{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:23:09Z","timestamp":1739424189698,"version":"3.37.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-01941-5","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T15:00:41Z","timestamp":1739372441000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary capicua transcriptional repressor-rearranged sarcoma in the thyroid gland with cervical lymph node and lung metastases: a case report and literature review"],"prefix":"10.1007","volume":"16","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WangWang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"1941_CR1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1097\/PAS.0000000000001552","volume":"45","author":"ME Kallen","year":"2021","unstructured":"Kallen ME, Hornick JL. The 2020 WHO classification: what\u2019s new in soft tissue tumor pathology? Am J Surg Pathol. 2021;45:e1-23. https:\/\/doi.org\/10.1097\/PAS.0000000000001552.","journal-title":"Am J Surg Pathol"},{"key":"1941_CR2","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1093\/hmg\/ddl136","volume":"15","author":"M Kawamura-Saito","year":"2006","unstructured":"Kawamura-Saito M, Yamazaki Y, Kaneko K, Kawaguchi N, Kanda H, Mukai H, Gotoh T, Motoi T, Fukayama M, Aburatani H, Takizawa T, Nakamura T. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet. 2006;15:2125\u201337. https:\/\/doi.org\/10.1093\/hmg\/ddl136.","journal-title":"Hum Mol Genet"},{"key":"1941_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/gcc.20945","volume":"51","author":"A Italiano","year":"2012","unstructured":"Italiano A, Sung YS, Zhang L, Singer S, Maki RG, Coindre JM, Antonescu CR. High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. Genes Chromosomes Cancer. 2012;51:207\u201318. https:\/\/doi.org\/10.1002\/gcc.20945.","journal-title":"Genes Chromosomes Cancer"},{"key":"1941_CR4","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1097\/PAS.0000000000000846","volume":"41","author":"CR Antonescu","year":"2017","unstructured":"Antonescu CR, Owosho AA, Zhang L, Chen S, Deniz K, Huryn JM, Kao YC, Huang SC, Singer S, Tap W, Schaefer IM, Fletcher CD. Sarcomas with CIC-rearrangements are a distinct pathologic entity with aggressive outcome: a clinicopathologic and molecular study of 115 cases. Am J Surg Pathol. 2017;41:941\u20139. https:\/\/doi.org\/10.1097\/PAS.0000000000000846.","journal-title":"Am J Surg Pathol"},{"key":"1941_CR5","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.prp.2017.06.008","volume":"213","author":"Y Tsukamoto","year":"2017","unstructured":"Tsukamoto Y, Futani H, Yoshiya S, Watanabe T, Kihara T, Matsuo S, Hirota S. Primary undifferentiated small round cell sarcoma of the deep abdominal wall with a novel variant of t(10;19) CIC-DUX4 gene fusion. Pathol Res Pract. 2017;213:1315\u201321. https:\/\/doi.org\/10.1016\/j.prp.2017.06.008.","journal-title":"Pathol Res Pract"},{"key":"1941_CR6","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1186\/s13104-017-2906-0","volume":"10","author":"H Maghrebi","year":"2017","unstructured":"Maghrebi H, Batti R, Zehani A, Chrait N, Rais H, Makni A, Haddad A, Ayadi M, Daghfous A, Jrad M, Kchir N, Bensafta Z, Mezlini A. Round cell sarcoma of the colon with CIC rearrangement. BMC Res Notes. 2017;10:582. https:\/\/doi.org\/10.1186\/s13104-017-2906-0.","journal-title":"BMC Res Notes"},{"key":"1941_CR7","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1097\/PAS.0000000000000335","volume":"38","author":"DA Solomon","year":"2014","unstructured":"Solomon DA, Brohl AS, Khan J, Miettinen M. Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion. Am J Surg Pathol. 2014;38:1724\u20135. https:\/\/doi.org\/10.1097\/PAS.0000000000000335.","journal-title":"Am J Surg Pathol"},{"key":"1941_CR8","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1097\/PAS.0000000000001098","volume":"42","author":"S Mangray","year":"2018","unstructured":"Mangray S, Kelly DR, LeGuellec S, Fridman E, Aggarwal S, Shago M, Matoso A, Madison R, Pramanik S, Zhong S, Li R, Lombardo KA, Cramer S, Pressey J, Ross JS, Corona RJ, Bratslavsky G, Argani P, Coindre JM, Somers GR, Ali SM, Yakirevich E. Clinicopathologic features of a series of primary renal CIC-rearranged sarcomas with comprehensive molecular analysis. Am J Surg Pathol. 2018;42:1360\u20139. https:\/\/doi.org\/10.1097\/PAS.0000000000001098.","journal-title":"Am J Surg Pathol"},{"key":"1941_CR9","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s12105-017-0808-z","volume":"11","author":"AA Owosho","year":"2017","unstructured":"Owosho AA, Estilo CL, Huryn JM, Zhang L, Fletcher CDM, Antonescu CR. Head and neck round cell sarcomas: a comparative clinicopathologic analysis of 2 molecular subsets: Ewing and CIC-rearranged sarcomas. Head Neck Pathol. 2017;11:450\u20139. https:\/\/doi.org\/10.1007\/s12105-017-0808-z.","journal-title":"Head Neck Pathol"},{"key":"1941_CR10","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1002\/dc.23520","volume":"44","author":"M Ito","year":"2016","unstructured":"Ito M, Ishikawa M, Kitajima M, Narita J, Hattori S, Endo O, Goto K. A case report of CIC-rearranged undifferentiated small round cell sarcoma in the cerebrum. Diagn Cytopathol. 2016;44:828\u201332. https:\/\/doi.org\/10.1002\/dc.23520.","journal-title":"Diagn Cytopathol"},{"key":"1941_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00428-018-2471-5","volume":"474","author":"F Bremmer","year":"2019","unstructured":"Bremmer F, Fichtner A, Triefenbach R, Inniger R, Mayer P, Lukat L, Str\u00f6bel P, Schildhaus HU. CIC fusion-positive sarcoma of the spermatic cord. Virchows Arch. 2019;474:253\u20137. https:\/\/doi.org\/10.1007\/s00428-018-2471-5.","journal-title":"Virchows Arch"},{"key":"1941_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsc.2022.102559","volume":"89","author":"M Marchese","year":"2023","unstructured":"Marchese M, Hafezi N, Jabiev A, Jawale R, Tashjian DB. CIC-rearranged round cell sarcoma presenting as a neck mass: a rare case in a pediatric patient. J Pediatr Surg Case Rep. 2023;89: 102559. https:\/\/doi.org\/10.1016\/j.epsc.2022.102559.","journal-title":"J Pediatr Surg Case Rep"},{"key":"1941_CR13","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1097\/PAS.0000000000000570","volume":"40","author":"A Yoshida","year":"2016","unstructured":"Yoshida A, Goto K, Kodaira M, Kobayashi E, Kawamoto H, Mori T, Yoshimoto S, Endo O, Kodama N, Kushima R, Hiraoka N, Motoi T, Kawai A. CIC-rearranged sarcomas: a study of 20 cases and comparisons with Ewing sarcomas. Am J Surg Pathol. 2016;40:313\u201323. https:\/\/doi.org\/10.1097\/PAS.0000000000000570.","journal-title":"Am J Surg Pathol"},{"key":"1941_CR14","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/his.12985","volume":"69","author":"M Gambarotti","year":"2016","unstructured":"Gambarotti M, Benini S, Gamberi G, Cocchi S, Palmerini E, Sbaraglia M, Donati D, Picci P, Vanel D, Ferrari S, Righi A, Dei Tos AP. CIC-DUX4 fusion-positive round-cell sarcomas of soft tissue and bone: a single-institution morphological and molecular analysis of seven cases. Histopathology. 2016;69:624\u201334. https:\/\/doi.org\/10.1111\/his.12985.","journal-title":"Histopathology"},{"issue":"2","key":"1941_CR15","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.humpath.2011.04.023","volume":"43","author":"C Graham","year":"2011","unstructured":"Graham C, Chilton-MacNeill S, Zielenska M, Somers GR. The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas. Hum Pathol. 2011;43(2):180\u20139. https:\/\/doi.org\/10.1016\/j.humpath.2011.04.023.","journal-title":"Hum Pathol"},{"key":"1941_CR16","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1002\/dc.24027","volume":"46","author":"S Tang","year":"2018","unstructured":"Tang S, Dodd LG. CIC-DUX4 sarcoma diagnosed by fine-needle aspiration cytology: a case report. Diagn Cytopathol. 2018;46:958\u201363. https:\/\/doi.org\/10.1002\/dc.24027.","journal-title":"Diagn Cytopathol"},{"key":"1941_CR17","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/cyt.12903","volume":"32","author":"B Rekhi","year":"2021","unstructured":"Rekhi B, Kembhavi P, Mishra SN. Cytomorphological features and literature review of CIC- DUX4-positive sarcoma, confirmed by reverse transcription polymerase chain reaction in a paediatric patient. Cytopathology. 2021;32:120\u20136. https:\/\/doi.org\/10.1111\/cyt.12903.","journal-title":"Cytopathology"},{"issue":"04","key":"1941_CR18","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/ped4.12264","volume":"5","author":"M Zhang","year":"2021","unstructured":"Zhang M, Yang Y, Guan X, et al. Primary cardiac CIC-rearranged undifferentiated sarcoma in an infant. Pediatric Investigation. 2021;5(04):313\u20137. https:\/\/doi.org\/10.1002\/ped4.12264.","journal-title":"Pediatric Investigation"},{"key":"1941_CR19","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/PAS.0000000000001187","volume":"43","author":"F Le Loarer","year":"2019","unstructured":"Le Loarer F, Pissaloux D, Watson S, Godfraind C, Galmiche-Rolland L, Silva K, Mayeur L, Italiano A, Michot A, Pierron G, Vasiljevic A, Ranch\u00e8re- Vince D, Coindre JM, Tirode F. Clinicopathologic features of CIC-NUTM1 sarcomas, a new molecular variant of the family of CIC-fused sarcomas. Am J Surg Pathol. 2019;43:268\u201376. https:\/\/doi.org\/10.1097\/PAS.0000000000001187.","journal-title":"Am J Surg Pathol"},{"key":"1941_CR20","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.pathol.2019.09.015","volume":"52","author":"I Br\u010di\u0107","year":"2020","unstructured":"Br\u010di\u0107 I, Brodowicz T, Cerroni L, Kashofer K, Serbanescu GL, Kasseroler MT, Amann G, Scheipl S, Szkandera J, Leithner A, Liegl-Atzwanger B. Undifferentiated round cell sarcomas with CIC-DUX4 gene fusion: expanding the clinical spectrum. Pathology. 2020;52:236\u201342. https:\/\/doi.org\/10.1016\/j.pathol.2019.09.015.","journal-title":"Pathology"},{"key":"1941_CR21","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/modpathol.2016.140","volume":"29","author":"YP Hung","year":"2016","unstructured":"Hung YP, Fletcher CD, Hornick JL. Evaluation of ETV4 and WT1 expression in CIC-rearranged sarcomas and histologic mimics. Mod Pathol. 2016;29:1324\u201334. https:\/\/doi.org\/10.1038\/modpathol.2016.140.","journal-title":"Mod Pathol"},{"key":"1941_CR22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00428-017-2072-8","volume":"470","author":"Y Yamada","year":"2017","unstructured":"Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y. Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes. Virchows Arch. 2017;470:373\u201380. https:\/\/doi.org\/10.1007\/s00428-017-2072-8.","journal-title":"Virchows Arch"},{"key":"1941_CR23","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1158\/0008-5472.CAN-16-3351","volume":"77","author":"T Yoshimoto","year":"2017","unstructured":"Yoshimoto T, Tanaka M, Homme M, Yamazaki Y, Takazawa Y, Antonescu CR, Nakamura T. CIC-DUX4 induces small round cell sarcomas distinct from Ewing sarcoma. Cancer Res. 2017;77:2927\u201337. https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-3351.","journal-title":"Cancer Res"},{"key":"1941_CR24","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.humpath.2017.01.012","volume":"65","author":"S Sugita","year":"2017","unstructured":"Sugita S, Arai Y, Aoyama T, Asanuma H, Mukai W, Hama N, Emori M, Shibata T, Hasegawa T. NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma. Hum Pathol. 2017;65:225\u201330. https:\/\/doi.org\/10.1016\/j.humpath.2017.01.012.","journal-title":"Hum Pathol"},{"key":"1941_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/his.14547","volume":"80","author":"F Le Loarer","year":"2022","unstructured":"Le Loarer F, Baud J, Azmani R, Michot A, Karanian M, Pissaloux D. Advances in the classification of round cell sarcomas. Histopathology. 2022;80:33\u201353. https:\/\/doi.org\/10.1111\/his.14547.","journal-title":"Histopathology"},{"issue":"8","key":"1941_CR26","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1056\/NEJMoa020890","volume":"348","author":"HE Grier","year":"2003","unstructured":"Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing\u2019s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003;348(8):694\u2013701. https:\/\/doi.org\/10.1056\/NEJMoa020890.","journal-title":"N Engl J Med"},{"key":"1941_CR27","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1002\/cam4.4580","volume":"11","author":"EA Connolly","year":"2022","unstructured":"Connolly EA, Bhadri VA, Wake J, Ingley KM, Lewin J, Bae S, Wong DD, Long AP, Pryor D, Thompson SR, Strach MC, Grimison PS, Mahar A, Bonar F, Maclean F, Hong A. Systemic treatments and outcomes in CIC-rearranged sarcoma: a national multi-centre clinicopathological series and literature review. Cancer Med. 2022;11:1805\u201316. https:\/\/doi.org\/10.1002\/cam4.4580.","journal-title":"Cancer Med"},{"key":"1941_CR28","doi-asserted-by":"publisher","first-page":"4712","DOI":"10.1038\/s41598-017-04967-0","volume":"7","author":"R Oyama","year":"2017","unstructured":"Oyama R, Takahashi M, Yoshida A, Sakumoto M, Takai Y, Kito F, Shiozawa K, Qiao Z, Arai Y, Shibata T, Araki Y, Endo M, Kawai A, Kondo T. Generation of novel patient-derived CIC-DUX4 sarcoma xenografts and cell lines. Sci Rep. 2017;7:4712. https:\/\/doi.org\/10.1038\/s41598-017-04967-0.","journal-title":"Sci Rep"},{"issue":"6","key":"1941_CR29","doi-asserted-by":"publisher","first-page":"735","DOI":"10.5858\/ARPA.2021-0153-OA","volume":"46","author":"S Yang","year":"2021","unstructured":"Yang S, Liu L, Yan Y, Jiang L, Han S, Shen D, Zhang B. CIC-NUTM1 sarcomas affecting the spine: a subset of CIC-rearranged sarcomas commonly present in the axial skeleton. Arch Pathol Lab Med. 2021;46(6):735\u201341. https:\/\/doi.org\/10.5858\/ARPA.2021-0153-OA.","journal-title":"Arch Pathol Lab Med"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-01941-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-01941-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-01941-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T15:00:43Z","timestamp":1739372443000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-01941-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1941"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-01941-5","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,12]]},"assertion":[{"value":"12 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Shaoxing People\u2019s Hospital (No. 2024\u2013004). The patient has consented to the submission of the case report for submission to the journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in Figs. , a, 2b, 2c, a, 3b, , and .","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"170"}}