1593_CR12","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev.biophys.050708.133744","volume":"38","author":"DR Critchley","year":"2009","unstructured":"Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys. 2009;38:235\u201354.","journal-title":"Annu Rev Biophys"},{"issue":"12","key":"1593_CR13","doi-asserted-by":"publisher","first-page":"8238","DOI":"10.1074\/jbc.M112.438119","volume":"288","author":"BT Goult","year":"2013","unstructured":"Goult BT, et al. RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. J Biol Chem. 2013;288(12):8238\u201349.","journal-title":"J Biol Chem"},{"key":"1593_CR14","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1242\/jcs.109.11.2715","volume":"109","author":"L Hemmings","year":"1996","unstructured":"Hemmings L, et al. Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site. J Cell Sci. 1996;109:2715\u201326.","journal-title":"J Cell Sci"},{"issue":"49","key":"1593_CR15","doi-asserted-by":"publisher","first-page":"15418","DOI":"10.1021\/bi0487239","volume":"43","author":"MA Senetar","year":"2004","unstructured":"Senetar MA, Foster SJ, McCann RO. Intrasteric inhibition mediates the interaction of the I\/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin. Biochemistry. 2004;43(49):15418\u201328.","journal-title":"Biochemistry"},{"issue":"11","key":"1593_CR16","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1073\/pnas.94.11.5679","volume":"94","author":"RO McCann","year":"1997","unstructured":"McCann RO, Craig SW. The I\/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals. Proc Natl Acad Sci USA. 1997;94(11):5679\u201384.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"1593_CR17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1006\/bbrc.1999.1776","volume":"266","author":"RO McCann","year":"1999","unstructured":"McCann RO, Craig SW. Functional genomic analysis reveals the utility of the I\/LWEQ module as a predictor of protein:actin interaction. Biochem Biophys Res Commun. 1999;266(1):135\u201340.","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"1593_CR18","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1002\/cm.20145","volume":"63","author":"SJ Franco","year":"2006","unstructured":"Franco SJ, et al. The conserved C-terminal I\/LWEQ module targets Talin1 to focal adhesions. CELL Motility Cytoskeleton. 2006;63(9):563\u201381.","journal-title":"CELL Motility Cytoskeleton"},{"issue":"1","key":"1593_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cell.2006.10.048","volume":"128","author":"KL Wegener","year":"2007","unstructured":"Wegener KL, et al. Structural basis of integrin activation by talin. Cell. 2007;128(1):171\u201382.","journal-title":"Cell"},{"issue":"1","key":"1593_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S1097-2765(02)00823-7","volume":"11","author":"B Garcia-Alvarez","year":"2003","unstructured":"Garcia-Alvarez B, et al. Structural determinants of integrin recognition by Talin. Mol Cell. 2003;11(1):49\u201358.","journal-title":"Mol Cell"},{"issue":"24","key":"1593_CR21","doi-asserted-by":"publisher","first-page":"21749","DOI":"10.1074\/jbc.M111996200","volume":"277","author":"DA Calderwood","year":"2002","unstructured":"Calderwood DA, et al. The phosphotyrosine binding-like domain of talin activates Integrins. J Biol Chem. 2002;277(24):21749\u201358.","journal-title":"J Biol Chem"},{"issue":"1","key":"1593_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.cell.2019.08.034","volume":"179","author":"D Dedden","year":"2019","unstructured":"Dedden D, et al. The architecture of talin1 reveals an autoinhibition mechanism. Cell. 2019;179(1):120.","journal-title":"Cell"},{"issue":"44","key":"1593_CR23","doi-asserted-by":"publisher","first-page":"37217","DOI":"10.1074\/jbc.M508060200","volume":"280","author":"AR Gingras","year":"2005","unstructured":"Gingras AR, et al. Mapping and consensus sequence identification for multiple vinculin binding sites within the Talin rod. J Biol Chem. 2005;280(44):37217\u201324.","journal-title":"J Biol Chem"},{"issue":"4","key":"1593_CR24","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1006\/jmbi.1994.1081","volume":"235","author":"AD McLachlan","year":"1994","unstructured":"McLachlan AD, et al. Analysis of repeated motifs in the talin rod. J Mol Biol. 1994;235(4):1278\u201390.","journal-title":"J Mol Biol"},{"issue":"6","key":"1593_CR25","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1083\/jcb.201810061","volume":"218","author":"AR Gingras","year":"2019","unstructured":"Gingras AR, et al. Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. J Cell Biol. 2019;218(6):1799\u2013809.","journal-title":"J Cell Biol"},{"issue":"6","key":"1593_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","volume":"110","author":"RO Hynes","year":"2002","unstructured":"Hynes RO. Integrins: Bidirectional, allosteric signaling machines. Cell. 2002;110(6):673\u201387.","journal-title":"Cell"},{"issue":"4","key":"1593_CR27","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/nrm2871","volume":"11","author":"SJ Shattil","year":"2010","unstructured":"Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 2010;11(4):288\u2013300.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"1593_CR28","doi-asserted-by":"publisher","first-page":"629","DOI":"10.15252\/embj.201695803","volume":"36","author":"J Li","year":"2017","unstructured":"Li J, et al. Conformational equilibria and intrinsic affinities define integrin activation. EMBO J. 2017;36(5):629\u201345.","journal-title":"EMBO J"},{"issue":"1","key":"1593_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41556-018-0234-9","volume":"21","author":"Z Sun","year":"2019","unstructured":"Sun Z, Costell M, Faessler R. Integrin activation by talin, kindlin and mechanical forces. Nat Cell Biol. 2019;21(1):25\u201331.","journal-title":"Nat Cell Biol"},{"issue":"26","key":"1593_CR30","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1182\/blood-2018-04-846766","volume":"132","author":"T Bromberger","year":"2018","unstructured":"Bromberger T, et al. Direct Rap1\/Talin1 interaction regulates platelet and neutrophil integrin activity in mice. Blood. 2018;132(26):2754\u201362.","journal-title":"Blood"},{"issue":"21","key":"1593_CR31","doi-asserted-by":"publisher","first-page":"3764","DOI":"10.1242\/jcs.205641","volume":"130","author":"J Gao","year":"2017","unstructured":"Gao J, et al. Kindlin supports platelet integrin alpha IIb beta 3 activation by interacting with paxillin. J Cell Sci. 2017;130(21):3764\u201375.","journal-title":"J Cell Sci"},{"issue":"13","key":"1593_CR32","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1084\/jem.20071827","volume":"204","author":"B Nieswandt","year":"2007","unstructured":"Nieswandt B, et al. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med. 2007;204(13):3113\u20138.","journal-title":"J Exp Med"},{"issue":"5","key":"1593_CR33","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1182\/blood-2010-09-305433","volume":"117","author":"JR Haling","year":"2011","unstructured":"Haling JR, et al. Talin-dependent integrin activation is required for fibrin clot retraction by platelets. Blood. 2011;117(5):1719\u201322.","journal-title":"Blood"},{"issue":"2","key":"1593_CR34","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1242\/jcs.018093","volume":"122","author":"DS Harburger","year":"2009","unstructured":"Harburger DS, Calderwood DA. Integrin signalling at a glance. J Cell Sci. 2009;122(2):159\u201363.","journal-title":"J Cell Sci"},{"key":"1593_CR35","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200454","author":"TCY Chau","year":"2022","unstructured":"Chau TCY, et al. Dynamically regulated focal adhesions coordinate endothelial cell remodelling in developing vasculature. Development. 2022. https:\/\/doi.org\/10.1242\/dev.200454.","journal-title":"Development"},{"issue":"6","key":"1593_CR36","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/emboj.2010.4","volume":"29","author":"BT Goult","year":"2010","unstructured":"Goult BT, et al. Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J. 2010;29(6):1069\u201380.","journal-title":"EMBO J"},{"issue":"11","key":"1593_CR37","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.1083\/jcb.201808061","volume":"217","author":"BT Goult","year":"2018","unstructured":"Goult BT, Yan J, Schwartz MA. Talin as a mechanosensitive signaling hub. J Cell Biol. 2018;217(11):3776\u201384.","journal-title":"J Cell Biol"},{"issue":"8","key":"1593_CR38","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nrm3624","volume":"14","author":"DA Calderwood","year":"2013","unstructured":"Calderwood DA, Campbell ID, Critchley DR. Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol. 2013;14(8):503\u201317.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"1593_CR39","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1083\/jcb.97.2.359","volume":"97","author":"K Burridge","year":"1983","unstructured":"Burridge K, Connell L. A new protein of adhesion plaques and ruffling membranes. J Cell Biol. 1983;97(2):359\u201367.","journal-title":"J Cell Biol"},{"issue":"5\u20136","key":"1593_CR40","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/cm.970030509","volume":"3","author":"K Burridge","year":"1983","unstructured":"Burridge K, Connell L. Talin: a cytoskeletal component concentrated in adhesion plaques and other sites of actin-membrane interaction. Cell Motil. 1983;3(5\u20136):405\u201317.","journal-title":"Cell Motil"},{"issue":"6062","key":"1593_CR41","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/320531a0","volume":"320","author":"A Horwitz","year":"1986","unstructured":"Horwitz A, et al. Interaction of plasma membrane fibronectin receptor with talin\u2013a transmembrane linkage. Nature. 1986;320(6062):531\u20133.","journal-title":"Nature"},{"issue":"4","key":"1593_CR42","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1083\/jcb.142.4.1121","volume":"142","author":"H Priddle","year":"1998","unstructured":"Priddle H, et al. Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells. J Cell Biol. 1998;142(4):1121\u201333.","journal-title":"J Cell Biol"},{"issue":"11","key":"1593_CR43","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1073\/pnas.94.11.5679","volume":"94","author":"RO McCann","year":"1997","unstructured":"McCann RO, Craig SW. The I\/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals. Proc Natl Acad Sci USA. 1997;94(11):5679\u201384.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"38","key":"1593_CR44","doi-asserted-by":"publisher","first-page":"10886","DOI":"10.1021\/bi700637a","volume":"46","author":"SJ Smith","year":"2007","unstructured":"Smith SJ, McCann RO. A C-terminal dimerization motif is required for focal adhesion targeting of Talin 1 and the interaction of the Talin 1 I\/LWEQ module with F-actin. Biochemistry. 2007;46(38):10886\u201398.","journal-title":"Biochemistry"},{"issue":"2","key":"1593_CR45","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/sj.emboj.7601965","volume":"27","author":"AR Gingras","year":"2008","unstructured":"Gingras AR, et al. The structure of the C-terminal actin-binding domain of talin. EMBO J. 2008;27(2):458\u201369.","journal-title":"EMBO J"},{"issue":"9","key":"1593_CR46","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ejcb.2010.05.003","volume":"89","author":"PM Kopp","year":"2010","unstructured":"Kopp PM, et al. Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1. Eur J Cell Biol. 2010;89(9):661\u201373.","journal-title":"Eur J Cell Biol"},{"issue":"5","key":"1593_CR47","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1083\/jcb.200703036","volume":"179","author":"JD Humphries","year":"2007","unstructured":"Humphries JD, et al. Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol. 2007;179(5):1043\u201357.","journal-title":"J Cell Biol"},{"issue":"6","key":"1593_CR48","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ejcb.2006.01.014","volume":"85","author":"RM Saunders","year":"2006","unstructured":"Saunders RM, et al. Role of vinculin in regulating focal adhesion turnover. Eur J Cell Biol. 2006;85(6):487\u2013500.","journal-title":"Eur J Cell Biol"},{"key":"1593_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16922-1","author":"C Vigouroux","year":"2020","unstructured":"Vigouroux C, Henriot V, Le Clainche C. Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force. Nature Commun. 2020. https:\/\/doi.org\/10.1038\/s41467-020-16922-1.","journal-title":"Nature Commun"},{"issue":"17","key":"1593_CR50","doi-asserted-by":"publisher","first-page":"13799","DOI":"10.1074\/jbc.M112.341214","volume":"287","author":"A Banno","year":"2012","unstructured":"Banno A, et al. Subcellular localization of talin is regulated by inter-domain interactions. J Biol Chem. 2012;287(17):13799\u2013812.","journal-title":"J Biol Chem"},{"issue":"22","key":"1593_CR51","doi-asserted-by":"publisher","first-page":"15097","DOI":"10.1074\/jbc.M900078200","volume":"284","author":"BT Goult","year":"2009","unstructured":"Goult BT, et al. The structure of an interdomain complex that regulates talin activity. J Biol Chem. 2009;284(22):15097\u2013106.","journal-title":"J Biol Chem"},{"issue":"1","key":"1593_CR52","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.molcel.2008.06.011","volume":"31","author":"E Goksoy","year":"2008","unstructured":"Goksoy E, et al. Structural basis for the autoinhibition of talin in regulating integrin activation. Mol Cell. 2008;31(1):124\u201333.","journal-title":"Mol Cell"},{"issue":"9","key":"1593_CR53","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.celrep.2018.10.098","volume":"25","author":"A Haage","year":"2018","unstructured":"Haage A, et al. Talin autoinhibition regulates cell-ECM adhesion dynamics and wound healing in vivo. Cell Rep. 2018;25(9):2401.","journal-title":"Cell Rep"},{"issue":"6","key":"1593_CR54","doi-asserted-by":"publisher","first-page":"703","DOI":"10.21873\/cgp.20353","volume":"19","author":"Z Fang","year":"2022","unstructured":"Fang Z, et al. Sex hormone-regulated CMG2 is involved in breast and prostate cancer progression. Cancer Genom Proteom. 2022;19(6):703\u201310.","journal-title":"Cancer Genom Proteom"},{"issue":"8","key":"1593_CR55","doi-asserted-by":"publisher","first-page":"e355","DOI":"10.1097\/MPH.0b013e318223d0dc","volume":"33","author":"YY Wang","year":"2011","unstructured":"Wang YY, et al. A novel splice site mutation in ANTXR2 (CMG2) gene results in systemic hyalinosis. J Pediatr Hematol Oncol. 2011;33(8):e355\u20137.","journal-title":"J Pediatr Hematol Oncol"},{"issue":"4","key":"1593_CR56","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000299R","volume":"35","author":"L Meng","year":"2021","unstructured":"Meng L, et al. Genetic deletion of CMG2 exacerbates systemic-to-pulmonary shunt-induced pulmonary arterial hypertension. Faseb J. 2021;35(4): e21421.","journal-title":"Faseb J"},{"issue":"2","key":"1593_CR57","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1021\/acschembio.0c00064","volume":"15","author":"JG Finnell","year":"2020","unstructured":"Finnell JG, et al. A canstatin-derived peptide provides insight into the role of capillary morphogenesis gene 2 in angiogenic regulation and matrix uptake. ACS Chem Biol. 2020;15(2):587\u201396.","journal-title":"ACS Chem Biol"},{"issue":"8","key":"1593_CR58","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3390\/cancers11081059","volume":"11","author":"T Greither","year":"2019","unstructured":"Greither T, et al. Increased soluble CMG2 serum protein concentration is associated with the progression of prostate carcinoma. Cancers. 2019;11(8):1059.","journal-title":"Cancers"},{"key":"1593_CR59","doi-asserted-by":"publisher","first-page":"15861","DOI":"10.1038\/ncomms15861","volume":"8","author":"J B\u00fcrgi","year":"2017","unstructured":"B\u00fcrgi J, et al. CMG2\/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome. Nat Commun. 2017;8:15861.","journal-title":"Nat Commun"},{"issue":"4","key":"1593_CR60","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1086\/378781","volume":"73","author":"O Dowling","year":"2003","unstructured":"Dowling O, et al. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003;73(4):957\u201366.","journal-title":"Am J Hum Genet"},{"issue":"4","key":"1593_CR61","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1086\/378418","volume":"73","author":"S Hanks","year":"2003","unstructured":"Hanks S, et al. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 2003;73(4):791\u2013800.","journal-title":"Am J Hum Genet"},{"issue":"4","key":"1593_CR62","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.devcel.2020.04.015","volume":"53","author":"J B\u00fcrgi","year":"2020","unstructured":"B\u00fcrgi J, et al. Ligand binding to the collagen vi receptor triggers A Talin-To-Rhoa switch that regulates receptor endocytosis. Dev Cell. 2020;53(4):418-430.e4.","journal-title":"Dev Cell"},{"issue":"8","key":"1593_CR63","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1080\/10428194.2017.1406089","volume":"59","author":"A Halder","year":"2018","unstructured":"Halder A, Nayak KB, Chakraborty S. Ecotopic viral integration site 1 (EVI1) transcriptionally targets talin1 (TLN1) and upregulates its expression in chronic myeloid leukemia. Leuk Lymphoma. 2018;59(8):2008\u201310.","journal-title":"Leuk Lymphoma"},{"issue":"42","key":"1593_CR64","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.1038\/onc.2014.108","volume":"33","author":"T Sato","year":"2014","unstructured":"Sato T, et al. Evil defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Oncogene. 2014;33(42):5028\u201338.","journal-title":"Oncogene"},{"issue":"1","key":"1593_CR65","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3390\/ijms18010221","volume":"18","author":"IR Lim","year":"2017","unstructured":"Lim IR, et al. Talin modulation by a synthetic N-acylurea derivative reduces angiogenesis in human endothelial cells. Int J Mol Sci. 2017;18(1):221.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1593_CR66","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/leu.2015.332","volume":"30","author":"M Martinez-Moreno","year":"2016","unstructured":"Martinez-Moreno M, et al. In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by alpha 4 beta 1 cytoplasmic-binding proteins. Leukemia. 2016;30(4):861\u201372.","journal-title":"Leukemia"},{"issue":"23","key":"1593_CR67","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","volume":"374","author":"E Papaemmanuil","year":"2016","unstructured":"Papaemmanuil E, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374(23):2209\u201321.","journal-title":"N Engl J Med"},{"issue":"9865","key":"1593_CR68","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/S0140-6736(12)61727-9","volume":"381","author":"F Ferrara","year":"2013","unstructured":"Ferrara F, Schiffer CA. Acute myeloid leukaemia in adults. Lancet. 2013;381(9865):484\u201395.","journal-title":"Lancet"},{"key":"1593_CR69","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10099-","author":"D Cui","year":"2022","unstructured":"Cui D, et al. Identification of TLN1 as a prognostic biomarker to effect cell proliferation and differentiation in acute myeloid leukemia. BMC Cancer. 2022. https:\/\/doi.org\/10.1186\/s12885-022-10099-.","journal-title":"BMC Cancer"},{"issue":"1","key":"1593_CR70","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ygyno.2003.12.039","volume":"93","author":"RG Moore","year":"2004","unstructured":"Moore RG, et al. Incidence of metastasis to the ovaries from nongenital tract primary tumors. Gynecol Oncol. 2004;93(1):87\u201391.","journal-title":"Gynecol Oncol"},{"issue":"5","key":"1593_CR71","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/PAP.0b013e3181b4fffa","volume":"16","author":"R Vang","year":"2009","unstructured":"Vang R, Shih I-M, Kurman RJ. Ovarian low-grade and high-grade serous carcinoma pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Adv Anat Pathol. 2009;16(5):267\u201382.","journal-title":"Adv Anat Pathol"},{"issue":"2","key":"1593_CR72","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3892\/ijmm.2013.1400","volume":"32","author":"H Tang","year":"2013","unstructured":"Tang H, et al. miR-9 functions as a tumor suppressor in ovarian serous carcinoma by targeting TLN1. Int J Mol Med. 2013;32(2):381\u20138.","journal-title":"Int J Mol Med"},{"issue":"1","key":"1593_CR73","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ejogrb.2012.06.031","volume":"165","author":"Y Huang","year":"2012","unstructured":"Huang Y, et al. Discovery of serum biomarkers implicated in the onset and progression of serous ovarian cancer in a rat model using iTRAQ technique. Eur J Obstetrics & Gynecol and Reproduct Biol. 2012;165(1):96\u2013103.","journal-title":"Eur J Obstetrics & Gynecol and Reproduct Biol"},{"issue":"3","key":"1593_CR74","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.ygyno.2014.03.564","volume":"133","author":"JK Chan","year":"2014","unstructured":"Chan JK, et al. MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer. Gynecol Oncol. 2014;133(3):568\u201374.","journal-title":"Gynecol Oncol"},{"issue":"24","key":"1593_CR75","doi-asserted-by":"publisher","first-page":"6433","DOI":"10.1158\/1078-0432.CCR-18-1727","volume":"24","author":"S Shelar","year":"2018","unstructured":"Shelar S, et al. Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer. Clin Cancer Res. 2018;24(24):6433\u201346.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"1593_CR76","doi-asserted-by":"publisher","first-page":"541","DOI":"10.7150\/jca.61437","volume":"13","author":"Y Ma","year":"2022","unstructured":"Ma Y, et al. CircRNA_400029 promotes the aggressive behaviors of cervical cancer by regulation of miR-1285-3p\/TLN1 axis. J Cancer. 2022;13(2):541\u201353.","journal-title":"J Cancer"},{"issue":"5","key":"1593_CR77","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/bjc.2014.350","volume":"111","author":"M Ong","year":"2014","unstructured":"Ong M, et al. Validation and utilisation of high-coverage next-generation sequencing to deliver the pharmacological audit trail. Br J Cancer. 2014;111(5):828\u201336.","journal-title":"Br J Cancer"},{"issue":"3","key":"1593_CR78","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S1470-2045(13)70611-9","volume":"15","author":"F Andre","year":"2014","unstructured":"Andre F, et al. Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01\/UNICANCER). Lancet Oncol. 2014;15(3):267\u201374.","journal-title":"Lancet Oncol"},{"issue":"5","key":"1593_CR79","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.3892\/ijo.2017.3919","volume":"50","author":"Y-S Chang","year":"2017","unstructured":"Chang Y-S, et al. Identification of novel mutations in endometrial cancer patients by whole-exome sequencing. Int J Oncol. 2017;50(5):1778\u201384.","journal-title":"Int J Oncol"},{"issue":"1","key":"1593_CR80","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2018. CA-A Cancer J Clin. 2018;68(1):7\u201330.","journal-title":"CA-A Cancer J Clin"},{"key":"1593_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/jcar.JCar_9_16","volume":"16","author":"YA Ghouri","year":"2017","unstructured":"Ghouri YA, Mian I, Rowe JH. Review of hepatocellular carcinoma: epidemiology, etiology, and carcinogenesis. J Carcinogen. 2017;16:1\u20131.","journal-title":"J Carcinogen"},{"key":"1593_CR82","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22239","author":"L Fu","year":"2018","unstructured":"Fu L, et al. Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance. J Clin Lab Anal. 2018. https:\/\/doi.org\/10.1002\/jcla.22239.","journal-title":"J Clin Lab Anal"},{"issue":"17","key":"1593_CR83","first-page":"1294","volume":"47","author":"H-M Xu","year":"2009","unstructured":"Xu H-M, Sun Z. The progress in early diagnosis and treatment of gastric cancer. Zhonghua wai ke za zhi. 2009;47(17):1294\u20137.","journal-title":"Zhonghua wai ke za zhi"},{"issue":"7","key":"1593_CR84","doi-asserted-by":"publisher","first-page":"68999","DOI":"10.1371\/journal.pone.0068999","volume":"8","author":"W-Q Li","year":"2013","unstructured":"Li W-Q, et al. Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a chinese population. PLOS ONE. 2013;8(7):68999.","journal-title":"PLOS ONE"},{"key":"1593_CR85","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23555","author":"H Yan","year":"2020","unstructured":"Yan H, et al. Promotive effect of Talin-1 protein on gastric cancer progression through PTK2-PXN-VCL-E-Cadherin-CAPN2-MAPK1 signaling axis. J Clin Lab Anal. 2020. https:\/\/doi.org\/10.1002\/jcla.23555.","journal-title":"J Clin Lab Anal"},{"issue":"8","key":"1593_CR86","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.tranon.2019.04.014","volume":"12","author":"S Meltzer","year":"2019","unstructured":"Meltzer S, et al. Circulating exosomal miR-141-3p and miR-375 in metastatic progression of rectal cancer. Trans Oncol. 2019;12(8):1038\u201344.","journal-title":"Trans Oncol"},{"issue":"1","key":"1593_CR87","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA-A Cancer J Clin. 2020;70(1):7\u201330.","journal-title":"CA-A Cancer J Clin"},{"issue":"17","key":"1593_CR88","first-page":"2533","volume":"18","author":"O Bostanci","year":"2014","unstructured":"Bostanci O, et al. A novel screening test for colon cancer: Talin-1. Eur Rev Med Pharmacol Sci. 2014;18(17):2533\u20137.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1593_CR89","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74810-6","author":"S Vafaei","year":"2020","unstructured":"Vafaei S, et al. Low expression of Talin1 is associated with advanced pathological features in colorectal cancer patients. Sci Rep. 2020. https:\/\/doi.org\/10.1038\/s41598-020-74810-6.","journal-title":"Sci Rep"},{"issue":"13","key":"1593_CR90","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1158\/0008-5472.CAN-16-1917","volume":"77","author":"J Barbazan","year":"2017","unstructured":"Barbazan J, et al. Liver metastasis is facilitated by the adherence of circulating tumor cells to vascular fibronectin deposits. Can Res. 2017;77(13):3431\u201341.","journal-title":"Can Res"},{"key":"1593_CR91","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201900017","author":"W Yang","year":"2019","unstructured":"Yang W, et al. Co-expression network analysis identified key proteins in association with hepatic metastatic colorectal cancer. Proteom Clin Appl. 2019. https:\/\/doi.org\/10.1002\/prca.201900017.","journal-title":"Proteom Clin Appl"},{"key":"1593_CR92","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221140683","author":"L Zhang","year":"2022","unstructured":"Zhang L, Qian Y. An epithelial-mesenchymal transition-related prognostic model for colorectal cancer based on weighted gene co-expression network analysis. J Int Med Res. 2022. https:\/\/doi.org\/10.1177\/03000605221140683.","journal-title":"J Int Med Res"},{"issue":"1","key":"1593_CR93","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA-A Cancer J Clin. 2019;69(1):7\u201334.","journal-title":"CA-A Cancer J Clin"},{"key":"1593_CR94","doi-asserted-by":"publisher","first-page":"11309","DOI":"10.2147\/CMAR.S256347","volume":"12","author":"S You","year":"2020","unstructured":"You S, et al. Tanshinone IIA suppresses glioma cell proliferation, migration and invasion both in vitro and in vivo partially through miR-16-5p\/Talin-1 (TLN1) Axis. Cancer Manage Res. 2020;12:11309\u201320.","journal-title":"Cancer Manage Res"},{"issue":"71","key":"1593_CR95","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1098\/rsif.2011.0567","volume":"9","author":"S Sen","year":"2012","unstructured":"Sen S, Ng WP, Kumar S. Contributions of talin-1 to glioma cell-matrix tensional homeostasis. J R Soc Interface. 2012;9(71):1311\u20137.","journal-title":"J R Soc Interface"},{"issue":"16","key":"1593_CR96","doi-asserted-by":"publisher","first-page":"9064","DOI":"10.1073\/pnas.1914505117","volume":"117","author":"D de Semir","year":"2020","unstructured":"de Semir D, et al. PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex. Proc Natl Acad Sci USA. 2020;117(16):9064\u201373.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"1593_CR97","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1007\/s00401-013-1218-2","volume":"127","author":"AM Saratsis","year":"2014","unstructured":"Saratsis AM, et al. Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes. Acta Neuropathol. 2014;127(6):881\u201395.","journal-title":"Acta Neuropathol"},{"issue":"8","key":"1593_CR98","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1002\/ijc.31937","volume":"144","author":"J Ferlay","year":"2019","unstructured":"Ferlay J, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941\u201353.","journal-title":"Int J Cancer"},{"key":"1593_CR99","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.9","author":"C Gridelli","year":"2015","unstructured":"Gridelli C, et al. Non-small-cell lung cancer. Nature Rev Dis Primers. 2015. https:\/\/doi.org\/10.1038\/nrdp.2015.9.","journal-title":"Nature Rev Dis Primers"},{"issue":"1","key":"1593_CR100","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.rcl.2013.08.006","volume":"52","author":"C Chiles","year":"2014","unstructured":"Chiles C. Lung cancer screening with low-dose computed tomography. Radiol Clin North Am. 2014;52(1):27.","journal-title":"Radiol Clin North Am"},{"key":"1593_CR101","doi-asserted-by":"publisher","first-page":"153321","DOI":"10.1016\/j.prp.2021.153551","volume":"224","author":"Y Wu","year":"2021","unstructured":"Wu Y, et al. Driver and novel genes correlated with metastasis of non-small cell lung cancer: a comprehensive analysis. Pathol Res Practice. 2021;224:153321.","journal-title":"Pathol Res Practice"},{"issue":"20","key":"1593_CR102","doi-asserted-by":"publisher","first-page":"6145","DOI":"10.3390\/molecules26206145","volume":"26","author":"SE Novikova","year":"2021","unstructured":"Novikova SE, et al. Proteomic signature of extracellular vesicles for lung cancer recognition. Molecules. 2021;26(20):6145.","journal-title":"Molecules"},{"issue":"4","key":"1593_CR103","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ng932","volume":"31","author":"BJ Feng","year":"2002","unstructured":"Feng BJ, et al. Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet. 2002;31(4):395\u20139.","journal-title":"Nat Genet"},{"issue":"1","key":"1593_CR104","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/annonc\/mdl320","volume":"18","author":"SHI Ou","year":"2007","unstructured":"Ou SHI, et al. Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. Ann Oncol. 2007;18(1):29\u201335.","journal-title":"Ann Oncol"},{"issue":"2","key":"1593_CR105","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10689-008-9213-9","volume":"8","author":"WT Ng","year":"2009","unstructured":"Ng WT, et al. Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening. Fam Cancer. 2009;8(2):103\u20138.","journal-title":"Fam Cancer"},{"issue":"4","key":"1593_CR106","first-page":"453","volume":"20","author":"P Busson","year":"2004","unstructured":"Busson P, Ooka T, Corbex M. Nasopharyngeal carcinomas and Epstein-Barr virus: from epidemiology and detection to therapy. M S-Med Sci. 2004;20(4):453\u20137.","journal-title":"M S-Med Sci"},{"key":"1593_CR107","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12935-019-0725-1","volume":"19","author":"Z Wang","year":"2019","unstructured":"Wang Z, et al. miR-429 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by downregulation of TLN1. Cancer Cell Int. 2019;19:10.","journal-title":"Cancer Cell Int"},{"issue":"11","key":"1593_CR108","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1056\/NEJMra0707975","volume":"359","author":"RI Haddad","year":"2008","unstructured":"Haddad RI, Shin DM. Recent advances in head and neck cancer. N Engl J Med. 2008;359(11):1143\u201354.","journal-title":"N Engl J Med"},{"issue":"4","key":"1593_CR109","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.path.2011.07.002","volume":"4","author":"JA Bishop","year":"2011","unstructured":"Bishop JA, Sciubba JJ, Westra WH. Squamous cell carcinoma of the oral cavity and oropharynx. Surg pathol Clin. 2011;4(4):1127\u201351.","journal-title":"Surg pathol Clin"},{"issue":"1","key":"1593_CR110","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1177\/154405910808700104","volume":"87","author":"S Choi","year":"2008","unstructured":"Choi S, Myers JN. Molecular pathogenesis of oral squamous cell carcinoma: Implications for therapy. J Dent Res. 2008;87(1):14\u201332.","journal-title":"J Dent Res"},{"issue":"5","key":"1593_CR111","doi-asserted-by":"publisher","first-page":"98208","DOI":"10.1371\/journal.pone.0098208","volume":"9","author":"DC Granato","year":"2014","unstructured":"Granato DC, et al. Integrated proteomics identified up-regulated focal adhesion-mediated proteins in human squamous cell carcinoma in an orthotopic murine model. PLOS ONE. 2014;9(5):98208.","journal-title":"PLOS ONE"},{"issue":"3","key":"1593_CR112","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1002\/path.2867","volume":"224","author":"M-T Lai","year":"2011","unstructured":"Lai M-T, et al. Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis. Journal of Pathology. 2011;224(3):367\u201376.","journal-title":"Journal of Pathology"},{"issue":"10","key":"1593_CR113","doi-asserted-by":"publisher","first-page":"955","DOI":"10.4161\/cbt.10.10.13879","volume":"10","author":"GK Malhotra","year":"2010","unstructured":"Malhotra GK, et al. Histological, molecular and functional subtypes of breast cancers. Cancer Biol Ther. 2010;10(10):955\u201360.","journal-title":"Cancer Biol Ther"},{"issue":"8","key":"1593_CR114","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1002\/ijc.32270","volume":"145","author":"JJ Arroyo-Crespo","year":"2019","unstructured":"Arroyo-Crespo JJ, et al. Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression. Int J Cancer. 2019;145(8):2267\u201381.","journal-title":"Int J Cancer"},{"issue":"4","key":"1593_CR115","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.cell.2018.03.041","volume":"173","author":"C Kim","year":"2018","unstructured":"Kim C, et al. Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing. Cell. 2018;173(4):879.","journal-title":"Cell."},{"key":"1593_CR116","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68481","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, et al. Binding blockade between TLN1 and integrin beta 1 represses triple-negative breast cancer. elife. 2022. https:\/\/doi.org\/10.7554\/eLife.68481.","journal-title":"elife"},{"issue":"7","key":"1593_CR117","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3390\/pharmaceutics11070309","volume":"11","author":"MA Ashaie","year":"2019","unstructured":"Ashaie MA, et al. Targeting cell adhesion molecules via carbonate apatite-mediated delivery of specific siRNAs to breast cancer cells in vitro and in vivo. Pharmaceutics. 2019;11(7):309.","journal-title":"Pharmaceutics"},{"issue":"8","key":"1593_CR118","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1158\/1078-0432.CCR-13-0082","volume":"19","author":"SM Singel","year":"2013","unstructured":"Singel SM, et al. A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clin Cancer Res. 2013;19(8):2061\u201370.","journal-title":"Clin Cancer Res"},{"issue":"10013","key":"1593_CR119","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S0140-6736(14)61947-4","volume":"387","author":"G Attard","year":"2016","unstructured":"Attard G, et al. Prostate cancer. Lancet. 2016;387(10013):70\u201382.","journal-title":"Lancet"},{"key":"1593_CR120","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-015-0189-x","author":"W Zhang","year":"2015","unstructured":"Zhang W, et al. MiR-124 suppresses cell motility and adhesion by targeting talin 1 in prostate cancer cells. Cancer Cell Int. 2015. https:\/\/doi.org\/10.1186\/s12935-015-0189-x.","journal-title":"Cancer Cell Int"},{"issue":"29","key":"1593_CR121","doi-asserted-by":"publisher","first-page":"4326","DOI":"10.1097\/MD.0000000000004326","volume":"95","author":"N Xu","year":"2016","unstructured":"Xu N, et al. Upregulation of Talin-1 expression associates with advanced pathological features and predicts lymph node metastases and biochemical recurrence of prostate cancer. Medicine. 2016;95(29):4326.","journal-title":"Medicine"},{"issue":"5\u20136","key":"1593_CR122","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.cca.2011.11.027","volume":"413","author":"DJ O'Rourke","year":"2012","unstructured":"O\u2019Rourke DJ, et al. Autoantibody signatures as biomarkers to distinguish prostate cancer from benign prostatic hyperplasia in patients with increased serum prostate specific antigen. Clin Chim Acta. 2012;413(5\u20136):561\u20137.","journal-title":"Clin Chim Acta"},{"issue":"3","key":"1593_CR123","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1245\/s10434-009-0825-6","volume":"17","author":"WH Cho","year":"2010","unstructured":"Cho WH, et al. Differential presentations, clinical courses, and survivals of osteosarcomas of the proximal humerus over other extremity locations. Ann Surg Oncol. 2010;17(3):702\u20138.","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"1593_CR124","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/pbc.22567","volume":"55","author":"ME Abate","year":"2010","unstructured":"Abate ME, et al. Non-metastatic osteosarcoma of the extremities in children aged 5 years or younger. Pediatr Blood Cancer. 2010;55(4):652\u20134.","journal-title":"Pediatr Blood Cancer"},{"issue":"10","key":"1593_CR125","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1200\/JCO.2003.08.132","volume":"21","author":"L Kager","year":"2003","unstructured":"Kager L, et al. Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 2003;21(10):2011\u20138.","journal-title":"J Clin Oncol"},{"issue":"13","key":"1593_CR126","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1016\/j.ejca.2009.03.005","volume":"45","author":"EE Pakos","year":"2009","unstructured":"Pakos EE, et al. Prognostic factors and outcomes for osteosarcoma: an international collaboration. Eur J Cancer. 2009;45(13):2367\u201375.","journal-title":"Eur J Cancer"},{"issue":"7","key":"1593_CR127","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.1074\/jbc.M111.287771","volume":"287","author":"M van der Deen","year":"2012","unstructured":"van der Deen M, et al. Genomic promoter occupancy of runt-related transcription factor runx2 in osteosarcoma cells identifies genes involved in cell adhesion and motility. J Biol Chem. 2012;287(7):4503\u201317.","journal-title":"J Biol Chem"},{"issue":"5","key":"1593_CR128","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1242\/jcs.01014","volume":"117","author":"DA Calderwood","year":"2004","unstructured":"Calderwood DA. Integrin activation. J Cell Sci. 2004;117(5):657\u201366.","journal-title":"J Cell Sci"},{"issue":"2","key":"1593_CR129","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.tcb.2003.12.009","volume":"14","author":"EJ Cram","year":"2004","unstructured":"Cram EJ, Schwarzbauer JE. The talin wags the dog: new insights into integrin activation. Trends Cell Biol. 2004;14(2):55\u20137.","journal-title":"Trends Cell Biol"},{"issue":"8","key":"1593_CR130","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1111\/j.1538-7836.2005.01362.x","volume":"3","author":"BI Ratnikov","year":"2005","unstructured":"Ratnikov BI, Partridge AW, Ginsberg MH. Integrin activation by talin. Journal Thrombosis Haemostasis. 2005;3(8):1783\u201390.","journal-title":"Journal Thrombosis Haemostasis"},{"issue":"8","key":"1593_CR131","doi-asserted-by":"publisher","first-page":"e005959","DOI":"10.1101\/cshperspect.a005959","volume":"7","author":"P Devreotes","year":"2015","unstructured":"Devreotes P, Horwitz AR. Signaling networks that regulate cell migration. Cold Spring Harbor Perspect Biol. 2015;7(8):e005959.","journal-title":"Cold Spring Harbor Perspect Biol"},{"issue":"9","key":"1593_CR132","doi-asserted-by":"publisher","first-page":"e005074","DOI":"10.1101\/cshperspect.a005074","volume":"3","author":"A Huttenlocher","year":"2011","unstructured":"Huttenlocher A, Horwitz AR. Integrins in cell migration. Cold Spring Harbor Perspect Biol. 2011;3(9):e005074.","journal-title":"Cold Spring Harbor Perspect Biol"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-024-01593-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-024-01593-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-024-01593-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T12:28:38Z","timestamp":1732624118000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-024-01593-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":132,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1593"],"URL":"https:\/\/doi.org\/10.1007\/s12672-024-01593-x","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]},"assertion":[{"value":"14 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"716"}}