{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:54:00Z","timestamp":1792194840133,"version":"4.4.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Mucinous (colloid) carcinoma (MC) of the breast typically affects postmenopausal and elderly women, with a more favorable prognosis compared to invasive breast carcinoma of no special type (IBC-NST). It is characterized by the presence of extracellular mucin and better outcomes. In our work, we presented a fifteen-year yield of a tertiary cancer center for MC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In this retrospective study, the data of the patients with MC from January 2009 to August 2023 were retrieved by searching the prospectively registered electronic database of the Oncology Center, Mansoura University. The patients\u2019 epidemiological, clinical, pathological, therapeutic, and oncological data were analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 152 patients with the pathology of MC of the breast were included. The mean age of patients was 55.38\u2009\u00b1\u200913.82 years. Imaging revealed a unifocal lesion in 93 patients (61.2%). The mean mass size by imaging was 37.25\u2009\u00b1\u200920.21\u00a0mm. Positive lymph nodes (LNs) were detected by imaging in 71 (46.7%) patients. Pathological variants were either pure MC (42.1%) or mixed mucinous ductal carcinoma (57.9%). Luminal A was the most common subtype. Neoadjuvant therapy (NAT) was received by 34.8% of the patients. Mastectomy was done for 103 patients (68.2%). Axillary lymph node dissection was done for 122 patients (80.3%), and sentinel lymph node biopsy (SLNB) was done for 30 patients (19.7%). Adjuvant chemotherapy and radiotherapy were received by 65.1% and 60.8% of patients, respectively, while adjuvant hormonal therapy was received by 84.5%. The mean disease-free survival (DFS) was 43\u2009\u00b1\u200934.02 months, while the mean overall survival (OAS) was 44.5\u2009\u00b1\u200933.46 months. Seventeen patients (11.2%) were reported dead during the follow-up period.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>MC of the breast is a unique type of breast cancer. It may mimic benign lesions on imaging. The primary treatment for MC is mostly surgery, followed by adjuvant radiotherapy and systemic therapy. Comparing MC to IBC-NST, the former had a better prognosis and fewer lymphatic metastases, especially with pure MC, which shows a better prognosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12672-025-03146-2","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T17:59:23Z","timestamp":1753293563000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mucinous carcinoma of the breast: epidemiological, clinical, and prognostic characteristics; a single-center experience"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-4207","authenticated-orcid":false,"given":"Omar","family":"Hamdy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosab","family":"Shetiwy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M.","family":"Saber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma A.","family":"Eldawody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shorouq A.","family":"Kassab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam H.","family":"Nabih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Abdelhakiem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa M.","family":"Yussif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abdelwahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"3146_CR1","doi-asserted-by":"crossref","unstructured":"Smolarz B, Nowak AZ, Romanowicz H. 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All procedures performed in the study involving human participants followed the institutional research committee\u2019s ethical standards and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All the patients signed informed consent for the surgical maneuvers whenever indicated. This is a retrospective study. Consent for participation in the study itself is not applicable. The authors are accountable for all aspects of the work and ensure that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1396"}}