{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:14:36Z","timestamp":1785503676169,"version":"3.56.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-02576-2","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:53:26Z","timestamp":1747148006000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expression of insulinoma-associated protein 1 (INSM1) in gastric neuroendocrine and non-neuroendocrine neoplasms"],"prefix":"10.1007","volume":"16","author":[{"given":"Sujeong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisu","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjung","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonsik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"issue":"2","key":"2576_CR1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/his.13975","volume":"76","author":"ID Nagtegaal","year":"2020","unstructured":"Nagtegaal ID, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76(2):182\u20138.","journal-title":"Histopathology"},{"issue":"12","key":"2576_CR2","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1038\/s41379-018-0110-y","volume":"31","author":"G Rindi","year":"2018","unstructured":"Rindi G, et al. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol. 2018;31(12):1770\u201386.","journal-title":"Mod Pathol"},{"key":"2576_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.humpath.2019.12.002","volume":"96","author":"AM Bellizzi","year":"2020","unstructured":"Bellizzi AM. Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you? Hum Pathol. 2020;96:8\u201333.","journal-title":"Hum Pathol"},{"issue":"1","key":"2576_CR4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41379-018-0122-7","volume":"32","author":"S Mukhopadhyay","year":"2019","unstructured":"Mukhopadhyay S, et al. Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections. Mod Pathol. 2019;32(1):100\u20139.","journal-title":"Mod Pathol"},{"issue":"11","key":"2576_CR5","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1097\/PAS.0000000000000916","volume":"41","author":"LM Rooper","year":"2017","unstructured":"Rooper LM, et al. INSM1 demonstrates superior performance to the individual and combined use of synaptophysin, chromogranin and CD56 for diagnosing neuroendocrine tumors of the thoracic cavity. Am J Surg Pathol. 2017;41(11):1561\u20139.","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2576_CR6","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/0046-8177(93)90064-N","volume":"24","author":"M Miettinen","year":"1993","unstructured":"Miettinen M, Cupo W. Neural cell adhesion molecule distribution in soft tissue tumors. Hum Pathol. 1993;24(1):62\u20136.","journal-title":"Hum Pathol"},{"issue":"12","key":"2576_CR7","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1016\/j.ajpath.2015.08.018","volume":"185","author":"K Fujino","year":"2015","unstructured":"Fujino K, et al. Insulinoma-associated protein 1 is a crucial regulator of neuroendocrine differentiation in lung cancer. Am J Pathol. 2015;185(12):3164\u201377.","journal-title":"Am J Pathol"},{"issue":"17","key":"2576_CR8","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1101\/gad.381806","volume":"20","author":"MS Gierl","year":"2006","unstructured":"Gierl MS, et al. The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev. 2006;20(17):2465\u201378.","journal-title":"Genes Dev"},{"issue":"21","key":"2576_CR9","doi-asserted-by":"publisher","first-page":"15252","DOI":"10.1016\/S0021-9258(18)42173-4","volume":"267","author":"Y Goto","year":"1992","unstructured":"Goto Y, et al. A novel human insulinoma-associated cDNA, IA-1, encodes a protein with \u201czinc-finger\u201d DNA-binding motifs. J Biol Chem. 1992;267(21):15252\u20137.","journal-title":"J Biol Chem"},{"issue":"5","key":"2576_CR10","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/PAS.0000000000001037","volume":"42","author":"LM Rooper","year":"2018","unstructured":"Rooper LM, Bishop JA, Westra WH. INSM1 is a sensitive and specific marker of neuroendocrine differentiation in head and neck tumors. Am J Surg Pathol. 2018;42(5):665\u201371.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"2576_CR11","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1093\/ajcp\/aqaa014","volume":"153","author":"KE McHugh","year":"2020","unstructured":"McHugh KE, et al. INSM1 Is a highly specific marker of neuroendocrine differentiation in primary neoplasms of the gastrointestinal tract, appendix, and pancreas. Am J Clin Pathol. 2020;153(6):811\u201320.","journal-title":"Am J Clin Pathol"},{"issue":"8","key":"2576_CR12","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1038\/s41379-020-0517-0","volume":"33","author":"HK Tsai","year":"2020","unstructured":"Tsai HK, Hornick JL, Vivero M. INSM1 expression in a subset of thoracic malignancies and small round cell tumors: rare potential pitfalls for small cell carcinoma. Mod Pathol. 2020;33(8):1571\u201380.","journal-title":"Mod Pathol"},{"issue":"5","key":"2576_CR13","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/modpathol.2017.189","volume":"31","author":"A Yoshida","year":"2018","unstructured":"Yoshida A, et al. INSM1 expression and its diagnostic significance in extraskeletal myxoid chondrosarcoma. Mod Pathol. 2018;31(5):744\u201352.","journal-title":"Mod Pathol"},{"key":"2576_CR14","doi-asserted-by":"publisher","first-page":"112106","DOI":"10.1016\/j.mce.2023.112106","volume":"581","author":"K Moller","year":"2024","unstructured":"Moller K, et al. Comparison of INSM1 immunostaining with established neuroendocrine markers synaptophysin and chromogranin A in over 14,000 neuroendocrine and non-neuroendocrine tumors. Mol Cell Endocrinol. 2024;581:112106.","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"2576_CR15","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s12022-021-09682-1","volume":"32","author":"J Metovic","year":"2021","unstructured":"Metovic J, et al. INSM1 expression in breast neoplasms with neuroedocrine features. Endocr Pathol. 2021;32(4):452\u201360.","journal-title":"Endocr Pathol"},{"issue":"4","key":"2576_CR16","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/cncy.21972","volume":"126","author":"EE Doxtader","year":"2018","unstructured":"Doxtader EE, Mukhopadhyay S. Insulinoma-associated protein 1 is a sensitive and specific marker of neuroendocrine lung neoplasms in cytology specimens. Cancer Cytopathol. 2018;126(4):243\u201352.","journal-title":"Cancer Cytopathol"},{"issue":"9","key":"2576_CR17","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.5858\/arpa.2019-0250-OA","volume":"144","author":"J Staaf","year":"2020","unstructured":"Staaf J, et al. Diagnostic value of insulinoma-associated protein 1 (INSM1) and comparison with established neuroendocrine markers in pulmonary cancers. Arch Pathol Lab Med. 2020;144(9):1075\u201385.","journal-title":"Arch Pathol Lab Med"},{"issue":"4","key":"2576_CR18","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/his.13899","volume":"75","author":"I Gonzalez","year":"2019","unstructured":"Gonzalez I, et al. Insulinoma-associated protein 1 expression in primary and metastatic neuroendocrine neoplasms of the gastrointestinal and pancreaticobiliary tracts. Histopathology. 2019;75(4):568\u201377.","journal-title":"Histopathology"},{"issue":"11","key":"2576_CR19","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1097\/PAS.0000000000001136","volume":"42","author":"MT Lilo","year":"2018","unstructured":"Lilo MT, Chen Y, LeBlanc RE. INSM1 Is more sensitive and interpretable than conventional immunohistochemical stains used to diagnose merkel cell carcinoma. Am J Surg Pathol. 2018;42(11):1541\u20138.","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"2576_CR20","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41568-019-0133-9","volume":"19","author":"CM Rudin","year":"2019","unstructured":"Rudin CM, et al. Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer. 2019;19(5):289\u201397.","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"2576_CR21","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1038\/s41374-020-00479-0","volume":"100","author":"Y Tenjin","year":"2020","unstructured":"Tenjin Y, et al. Distinct transcriptional programs of SOX2 in different types of small cell lung cancers. Lab Invest. 2020;100(12):1575\u201388.","journal-title":"Lab Invest"},{"issue":"6","key":"2576_CR22","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.jtho.2021.02.008","volume":"16","author":"Y Yamada","year":"2021","unstructured":"Yamada Y, et al. A tuft cell-like signature is highly prevalent in thymic squamous cell carcinoma and delineates new molecular subsets among the major lung cancer histotypes. J Thorac Oncol. 2021;16(6):1003\u201316.","journal-title":"J Thorac Oncol"},{"issue":"1","key":"2576_CR23","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1042\/BJ20051669","volume":"397","author":"WD Liu","year":"2006","unstructured":"Liu WD, et al. INSM1 functions as a transcriptional repressor of the neuroD\/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. Biochem J. 2006;397(1):169\u201377.","journal-title":"Biochem J"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-02576-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-02576-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-02576-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:53:27Z","timestamp":1747148007000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-02576-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2576"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-02576-2","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"4 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the guidelines of the Declaration of Helsinki and approved by the Kyungpook National University Chilgok Hospital Institutional Review Board (No. KNUCH IRB 2023-09-014). The requirement for written informed consent from the patients was waived because of the retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"754"}}