{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:39:05Z","timestamp":1763552345143,"version":"3.40.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-02104-2","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T20:11:46Z","timestamp":1743365506000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early-stage small cell carcinoma of the ovary hypercalcemic type: autologous stem cell transplantation as standard primary treatment"],"prefix":"10.1007","volume":"16","author":[{"given":"Teresa Lopes","family":"Bruno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"issue":"15","key":"2104_CR1","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.3390\/cancers15153794","volume":"15","author":"FSPL Wens","year":"2023","unstructured":"Wens FSPL, Hulsker CCC, Fiocco M, Zsiros J, Smetsers SE, de Krijger RR, et al. Small cell carcinoma of the ovary, Hypercalcemic type (SCCOHT): patient characteristics, treatment, and outcome\u2014a systematic review. Cancers (Basel). 2023;15(15):3794.","journal-title":"Cancers (Basel)"},{"issue":"3","key":"2104_CR2","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ygyno.2020.06.160","volume":"158","author":"JG Pressey","year":"2020","unstructured":"Pressey JG, Dandoy CE, Pater LE, Sroga Rios J, Sisson R, Dasgupta R, et al. Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): comprehensive management of a newly diagnosed young adult. Gynecol Oncol. 2020;158(3):538\u201346.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"2104_CR3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<145::AID-PATH420>3.0.CO;2-F","volume":"189","author":"CS Herrington","year":"1999","unstructured":"Herrington CS. Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament. Atlas of tumor pathology. Third series, fascicle 23 Robert E. Scully, Robert H. Young and Philip B. Clement. Armed forces institute of pathology, Washington, DC, 1998. No. of pages: 527. Price: $95.00. ISBN: 1881041 43 3. Fascicle J Pathol. 1999;189(1):145\u2013145.","journal-title":"Fascicle J Pathol"},{"issue":"5","key":"2104_CR4","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/ng.2931","volume":"46","author":"L Witkowski","year":"2014","unstructured":"Witkowski L, Carrot-Zhang J, Albrecht S, Fahiminiya S, Hamel N, Tomiak E, et al. Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. Nat Genet. 2014;46(5):438\u201343.","journal-title":"Nat Genet"},{"issue":"1","key":"2104_CR5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.7150\/jca.26978","volume":"10","author":"B Lu","year":"2019","unstructured":"Lu B, Shi H. An in-depth look at small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): clinical implications from recent molecular findings. J Cancer. 2019;10(1):223\u201337.","journal-title":"J Cancer"},{"issue":"3","key":"2104_CR6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ygyno.2016.03.013","volume":"141","author":"L Witkowski","year":"2016","unstructured":"Witkowski L, Goudie C, Ramos P, Boshari T, Brunet JS, Karnezis AN, et al. The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. Gynecol Oncol. 2016;141(3):454\u201360.","journal-title":"Gynecol Oncol"},{"issue":"7","key":"2104_CR7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41571-020-0357-3","volume":"17","author":"P Mittal","year":"2020","unstructured":"Mittal P, Roberts CWM. The SWI\/SNF complex in cancer\u2014biology, biomarkers and therapy. Nat Rev Clin Oncol. 2020;17(7):435\u201348.","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"2104_CR8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10689-016-9957-6","volume":"16","author":"L Witkowski","year":"2017","unstructured":"Witkowski L, Donini N, Byler-Dann R, Knost JA, Albrecht S, Berchuck A, et al. The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases. Fam Cancer. 2017;16(3):395\u20139.","journal-title":"Fam Cancer"},{"issue":"1","key":"2104_CR9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1158\/1078-0432.CCR-13-0280","volume":"20","author":"X Wang","year":"2014","unstructured":"Wang X, Haswell JR, Roberts CWM. Molecular pathways: SWI\/SNF (BAF) complexes are frequently mutated in cancer\u2014mechanisms and potential therapeutic insights. Clin Cancer Res. 2014;20(1):21\u20137.","journal-title":"Clin Cancer Res"},{"key":"2104_CR10","doi-asserted-by":"crossref","unstructured":"Young RH, Oliva E, Scully RE. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J Surg Pathol. 1994;18(11):1102\u201316.","DOI":"10.1097\/00000478-199411000-00004"},{"key":"2104_CR11","doi-asserted-by":"crossref","unstructured":"Harrison ML, Hoskins P, du Bois A, Quinn M, Rustin GJS, Ledermann JA, et al. Small cell of the ovary, hypercalcemic type -- analysis of combined experience and recommendation for management. A GCIG study. Gynecol Oncol. 2006;100(2):233\u20138.","DOI":"10.1016\/j.ygyno.2005.10.024"},{"key":"2104_CR12","doi-asserted-by":"crossref","unstructured":"Pautier P, Ribrag V, Duvillard P, Rey A, Elghissassi I, Sillet-Bach I. Results of a prospective dose-intensive regimen in 27 pat ients with small cell carcinoma of the ovary of the hypercalcemic type. Ann Oncol. 2007;18(12):1985\u20139.","DOI":"10.1093\/annonc\/mdm376"},{"key":"2104_CR13","doi-asserted-by":"crossref","unstructured":"Rebecca E, Andreas H, Matthias K, Karsten M. Small cell carcinoma of the ovary of the hypercalca emic type: an analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature. Archives of Gynecology and Obstetrics. 2011;284(5):1277\u201382.","DOI":"10.1007\/s00404-011-1846-5"},{"key":"2104_CR14","doi-asserted-by":"crossref","unstructured":"Callegaro-Filho D, Gershenson DM, Nick AM, Munsell MF, Ramirez PT, Eifel PJ, et al. Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT): a review of 47 cases. Gynecol Oncol. 2016;140(1):53\u20137.","DOI":"10.1016\/j.ygyno.2015.11.004"},{"key":"2104_CR15","doi-asserted-by":"crossref","unstructured":"Guo Y-R, Cao Q-D, Hong Z-S, Tan Y-Y, Chen S-D, Jin H-J, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020;7(1):11.","DOI":"10.1186\/s40779-020-00240-0"},{"key":"2104_CR16","doi-asserted-by":"crossref","unstructured":"Han Q, Guo H. Multi-modality therapies for advanced small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): three case reports and literature review. Eur J Gynaecol Oncol. 2022;43(1):153.","DOI":"10.31083\/j.ejgo4301002"},{"key":"2104_CR17","doi-asserted-by":"crossref","unstructured":"Venkatramani R, Shoureshi P, Malvar J, Zhou S, Mascarenhas L. High dose alkylator therapy for extracranial malignant rhabdoid tumors in children: malignant Rhabdoid Tumor. Pediatr Blood Cancer. 2014;61(8):1357\u201361.","DOI":"10.1002\/pbc.25093"},{"key":"2104_CR18","doi-asserted-by":"crossref","unstructured":"Qin Q, Ajewole VB, Sheu TG, Donohue R, Singh M. Successful treatment of a stage IIIC small-cell carcinoma of the ovary hyperc alcemic subtype using multi-modality therapeutic approach. Ecancermedicalscience. 2018;3:12.","DOI":"10.3332\/ecancer.2018.832"},{"key":"2104_CR19","doi-asserted-by":"crossref","unstructured":"lanc-Durand F, Lefeuvre-Plesse C, Ray-Coquard I, Chaltiel D, Floquet A, Meriaux \u00c9, et al. Dose-intensive regimen treatment for small-cell carcinoma of the ovary of hypercalcemic type (SCCOHT). Gynecol Oncol. 2020;159(1):129\u201335.","DOI":"10.1016\/j.ygyno.2020.07.019"},{"key":"2104_CR20","doi-asserted-by":"crossref","unstructured":"Sanders BE, Wolsky R, Doughty ES, Wells KL, Ghosh D, Ku L. Small cell carcinoma of the ovary hypercalcemic type (SCC OHT): a review and novel case with dual germline SMARCA4 and BRCA2 mutations. Gynecol Oncol Rep. 2022;44:101077.","DOI":"10.1016\/j.gore.2022.101077"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-02104-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-02104-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-02104-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T20:12:01Z","timestamp":1743365521000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-02104-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2104"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-02104-2","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"18 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and accompanying images. This study was conducted in accordance with the ethical standards of the institutional and national research committee, as well as the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the Ethics Committee of Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"414"}}