{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:42:17Z","timestamp":1789040537260,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Hunan Provincial Clinical Medical Technology Demonstration Base for Prevention and Treatment of Thyroid Diseases","award":["No. 2023SK4080"],"award-info":[{"award-number":["No. 2023SK4080"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-01993-7","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T02:39:31Z","timestamp":1741228771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["lncRNA ACVR2B-AS1 modulates thyroid cancer progression by regulating miR-195-5p"],"prefix":"10.1007","volume":"16","author":[{"given":"Tianshi","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqiang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henghua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlong","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"issue":"12","key":"1993_CR1","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41419-021-04386-0","volume":"12","author":"K Guo","year":"2021","unstructured":"Guo K, Qian K, Shi Y, Sun T, Wang Z. LncRNA-MIAT promotes thyroid cancer progression and function as ceRNA to target EZH2 by sponging miR-150-5p. Cell Death Dis. 2021;12(12):1097.","journal-title":"Cell Death Dis"},{"issue":"1","key":"1993_CR2","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s12885-022-09360-3","volume":"22","author":"X Zhang","year":"2022","unstructured":"Zhang X, Zhang X, Jia Q, Li H, Ma R, Yang G, et al. LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression via sponging miR-20a-5p\/RBM38 axis. BMC Cancer. 2022;22(1):344.","journal-title":"BMC Cancer"},{"issue":"5","key":"1993_CR3","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/ijc.33690","volume":"149","author":"F Nabhan","year":"2021","unstructured":"Nabhan F, Dedhia PH, Ringel MD. Thyroid cancer, recent advances in diagnosis and therapy. Int J Cancer. 2021;149(5):984\u201392.","journal-title":"Int J Cancer"},{"issue":"1","key":"1993_CR4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ecl.2018.10.002","volume":"48","author":"CD Seib","year":"2019","unstructured":"Seib CD, Sosa JA. Evolving understanding of the epidemiology of thyroid cancer. Endocrinol Metab Clin North Am. 2019;48(1):23\u201335.","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"24","key":"1993_CR5","doi-asserted-by":"publisher","first-page":"14930","DOI":"10.18632\/aging.205321","volume":"15","author":"Z Zeng","year":"2023","unstructured":"Zeng Z, Tang S, Chen L, Hou H, Liu Y, Li J. LncRNA HAGLROS contribute to papillary thyroid cancer progression by modulating miR-206\/HMGA2 expression. Aging. 2023;15(24):14930\u201344.","journal-title":"Aging"},{"issue":"1","key":"1993_CR6","doi-asserted-by":"publisher","first-page":"14374","DOI":"10.1038\/s41598-019-50913-7","volume":"9","author":"B Luz\u00f3n-Toro","year":"2019","unstructured":"Luz\u00f3n-Toro B, Fern\u00e1ndez RM, Martos-Mart\u00ednez JM, Rubio-Manzanares-Dorado M, Anti\u00f1olo G, Borrego S. LncRNA LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer. Sci Rep. 2019;9(1):14374.","journal-title":"Sci Rep"},{"issue":"2","key":"1993_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/cac2.12108","volume":"41","author":"YT Tan","year":"2021","unstructured":"Tan YT, Lin JF, Li T, Li JJ, Xu RH, Ju HQ. LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer. Cancer Commun. 2021;41(2):109\u201320.","journal-title":"Cancer Commun"},{"issue":"6","key":"1993_CR8","first-page":"659","volume":"38","author":"S Hu","year":"2023","unstructured":"Hu S, Zhou H, Zhao X, Qian F, Jin C. MiR-195-5p suppresses gastric adenocarcinoma cell progression via targeting OTX1. Histol Histopathol. 2023;38(6):659\u201368.","journal-title":"Histol Histopathol"},{"key":"1993_CR9","doi-asserted-by":"publisher","first-page":"4602371","DOI":"10.1155\/2019\/4602371","volume":"2019","author":"Y Nie","year":"2019","unstructured":"Nie Y, Jiao Y, Li Y, Li W. Investigation of the clinical significance and prognostic value of the lncRNA ACVR2B-As1 in liver cancer. Biomed Res Int. 2019;2019:4602371.","journal-title":"Biomed Res Int"},{"issue":"13","key":"1993_CR10","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.2174\/1386207325666220223123917","volume":"25","author":"Z Li","year":"2022","unstructured":"Li Z, Wang H, Deng X, Zhang J, Wang L, Tang W, et al. Construction and validation of an immune-related lncRNA prognosis model for thyroid cancer. Comb Chem High Throughput Screen. 2022;25(13):2217\u201327.","journal-title":"Comb Chem High Throughput Screen"},{"issue":"5","key":"1993_CR11","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1093\/bib\/bby054","volume":"20","author":"L Chen","year":"2019","unstructured":"Chen L, Heikkinen L, Wang C, Yang Y, Sun H, Wong G. Trends in the development of miRNA bioinformatics tools. Brief Bioinform. 2019;20(5):1836\u201352.","journal-title":"Brief Bioinform"},{"issue":"4","key":"1993_CR12","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","volume":"141","author":"TX Lu","year":"2018","unstructured":"Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141(4):1202\u20137.","journal-title":"J Allergy Clin Immunol"},{"key":"1993_CR13","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.047662","author":"M Hill","year":"2021","unstructured":"Hill M, Tran N. miRNA interplay: mechanisms and consequences in cancer. Dis Models Mech. 2021. https:\/\/doi.org\/10.1242\/dmm.047662.","journal-title":"Dis Models Mech"},{"key":"1993_CR14","doi-asserted-by":"publisher","first-page":"112885","DOI":"10.1016\/j.biopha.2022.112885","volume":"150","author":"Q Xu","year":"2022","unstructured":"Xu Q, Xu JL, Chen WQ, Xu WX, Song YX, Tang WJ, et al. Roles and mechanisms of miR-195\u20135p in human solid cancers. Biomed Pharmacother Biomed Pharmacother. 2022;150:112885.","journal-title":"Biomed Pharmacother Biomed Pharmacother"},{"issue":"1","key":"1993_CR15","doi-asserted-by":"publisher","first-page":"2257538","DOI":"10.1080\/15592294.2023.2257538","volume":"18","author":"X Liu","year":"2023","unstructured":"Liu X, Liu Z, Liu Y, Wang N. ATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells. Epigenetics. 2023;18(1):2257538.","journal-title":"Epigenetics"},{"issue":"2","key":"1993_CR16","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1002\/jcp.29016","volume":"235","author":"P Du","year":"2020","unstructured":"Du P, Liu F, Liu Y, Shao M, Li X, Qin G. Linc00210 enhances the malignancy of thyroid cancer cells by modulating miR-195-5p\/IGF1R\/Akt axis. J Cell Physiol. 2020;235(2):1001\u201312.","journal-title":"J Cell Physiol"},{"issue":"5","key":"1993_CR17","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1089\/hum.2018.109","volume":"30","author":"L Jiang","year":"2019","unstructured":"Jiang L, Wu Z, Meng X, Chu X, Huang H, Xu C. LncRNA HOXA-AS2 facilitates tumorigenesis and progression of papillary thyroid cancer by modulating the miR-15a-5p\/HOXA3 Axis. Hum Gene Ther. 2019;30(5):618\u201331.","journal-title":"Hum Gene Ther"},{"issue":"10","key":"1993_CR18","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1158\/1078-0432.CCR-18-2953","volume":"25","author":"I Landa","year":"2019","unstructured":"Landa I, Pozdeyev N, Korch C, Marlow LA, Smallridge RC, Copland JA, et al. Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies. Clin Cancer Res. 2019;25(10):3141\u201351.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1993_CR19","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/s41598-023-50369-w","volume":"14","author":"X Yang","year":"2024","unstructured":"Yang X, Li W, Han X, Wang J, Dai J, Ye X, et al. Apatinib weakens proliferation, migration, invasion, and angiogenesis of thyroid cancer cells through downregulating pyruvate kinase M2. Sci Rep. 2024;14(1):879.","journal-title":"Sci Rep"},{"key":"1993_CR20","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20160403","author":"Z Zhou","year":"2016","unstructured":"Zhou Z, Li Y, Yan X, Wang X, Chen S, Xiao J. Characteristics of a thyroid carcinoma cell line derived from spinal metastasis. 2016. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20160403."},{"key":"1993_CR21","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202009045","author":"MC Bridges","year":"2021","unstructured":"Bridges MC, Daulagala AC, Kourtidis A. LNCcation: lncRNA localization and function. J Cell Biol. 2021. https:\/\/doi.org\/10.1083\/jcb.202009045.","journal-title":"J Cell Biol"},{"issue":"1","key":"1993_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12920-022-01332-7","volume":"15","author":"B Song","year":"2022","unstructured":"Song B, Tian L, Zhang F, Lin Z, Gong B, Liu T, et al. A novel signature to predict thyroid cancer prognosis and immune landscape using immune-related LncRNA pairs. BMC Med Genomics. 2022;15(1):183.","journal-title":"BMC Med Genomics"},{"issue":"2","key":"1993_CR23","doi-asserted-by":"publisher","first-page":"281","DOI":"10.31557\/APJCP.2020.21.2.281","volume":"21","author":"Z Javed","year":"2020","unstructured":"Javed Z, Ahmed Shah F, Rajabi S, Raza Q, Iqbal Z, Ullah M, et al. LncRNAs as potential therapeutic targets in thyroid cancer. Asian Pacific J Cancer Prevent APJCP. 2020;21(2):281\u20137.","journal-title":"Asian Pacific J Cancer Prevent APJCP"},{"issue":"6","key":"1993_CR24","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1097\/CAD.0000000000001438","volume":"34","author":"Q Du","year":"2023","unstructured":"Du Q, Huang L, Guo W. LncRNA ARAP1-AS1 targets miR-516b-5p\/PDE5A axis to facilitate the progression of thyroid cancer. Anticancer Drugs. 2023;34(6):735\u201346.","journal-title":"Anticancer Drugs"},{"key":"1993_CR25","doi-asserted-by":"publisher","first-page":"4317480","DOI":"10.1155\/2022\/4317480","volume":"2022","author":"C Xue","year":"2022","unstructured":"Xue C, Yi C, Lin H, Zhao J, Yuan J, Chen Y, et al. lncRNA CDKN2B-AS1 could be an indicator to identify prognosis and status of immune microenvironment in thyroid cancer. Dis Markers. 2022;2022:4317480.","journal-title":"Dis Markers"},{"key":"1993_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115731","volume":"215","author":"JM Peng","year":"2023","unstructured":"Peng JM, Su YL. Lymph node metastasis and tumor-educated immune tolerance: potential therapeutic targets against distant metastasis. Biochem Pharmacol. 2023;215: 115731.","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"1993_CR27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3233\/CBM-181287","volume":"23","author":"L Pang","year":"2018","unstructured":"Pang L, Wang J, Fan Y, Xu R, Bai Y, Bai L. Correlations of TNM staging and lymph node metastasis of gastric cancer with MRI features and VEGF expression. Cancer Biomarkers Sect A Dis Markers. 2018;23(1):53\u20139.","journal-title":"Cancer Biomarkers Sect A Dis Markers"},{"issue":"2","key":"1993_CR28","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00335-021-09901-4","volume":"33","author":"I Grammatikakis","year":"2022","unstructured":"Grammatikakis I, Lal A. Significance of lncRNA abundance to function. Mamm Genome Off J Int Mamm Genome Soc. 2022;33(2):271\u201380.","journal-title":"Mamm Genome Off J Int Mamm Genome Soc"},{"issue":"3","key":"1993_CR29","first-page":"1012","volume":"23","author":"HL Cao","year":"2019","unstructured":"Cao HL, Liu ZJ, Huang PL, Yue YL, Xi JN. lncRNA-RMRP promotes proliferation, migration and invasion of bladder cancer via miR-206. Eur Rev Med Pharmacol Sci. 2019;23(3):1012\u201321.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1993_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194372","author":"S Yang","year":"2020","unstructured":"Yang S, Wang Y, Lin Y, Shao D, He K, Huang L. LncMirNet: predicting LncRNA-miRNA interaction based on deep learning of ribonucleic acid sequences. Molecules. 2020. https:\/\/doi.org\/10.3390\/molecules25194372.","journal-title":"Molecules"},{"issue":"1","key":"1993_CR31","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12920-019-0570-z","volume":"12","author":"J Liao","year":"2019","unstructured":"Liao J, Wang J, Liu Y, Li J, Duan L. Transcriptome sequencing of lncRNA, miRNA, mRNA and interaction network constructing in coronary heart disease. BMC Med Genomics. 2019;12(1):124.","journal-title":"BMC Med Genomics"},{"issue":"4","key":"1993_CR32","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s13402-023-00806-9","volume":"46","author":"R Bhattacharjee","year":"2023","unstructured":"Bhattacharjee R, Prabhakar N, Kumar L, Bhattacharjee A, Kar S, Malik S, et al. Crosstalk between long noncoding RNA and microRNA in cancer. Cell Oncol. 2023;46(4):885\u2013908.","journal-title":"Cell Oncol"},{"key":"1993_CR33","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3389\/fonc.2019.00669","volume":"9","author":"E L\u00f3pez-Urrutia","year":"2019","unstructured":"L\u00f3pez-Urrutia E, Montes LPB, Cervantes DLDG, Perez-Plasencia C. Parra ADCJFiO crosstalk between long non-coding RNAs, Micro-RNAs and mRNAs: deciphering molecular mechanisms of master regulators in cancer. Front Oncol. 2019;9:669.","journal-title":"Front Oncol"},{"key":"1993_CR34","doi-asserted-by":"publisher","first-page":"RP87900","DOI":"10.7554\/eLife.87900","volume":"12","author":"BD Wheeler","year":"2023","unstructured":"Wheeler BD, Gagnon JD, Zhu WS, Mu\u00f1oz-Sandoval P, Wong SK, Simeonov DS, et al. The lncRNA Malat1 inhibits miR-15\/16 to enhance cytotoxic T cell activation and memory cell formation. Elife. 2023;12:RP87900.","journal-title":"Elife"},{"issue":"9","key":"1993_CR35","doi-asserted-by":"publisher","first-page":"5190","DOI":"10.21037\/tcr-20-1083","volume":"9","author":"D Liu","year":"2020","unstructured":"Liu D, Li P, Wang X, Wang W. hsa-miR-195-5p inhibits cell proliferation of human thyroid carcinoma cells via modulation of p21\/cyclin D1 axis. Trans Cancer Res. 2020;9(9):5190\u20139.","journal-title":"Trans Cancer Res"},{"issue":"11","key":"1993_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32272","volume":"10","author":"H Chen","year":"2024","unstructured":"Chen H, Du X. Increased FGF2 expression promotes immune cell infiltration and correlates with an unfavorable prognosis in thyroid cancer. Heliyon. 2024;10(11): e32272.","journal-title":"Heliyon"},{"key":"1993_CR37","doi-asserted-by":"publisher","first-page":"6180425","DOI":"10.1155\/2017\/6180425","volume":"2017","author":"Y Yin","year":"2017","unstructured":"Yin Y, Hong S, Yu S, Huang Y, Chen S, Liu Y, et al. MiR-195 inhibits tumor growth and metastasis in papillary thyroid carcinoma cell lines by targeting CCND1 and FGF2. Int J Endocrinol. 2017;2017:6180425.","journal-title":"Int J Endocrinol"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-01993-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-01993-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-01993-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T14:31:43Z","timestamp":1741271503000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-01993-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1993"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-01993-7","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"13 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"267"}}