{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:44:18Z","timestamp":1775076258782,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-02465-8","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T21:42:00Z","timestamp":1745876520000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gene expression profiling of lncRNA-HOTAIR and lncRNA-MALAT1 in esophageal cancer: uncovering links to lifestyle factors and diagnostic significance"],"prefix":"10.1007","volume":"16","author":[{"given":"Vahid","family":"Ghorbani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0780-3159","authenticated-orcid":false,"given":"Saeid","family":"Ghorbian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"issue":"6","key":"2465_CR1","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1007\/s12328-020-01237-x","volume":"13","author":"DJ Uhlenhopp","year":"2020","unstructured":"Uhlenhopp DJ, Then EO, Sunkara T, Gaduputi V. Epidemiology of esophageal cancer: update in global trends, etiology and risk factors. Clin J Gastroenterol. 2020;13(6):1010\u201321.","journal-title":"Clin J Gastroenterol"},{"issue":"1","key":"2465_CR2","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s11033-022-07962-5","volume":"50","author":"F Amirmahani","year":"2023","unstructured":"Amirmahani F, Vallian S, Asadi MH. The LncRNA MIAT is identified as a regulator of stemness-associated transcript in glioma. Mol Biol Rep. 2023;50(1):517\u201330.","journal-title":"Mol Biol Rep"},{"key":"2465_CR3","first-page":"422","volume":"18","author":"M Razavi","year":"2019","unstructured":"Razavi M, Ghorbian S. Up-regulation of long non-coding RNA-PCAT-1 promotes invasion and metastasis in esophageal squamous cell carcinoma. EXCLI J. 2019;18:422.","journal-title":"EXCLI J"},{"issue":"1","key":"2465_CR4","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s11033-018-4556-2","volume":"46","author":"S Sadeghpour","year":"2019","unstructured":"Sadeghpour S, Ghorbian S. Evaluation of the potential clinical prognostic value of lncRNA-BANCR gene in esophageal squamous cell carcinoma. Mol Biol Rep. 2019;46(1):991\u20135.","journal-title":"Mol Biol Rep"},{"issue":"3","key":"2465_CR5","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1007\/s12253-019-00711-3","volume":"26","author":"H Aalijahan","year":"2020","unstructured":"Aalijahan H, Ghorbian S. Clinical application of long non-coding RNA-UCA1 as a candidate gene in progression of esophageal cancer. Pathol Oncol Res. 2020;26(3):1441\u20136.","journal-title":"Pathol Oncol Res"},{"issue":"1","key":"2465_CR6","first-page":"3","volume":"4","author":"S Ghorbian","year":"2012","unstructured":"Ghorbian S, Ardekani AM. Non-invasive detection of esophageal cancer using genetic changes in circulating cell-free DNA. Avicenna J Med Biotechnol. 2012;4(1):3.","journal-title":"Avicenna J Med Biotechnol"},{"issue":"2","key":"2465_CR7","doi-asserted-by":"publisher","first-page":"e136290","DOI":"10.5812\/jkums-136290","volume":"27","author":"S Ghasemzadeh","year":"2023","unstructured":"Ghasemzadeh S, Ghorbian S. Investigation of clinical significant utility of LncRNA-linc02389 in patients with esophageal squamous cell carcinoma. J Kermanshah Univ Med Sci.2023; 27(2):e136290. https:\/\/doi.org\/10.5812\/jkums-136290.","journal-title":"J Kermanshah Univ Med Sci"},{"issue":"4","key":"2465_CR8","first-page":"253","volume":"26","author":"AJ Oliayi","year":"2019","unstructured":"Oliayi AJ, Asadi MH, Amirmahani F. SNHG6 203 transcript could be applied as an auxiliary factor for more precise staging of breast cancer. J Kerman Univ Med Sci. 2019;26(4):253\u20139.","journal-title":"J Kerman Univ Med Sci"},{"issue":"2","key":"2465_CR9","first-page":"219","volume":"14","author":"F Amirmahani","year":"2023","unstructured":"Amirmahani F, Asadi MH, Jannat AF. LncRNA MIAT promotes the proliferation and invasion of colorectal cancer via suppressing apoptosis and senescence. Middle East J Cancer. 2023;14(2):219\u201329.","journal-title":"Middle East J Cancer"},{"issue":"6","key":"2465_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ol.2024.14388","volume":"27","author":"L Zhang","year":"2024","unstructured":"Zhang L, Wang Y, Gao J, Zhou X, Huang M, Wang X, He Z. Non-coding RNA: a promising diagnostic biomarker and therapeutic target for esophageal squamous cell carcinoma. Oncol Lett. 2024;27(6):1\u20135.","journal-title":"Oncol Lett"},{"issue":"1","key":"2465_CR11","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1186\/s40001-024-02033-w","volume":"29","author":"P Li","year":"2024","unstructured":"Li P, Ma X, Huang D. Role of the lncRNA\/Wnt signaling pathway in digestive system cancer: a literature review. Eur J Med Res. 2024;29(1):447.","journal-title":"Eur J Med Res"},{"key":"2465_CR12","doi-asserted-by":"publisher","first-page":"1414651","DOI":"10.3389\/fmolb.2024.1414651","volume":"11","author":"M Cantile","year":"2024","unstructured":"Cantile M, Belli V, Scognamiglio G, Martorana A, De Pietro G, Tracey M, Budillon A. The role of HOTAIR in the modulation of resistance to anticancer therapy. Front Mol Biosci. 2024;11:1414651.","journal-title":"Front Mol Biosci"},{"issue":"2","key":"2465_CR13","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.ncrna.2024.02.005","volume":"9","author":"S Mishra","year":"2024","unstructured":"Mishra S, Srivastava P, Pandey A, Agarwal A, Shukla S, Husain N. Panel of serum long non-coding RNAs as potential non-invasive biomarkers for gallbladder carcinoma. Non-coding RNA Res. 2024;9(2):583\u201393.","journal-title":"Non-coding RNA Res"},{"issue":"10","key":"2465_CR14","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.3390\/cancers16101876","volume":"16","author":"J Li","year":"2024","unstructured":"Li J, Dhilipkannah P, Holden VK, Sachdeva A, Todd NW, Jiang F. Dysregulation of lncRNA MALAT1 contributes to lung cancer in African Americans by modulating the tumor immune microenvironment. Cancers. 2024;16(10):1876.","journal-title":"Cancers"},{"key":"2465_CR15","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.2147\/DDDT.S448707","volume":"31","author":"J Zhang","year":"2024","unstructured":"Zhang J, Wu L, Wang C, Xie X, Han Y. Research progress of long non-coding RNA in tumor drug resistance: a new paradigm. Drug Des Dev Ther. 2024;31:1385\u201398.","journal-title":"Drug Des Dev Ther"},{"issue":"3","key":"2465_CR16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/abbs\/gmq008","volume":"42","author":"F Guo","year":"2010","unstructured":"Guo F, Li Y, Liu Y, Wang J, Li Y, Li G. Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. Acta Biochim Biophys Sin. 2010;42(3):224\u20139.","journal-title":"Acta Biochim Biophys Sin"},{"key":"2465_CR17","first-page":"1","volume":"28","author":"A Hjazi","year":"2024","unstructured":"Hjazi A, Jasim SA, Altalbawy FM, Kaur H, Hamzah HF, Kaur I, Deorari M, Kumar A, Elawady A, Fenjan MN. Relationship between lncRNA MALAT1 and chemo-radiotherapy resistance of cancer cells: uncovered truths. Cell Biochem Biophys. 2024;28:1\u20135.","journal-title":"Cell Biochem Biophys"},{"key":"2465_CR18","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1007\/s10620-018-5127-z","volume":"63","author":"K Lin","year":"2018","unstructured":"Lin K, Jiang H, Zhang LL, Jiang Y, Yang YX, Qiu GD, She YQ, Zheng JT, Chen C, Fang L, Zhang SY. Down-regulated LncRNA-HOTAIR suppressed colorectal cancer cell proliferation, invasion, and migration by mediating p21. Dig Dis Sci. 2018;63:2320\u201331.","journal-title":"Dig Dis Sci"},{"issue":"6","key":"2465_CR19","doi-asserted-by":"publisher","first-page":"4841","DOI":"10.1007\/s11033-022-07337-w","volume":"49","author":"DG Gupta","year":"2022","unstructured":"Gupta DG, Varma N, Kumar A, Naseem S, Sachdeva MU, Bose P, Binota J, Gupta M, Sonam P, Rana P, Malhotra P. Identification and validation of suitable housekeeping genes for gene expression studies in BCR-ABL1 positive B-lineage acute lymphoblastic leukemia. Mol Biol Rep. 2022;49(6):4841\u20138.","journal-title":"Mol Biol Rep"},{"issue":"8","key":"2465_CR20","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1007\/s10238-023-01131-z","volume":"23","author":"DG Gupta","year":"2023","unstructured":"Gupta DG, Varma N, Abdulkadir SA, Singh P, Sachdeva MU, Naseem S, Siddiqui MR, Bose P, Binota J, Malhotra P, Khadwal A. Identification and validation of the optimal reference genes for standardizing the gene expression profiling diagnostic panel of Ph-like B-lineage acute lymphoblastic leukemia. Clin Exp Med. 2023;23(8):4539\u201351.","journal-title":"Clin Exp Med"},{"issue":"4","key":"2465_CR21","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.gande.2024.06.001","volume":"2","author":"F Abam","year":"2024","unstructured":"Abam F, Ghorbian S. The dual role of LncRNAs in hepatocellular carcinoma: friend and foe. Gastroenterol Endosc. 2024;2(4):186\u201395.","journal-title":"Gastroenterol Endosc"},{"issue":"8","key":"2465_CR22","doi-asserted-by":"publisher","first-page":"e2152","DOI":"10.1002\/cnr2.2152","volume":"7","author":"A Moghimi","year":"2024","unstructured":"Moghimi A, Bani Hosseinian N, Mahdipour M, Ahmadpour E, Miranda-Bedate A, Ghorbian S. Deciphering the molecular complexity of hepatocellular carcinoma: unveiling novel biomarkers and therapeutic targets through advanced bioinformatics analysis. Cancer Rep. 2024;7(8):e2152.","journal-title":"Cancer Rep"},{"key":"2465_CR23","doi-asserted-by":"publisher","first-page":"100787","DOI":"10.1016\/j.ctarc.2023.100787","volume":"38","author":"R Bagheri","year":"2024","unstructured":"Bagheri R, Ghorbian M, Ghorbian S. Tumor circulating biomarkers in colorectal cancer. Cancer Treat Res Commun. 2024;38:100787.","journal-title":"Cancer Treat Res Commun"},{"issue":"13","key":"2465_CR24","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1038\/onc.2012.193","volume":"32","author":"K Kim","year":"2013","unstructured":"Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 2013;32(13):1616\u201325.","journal-title":"Oncogene"},{"issue":"10","key":"2465_CR25","doi-asserted-by":"publisher","first-page":"7421","DOI":"10.1007\/s11033-020-05797-6","volume":"47","author":"N Saeedi","year":"2020","unstructured":"Saeedi N, Ghorbian S. Analysis of clinical important of LncRNA-HOTAIR gene variations and ovarian cancer susceptibility. Mol Biol Rep. 2020;47(10):7421\u20137.","journal-title":"Mol Biol Rep"},{"issue":"1","key":"2465_CR26","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41420-022-01174-3","volume":"8","author":"C Zhu","year":"2022","unstructured":"Zhu C, Wang X, Wang Y, Wang K. Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance. Cell Death Discov. 2022;8(1):383.","journal-title":"Cell Death Discov"},{"issue":"6","key":"2465_CR27","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.tranon.2016.09.005","volume":"9","author":"K Ren","year":"2016","unstructured":"Ren K, Li Y, Lu H, Li Z, Li Z, Wu K, Li Z, Han X. Long noncoding RNA HOTAIR controls cell cycle by functioning as a competing endogenous RNA in esophageal squamous cell carcinoma. Transl Oncol. 2016;9(6):489\u201397.","journal-title":"Transl Oncol"},{"key":"2465_CR28","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.biopha.2017.03.103","volume":"90","author":"F Xu","year":"2017","unstructured":"Xu F, Zhang J. Long non-coding RNA HOTAIR functions as miRNA sponge to promote the epithelial to mesenchymal transition in esophageal cancer. Biomed Pharmacother. 2017;90:888\u201396.","journal-title":"Biomed Pharmacother"},{"key":"2465_CR29","doi-asserted-by":"publisher","first-page":"885075","DOI":"10.3389\/fphar.2022.885075","volume":"13","author":"Y Han","year":"2022","unstructured":"Han Y, Zhao G, Shi X, Wang Y, Wen X, Zhang L, Guo X. The emerging role of long non-coding RNAs in esophageal cancer: functions in tumorigenesis and clinical implications. Front Pharmacol. 2022;13:885075.","journal-title":"Front Pharmacol"},{"issue":"6","key":"2465_CR30","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.2337\/db21-0918","volume":"71","author":"A Miyashita","year":"2022","unstructured":"Miyashita A, Kobayashi M, Ishibashi S, Nagata T, Chandrasekhar A, Zochodne DW, Yokota T. The role of long noncoding RNA MALAT1 in diabetic polyneuropathy and the impact of its silencing in the dorsal root ganglion by a DNA\/RNA heteroduplex oligonucleotide. Diabetes. 2022;71(6):1299\u2013312.","journal-title":"Diabetes"},{"issue":"2","key":"2465_CR31","doi-asserted-by":"publisher","first-page":"39","DOI":"10.55529\/jpdmhd.42.39.52","volume":"4","author":"R Bhat","year":"2024","unstructured":"Bhat R, Shanbhag P. Long non-coding RNAs in kidney injury: a comprehensive review. J Prev Diagn Manag Hum Dis. 2024;4(2):39\u201352.","journal-title":"J Prev Diagn Manag Hum Dis"},{"issue":"7","key":"2465_CR32","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1158\/0008-5472.CAN-14-2931","volume":"75","author":"H Hirata","year":"2015","unstructured":"Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, Tabatabai ZL, Ishii N, Dahiya R. Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205. Can Res. 2015;75(7):1322\u201331.","journal-title":"Can Res"},{"issue":"1","key":"2465_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00438-017-1370-9","volume":"293","author":"H Bunch","year":"2018","unstructured":"Bunch H. Gene regulation of mammalian long non-coding RNA. Mol Genet Genomics. 2018;293(1):1\u20135.","journal-title":"Mol Genet Genomics"},{"issue":"2","key":"2465_CR34","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.bbrc.2014.02.006","volume":"445","author":"Z Zhao","year":"2014","unstructured":"Zhao Z, Chen C, Liu Y, Wu C. 17\u03b2-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level. Biochem Biophys Res Commun. 2014;445(2):388\u201393.","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"2465_CR35","doi-asserted-by":"publisher","first-page":"e0291725","DOI":"10.1371\/journal.pone.0291725","volume":"18","author":"S Iordanishvili","year":"2023","unstructured":"Iordanishvili S, Metreveli T, Lipartia E, Gachechiladze K, Khuntsaria I, Qobulashvili T, Jorbenadze M, Revazishvili T, Kldiashvili E, Kaufmann AM. The HPV-TP53-MALAT1 Axis: unravelling interactions in cervical cancer development. PLoS ONE. 2023;18(10):e0291725.","journal-title":"PLoS ONE"},{"issue":"8","key":"2465_CR36","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/jcp.24918","volume":"230","author":"JY Kan","year":"2015","unstructured":"Kan JY, Wu DC, Yu FJ, Wu CY, Ho YW, Chiu YJ, Jian SF, Hung JY, Wang JY, Kuo PL. Chemokine (C-C motif) ligand 5 is involved in tumor-associated dendritic cell-mediated colon cancer progression through non-coding RNA MALAT-1. J Cell Physiol. 2015;230(8):1883\u201394.","journal-title":"J Cell Physiol"},{"issue":"11","key":"2465_CR37","doi-asserted-by":"publisher","first-page":"e78700","DOI":"10.1371\/journal.pone.0078700","volume":"8","author":"Q Ji","year":"2013","unstructured":"Ji Q, Liu X, Fu X, Zhang L, Sui H, Zhou L, Sun J, Cai J, Qin J, Ren J, Li Q. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt\/\u03b2-catenin signal pathway. PLoS ONE. 2013;8(11):e78700.","journal-title":"PLoS ONE"},{"issue":"7","key":"2465_CR38","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1074\/jbc.M114.596866","volume":"290","author":"X Wang","year":"2015","unstructured":"Wang X, Li M, Wang Z, Han S, Tang X, Ge Y, Zhou L, Zhou C, Yuan Q, Yang M. Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. J Biol Chem. 2015;290(7):3925\u201335.","journal-title":"J Biol Chem"},{"issue":"12","key":"2465_CR39","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1093\/carcin\/bgu200","volume":"35","author":"Y Okugawa","year":"2014","unstructured":"Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR, Goel A. Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis. 2014;35(12):2731\u20139.","journal-title":"Carcinogenesis"},{"issue":"2","key":"2465_CR40","first-page":"2159","volume":"17","author":"C Wang","year":"2019","unstructured":"Wang C, Zhang Q, Hu Y, Zhu J, Yang J. Emerging role of long non-coding RNA MALAT1 in predicting clinical outcomes of patients with digestive system malignancies: a meta-analysis. Oncol Lett. 2019;17(2):2159\u201370.","journal-title":"Oncol Lett"},{"key":"2465_CR41","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.semcancer.2020.12.012","volume":"75","author":"EM McCabe","year":"2021","unstructured":"McCabe EM, Rasmussen TP. lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions. Semin Cancer Biol. 2021;75:38\u201348.","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"2465_CR42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13046-015-0123-z","volume":"34","author":"L Hu","year":"2015","unstructured":"Hu L, Wu Y, Tan D, Meng H, Wang K, Bai Y, Yang K. Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma. J Exp Clin Cancer Res. 2015;34(1):7.","journal-title":"J Exp Clin Cancer Res"},{"issue":"5","key":"2465_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ol.2021.12604","volume":"21","author":"A Syllaios","year":"2021","unstructured":"Syllaios A, Moris D, Karachaliou GS, Sakellariou S, Karavokyros I, Gazouli M, Schizas D. Pathways and role of MALAT1 in esophageal and gastric cancer. Oncol Lett. 2021;21(5):1\u20137.","journal-title":"Oncol Lett"},{"issue":"8","key":"2465_CR44","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/jop.12538","volume":"46","author":"Z Li","year":"2017","unstructured":"Li Z, Zhou Y, Tu B, Bu Y, Liu A, Kong J. Long noncoding RNA MALAT 1 affects the efficacy of radiotherapy for esophageal squamous cell carcinoma by regulating Cks1 expression. J Oral Pathol Med. 2017;46(8):583\u201390.","journal-title":"J Oral Pathol Med"},{"issue":"11","key":"2465_CR45","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.21037\/jtd-22-1449","volume":"14","author":"T Huang","year":"2022","unstructured":"Huang T, Wu Z, Zhu S. The roles and mechanisms of the lncRNA-miRNA axis in the progression of esophageal cancer: a narrative review. J Thorac Dis. 2022;14(11):4545.","journal-title":"J Thorac Dis"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-02465-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-02465-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-02465-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T10:05:24Z","timestamp":1745921124000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-02465-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2465"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-02465-8","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"25 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The work was approved by the Ahar Branch Islamic Azad University (MSc.ID: 950187436), and informed written consent was filled out by all participants. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"630"}}