{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:43:11Z","timestamp":1793763791135,"version":"4.6.1"},"reference-count":124,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-01958-w","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T01:23:16Z","timestamp":1739582596000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Diffuse large B cell lymphoma (DLBCL): epidemiology, pathophysiology, risk stratification, advancement in diagnostic approaches and prospects: narrative review"],"prefix":"10.1007","volume":"16","author":[{"given":"Ayenew","family":"Berhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andargachew","family":"Almaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shewaneh","family":"Damtie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenealem","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"key":"1958_CR1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"SH Swerdlow","year":"2017","unstructured":"Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC; 2017.","edition":"4"},{"issue":"7","key":"1958_CR2","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, et al. The 5th editon of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022;36(7):1720\u201348.","journal-title":"Leukemia"},{"issue":"20","key":"1958_CR3","first-page":"2375","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood, J Am Soc Hematol. 2016;127(20):2375\u201390.","journal-title":"Blood, J Am Soc Hematol"},{"issue":"6769","key":"1958_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/35000501","volume":"403","author":"AA Alizadeh","year":"2000","unstructured":"Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403(6769):503\u201311.","journal-title":"Nature"},{"issue":"25","key":"1958_CR5","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1056\/NEJMoa012914","volume":"346","author":"A Rosenwald","year":"2002","unstructured":"Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(25):1937\u201347.","journal-title":"N Engl J Med"},{"key":"1958_CR6","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.01.008","author":"RM Young","year":"2015","unstructured":"Young RM, Shaffer AL III, Phelan JD, Staudt LM. B-cell receptor signaling in diffuse large B-cell lymphoma. Semin Hematol. 2015. https:\/\/doi.org\/10.1053\/j.seminhematol.2015.01.008.","journal-title":"Semin Hematol"},{"issue":"7277","key":"1958_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature08638","volume":"463","author":"RE Davis","year":"2010","unstructured":"Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010;463(7277):88\u201392.","journal-title":"Nature"},{"issue":"15","key":"1958_CR8","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1056\/NEJMra0807082","volume":"362","author":"G Lenz","year":"2010","unstructured":"Lenz G, Staudt LM. Aggressive lymphomas. N Engl J Med. 2010;362(15):1417\u201329.","journal-title":"N Engl J Med"},{"issue":"17","key":"1958_CR9","doi-asserted-by":"publisher","first-page":"9991","DOI":"10.1073\/pnas.1732008100","volume":"100","author":"G Wright","year":"2003","unstructured":"Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci. 2003;100(17):9991\u20136.","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"1958_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11864-018-0555-8","volume":"19","author":"TA Ollila","year":"2018","unstructured":"Ollila TA, Olszewski AJ. Extranodal diffuse large B cell lymphoma: molecular features, prognosis, and risk of central nervous system recurrence. Curr Treat Options Oncol. 2018;19(8):1\u201320.","journal-title":"Curr Treat Options Oncol"},{"issue":"12","key":"1958_CR11","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.3324\/haematol.2011.050617","volume":"96","author":"S Mareschal","year":"2011","unstructured":"Mareschal S, Lanic H, Ruminy P, Bastard C, Tilly H, Jardin F. The proportion of activated B-cell like subtype among de novo diffuse large B-cell lymphoma increases with age. Haematologica. 2011;96(12):1888.","journal-title":"Haematologica"},{"issue":"5","key":"1958_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41591-018-0016-8","volume":"24","author":"B Chapuy","year":"2018","unstructured":"Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018;24(5):679\u201390.","journal-title":"Nat Med"},{"issue":"4","key":"1958_CR13","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.ccell.2020.03.015","volume":"37","author":"GW Wright","year":"2020","unstructured":"Wright GW, Phelan JD, Coulibaly ZA, Roulland S, Young RM, Wang JQ, et al. A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications. Cancer Cell. 2020;37(4):551\u201368.","journal-title":"Cancer Cell"},{"issue":"20","key":"1958_CR14","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1182\/blood.2019003535","volume":"135","author":"SE Lacy","year":"2020","unstructured":"Lacy SE, Barrans SL, Beer PA, Painter D, Smith AG, Roman E, et al. Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a haematological malignancy research network report. Blood. 2020;135(20):1759\u201371.","journal-title":"Blood"},{"key":"1958_CR15","unstructured":"World Health Organization (WHO) international research on cancer. GLOBOCAN. Non-Hodgkins lymphoma fact sheet. 2020. Accessed in August 2022. Available from: http:\/\/gco.iarc.fr\/today\/home"},{"key":"1958_CR16","volume-title":"Pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"World Health Organization","year":"2001","unstructured":"World Health Organization. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: International Agency for Research on Cancer; 2001."},{"issue":"1","key":"1958_CR17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1080\/10428194.2021.1975188","volume":"63","author":"G Kanas","year":"2022","unstructured":"Kanas G, Ge W, Quek RG, Keeven K, Nersesyan K, Arnason JE. Epidemiology of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in the United States and Western Europe: population-level projections for 2020\u20132025. Leuk Lymphoma. 2022;63(1):54\u201363.","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"1958_CR18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.12968\/indn.2022.1.14","volume":"2022","author":"GF Cope","year":"2022","unstructured":"Cope GF, Bloodworth C. Diffuse large B cell lymphoma\u2013an increasingly common disorder. Indep Nurse. 2022;2022(1):14\u20137.","journal-title":"Indep Nurse"},{"key":"1958_CR19","unstructured":"Saudi Cancer Registry. Cancer Incidence Report in Saudi Arabia 2015. Riyadh (KSA): Saudi Cancer Registry; 2018."},{"issue":"2","key":"1958_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00277-015-2543-4","volume":"95","author":"AM Perry","year":"2016","unstructured":"Perry AM, Diebold J, Nathwani BN, MacLennan KA, M\u00fcller-Hermelink HK, Bast M, et al. Non-Hodgkin lymphoma in the Far East: review of 730 cases from the international non-Hodgkin lymphoma classification project. Ann Hematol. 2016;95(2):245\u201351.","journal-title":"Ann Hematol"},{"issue":"1","key":"1958_CR21","doi-asserted-by":"publisher","first-page":"28","DOI":"10.14740\/wjon1351","volume":"12","author":"E Hernandez-Ruiz","year":"2021","unstructured":"Hernandez-Ruiz E, Alvarado-Ibarra M, Lien-Chang LEJ, Banda-Garcia L, Aquino-Salgado JL, Barragan-Ibanez G, et al. Epidemiology and clinical characteristics of Non-Hodgkin lymphoma in Mexico. World J Oncol. 2021;12(1):28.","journal-title":"World J Oncol"},{"issue":"10","key":"1958_CR22","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.3324\/haematol.2016.148809","volume":"101","author":"AM Perry","year":"2016","unstructured":"Perry AM, Diebold J, Nathwani BN, MacLennan KA, M\u00fcller-Hermelink HK, Bast M, et al. Non-Hodgkin lymphoma in the developing world: review of 4539 cases from the International Non-Hodgkin lymphoma classification project. Haematologica. 2016;101(10):1244.","journal-title":"Haematologica"},{"issue":"22","key":"1958_CR23","doi-asserted-by":"publisher","first-page":"5403","DOI":"10.1182\/blood.V128.22.5403.5403","volume":"128","author":"S Hamdi","year":"2016","unstructured":"Hamdi S, Bentahar I, Harbadji H, Grifi F, Bougherira S, Filali T, et al. Epidemiology of extranodal diffuse large B cell lymphomas in algeria: a study of the algerian group of extranodal lymphomas (GALEG). Blood. 2016;128(22):5403.","journal-title":"Blood"},{"issue":"5","key":"1958_CR24","first-page":"2513","volume":"17","author":"A Benhassine","year":"2016","unstructured":"Benhassine A, Khadhra HB, Khiari H, Hsairi M, Elgaaied AB. Incidence trend for Non-Hodgkin lymphoma in the North Tunisian population, 1998\u20132009. Asian Pac J Cancer Prev: APJCP. 2016;17(5):2513\u20138.","journal-title":"Asian Pac J Cancer Prev: APJCP"},{"issue":"1","key":"1958_CR25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s41043-021-00261-y","volume":"40","author":"P Polepole","year":"2021","unstructured":"Polepole P, Mudenda VC, Munsaka SM, Zhang L. Spectrum of common Hodgkin lymphoma and non-Hodgkin lymphomas subtypes in Zambia: a 3-year records review. J Health Popul Nutr. 2021;40(1):37.","journal-title":"J Health Popul Nutr"},{"issue":"5","key":"1958_CR26","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1111\/bjh.13885","volume":"172","author":"AM Perry","year":"2016","unstructured":"Perry AM, Perner Y, Diebold J, Nathwani BN, MacLennan KA, M\u00fcller-Hermelink HK, et al. Non-Hodgkin lymphoma in Southern Africa: review of 487 cases from the international Non-Hodgkin lymphoma classification project. Br J Haematol. 2016;172(5):716\u201323.","journal-title":"Br J Haematol"},{"issue":"2","key":"1958_CR27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.critrevonc.2012.12.009","volume":"87","author":"M Martelli","year":"2013","unstructured":"Martelli M, Ferreri AJ, Agostinelli C, Di Rocco A, Pfreundschuh M, Pileri SA. Diffuse large B-cell lymphoma. Crit Rev Oncol Hematol. 2013;87(2):146\u201371.","journal-title":"Crit Rev Oncol Hematol"},{"key":"1958_CR28","unstructured":"National Cancer Institute. Surveillance, Epidemiology, and End Results (SEER) Program. seer.cancer.gov. Released Apr 2020, based on the Nov 2019 submission (1975\u20132017). Accessed August 2022."},{"key":"1958_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/medsci9010005","author":"KC Thandra","year":"2021","unstructured":"Thandra KC, Barsouk A, Saginala K, Padala SA. Epidemiology of Non-Hodgkin\u2019s lymphoma. Med Sci. 2021. https:\/\/doi.org\/10.3390\/medsci9010005.","journal-title":"Med Sci"},{"issue":"4","key":"1958_CR30","first-page":"531","volume":"6","author":"MB Abid","year":"2005","unstructured":"Abid MB, Nasim F, Anwar K, Pervez S. Diffuse large B cell lymphoma (DLBCL) in Pakistan: an emerging epidemic? Asian Pac J Cancer Prev. 2005;6(4):531.","journal-title":"Asian Pac J Cancer Prev"},{"key":"1958_CR31","unstructured":"National Cancer Institute (NIH) surveillance, epidemiology, and end result program. Cancer stat facts: NHL Diffuse large B-Cell Lymphoma (DLBCL). Available at: https:\/\/seer.cancer.gov\/statfacts\/html\/dlbcl.html. Accessed in August 26, 2022."},{"issue":"48","key":"1958_CR32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/jncimonographs\/lgu010","volume":"2014","author":"JR Cerhan","year":"2014","unstructured":"Cerhan JR, Kricker A, Paltiel O, Flowers CR, Wang SS, Monnereau A, et al. Medical history, lifestyle, family history, and occupational risk factors for diffuse large B-cell lymphoma: the InterLymph Non-Hodgkin lymphoma subtypes project. J Natl Cancer Inst Monogr. 2014;2014(48):15\u201325.","journal-title":"J Natl Cancer Inst Monogr"},{"issue":"8","key":"1958_CR33","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1182\/blood-2007-10-119974","volume":"111","author":"K Ekstr\u00f6m Smedby","year":"2008","unstructured":"Ekstr\u00f6m Smedby K, Vajdic CM, Falster M, Engels EA, Mart\u00ednez-Maza O, Turner J, et al. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph consortium. Blood. 2008;111(8):4029\u201338.","journal-title":"Blood"},{"issue":"2","key":"1958_CR34","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/ijc.24287","volume":"125","author":"LA Anderson","year":"2009","unstructured":"Anderson LA, Gadalla S, Morton LM, Landgren O, Pfeiffer R, Warren JL, et al. Population-based study of autoimmune conditions and the risk of specific lymphoid malignancies. Int J Cancer. 2009;125(2):398\u2013405.","journal-title":"Int J Cancer"},{"issue":"1","key":"1958_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MD.0b013e31824125e4","volume":"91","author":"M Voulgarelis","year":"2012","unstructured":"Voulgarelis M, Ziakas PD, Papageorgiou A, Baimpa E, Tzioufas AG, Moutsopoulos HM. Prognosis and outcome of non-Hodgkin lymphoma in primary Sj\u00f6gren syndrome. Medicine. 2012;91(1):1\u20139.","journal-title":"Medicine"},{"issue":"9","key":"1958_CR36","first-page":"842","volume":"384","author":"LH Sehn","year":"2021","unstructured":"Sehn LH, Salles G. Diffuse large B-cell. Lymphoma. 2021;384(9):842\u201358.","journal-title":"Lymphoma"},{"key":"1958_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2147\/BLCTT.S361320","volume":"12","author":"A Berhan","year":"2022","unstructured":"Berhan A, Bayleyegn B, Getaneh Z. HIV\/AIDS associated lymphoma: review. Blood Lymphatic Cancer: Targets Ther. 2022;12:31\u201345.","journal-title":"Blood Lymphatic Cancer: Targets Ther"},{"issue":"11","key":"1958_CR38","doi-asserted-by":"publisher","first-page":"e495","DOI":"10.1016\/S2352-3018(17)30125-X","volume":"4","author":"RU Hern\u00e1ndez-Ram\u00edrez","year":"2017","unstructured":"Hern\u00e1ndez-Ram\u00edrez RU, Shiels MS, Dubrow R, Engels EA. Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. The lancet HIV. 2017;4(11):e495\u2013504.","journal-title":"The lancet HIV"},{"issue":"Pt 1","key":"1958_CR39","first-page":"315","volume":"390","author":"JA Healy","year":"2015","unstructured":"Healy JA, Dave SS. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. Curr Top Microbiol Immunol. 2015;390(Pt 1):315\u201337.","journal-title":"Curr Top Microbiol Immunol"},{"issue":"3","key":"1958_CR40","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/1055-9965.EPI-06-1056","volume":"16","author":"EA Engels","year":"2007","unstructured":"Engels EA. Infectious agents as causes of non-Hodgkin lymphoma. Cancer Epidemiol, Biomark Prev. 2007;16(3):401\u20134.","journal-title":"Cancer Epidemiol, Biomark Prev"},{"issue":"11","key":"1958_CR41","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1038\/ng.3105","volume":"46","author":"JR Cerhan","year":"2014","unstructured":"Cerhan JR, Berndt SI, Vijai J. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genetics. 2014;46(11):1233\u20138.","journal-title":"Nat Genetics"},{"issue":"11","key":"1958_CR42","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1038\/ng.3105","volume":"46","author":"JR Cerhan","year":"2014","unstructured":"Cerhan JR, Berndt SI, Vijai J, Ghesqui\u00e8res H, McKay J, Wang SS, et al. Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nat Genet. 2014;46(11):1233\u20138.","journal-title":"Nat Genet"},{"issue":"48","key":"1958_CR43","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/jncimonographs\/lgu006","volume":"2014","author":"MS Linet","year":"2014","unstructured":"Linet MS, Vajdic CM, Morton LM, de Roos AJ, Skibola CF, Boffetta P, et al. Medical history, lifestyle, family history, and occupational risk factors for follicular lymphoma: the InterLymph Non-Hodgkin lymphoma subtypes project. J Natl Cancer Inst Monogr. 2014;2014(48):26\u201340.","journal-title":"J Natl Cancer Inst Monogr"},{"issue":"16","key":"1958_CR44","doi-asserted-by":"publisher","first-page":"6482","DOI":"10.1158\/0008-5472.CAN-08-4372","volume":"69","author":"CM Vajdic","year":"2009","unstructured":"Vajdic CM, Falster MO, De Sanjose S, Mart\u00ednez-Maza O, Becker N, Bracci PM, et al. Atopic disease and risk of non\u2013Hodgkin lymphoma: An interlymph pooled analysis. Can Res. 2009;69(16):6482\u20139.","journal-title":"Can Res"},{"issue":"1","key":"1958_CR45","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/ijc.23003","volume":"122","author":"A Kricker","year":"2008","unstructured":"Kricker A, Armstrong BK, Hughes AM, Goumas C, Smedby KE, Zheng T, et al. Personal sun exposure and risk of non Hodgkin lymphoma: a pooled analysis from the interlymph consortium. Int J Cancer. 2008;122(1):144\u201354.","journal-title":"Int J Cancer"},{"issue":"4","key":"1958_CR46","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1002\/ijc.21913","volume":"119","author":"H Besson","year":"2006","unstructured":"Besson H, Brennan P, Becker N, Nieters A, De Sanjos\u00e9 S, Font R, et al. Tobacco smoking, alcohol drinking and non-Hodgkin\u2019s lymphoma: a European multicenter case-control study (Epilymph). Int J Cancer. 2006;119(4):901\u20138.","journal-title":"Int J Cancer"},{"issue":"7","key":"1958_CR47","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S1470-2045(05)70214-X","volume":"6","author":"LM Morton","year":"2005","unstructured":"Morton LM, Zheng T, Holford TR, Holly EA, Chiu BC, Costantini AS, et al. Alcohol consumption and risk of non-Hodgkin lymphoma: a pooled analysis. Lancet Oncol. 2005;6(7):469\u201376.","journal-title":"Lancet Oncol"},{"key":"1958_CR48","doi-asserted-by":"crossref","unstructured":"Shipp MA. Prognostic factors in aggressive non-Hodgkin's lymphoma: who has\" high-risk\" disease? 1994.","DOI":"10.1182\/blood.V83.5.1165.bloodjournal8351165"},{"key":"1958_CR49","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJM199309303291402","volume":"329","author":"The International Non-Hodgkin\u2019s Lymphoma Prognostic Factors Project","year":"1993","unstructured":"The International Non-Hodgkin\u2019s Lymphoma Prognostic Factors Project. A predictive model for aggressive nonHodgkin\u2019s lymphoma. N Engl J Med. 1993;329:987\u201394.","journal-title":"N Engl J Med"},{"key":"1958_CR50","doi-asserted-by":"publisher","DOI":"10.7322\/abcs.v33i3.155","author":"GR dos Santos","year":"2008","unstructured":"dos Santos GR, Caputto LZ, Fonseca ALA, Pereira J, Fonseca FLA. Exames laboratoriais complementares indicados no apoio ao diagn\u00f3stico do Linfoma Difuso de Grandes C\u00e9lulas B (LDGCB). Arquivos Brasileiros de Ci\u00eancias da Sa\u00fade. 2008. https:\/\/doi.org\/10.7322\/abcs.v33i3.155.","journal-title":"Arquivos Brasileiros de Ci\u00eancias da Sa\u00fade"},{"issue":"3","key":"1958_CR51","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","volume":"45","author":"L Mesin","year":"2016","unstructured":"Mesin L, Ersching J, Victora GD. Germinal center B cell dynamics. Immunity. 2016;45(3):471\u201382.","journal-title":"Immunity"},{"issue":"3","key":"1958_CR52","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/nri3804","volume":"15","author":"NS De Silva","year":"2015","unstructured":"De Silva NS, Klein U. Dynamics of B cells in germinal centres. Nat Rev Immunol. 2015;15(3):137\u201348.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"1958_CR53","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nri3814","volume":"15","author":"K Basso","year":"2015","unstructured":"Basso K, Dalla-Favera R. Germinal centres and B cell lymphomagenesis. Nat Rev Immunol. 2015;15(3):172\u201384.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"1958_CR54","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/imr.12755","volume":"288","author":"C Mlynarczyk","year":"2019","unstructured":"Mlynarczyk C, Font\u00e1n L, Melnick A. Germinal center-derived lymphomas: the darkest side of humoral immunity. Immunol Rev. 2019;288(1):214\u201339.","journal-title":"Immunol Rev"},{"issue":"1","key":"1958_CR55","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/imr.12745","volume":"288","author":"L Pasqualucci","year":"2019","unstructured":"Pasqualucci L. Molecular pathogenesis of germinal center-derived B cell lymphomas. Immunol Rev. 2019;288(1):240\u201361.","journal-title":"Immunol Rev"},{"issue":"40","key":"1958_CR56","doi-asserted-by":"publisher","first-page":"5580","DOI":"10.1038\/sj.onc.1204640","volume":"20","author":"R K\u00fcppers","year":"2001","unstructured":"K\u00fcppers R, Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene. 2001;20(40):5580\u201394.","journal-title":"Oncogene"},{"issue":"10","key":"1958_CR57","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/s41571-019-0225-1","volume":"16","author":"Y Miao","year":"2019","unstructured":"Miao Y, Medeiros LJ, Li Y, Li J, Young KH. Genetic alterations and their clinical implications in DLBCL. Nat Rev Clin Oncol. 2019;16(10):634\u201352.","journal-title":"Nat Rev Clin Oncol"},{"issue":"21","key":"1958_CR58","first-page":"2307","volume":"131","author":"L Pasqualucci","year":"2018","unstructured":"Pasqualucci L, Dalla-Favera RJB. Genetics of diffuse large B-cell lymphoma. J Am Soc Hematol. 2018;131(21):2307\u201319.","journal-title":"J Am Soc Hematol"},{"issue":"11","key":"1958_CR59","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/ni.2428","volume":"13","author":"D Dominguez-Sola","year":"2012","unstructured":"Dominguez-Sola D, Victora GD, Ying CY, Phan RT, Saito M, Nussenzweig MC, et al. The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol. 2012;13(11):1083\u201391.","journal-title":"Nat Immunol"},{"issue":"27","key":"1958_CR60","doi-asserted-by":"publisher","first-page":"11294","DOI":"10.1073\/pnas.0903854106","volume":"106","author":"M Saito","year":"2009","unstructured":"Saito M, Novak U, Piovan E, Basso K, Sumazin P, Schneider C, et al. BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. Proc Natl Acad Sci. 2009;106(27):11294\u20139.","journal-title":"Proc Natl Acad Sci"},{"key":"1958_CR61","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00743","author":"A Rosenwald","year":"2019","unstructured":"Rosenwald A, Bens S, Advani R, Barrans S, Copie-Bergman C, Elsensohn M-H, et al. Prognostic significance of MYC rearrangement and translocation partner in diffuse large B-cell lymphoma: a study by the lunenburg lymphoma biomarker consortium. J Clin Oncol. 2019. https:\/\/doi.org\/10.1200\/JCO.19.00743.","journal-title":"J Clin Oncol"},{"issue":"22","key":"1958_CR62","first-page":"5536","volume":"113","author":"W Ci","year":"2009","unstructured":"Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, et al. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood, J Am Soc Hematol. 2009;113(22):5536\u201348.","journal-title":"Blood, J Am Soc Hematol"},{"issue":"6","key":"1958_CR63","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1200\/JCO.2005.03.4264","volume":"24","author":"J Iqbal","year":"2006","unstructured":"Iqbal J, Neppalli VT, Wright G, Dave BJ, Horsman DE, Rosenwald A, et al. BCL2 expression is a prognostic marker for the activated B-cell\u2013like type of diffuse large B-cell lymphoma. J Clin Oncol. 2006;24(6):961\u20138.","journal-title":"J Clin Oncol"},{"issue":"1","key":"1958_CR64","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0002-9440(10)63284-1","volume":"165","author":"J Iqbal","year":"2004","unstructured":"Iqbal J, Sanger WG, Horsman DE, Rosenwald A, Pickering DL, Dave B, et al. BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. Am J Pathol. 2004;165(1):159\u201366.","journal-title":"Am J Pathol"},{"issue":"1","key":"1958_CR65","doi-asserted-by":"publisher","first-page":"a014357","DOI":"10.1101\/cshperspect.a014357","volume":"4","author":"M Conacci-Sorrell","year":"2014","unstructured":"Conacci-Sorrell M, McFerrin L, Eisenman RN. An overview of MYC and its interactome. Cold Spring Harb Perspect Med. 2014;4(1):a014357.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1958_CR66","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.01.009","author":"K Karube","year":"2015","unstructured":"Karube K, Campo E. MYC alterations in diffuse large B-cell lymphomas. Semin Hematol. 2015. https:\/\/doi.org\/10.1053\/j.seminhematol.2015.01.009.","journal-title":"Semin Hematol"},{"issue":"5","key":"1958_CR67","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1182\/blood-2004-07-2947","volume":"105","author":"S Monti","year":"2005","unstructured":"Monti S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M, et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood. 2005;105(5):1851\u201361.","journal-title":"Blood"},{"issue":"6844","key":"1958_CR68","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/35085588","volume":"412","author":"L Pasqualucci","year":"2001","unstructured":"Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti R, K\u00fcppers R, et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature. 2001;412(6844):341\u20136.","journal-title":"Nature"},{"issue":"11","key":"1958_CR69","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.18632\/oncotarget.653","volume":"3","author":"AH Khodabakhshi","year":"2012","unstructured":"Khodabakhshi AH, Morin RD, Fejes AP, Mungall AJ, Mungall KL, Bolger-Munro M, et al. Recurrent targets of aberrant somatic hypermutation in lymphoma. Oncotarget. 2012;3(11):1308.","journal-title":"Oncotarget"},{"issue":"4","key":"1958_CR70","doi-asserted-by":"publisher","first-page":"320","DOI":"10.18632\/oncoscience.155","volume":"2","author":"S Rebhandl","year":"2015","unstructured":"Rebhandl S, Huemer M, Greil R, Geisberger R. AID\/APOBEC deaminases and cancer. Oncoscience. 2015;2(4):320\u201333.","journal-title":"Oncoscience"},{"issue":"6","key":"1958_CR71","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrc.2016.40","volume":"16","author":"MR Lieber","year":"2016","unstructured":"Lieber MR. Mechanisms of human lymphoid chromosomal translocations. Nat Rev Cancer. 2016;16(6):387\u201398.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"1958_CR72","first-page":"808","volume":"96","author":"TG Willis","year":"2000","unstructured":"Willis TG, Dyer MJ. The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. Blood, J Am Soc Hematol. 2000;96(3):808\u201322.","journal-title":"Blood, J Am Soc Hematol"},{"issue":"3","key":"1958_CR73","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1084\/jem.20062041","volume":"204","author":"G Lenz","year":"2007","unstructured":"Lenz G, Nagel I, Siebert R, Roschke AV, Sanger W, Wright GW, et al. Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell\u2013like diffuse large B cell lymphoma. J Exp Med. 2007;204(3):633\u201343.","journal-title":"J Exp Med"},{"issue":"15","key":"1958_CR74","doi-asserted-by":"publisher","first-page":"13229","DOI":"10.18632\/oncotarget.3644","volume":"6","author":"G Cowan","year":"2015","unstructured":"Cowan G, Weston-Bell NJ, Bryant D, Seckinger A, Hose D, Zojer N, et al. Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma. Oncotarget. 2015;6(15):13229.","journal-title":"Oncotarget"},{"issue":"1","key":"1958_CR75","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2217\/pgs-2022-0140","volume":"24","author":"Y Wang","year":"2023","unstructured":"Wang Y, Jia S, Cao X, Ge S, Yu K, Chen Y. Application of next-generation sequencing in diffuse large B-cell lymphoma. Pharmacogenomics. 2023;24(1):59\u201368.","journal-title":"Pharmacogenomics"},{"key":"1958_CR76","doi-asserted-by":"publisher","first-page":"v116","DOI":"10.1093\/annonc\/mdv304","volume":"26","author":"H Tilly","year":"2015","unstructured":"Tilly H, Da Silva MG, Vitolo U, Jack A, Meignan M, Lopez-Guillermo A, et al. Diffuse large B-cell lymphoma (DLBCL): ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26:v116\u201325.","journal-title":"Ann Oncol"},{"issue":"5","key":"1958_CR77","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/ajh.25460","volume":"94","author":"Y Liu","year":"2019","unstructured":"Liu Y, Barta SK. Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment. Am J Hematol. 2019;94(5):604\u201316.","journal-title":"Am J Hematol"},{"issue":"23","key":"1958_CR78","first-page":"4916","volume":"116","author":"G Ott","year":"2010","unstructured":"Ott G, Ziepert M, Klapper W, Horn H, Szczepanowski M, Bernd H-W, et al. Immunoblastic morphology but not the immunohistochemical GCB\/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL. Blood, J Am Soc Hematol. 2010;116(23):4916\u201325.","journal-title":"Blood, J Am Soc Hematol"},{"issue":"Suppl 1","key":"1958_CR79","doi-asserted-by":"publisher","first-page":"55","DOI":"10.5045\/br.2022.2022037","volume":"57","author":"J Cho","year":"2022","unstructured":"Cho J. Basic immunohistochemistry for lymphoma diagnosis. Blood research. 2022;57(Suppl 1):55.","journal-title":"Blood research"},{"issue":"6","key":"1958_CR80","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/PAP.0000000000000161","volume":"24","author":"S Hendry","year":"2017","unstructured":"Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, et al. Assessing tumor infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in melanoma, gastrointestinal tract carcinomas, non-small cell lung carcinoma and mesothelioma, endometrial and ovarian carcinomas, squamous cell carcinoma of the head and neck, genitourinary carcinomas, and primary brain tumors. Adv Anat Pathol. 2017;24(6):311.","journal-title":"Adv Anat Pathol"},{"key":"1958_CR81","doi-asserted-by":"publisher","first-page":"707","DOI":"10.4103\/2278-0513.165524","volume":"4","author":"K Dewan","year":"2015","unstructured":"Dewan K, Mann N, Chatterjee T. Comparing flow cytometry immunophenotypic and immunohistochemical analyses in diagnosis and prognosis of chronic lymphoproliferative disorders: experience from a tertiary care center. Clin Cancer Investig J. 2015;4:707\u201312.","journal-title":"Clin Cancer Investig J"},{"issue":"2","key":"1958_CR82","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/PAI.0b013e3181845ef4","volume":"17","author":"H Adams","year":"2009","unstructured":"Adams H, Liebisch P, Schmid P, Dirnhofer S, Tzankov A. Diagnostic utility of the B-cell lineage markers CD20, CD79a, PAX5, and CD19 in paraffin-embedded tissues from lymphoid neoplasms. Appl Immunohistochem Mol Morphol. 2009;17(2):96\u2013101.","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"2","key":"1958_CR83","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3109\/10428190903370338","volume":"51","author":"A Tzankov","year":"2010","unstructured":"Tzankov A, Zlobec I, Went P, Robl H, Hoeller S, Dirnhofer S. Prognostic immunophenotypic biomarker studies in diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores. Leuk Lymphoma. 2010;51(2):199\u2013212.","journal-title":"Leuk Lymphoma"},{"issue":"14","key":"1958_CR84","first-page":"2715","volume":"121","author":"S Hu","year":"2013","unstructured":"Hu S, Xu-Monette ZY, Balasubramanyam A, Manyam GC, Visco C, Tzankov A, et al. CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL rituximab-CHOP consortium program study. Blood, J Am Soc Hematol. 2013;121(14):2715\u201324.","journal-title":"Blood, J Am Soc Hematol"},{"issue":"17","key":"1958_CR85","doi-asserted-by":"publisher","first-page":"5494","DOI":"10.1158\/1078-0432.CCR-09-0113","volume":"15","author":"WW Choi","year":"2009","unstructured":"Choi WW, Weisenburger DD, Greiner TC, Piris MA, Banham AH, Delabie J, et al. A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. Clin Cancer Res. 2009;15(17):5494\u2013502.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1958_CR86","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","volume":"103","author":"CP Hans","year":"2004","unstructured":"Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103(1):275\u201382.","journal-title":"Blood"},{"issue":"5","key":"1958_CR87","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/ajcp\/aqw060","volume":"145","author":"MG Disanto","year":"2016","unstructured":"Disanto MG, Ambrosio MR, Rocca BJ, Ibrahim HA, Leoncini L, Naresh KN. Optimal minimal panels of immunohistochemistry for diagnosis of B-cell lymphoma for application in countries with limited resources and for triaging cases before referral to specialist centers. Am J Clin Pathol. 2016;145(5):687\u201395.","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"1958_CR88","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/bjh.17811","volume":"196","author":"RD Morin","year":"2022","unstructured":"Morin RD, Arthur SE, Hodson DJ. Molecular profiling in diffuse large B-cell lymphoma: why so many types of subtypes? Br J Haematol. 2022;196(4):814\u201329.","journal-title":"Br J Haematol"},{"issue":"22","key":"1958_CR89","first-page":"2466","volume":"126","author":"C Copie-Bergman","year":"2015","unstructured":"Copie-Bergman C, Cuilli\u00e8re-Dartigues P, Baia M, Briere J, Delarue R, Canioni D, et al. MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA\/LYSA study. Blood, J Am Soc Hematol. 2015;126(22):2466\u201374.","journal-title":"Blood, J Am Soc Hematol"},{"issue":"5","key":"1958_CR90","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1182\/blood-2005-02-0542","volume":"106","author":"H Tagawa","year":"2005","unstructured":"Tagawa H, Suguro M, Tsuzuki S, Matsuo K, Karnan S, Ohshima K, et al. Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma. Blood. 2005;106(5):1770\u20137.","journal-title":"Blood"},{"issue":"4","key":"1958_CR91","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3324\/haematol.2013.091827","volume":"99","author":"SM Aukema","year":"2014","unstructured":"Aukema SM, Kreuz M, Kohler CW, Rosolowski M, Hasenclever D, Hummel M, et al. Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma. Haematologica. 2014;99(4):726.","journal-title":"Haematologica"},{"issue":"8","key":"1958_CR92","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1182\/blood-2013-11-536433","volume":"123","author":"DW Scott","year":"2014","unstructured":"Scott DW, Wright GW, Williams PM, Lih CJ, Walsh W, Jaffe ES, et al. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. Blood. 2014;123(8):1214\u20137.","journal-title":"Blood"},{"issue":"1","key":"1958_CR93","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12308-019-00344-0","volume":"12","author":"RS Robetorye","year":"2019","unstructured":"Robetorye RS, Ramsower CA, Rosenthal AC, Yip TK, Wendel Spiczka AJ, Glinsmann-Gibson BJ, et al. Incorporation of digital gene expression profiling for cell-of-origin determination (Lymph2Cx testing) into the routine work-up of diffuse large B-cell lymphoma. J Hematop. 2019;12(1):3\u201310.","journal-title":"J Hematop"},{"issue":"3","key":"1958_CR94","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1200\/JCO.18.01583","volume":"37","author":"D Ennishi","year":"2019","unstructured":"Ennishi D, Jiang A, Boyle M, Collinge B, Grande BM, Ben-Neriah S, et al. Double-hit gene expression signature defines a distinct subgroup of germinal center B-cell-like diffuse large B-cell lymphoma. J Clin Oncol. 2019;37(3):190\u2013201.","journal-title":"J Clin Oncol"},{"issue":"364","key":"1958_CR95","doi-asserted-by":"publisher","first-page":"364ra155","DOI":"10.1126\/scitranslmed.aai8545","volume":"8","author":"F Scherer","year":"2016","unstructured":"Scherer F, Kurtz DM, Newman AM, Stehr H, Craig AF, Esfahani MS, et al. Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA. Sci Transl Med. 2016;8(364):364ra155.","journal-title":"Sci Transl Med"},{"issue":"15","key":"1958_CR96","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","volume":"378","author":"R Schmitz","year":"2018","unstructured":"Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, et al. Genetics and pathogenesis of diffuse large B-cell lymphoma. N Engl J Med. 2018;378(15):1396\u2013407.","journal-title":"N Engl J Med"},{"key":"1958_CR97","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3389\/fonc.2020.00803","volume":"10","author":"W-H Yan","year":"2020","unstructured":"Yan W-H, Jiang X-N, Wang W-G, Sun Y-F, Wo Y-X, Luo Z-Z, et al. Cell-of-origin subtyping of diffuse large B-cell lymphoma by using a qPCR-based gene expression assay on formalin-fixed paraffin-embedded tissues. Front Oncol. 2020;10:803.","journal-title":"Front Oncol"},{"issue":"4","key":"1958_CR98","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.jmoldx.2015.03.010","volume":"17","author":"JS Hall","year":"2015","unstructured":"Hall JS, Usher S, Byers RJ, Higgins RC, Memon D, Radford JA, et al. QuantiGene Plex represents a promising diagnostic tool for cell-of-origin subtyping of diffuse large B-cell lymphoma. J Mol Diagn. 2015;17(4):402\u201311.","journal-title":"J Mol Diagn"},{"issue":"3","key":"1958_CR99","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jmoldx.2015.01.007","volume":"17","author":"S Mareschal","year":"2015","unstructured":"Mareschal S, Ruminy P, Bagacean C, Marchand V, Cornic M, Jais J-P, et al. Accurate classification of germinal center B-cell\u2013like\/activated B-cell\u2013like diffuse large B-cell lymphoma using a simple and rapid reverse transcriptase\u2013multiplex ligation-dependent probe amplification assay: a CALYM study. J Mol Diagn. 2015;17(3):273\u201383.","journal-title":"J Mol Diagn"},{"issue":"3","key":"1958_CR100","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jmoldx.2020.11.013","volume":"23","author":"R Ta","year":"2021","unstructured":"Ta R, Santini C, Gou P, Lee G, Tai YC, O\u2019Brien C, et al. Molecular subtyping of diffuse large B-cell lymphoma using a novel quantitative RT-PCR assay. J Mol Diagn. 2021;23(3):323\u201340.","journal-title":"J Mol Diagn"},{"issue":"1","key":"1958_CR101","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/labinvest.2014.136","volume":"95","author":"X Xue","year":"2015","unstructured":"Xue X, Zeng N, Gao Z, Du M-Q. Diffuse large B-cell lymphoma: sub-classification by massive parallel quantitative RT-PCR. Lab Invest. 2015;95(1):113\u201320.","journal-title":"Lab Invest"},{"issue":"12","key":"1958_CR102","first-page":"5509","volume":"111","author":"R Malumbres","year":"2008","unstructured":"Malumbres R, Chen J, Tibshirani R, Johnson NA, Sehn LH, Natkunam Y, et al. Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOP. Blood, J Am Soc Hematol. 2008;111(12):5509\u201314.","journal-title":"Blood, J Am Soc Hematol"},{"key":"1958_CR103","doi-asserted-by":"crossref","unstructured":"Vishnoi A, Rani S. miRNA Biogenesis and Regulation of Diseases: An Updated Overview. MicroRNA Profiling: Methods and Protocols. 2022:1\u201312.","DOI":"10.1007\/978-1-0716-2823-2_1"},{"issue":"5","key":"1958_CR104","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/leu.2014.351","volume":"29","author":"K Musilov\u00e1","year":"2015","unstructured":"Musilov\u00e1 K, Mr\u00e1z M. MicroRNAs in B-cell lymphomas: how a complex biology gets more complex. Leukemia. 2015;29(5):1004\u201317.","journal-title":"Leukemia"},{"issue":"11","key":"1958_CR105","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1093\/embo-reports\/kve230","volume":"2","author":"JS Mattick","year":"2001","unstructured":"Mattick JS. Non-coding RNAs: the architects of eukaryotic complexity. EMBO Rep. 2001;2(11):986\u201391.","journal-title":"EMBO Rep"},{"issue":"5","key":"1958_CR106","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2174\/1389202916666150707160147","volume":"16","author":"M Fernandez-Mercado","year":"2015","unstructured":"Fernandez-Mercado M, Manterola L, Lawrie CH. MicroRNAs in lymphoma: regulatory role and biomarker potential. Curr Genomics. 2015;16(5):349\u201358.","journal-title":"Curr Genomics"},{"issue":"7","key":"1958_CR107","first-page":"1137","volume":"125","author":"J Iqbal","year":"2015","unstructured":"Iqbal J, Shen Y, Huang X, Liu Y, Wake L, Liu C, et al. Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma. Blood, J Am Soc Hematol. 2015;125(7):1137\u201345.","journal-title":"Blood, J Am Soc Hematol"},{"issue":"12","key":"1958_CR108","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1038\/leu.2011.156","volume":"25","author":"D Lenze","year":"2011","unstructured":"Lenze D, Leoncini L, Hummel M, Volinia S, Liu C, Amato T, et al. The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma. Leukemia. 2011;25(12):1869\u201376.","journal-title":"Leukemia"},{"issue":"1","key":"1958_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-018-0768-5","volume":"37","author":"F Marchesi","year":"2018","unstructured":"Marchesi F, Regazzo G, Palombi F, Terrenato I, Sacconi A, Spagnuolo M, et al. Serum miR-22 as potential non-invasive predictor of poor clinical outcome in newly diagnosed, uniformly treated patients with diffuse large B-cell lymphoma: An explorative pilot study. J Exp Clin Cancer Res. 2018;37(1):1\u201312.","journal-title":"J Exp Clin Cancer Res"},{"key":"1958_CR110","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00277-011-1350-9","volume":"91","author":"C Fang","year":"2012","unstructured":"Fang C, Zhu D-X, Dong H-J, Zhou Z-J, Wang Y-H, Liu L, et al. Serum microRNAs are promising novel biomarkers for diffuse large B cell lymphoma. Ann Hematol. 2012;91:553\u20139.","journal-title":"Ann Hematol"},{"issue":"19","key":"1958_CR111","doi-asserted-by":"publisher","first-page":"27208","DOI":"10.18632\/oncotarget.8349","volume":"7","author":"F Bertucci","year":"2016","unstructured":"Bertucci F, Finetti P, Guille A, Ad\u00e9la\u00efde J, Garnier S, Carbuccia N, et al. Comparative genomic analysis of primary tumors and metastases in breast cancer. Oncotarget. 2016;7(19):27208.","journal-title":"Oncotarget"},{"issue":"1","key":"1958_CR112","first-page":"45","volume":"1","author":"A Theisen","year":"2008","unstructured":"Theisen A. Microarray-based comparative genomic hybridization (aCGH). Nat Educ. 2008;1(1):45.","journal-title":"Nat Educ"},{"issue":"9","key":"1958_CR113","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/GIM.0b013e3181461c4a","volume":"9","author":"NJ Nowak","year":"2007","unstructured":"Nowak NJ, Miecznikowski J, Moore SR, Gaile D, Bobadilla D, Smith DD, et al. Challenges in array comparative genomic hybridization for the analysis of cancer samples. Genet Med. 2007;9(9):585\u201395.","journal-title":"Genet Med"},{"issue":"6","key":"1958_CR114","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/jhg.2011.35","volume":"56","author":"V Kumar","year":"2011","unstructured":"Kumar V, Matsuo K, Takahashi A, Hosono N, Tsunoda T, Kamatani N, et al. Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility. J Hum Genet. 2011;56(6):436\u20139.","journal-title":"J Hum Genet"},{"issue":"8","key":"1958_CR115","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.3109\/10428194.2010.492486","volume":"51","author":"U Thunberg","year":"2010","unstructured":"Thunberg U, Enblad G, Turesson I, Berglund M. Genetic variation in tumor necrosis factor and risk of diffuse large B-cell lymphoma and follicular lymphoma: differences between subgroups in Swedish patients. Leuk Lymphoma. 2010;51(8):1563\u20136.","journal-title":"Leuk Lymphoma"},{"issue":"36","key":"1958_CR116","doi-asserted-by":"publisher","first-page":"13520","DOI":"10.1073\/pnas.0804295105","volume":"105","author":"G Lenz","year":"2008","unstructured":"Lenz G, Wright GW, Emre NT, Kohlhammer H, Dave SS, Davis RE, et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci. 2008;105(36):13520\u20135.","journal-title":"Proc Natl Acad Sci"},{"issue":"7043","key":"1958_CR117","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/nature03677","volume":"435","author":"KA O'Donnell","year":"2005","unstructured":"O\u2019Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005;435(7043):839\u201343.","journal-title":"Nature"},{"key":"1958_CR118","doi-asserted-by":"publisher","DOI":"10.2051\/2394-4722.2019.020","author":"R Moia","year":"2019","unstructured":"Moia R, Favini C, Rasi S, Deambrogi C, Ferri V, Schipani M, et al. Liquid biopsy in lymphomas: a potential tool for refining diagnosis and disease monitoring. J Cancer Meta Treat. 2019. https:\/\/doi.org\/10.2051\/2394-4722.2019.020.","journal-title":"J Cancer Meta Treat"},{"key":"1958_CR119","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10070443","author":"D Fern\u00e1ndez-L\u00e1zaro","year":"2020","unstructured":"Fern\u00e1ndez-L\u00e1zaro D, Hern\u00e1ndez JLG, Garc\u00eda AC, Castillo ACD, Hueso MV, Cruz-Hern\u00e1ndez JJ. Clinical perspective and translational oncology of liquid biopsy. Diagnostics. 2020. https:\/\/doi.org\/10.3390\/diagnostics10070443.","journal-title":"Diagnostics"},{"issue":"7","key":"1958_CR120","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/s41419-019-1770-3","volume":"10","author":"I Alborelli","year":"2019","unstructured":"Alborelli I, Generali D, Jermann P, Cappelletti MR, Ferrero G, Scaggiante B, et al. Cell-free DNA analysis in healthy individuals by next-generation sequencing: a proof of concept and technical validation study. Cell Death Dis. 2019;10(7):534.","journal-title":"Cell Death Dis"},{"issue":"2","key":"1958_CR121","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5045\/br.2019.54.2.114","volume":"54","author":"M Eskandari","year":"2019","unstructured":"Eskandari M, Manoochehrabadi S, Pashaiefar H, Zaimy MA, Ahmadvand M. Clinical significance of cell-free DNA as a prognostic biomarker in patients with diffuse large B-cell lymphoma. Blood Res. 2019;54(2):114\u20139.","journal-title":"Blood Res"},{"issue":"8","key":"1958_CR122","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1093\/annonc\/mdp006","volume":"20","author":"S Hohaus","year":"2009","unstructured":"Hohaus S, Giachelia M, Massini G, Mansueto G, Vannata B, Bozzoli V, et al. Cell-free circulating DNA in Hodgkin\u2019s and non-Hodgkin\u2019s lymphomas. Ann Oncol. 2009;20(8):1408\u201313.","journal-title":"Ann Oncol"},{"issue":"6","key":"1958_CR123","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s00277-020-04008-3","volume":"99","author":"JY Hur","year":"2020","unstructured":"Hur JY, Kim YJ, Yoon SE, Son DS, Park WY, Kim SJ, et al. Plasma cell-free DNA is a prognostic biomarker for survival in patients with aggressive non-Hodgkin lymphomas. Ann Hematol. 2020;99(6):1293\u2013302.","journal-title":"Ann Hematol"},{"issue":"9","key":"1958_CR124","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.3109\/10428194.2016.1139703","volume":"57","author":"V Camus","year":"2016","unstructured":"Camus V, Sarafan-Vasseur N, Bohers E, Dubois S, Mareschal S, Bertrand P, et al. Digital PCR for quantification of recurrent and potentially actionable somatic mutations in circulating free DNA from patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2016;57(9):2171\u20139.","journal-title":"Leuk Lymphoma"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-01958-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-01958-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-01958-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T01:25:35Z","timestamp":1739582735000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-01958-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,15]]},"references-count":124,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1958"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-01958-w","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,15]]},"assertion":[{"value":"28 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"184"}}