{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:33:49Z","timestamp":1769121229747,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82371130"],"award-info":[{"award-number":["No. 82371130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82371130"],"award-info":[{"award-number":["No. 82371130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82371130"],"award-info":[{"award-number":["No. 82371130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82371130"],"award-info":[{"award-number":["No. 82371130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82371130"],"award-info":[{"award-number":["No. 82371130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Research Project of Nantong","award":["JC22022006"],"award-info":[{"award-number":["JC22022006"]}]},{"name":"Basic Research Project of Nantong","award":["JC22022006"],"award-info":[{"award-number":["JC22022006"]}]},{"name":"Basic Research Project of Nantong","award":["JC22022006"],"award-info":[{"award-number":["JC22022006"]}]},{"name":"Basic Research Project of Nantong","award":["JC22022006"],"award-info":[{"award-number":["JC22022006"]}]},{"name":"Basic Research Project of Nantong","award":["JC22022006"],"award-info":[{"award-number":["JC22022006"]}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX21-1468"],"award-info":[{"award-number":["SJCX21-1468"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX21-1468"],"award-info":[{"award-number":["SJCX21-1468"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX21-1468"],"award-info":[{"award-number":["SJCX21-1468"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX21-1468"],"award-info":[{"award-number":["SJCX21-1468"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["SJCX21-1468"],"award-info":[{"award-number":["SJCX21-1468"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Research Project of Nantong Municipal Health Commission","award":["QN2024027"],"award-info":[{"award-number":["QN2024027"]}]},{"name":"Special Research Project of Nantong Municipal Health Commission","award":["QN2024027"],"award-info":[{"award-number":["QN2024027"]}]},{"name":"Special Research Project of Nantong Municipal Health Commission","award":["QN2024027"],"award-info":[{"award-number":["QN2024027"]}]},{"name":"Special Research Project of Nantong Municipal Health Commission","award":["QN2024027"],"award-info":[{"award-number":["QN2024027"]}]},{"name":"Special Research Project of Nantong Municipal Health Commission","award":["QN2024027"],"award-info":[{"award-number":["QN2024027"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-03139-1","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:35:54Z","timestamp":1752140154000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal impact of air pollution on head and neck cancer: a Mendelian randomization study"],"prefix":"10.1007","volume":"16","author":[{"given":"Dong-ling","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-shuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-sheng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"3139_CR1","doi-asserted-by":"crossref","unstructured":"Wang X, Wang X, Gao C et al. Relationship between outdoor air pollutant exposure and premature delivery in China- systematic review and Meta-Analysis. Int J Public Health. 2023;68.","DOI":"10.3389\/ijph.2023.1606226"},{"key":"3139_CR2","doi-asserted-by":"crossref","unstructured":"Hung TH, Hsu TY, Hsu J et al. Influence of gestational hypertension and maternal air pollutant exposure on birth outcomes. Environ Sci Pollut Res Int. 2024.","DOI":"10.1007\/s11356-024-33944-0"},{"key":"3139_CR3","doi-asserted-by":"publisher","first-page":"779192","DOI":"10.3389\/fpubh.2021.779192","volume":"9","author":"KC Wang","year":"2021","unstructured":"Wang KC, Lo YC, Liao CC, et al. Associations between symptoms of depression and air pollutant exposure among older adults: results from the Taiwan longitudinal study on aging (TLSA). Front Public Health. 2021;9:779192.","journal-title":"Front Public Health"},{"key":"3139_CR4","doi-asserted-by":"publisher","first-page":"121522","DOI":"10.1016\/j.envpol.2023.121522","volume":"327","author":"J Liao","year":"2023","unstructured":"Liao J, Goodrich J, Walker DI, et al. Metabolic pathways altered by air pollutant exposure in association with lipid profiles in young adults. Environ Pollut. 2023;327:121522.","journal-title":"Environ Pollut"},{"key":"3139_CR5","doi-asserted-by":"crossref","unstructured":"Tran PM, Warren JL, Leifheit EC et al. Associations between long-term air pollutant exposure and 30-day all-cause hospital readmissions in US patients with Stroke. Stroke. 2023;54(4).","DOI":"10.1161\/STROKEAHA.122.042265"},{"issue":"6","key":"3139_CR6","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1177\/1945892421993655","volume":"35","author":"TR Patel","year":"2021","unstructured":"Patel TR, Tajudeen BA, Brown H, et al. Association of air pollutant exposure and sinonasal histopathology findings in chronic rhinosinusitis. Am J Rhinol Allergy. 2021;35(6):761\u20137.","journal-title":"Am J Rhinol Allergy"},{"key":"3139_CR7","doi-asserted-by":"crossref","unstructured":"Tsai CY, Liu M, Huang HT et al. Association between air pollutant exposure, body water distribution and sleep disorder indices in individuals with low-arousal-threshold obstructive sleep apnoea. BMJ Open Respir Res. 2023;10(1).","DOI":"10.1136\/bmjresp-2023-001802"},{"issue":"10","key":"3139_CR8","doi-asserted-by":"publisher","first-page":"5353","DOI":"10.3390\/ijerph18105353","volume":"18","author":"Q Yu","year":"2021","unstructured":"Yu Q, Zhang L, Hou K, et al. Relationship between air pollutant exposure and gynecologic cancer risk. Int J Environ Res Public Health. 2021;18(10):5353.","journal-title":"Int J Environ Res Public Health"},{"issue":"23","key":"3139_CR9","doi-asserted-by":"publisher","first-page":"9140","DOI":"10.3390\/ijerph17239140","volume":"17","author":"S Hong","year":"2020","unstructured":"Hong S, Wan L, Lin H, et al. Long-Term ambient air pollutant exposure and risk of recurrent headache in children: a 12-Year cohort Study. Int J Environ Res Public Health. 2020;17(23):9140.","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"3139_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.5056\/jnm18135","volume":"25","author":"TK Tan","year":"2019","unstructured":"Tan TK, Saps M, Lin CL, et al. Is Long-term ambient air pollutant exposure a risk factor for irritable bowel syndrome in children?? A 12-year longitudinal cohort Study. J Neurogastroenterol Motil. 2019;25(2):241\u20139.","journal-title":"J Neurogastroenterol Motil"},{"issue":"10318","key":"3139_CR11","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1016\/S0140-6736(21)01550-6","volume":"398","author":"MD Mody","year":"2021","unstructured":"Mody MD, Rocco JW, Yom SS, et al. Head and neck cancer. Lancet. 2021;398(10318):2289\u201399.","journal-title":"Lancet"},{"key":"3139_CR12","doi-asserted-by":"crossref","unstructured":"Cuzziol CI, Marzochi LL, Possebon VS et al. Regulation of VEGFA, KRAS, and NFE2L2 oncogenes by MicroRNAs in head and neck Cancer. Int J Mol Sci. 2022;23(13).","DOI":"10.3390\/ijms23137483"},{"issue":"1","key":"3139_CR13","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12920-023-01634-4","volume":"16","author":"L Gui","year":"2023","unstructured":"Gui L, He X, Tang L, et al. Obesity and head and neck cancer risk: a Mendelian randomization study. BMC Med Genom. 2023;16(1):200.","journal-title":"BMC Med Genomics"},{"issue":"1","key":"3139_CR14","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1186\/s12967-023-04357-3","volume":"21","author":"Z Dong","year":"2023","unstructured":"Dong Z, Xu M, Sun X, et al. Mendelian randomization and transcriptomic analysis reveal an inverse causal relationship between alzheimer\u2019s disease and cancer. J Transl Med. 2023;21(1):527.","journal-title":"J Transl Med"},{"issue":"19","key":"3139_CR15","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CA Emdin","year":"2017","unstructured":"Emdin CA, Khera AV, Kathiresan S. Mendelian Randomization JAMA. 2017;318(19):1925\u20136.","journal-title":"Mendelian Randomization JAMA"},{"key":"3139_CR16","doi-asserted-by":"crossref","unstructured":"Wen J, Zhang J, Zhang H et al. Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases. J Transl Med. 2024;22(1).","DOI":"10.1186\/s12967-024-04928-y"},{"issue":"16","key":"3139_CR17","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf B, et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR Statement. JAMA. 2021;326(16):1614\u201321.","journal-title":"JAMA"},{"issue":"3","key":"3139_CR18","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess S, Thompson SG. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011;40(3):755\u201364.","journal-title":"Int J Epidemiol"},{"key":"3139_CR19","doi-asserted-by":"crossref","unstructured":"Karageorgiou V, Gill D, Bowden J et al. Sparse dimensionality reduction approaches in Mendelian randomisation with highly correlated exposures. Elife. 2023;12.","DOI":"10.7554\/eLife.80063"},{"issue":"4","key":"3139_CR20","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/gepi.22522","volume":"47","author":"N Mounier","year":"2023","unstructured":"Mounier N, Kutalik Z. Bias correction for inverse variance weighting Mendelian randomization. Genet Epidemiol. 2023;47(4):314\u201331.","journal-title":"Genet Epidemiol"},{"issue":"1","key":"3139_CR21","doi-asserted-by":"publisher","first-page":"6143","DOI":"10.1038\/s41467-022-33675-1","volume":"13","author":"L Chen","year":"2022","unstructured":"Chen L, Peters JE, Prins B, et al. Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke. Nat Commun. 2022;13(1):6143.","journal-title":"Nat Commun"},{"issue":"7708","key":"3139_CR22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","volume":"558","author":"BB Sun","year":"2018","unstructured":"Sun BB, Maranville JC, Peters JE, et al. Genomic atlas of the human plasma proteome. Nature. 2018;558(7708):73\u20139.","journal-title":"Nature"},{"issue":"6509","key":"3139_CR23","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.aaz1776","volume":"369","author":"The GTEx","year":"2020","unstructured":"The GTEx. Consortium atlas of genetic regulatory effects across human tissues. Science. 2020;369(6509):1318\u201330.","journal-title":"Science"},{"issue":"1","key":"3139_CR24","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523.","journal-title":"Nat Commun"},{"key":"3139_CR25","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.chemosphere.2018.12.095","volume":"220","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, Zhan Y, Wang B, et al. Spatiotemporally mapping of the relationship between NO(2) pollution and urbanization for a megacity in Southwest China during 2005\u20132016. Chemosphere. 2019;220:155\u201362.","journal-title":"Chemosphere"},{"key":"3139_CR26","doi-asserted-by":"publisher","first-page":"939564","DOI":"10.3389\/fonc.2022.939564","volume":"12","author":"W Wang","year":"2022","unstructured":"Wang W, Meng L, Hu Z, et al. The association between outdoor air pollution and lung cancer risk in seven Eastern metropolises of china: trends in 2006\u20132014 and sex differences. Front Oncol. 2022;12:939564.","journal-title":"Front Oncol"},{"issue":"1","key":"3139_CR27","doi-asserted-by":"publisher","first-page":"5392","DOI":"10.1038\/s41598-020-62200-x","volume":"10","author":"J Hwang","year":"2020","unstructured":"Hwang J, Bae H, Choi S, et al. Impact of air pollution on breast cancer incidence and mortality: a nationwide analysis in South Korea. Sci Rep. 2020;10(1):5392.","journal-title":"Sci Rep"},{"key":"3139_CR28","doi-asserted-by":"crossref","unstructured":"Gawelko J, Cierpial-Wolan M, Bwanakare S et al. Association between air pollution and squamous cell lung Cancer in South-Eastern Poland. Int J Environ Res Public Health. 2022;19(18).","DOI":"10.3390\/ijerph191811598"},{"issue":"Pt 3","key":"3139_CR29","doi-asserted-by":"publisher","first-page":"132255","DOI":"10.1016\/j.chemosphere.2021.132255","volume":"287","author":"P Gao","year":"2022","unstructured":"Gao P, Wu Y, He L, et al. Acute effects of ambient nitrogen oxides and interactions with temperature on cardiovascular mortality in shenzhen, China. Chemosphere. 2022;287(Pt 3):132255.","journal-title":"Chemosphere"},{"issue":"1","key":"3139_CR30","doi-asserted-by":"publisher","first-page":"11331","DOI":"10.1038\/s41598-020-68242-5","volume":"10","author":"W Lee","year":"2020","unstructured":"Lee W, Kang MY, Kim J, et al. Cancer risk in road transportation workers: a National representative cohort study with 600,000 person-years of follow-up. Sci Rep. 2020;10(1):11331.","journal-title":"Sci Rep"},{"issue":"2","key":"3139_CR31","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s40471-018-0143-2","volume":"5","author":"AJ White","year":"2018","unstructured":"White AJ, Bradshaw PT, Hamra GB. Air pollution and breast cancer: A Review. Curr Epidemiol Rep. 2018;5(2):92\u2013100.","journal-title":"Curr Epidemiol Rep"},{"key":"3139_CR32","doi-asserted-by":"publisher","first-page":"112275","DOI":"10.1016\/j.envres.2021.112275","volume":"206","author":"L He","year":"2022","unstructured":"He L, Norris C, Cui X, et al. Oral cavity response to air pollutant exposure and association with pulmonary inflammation and symptoms in asthmatic children. Environ Res. 2022;206:112275.","journal-title":"Environ Res"},{"issue":"1","key":"3139_CR33","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1038\/s41467-025-56963-y","volume":"16","author":"S Yang","year":"2025","unstructured":"Yang S, Li M, Guo C, et al. Associations of long-term exposure to nitrogen oxides with all-cause and cause-specific mortality. Nat Commun. 2025;16(1):1730.","journal-title":"Nat Commun"},{"key":"3139_CR34","doi-asserted-by":"crossref","unstructured":"Korbecki J, Bosiacki M, Szatkowska I et al. The clinical significance and involvement in molecular Cancer processes of chemokine CXCL1 in selected Tumors. Int J Mol Sci. 2024;25(8).","DOI":"10.3390\/ijms25084365"},{"issue":"16","key":"3139_CR35","doi-asserted-by":"publisher","first-page":"5318","DOI":"10.7150\/jca.97537","volume":"15","author":"WT Kuo","year":"2024","unstructured":"Kuo WT, Lee YC, Yang YF, et al. Sushi domain containing 2 dysfunction contributes to Cancer progression in patients with bladder Cancer. J Cancer. 2024;15(16):5318\u201328.","journal-title":"J Cancer"},{"key":"3139_CR36","doi-asserted-by":"publisher","first-page":"6812","DOI":"10.1038\/srep06812","volume":"4","author":"W Pan","year":"2014","unstructured":"Pan W, Cheng Y, Zhang H, et al. CSBF\/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest. Sci Rep. 2014;4:6812.","journal-title":"Sci Rep"},{"issue":"1","key":"3139_CR37","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1158\/1541-7786.MCR-12-0501-T","volume":"11","author":"AP Watson","year":"2013","unstructured":"Watson AP, Evans RL, Egland KA. Multiple functions of Sushi domain containing 2 (SUSD2) in breast tumorigenesis. Mol Cancer Res. 2013;11(1):74\u201385.","journal-title":"Mol Cancer Res"},{"key":"3139_CR38","doi-asserted-by":"crossref","unstructured":"Holzinger JM, Toelge M, Werner M et al. Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis. Elife. 2023;12.","DOI":"10.7554\/eLife.86369"},{"key":"3139_CR39","doi-asserted-by":"publisher","first-page":"104133","DOI":"10.1016\/j.dci.2021.104133","volume":"123","author":"Y Liu","year":"2021","unstructured":"Liu Y, Zha H, Han X, et al. Molecular characterization and functional analysis of the bactericidal permeability-increasing protein\/LPS-binding protein (BPI\/LBP) from roughskin sculpin (Trachidermus fasciatus). Dev Comp Immunol. 2021;123:104133.","journal-title":"Dev Comp Immunol"},{"issue":"15","key":"3139_CR40","doi-asserted-by":"publisher","first-page":"10119","DOI":"10.1021\/acs.jmedchem.2c00325","volume":"65","author":"Q Zheng","year":"2022","unstructured":"Zheng Q, Zhang W, Rao GW. Protein lysine methyltransferase SMYD2: A promising small molecule target for Cancer Therapy. J Med Chem. 2022;65(15):10119\u201332.","journal-title":"J Med Chem"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03139-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-03139-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03139-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T04:11:13Z","timestamp":1757218273000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-03139-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3139"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-03139-1","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"28 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"1290"}}