{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:08:19Z","timestamp":1785150499807,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82102961"],"award-info":[{"award-number":["82102961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82072635"],"award-info":[{"award-number":["82072635"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82072637"],"award-info":[{"award-number":["82072637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"High-level Hospital Construction Research Project of Heyuan People's Hospital","award":["YNKT202202"],"award-info":[{"award-number":["YNKT202202"]}]},{"name":"Guangdong Province's Special Fund for Science and Technology Innovation Strategy (\"Major Project + Task List\") Project of Heyuan","award":["23051017147335\/2022001"],"award-info":[{"award-number":["23051017147335\/2022001"]}]},{"name":"the Science and Technology Program of Guangzhou","award":["2024A04J10016"],"award-info":[{"award-number":["2024A04J10016"]}]},{"name":"the Science and Technology Program of Guangzhou","award":["202201011642"],"award-info":[{"award-number":["202201011642"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-02061-w","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T10:43:19Z","timestamp":1742294599000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pan-cancer analysis of the prognosis and immune infiltration of NSUN7 and its potential function in renal clear cell carcinoma"],"prefix":"10.1007","volume":"16","author":[{"given":"Jinwei","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiye","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jike","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianlong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanzhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"1","key":"2061_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"2061_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41568-022-00529-3","volume":"23","author":"A Wahida","year":"2023","unstructured":"Wahida A, et al. The coming decade in precision oncology: six riddles. Nat Rev Cancer. 2023;23(1):43\u201354.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"2061_CR3","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/s41588-024-01662-5","volume":"56","author":"J Hu","year":"2024","unstructured":"Hu J, et al. Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression. Nat Genet. 2024;56(3):442\u201357.","journal-title":"Nat Genet"},{"issue":"1","key":"2061_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13045-024-01532-x","volume":"17","author":"K He","year":"2024","unstructured":"He K, et al. Decoding the glycoproteome: a new frontier for biomarker discovery in cancer. J Hematol Oncol. 2024;17(1):12.","journal-title":"J Hematol Oncol"},{"key":"2061_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-02033-x","author":"J Hedou","year":"2024","unstructured":"Hedou J, et al. Discovery of sparse, reliable omic biomarkers with Stabl. Nat Biotechnol. 2024. https:\/\/doi.org\/10.1038\/s41587-023-02033-x.","journal-title":"Nat Biotechnol"},{"issue":"1","key":"2061_CR6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12943-023-01752-8","volume":"22","author":"Y Qin","year":"2023","unstructured":"Qin Y, et al. Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis. Mol Cancer. 2023;22(1):59.","journal-title":"Mol Cancer"},{"issue":"1","key":"2061_CR7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41392-024-01777-5","volume":"9","author":"WW Liu","year":"2024","unstructured":"Liu WW, et al. RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy. Signal Transduct Target Ther. 2024;9(1):70.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"2061_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40364-022-00362-8","volume":"10","author":"H Song","year":"2022","unstructured":"Song H, et al. Biological roles of RNA m (5)C modification and its implications in cancer immunotherapy. Biomark Res. 2022;10(1):15.","journal-title":"Biomark Res"},{"issue":"1","key":"2061_CR9","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12967-022-03427-2","volume":"20","author":"M Li","year":"2022","unstructured":"Li M, et al. 5-methylcytosine RNA methyltransferases and their potential roles in cancer. J Transl Med. 2022;20(1):214.","journal-title":"J Transl Med"},{"key":"2061_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102975","volume":"69","author":"SJ Chen","year":"2024","unstructured":"Chen SJ, et al. Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m (5)C modification of SLC7A11 mRNA. Redox Biol. 2024;69: 102975.","journal-title":"Redox Biol"},{"issue":"10","key":"2061_CR11","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1016\/j.cmet.2023.07.009","volume":"35","author":"T Chen","year":"2023","unstructured":"Chen T, et al. NSUN2 is a glucose sensor suppressing cGAS\/STING to maintain tumorigenesis and immunotherapy resistance. Cell Metab. 2023;35(10):1782-1798 e8.","journal-title":"Cell Metab"},{"issue":"1","key":"2061_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12943-023-01780-4","volume":"22","author":"Y Wang","year":"2023","unstructured":"Wang Y, et al. Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2\/YBX1\/QSOX1 axis in EGFR-mutant non-small-cell lung cancer. Mol Cancer. 2023;22(1):81.","journal-title":"Mol Cancer"},{"issue":"12","key":"2061_CR13","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1038\/s41418-023-01223-z","volume":"30","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, et al. CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA. Cell Death Differ. 2023;30(12):2462\u201376.","journal-title":"Cell Death Differ"},{"issue":"1","key":"2061_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12943-023-01785-z","volume":"22","author":"V Ortiz-Barahona","year":"2023","unstructured":"Ortiz-Barahona V, et al. Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer. Mol Cancer. 2023;22(1):83.","journal-title":"Mol Cancer"},{"issue":"3","key":"2061_CR15","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.celrep.2015.12.043","volume":"14","author":"F Aguilo","year":"2016","unstructured":"Aguilo F, et al. Deposition of 5-methylcytosine on enhancer RNAs enables the coactivator function of PGC-1alpha. Cell Rep. 2016;14(3):479\u201392.","journal-title":"Cell Rep"},{"key":"2061_CR16","doi-asserted-by":"publisher","first-page":"1231898","DOI":"10.3389\/fimmu.2023.1231898","volume":"14","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, et al. Identification and validation of key biomarkers based on RNA methylation genes in sepsis. Front Immunol. 2023;14:1231898.","journal-title":"Front Immunol"},{"key":"2061_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076520","author":"L Tian","year":"2023","unstructured":"Tian L, et al. Prognostic value and genome signature of m6A\/m5C regulated genes in early-stage lung adenocarcinoma. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24076520.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2061_CR18","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1007\/s12035-022-03195-6","volume":"60","author":"A PerezGrovas-Saltijeral","year":"2023","unstructured":"PerezGrovas-Saltijeral A, Rajkumar AP, Knight HM. Differential expression of m (5)C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer\u2019s disease and traumatic brain injury. Mol Neurobiol. 2023;60(4):2223\u201335.","journal-title":"Mol Neurobiol"},{"key":"2061_CR19","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research, N., et al., The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013;45(10): 1113\u201320.","DOI":"10.1038\/ng.2764"},{"issue":"W1","key":"2061_CR20","doi-asserted-by":"publisher","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","volume":"48","author":"T Li","year":"2020","unstructured":"Li T, et al. TIMER20 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 2020;48(W1):W509\u201314.","journal-title":"Nucleic Acids Res"},{"issue":"20","key":"2061_CR21","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","volume":"35","author":"B Ru","year":"2019","unstructured":"Ru B, et al. TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019;35(20):4200\u20132.","journal-title":"Bioinformatics"},{"issue":"1","key":"2061_CR22","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1038\/s41467-022-30342-3","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, et al. Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways. Nat Commun. 2022;13(1):2669.","journal-title":"Nat Commun"},{"issue":"1","key":"2061_CR23","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1038\/s41467-019-13528-0","volume":"10","author":"F Chen","year":"2019","unstructured":"Chen F, et al. Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers. Nat Commun. 2019;10(1):5679.","journal-title":"Nat Commun"},{"key":"2061_CR24","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","volume":"25","author":"DS Chandrashekar","year":"2022","unstructured":"Chandrashekar DS, et al. UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 2022;25:18\u201327.","journal-title":"Neoplasia"},{"issue":"4","key":"2061_CR25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nmeth0409-239","volume":"6","author":"J Zhu","year":"2009","unstructured":"Zhu J, et al. The UCSC cancer genomics browser. Nat Methods. 2009;6(4):239\u201340.","journal-title":"Nat Methods"},{"issue":"1","key":"2061_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"D Aran","year":"2017","unstructured":"Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18(1):220.","journal-title":"Genome Biol"},{"issue":"1","key":"2061_CR27","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13059-016-1028-7","volume":"17","author":"B Li","year":"2016","unstructured":"Li B, et al. Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. Genome Biol. 2016;17(1):174.","journal-title":"Genome Biol"},{"issue":"5","key":"2061_CR28","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401\u20134.","journal-title":"Cancer Discov"},{"issue":"2","key":"2061_CR29","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.cell.2018.03.034","volume":"173","author":"TM Malta","year":"2018","unstructured":"Malta TM, et al. Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell. 2018;173(2):338-354 e15.","journal-title":"Cell"},{"issue":"D1","key":"2061_CR30","doi-asserted-by":"publisher","first-page":"D900","DOI":"10.1093\/nar\/gky939","volume":"47","author":"H Yuan","year":"2019","unstructured":"Yuan H, et al. CancerSEA: a cancer single-cell state atlas. Nucleic Acids Res. 2019;47(D1):D900\u20138.","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"2061_CR31","doi-asserted-by":"publisher","first-page":"D1425","DOI":"10.1093\/nar\/gkac959","volume":"51","author":"Y Han","year":"2023","unstructured":"Han Y, et al. TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment. Nucleic Acids Res. 2023;51(D1):D1425\u201331.","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"2061_CR32","doi-asserted-by":"publisher","first-page":"W60","DOI":"10.1093\/nar\/gky311","volume":"46","author":"M Franz","year":"2018","unstructured":"Franz M, et al. GeneMANIA update 2018. Nucleic Acids Res. 2018;46(W1):W60\u20134.","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"2061_CR33","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s41571-024-00891-1","volume":"21","author":"E Hoffmann","year":"2024","unstructured":"Hoffmann E, et al. Multiparametric MRI for characterization of the tumour microenvironment. Nat Rev Clin Oncol. 2024;21(6):428\u201348.","journal-title":"Nat Rev Clin Oncol"},{"issue":"2","key":"2061_CR34","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1158\/0008-5472.CAN-23-1418","volume":"84","author":"Y Du","year":"2024","unstructured":"Du Y, et al. Integration of pan-cancer single-cell and spatial transcriptomics reveals stromal cell features and therapeutic targets in tumor microenvironment. Cancer Res. 2024;84(2):192\u2013210.","journal-title":"Cancer Res"},{"key":"2061_CR35","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332034","author":"H El-Serag","year":"2024","unstructured":"El-Serag H, et al. Serum biomarker signature is predictive of the risk of hepatocellular cancer in patients with cirrhosis. Gut. 2024. https:\/\/doi.org\/10.1136\/gutjnl-2024-332034.","journal-title":"Gut"},{"issue":"1","key":"2061_CR36","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12943-023-01920-w","volume":"23","author":"X Huang","year":"2024","unstructured":"Huang X, et al. Identification of HSP90B1 in pan-cancer hallmarks to aid development of a potential therapeutic target. Mol Cancer. 2024;23(1):19.","journal-title":"Mol Cancer"},{"issue":"1","key":"2061_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12943-023-01915-7","volume":"23","author":"P Wu","year":"2024","unstructured":"Wu P, et al. Pan-cancer characterization of cell-free immune-related miRNA identified as a robust biomarker for cancer diagnosis. Mol Cancer. 2024;23(1):31.","journal-title":"Mol Cancer"},{"issue":"7964","key":"2061_CR38","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41586-023-06054-z","volume":"618","author":"F Martinez-Jimenez","year":"2023","unstructured":"Martinez-Jimenez F, et al. Pan-cancer whole-genome comparison of primary and metastatic solid tumours. Nature. 2023;618(7964):333\u201341.","journal-title":"Nature"},{"key":"2061_CR39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146915","author":"DD Lee","year":"2021","unstructured":"Lee DD, et al. Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer. J Clin Invest. 2021. https:\/\/doi.org\/10.1172\/JCI146915.","journal-title":"J Clin Invest"},{"issue":"4","key":"2061_CR40","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2024.01.008","volume":"187","author":"G Leuzzi","year":"2024","unstructured":"Leuzzi G, et al. SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion. Cell. 2024;187(4):861-881 e32.","journal-title":"Cell"},{"issue":"5","key":"2061_CR41","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.ccell.2024.03.005","volume":"42","author":"N Niu","year":"2024","unstructured":"Niu N, et al. Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer. Cancer Cell. 2024;42(5):869-884 e9.","journal-title":"Cancer Cell"},{"issue":"6","key":"2061_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304845","volume":"36","author":"D Liu","year":"2024","unstructured":"Liu D, et al. Tumor microenvironment-responsive nanoparticles amplifying STING signaling pathway for cancer immunotherapy. Adv Mater. 2024;36(6): e2304845.","journal-title":"Adv Mater"},{"issue":"10","key":"2061_CR43","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1038\/s41588-023-01499-4","volume":"55","author":"PMK Westcott","year":"2023","unstructured":"Westcott PMK, et al. Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity. Nat Genet. 2023;55(10):1686\u201395.","journal-title":"Nat Genet"},{"issue":"7","key":"2061_CR44","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/j.cell.2024.02.009","volume":"187","author":"C Swanton","year":"2024","unstructured":"Swanton C, et al. Embracing cancer complexity: hallmarks of systemic disease. Cell. 2024;187(7):1589\u2013616.","journal-title":"Cell"},{"issue":"1","key":"2061_CR45","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13045-020-00883-5","volume":"13","author":"P Chai","year":"2020","unstructured":"Chai P, et al. Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis. J Hematol Oncol. 2020;13(1):43.","journal-title":"J Hematol Oncol"},{"issue":"1","key":"2061_CR46","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41580-021-00404-3","volume":"23","author":"HK Matthews","year":"2022","unstructured":"Matthews HK, Bertoli C, de Bruin RAM. Cell cycle control in cancer. Nat Rev Mol Cell Biol. 2022;23(1):74\u201388.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2061_CR47","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41591-023-02682-0","volume":"30","author":"A Sosinsky","year":"2024","unstructured":"Sosinsky A, et al. Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. Nat Med. 2024;30(1):279\u201389.","journal-title":"Nat Med"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-02061-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-02061-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-02061-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T10:53:24Z","timestamp":1742295204000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-02061-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2061"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-02061-w","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]},"assertion":[{"value":"18 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"345"}}