{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:31:36Z","timestamp":1764937896711,"version":"3.44.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32470963"],"award-info":[{"award-number":["32470963"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Administration of Traditional Chinese Medicine","award":["BJZYYB-2023-69"],"award-info":[{"award-number":["BJZYYB-2023-69"]}]},{"name":"China National Center for Biotechnology Development, National Health Commission, Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0502500"],"award-info":[{"award-number":["2023ZD0502500"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-03370-w","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:38:23Z","timestamp":1754559503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic evidence for causal effects of inflammatory protein factors on breast cancer"],"prefix":"10.1007","volume":"16","author":[{"given":"Xinqi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizhi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenglong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"3370_CR1","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","volume":"397","author":"S Loibl","year":"2021","unstructured":"Loibl S, Poortmans P, Morrow M, Denkert C, Curigliano G. Breast cancer. Lancet. 2021;397:1750\u201369.","journal-title":"Lancet"},{"key":"3370_CR2","doi-asserted-by":"crossref","unstructured":"Chen Z et al. Expressions of ZNF436, \u03b2-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances. Eur J Histochem. 2021;65(1):3173.","DOI":"10.4081\/ejh.2021.3173"},{"key":"3370_CR3","doi-asserted-by":"publisher","first-page":"118435","DOI":"10.1016\/j.lfs.2020.118435","volume":"261","author":"D Sun","year":"2020","unstructured":"Sun D, Luo X, Ma L, Wang Y, Zhang F. Identifying of miR-98-5p\/IGF1 axis contributes breast cancer progression using comprehensive bioinformatic analyses methods and experiments validation. Life Sci. 2020;261:118435.","journal-title":"Life Sci"},{"key":"3370_CR4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1055\/s-0044-101613","volume":"78","author":"FA Taran","year":"2018","unstructured":"Taran FA, et al. Update breast cancer 2018 (Part 1) - Primary breast cancer and biomarkers. Geburtshilfe Frauenheilkd. 2018;78:237\u201345.","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"3370_CR5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1476-4598-13-64","volume":"13","author":"KJ Dery","year":"2014","unstructured":"Dery KJ, et al. IRF-1 regulates alternative mRNA splicing of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in breast epithelial cells generating an immunoreceptor tyrosine-based Inhibition motif (ITIM) containing isoform. Mol Cancer. 2014;13:64.","journal-title":"Mol Cancer"},{"key":"3370_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.trsl.2020.03.013","volume":"221","author":"KK Ness","year":"2020","unstructured":"Ness KK, Wogksch MD. Frailty and aging in cancer survivors. Transl Res. 2020;221:65\u201382.","journal-title":"Transl Res"},{"key":"3370_CR7","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.ccr.2011.02.006","volume":"19","author":"J Chen","year":"2011","unstructured":"Chen J, et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell. 2011;19:541\u201355.","journal-title":"Cancer Cell"},{"key":"3370_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12943-022-01710-w","volume":"22","author":"P Stejskal","year":"2023","unstructured":"Stejskal P, et al. Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance. Mol Cancer. 2023;22:15.","journal-title":"Mol Cancer"},{"key":"3370_CR9","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41467-018-03080-8","volume":"9","author":"M Massara","year":"2018","unstructured":"Massara M, et al. ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity. Nat Commun. 2018;9:676.","journal-title":"Nat Commun"},{"key":"3370_CR10","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.molcel.2017.05.003","volume":"66","author":"I Jaco","year":"2017","unstructured":"Jaco I, et al. MK2 phosphorylates RIPK1 to prevent TNF-Induced cell death. Mol Cell. 2017;66:698\u2013e710695.","journal-title":"Mol Cell"},{"key":"3370_CR11","doi-asserted-by":"crossref","unstructured":"Reschke R, Enk AH, Hassel JC. Chemokines and cytokines in immunotherapy of melanoma and other tumors: from biomarkers to therapeutic targets. Int J Mol Sci. 2024;25(12):6532.","DOI":"10.3390\/ijms25126532"},{"key":"3370_CR12","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12943-019-0973-7","volume":"18","author":"X Bian","year":"2019","unstructured":"Bian X, et al. Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression. Mol Cancer. 2019;18:50.","journal-title":"Mol Cancer"},{"key":"3370_CR13","doi-asserted-by":"publisher","first-page":"1400713","DOI":"10.3389\/fnut.2024.1400713","volume":"11","author":"Q Su","year":"2024","unstructured":"Su Q, et al. Anorexia and bulimia in relation to ulcerative colitis: a Mendelian randomization study. Front Nutr. 2024;11:1400713.","journal-title":"Front Nutr"},{"key":"3370_CR14","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/s41598-024-84447-4","volume":"15","author":"Q Su","year":"2025","unstructured":"Su Q, et al. Assessing inflammatory protein factors in inflammatory bowel disease using multivariable Mendelian randomization. Sci Rep. 2025;15:210.","journal-title":"Sci Rep"},{"key":"3370_CR15","first-page":"962","volume":"46","author":"L Zuccolo","year":"2017","unstructured":"Zuccolo L, Holmes MV, Commentary. Mendelian randomization-inspired causal inference in the absence of genetic data. Int J Epidemiol. 2017;46:962\u20135.","journal-title":"Int J Epidemiol"},{"key":"3370_CR16","doi-asserted-by":"publisher","first-page":"e70570","DOI":"10.1002\/cam4.70570","volume":"14","author":"Q Yue","year":"2025","unstructured":"Yue Q, et al. Assessing the causal effect of Circulating Protein-To-Protein ratio on the risk of morbidity of hepatocellular carcinoma. Cancer Med. 2025;14:e70570.","journal-title":"Cancer Med"},{"key":"3370_CR17","doi-asserted-by":"publisher","first-page":"e70070","DOI":"10.1002\/lio2.70070","volume":"10","author":"Y Xu","year":"2025","unstructured":"Xu Y, et al. Causal associations between dietary factors with head and neck cancer: A two-sample Mendelian randomization study. Laryngoscope Investig Otolaryngol. 2025;10:e70070.","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"3370_CR18","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41590-023-01588-w","volume":"24","author":"JH Zhao","year":"2023","unstructured":"Zhao JH, et al. Genetics of Circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets. Nat Immunol. 2023;24:1540\u201351.","journal-title":"Nat Immunol"},{"key":"3370_CR19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613:508\u201318.","journal-title":"Nature"},{"key":"3370_CR20","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1093\/schbul\/sbz138","volume":"46","author":"J Yang","year":"2020","unstructured":"Yang J, et al. Assessing the causal effects of human serum metabolites on 5 major psychiatric disorders. Schizophr Bull. 2020;46:804\u201313.","journal-title":"Schizophr Bull"},{"key":"3370_CR21","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"S Burgess","year":"2013","unstructured":"Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37:658\u201365.","journal-title":"Genet Epidemiol"},{"key":"3370_CR22","doi-asserted-by":"publisher","first-page":"n2233","DOI":"10.1136\/bmj.n2233","volume":"375","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ. 2021;375:n2233.","journal-title":"BMJ"},{"key":"3370_CR23","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. JAMA. 2021;326:1614\u201321.","journal-title":"JAMA"},{"key":"3370_CR24","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1002\/sim.6835","volume":"35","author":"S Burgess","year":"2016","unstructured":"Burgess S, Dudbridge F, Thompson SG. Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods. Stat Med. 2016;35:1880\u2013906.","journal-title":"Stat Med"},{"key":"3370_CR25","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1002\/ehf2.14446","volume":"10","author":"F Zhang","year":"2023","unstructured":"Zhang F, et al. Causality between heart failure and epigenetic age: a bidirectional Mendelian randomization study. ESC Heart Fail. 2023;10:2903\u201313.","journal-title":"ESC Heart Fail"},{"key":"3370_CR26","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/hep.32534","volume":"77","author":"Z Ren","year":"2023","unstructured":"Ren Z, Simons P, Wesselius A, Stehouwer CDA, Brouwers M. Relationship between NAFLD and coronary artery disease: A Mendelian randomization study. Hepatology. 2023;77:230\u20138.","journal-title":"Hepatology"},{"key":"3370_CR27","doi-asserted-by":"publisher","first-page":"32043","DOI":"10.1038\/s41598-024-83795-5","volume":"14","author":"K Yang","year":"2024","unstructured":"Yang K, et al. Evaluating the impact of smoking on the risk of dry eye disease: a two-sample Mendelian randomization study. Sci Rep. 2024;14:32043.","journal-title":"Sci Rep"},{"key":"3370_CR28","doi-asserted-by":"crossref","unstructured":"Xu J et al. Genetic causal association between iron status and osteoarthritis: A Two-Sample Mendelian randomization. Nutrients. 2022;14(18):3683.","DOI":"10.3390\/nu14183683"},{"key":"3370_CR29","doi-asserted-by":"publisher","first-page":"808832","DOI":"10.3389\/fimmu.2022.808832","volume":"13","author":"KJ Yin","year":"2022","unstructured":"Yin KJ, et al. No genetic causal association between periodontitis and arthritis: A bidirectional Two-Sample Mendelian randomization analysis. Front Immunol. 2022;13:808832.","journal-title":"Front Immunol"},{"key":"3370_CR30","doi-asserted-by":"publisher","first-page":"1330560","DOI":"10.3389\/fimmu.2024.1330560","volume":"15","author":"Z Jiang","year":"2024","unstructured":"Jiang Z, et al. Associations of the Circulating levels of cytokines with risk of systemic sclerosis: a bidirectional Mendelian randomized study. Front Immunol. 2024;15:1330560.","journal-title":"Front Immunol"},{"key":"3370_CR31","doi-asserted-by":"publisher","first-page":"1354528","DOI":"10.3389\/fendo.2024.1354528","volume":"15","author":"R Li","year":"2024","unstructured":"Li R, Peng L, Deng D, Li G, Wu S. Causal relationship between alzheimer\u2019s disease and prostate cancer: a bidirectional Mendelian randomization analysis. Front Endocrinol (Lausanne). 2024;15:1354528.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3370_CR32","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1186\/s12967-022-03691-2","volume":"20","author":"G Xiao","year":"2022","unstructured":"Xiao G, et al. Causality of genetically determined metabolites on anxiety disorders: a two-sample Mendelian randomization study. J Transl Med. 2022;20:475.","journal-title":"J Transl Med"},{"key":"3370_CR33","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1016\/j.jacc.2012.09.017","volume":"60","author":"BA Ference","year":"2012","unstructured":"Ference BA, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol. 2012;60:2631\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"3370_CR34","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect Estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44:512\u201325.","journal-title":"Int J Epidemiol"},{"key":"3370_CR35","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal Pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50:693\u20138.","journal-title":"Nat Genet"},{"key":"3370_CR36","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s10194-024-01836-w","volume":"25","author":"X Duan","year":"2024","unstructured":"Duan X, et al. Causality between migraine and cardiovascular disease: a bidirectional Mendelian randomization study. J Headache Pain. 2024;25:130.","journal-title":"J Headache Pain"},{"key":"3370_CR37","doi-asserted-by":"publisher","first-page":"803238","DOI":"10.3389\/fgene.2022.803238","volume":"13","author":"FIN Mbutiwi","year":"2022","unstructured":"Mbutiwi FIN, Dessy T, Sylvestre MP, Mendelian Randomization. A review of methods for the prevention, assessment, and discussion of Pleiotropy in studies using the fat mass and Obesity-Associated gene as an instrument for adiposity. Front Genet. 2022;13:803238.","journal-title":"Front Genet"},{"key":"3370_CR38","doi-asserted-by":"publisher","first-page":"e1007081","DOI":"10.1371\/journal.pgen.1007081","volume":"13","author":"G Hemani","year":"2017","unstructured":"Hemani G, Tilling K. Davey smith, G. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 2017;13:e1007081.","journal-title":"PLoS Genet"},{"key":"3370_CR39","doi-asserted-by":"crossref","unstructured":"Sanderson E. Multivariable Mendelian randomization and mediation. Cold Spring Harb Perspect Med. 2021;11(2):a038984.","DOI":"10.1101\/cshperspect.a038984"},{"key":"3370_CR40","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/aje\/kwu283","volume":"181","author":"S Burgess","year":"2015","unstructured":"Burgess S, Thompson SG. Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol. 2015;181:251\u201360.","journal-title":"Am J Epidemiol"},{"key":"3370_CR41","doi-asserted-by":"publisher","first-page":"675","DOI":"10.2147\/IJGM.S346790","volume":"15","author":"S Xiao","year":"2022","unstructured":"Xiao S, et al. A Six-microRNA signature nomogram for preoperative prediction of tumor deposits in colorectal cancer. Int J Gen Med. 2022;15:675\u201387.","journal-title":"Int J Gen Med"},{"key":"3370_CR42","doi-asserted-by":"publisher","first-page":"5813","DOI":"10.1002\/sim.9156","volume":"40","author":"AJ Grant","year":"2021","unstructured":"Grant AJ, Burgess S. Pleiotropy robust methods for multivariable Mendelian randomization. Stat Med. 2021;40:5813\u201330.","journal-title":"Stat Med"},{"key":"3370_CR43","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","volume":"47","author":"B Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan B, et al. An atlas of genetic correlations across human diseases and traits. Nat Genet. 2015;47:1236\u201341.","journal-title":"Nat Genet"},{"key":"3370_CR44","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/s41588-019-0404-0","volume":"51","author":"B Liu","year":"2019","unstructured":"Liu B, Gloudemans MJ, Rao AS, Ingelsson E, Montgomery SB. Abundant associations with gene expression complicate GWAS follow-up. Nat Genet. 2019;51:768\u20139.","journal-title":"Nat Genet"},{"key":"3370_CR45","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s41467-020-20885-8","volume":"12","author":"CN Foley","year":"2021","unstructured":"Foley CN, et al. A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits. Nat Commun. 2021;12:764.","journal-title":"Nat Commun"},{"key":"3370_CR46","doi-asserted-by":"publisher","first-page":"13784","DOI":"10.1002\/cam4.6022","volume":"12","author":"Z Yun","year":"2023","unstructured":"Yun Z, et al. Genetically predicted 486 blood metabolites in relation to risk of colorectal cancer: A Mendelian randomization study. Cancer Med. 2023;12:13784\u201399.","journal-title":"Cancer Med"},{"key":"3370_CR47","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/nm.2940","volume":"18","author":"D Chen","year":"2012","unstructured":"Chen D, et al. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 2012;18:1511\u20137.","journal-title":"Nat Med"},{"key":"3370_CR48","doi-asserted-by":"publisher","first-page":"2271638","DOI":"10.1080\/15384047.2023.2271638","volume":"24","author":"WS Streitfeld","year":"2023","unstructured":"Streitfeld WS, Dalton AC, Howley BV, Howe PH. PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness. Cancer Biol Ther. 2023;24:2271638.","journal-title":"Cancer Biol Ther"},{"key":"3370_CR49","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/ncb3408","volume":"18","author":"RW Johnson","year":"2016","unstructured":"Johnson RW, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078\u201389.","journal-title":"Nat Cell Biol"},{"key":"3370_CR50","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.cell.2016.05.017","volume":"165","author":"N Kubben","year":"2016","unstructured":"Kubben N, et al. Repression of the antioxidant NRF2 pathway in premature aging. Cell. 2016;165:1361\u201374.","journal-title":"Cell"},{"key":"3370_CR51","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.molmed.2016.05.002","volume":"22","author":"S Menegon","year":"2016","unstructured":"Menegon S, Columbano A, Giordano S. The dual roles of NRF2 in cancer. Trends Mol Med. 2016;22:578\u201393.","journal-title":"Trends Mol Med"},{"key":"3370_CR52","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.ccell.2017.09.008","volume":"32","author":"W Ge","year":"2017","unstructured":"Ge W, et al. iASPP is an antioxidative factor and drives cancer growth and drug resistance by competing with Nrf2 for Keap1 binding. Cancer Cell. 2017;32:561\u2013e573566.","journal-title":"Cancer Cell"},{"key":"3370_CR53","doi-asserted-by":"publisher","first-page":"4028","DOI":"10.1038\/s41388-019-0698-5","volume":"38","author":"XL Zhou","year":"2019","unstructured":"Zhou XL, Zhu CY, Wu ZG, Guo X, Zou W. The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis. Oncogene. 2019;38:4028\u201346.","journal-title":"Oncogene"},{"key":"3370_CR54","doi-asserted-by":"crossref","unstructured":"Taguchi K, Yamamoto M. The KEAP1-NRF2 system as a molecular target of cancer treatment. Cancers (Basel). 2020;13(1):46.","DOI":"10.3390\/cancers13010046"},{"key":"3370_CR55","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/cac2.12010","volume":"40","author":"W Zhang","year":"2020","unstructured":"Zhang W, et al. CXCL5\/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target. Cancer Commun (Lond). 2020;40:69\u201380.","journal-title":"Cancer Commun (Lond)"},{"key":"3370_CR56","doi-asserted-by":"publisher","first-page":"110235","DOI":"10.1016\/j.intimp.2023.110235","volume":"120","author":"H Li","year":"2023","unstructured":"Li H, Li J, Bai Z, Yan S, Li J. Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer. Int Immunopharmacol. 2023;120:110235.","journal-title":"Int Immunopharmacol"},{"key":"3370_CR57","doi-asserted-by":"publisher","first-page":"15437","DOI":"10.1038\/s41598-022-19290-6","volume":"12","author":"YY Wang","year":"2022","unstructured":"Wang YY, et al. ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model. Sci Rep. 2022;12:15437.","journal-title":"Sci Rep"},{"key":"3370_CR58","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.ccell.2016.04.014","volume":"29","author":"CW Steele","year":"2016","unstructured":"Steele CW, et al. CXCR2 Inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell. 2016;29:832\u201345.","journal-title":"Cancer Cell"},{"key":"3370_CR59","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1016\/j.ejca.2011.11.032","volume":"48","author":"M Kawamura","year":"2012","unstructured":"Kawamura M, et al. CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer. Eur J Cancer. 2012;48:2244\u201351.","journal-title":"Eur J Cancer"},{"key":"3370_CR60","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1016\/j.celrep.2017.04.078","volume":"19","author":"D Powell","year":"2017","unstructured":"Powell D, et al. Chemokine signaling and the regulation of bidirectional leukocyte migration in interstitial tissues. Cell Rep. 2017;19:1572\u201385.","journal-title":"Cell Rep"},{"key":"3370_CR61","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.4049\/jimmunol.0900305","volume":"183","author":"MW Nasser","year":"2009","unstructured":"Nasser MW, et al. Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer. J Immunol. 2009;183:3425\u201332.","journal-title":"J Immunol"},{"key":"3370_CR62","unstructured":"Cai L. Understanding And Targeting The Immunosuppressive Tumor Microenvironment. (2022)."},{"key":"3370_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biochi.2018.02.009","volume":"148","author":"D Cui","year":"2018","unstructured":"Cui D, Zhao Y, Xu J. Activated CXCL5-CXCR2 axis promotes the migration, invasion and EMT of papillary thyroid carcinoma cells via modulation of \u03b2-catenin pathway. Biochimie. 2018;148:1\u201311.","journal-title":"Biochimie"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03370-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-03370-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03370-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T15:37:26Z","timestamp":1757345846000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-03370-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3370"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-03370-w","relation":{},"ISSN":["2730-6011"],"issn-type":[{"type":"electronic","value":"2730-6011"}],"subject":[],"published":{"date-parts":[[2025,8,7]]},"assertion":[{"value":"24 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study utilized publicly available summary-level GWAS data and did not require additional ethical approval. All original studies from which the data were derived (UK Biobank and FinnGen) obtained appropriate ethical approval from their respective institutional review boards and ethics committees. The UK Biobank study received ethical approval from the North West Multi-Centre Research Ethics Committee (REC reference: 11\/NW\/0382), and the FinnGen study was approved by the Finnish Institute for Health and Welfare (THL) and the Ethics Committee of the Hospital District of Helsinki and Uusimaa (HUS). No direct participant consent was required for this study as it exclusively used publicly available summary-level GWAS data. All participants in the original studies (UK Biobank and FinnGen) provided informed consent for participation in genetic research, including the use of their anonymized data in approved research projects. The current study did not involve direct contact with participants or access to individual-level data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"No specific consent to publish was required for this study as it utilized publicly available summary-level GWAS data that have been previously published and made available for research purposes. All original studies obtained appropriate consent from participants for the publication of research findings derived from their anonymized data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1490"}}