{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T20:59:42Z","timestamp":1757624382403,"version":"3.44.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-03476-1","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T13:43:27Z","timestamp":1756043007000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of diabetes-related signatures as prognostic and therapeutic biomarkers in colon cancer"],"prefix":"10.1007","volume":"16","author":[{"given":"Ming","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghai","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zelian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,24]]},"reference":[{"issue":"3","key":"3476_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"3476_CR2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12889-023-17571-x","volume":"24","author":"J Cui","year":"2024","unstructured":"Cui J, Ding R, Liu H, et al. Trends in the incidence and survival of cancer in individuals aged 55 years and older in the united states, 1975\u20132019. BMC Public Health. 2024;24(1):72.","journal-title":"BMC Public Health"},{"issue":"1","key":"3476_CR3","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/s12885-022-09460-0","volume":"22","author":"T Olenius","year":"2022","unstructured":"Olenius T, Koskenvuo L, Koskensalo S, et al. Long-term survival among colorectal cancer patients in finland, 1991\u20132015: a nationwide population-based registry study. BMC Cancer. 2022;22(1):356.","journal-title":"BMC Cancer"},{"key":"3476_CR4","doi-asserted-by":"publisher","first-page":"109119","DOI":"10.1016\/j.diabres.2021.109119","volume":"183","author":"H Sun","year":"2022","unstructured":"Sun H, Saeedi P, Karuranga S, et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119.","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"3476_CR5","doi-asserted-by":"publisher","first-page":"e3588","DOI":"10.1002\/dmrr.3588","volume":"39","author":"G Li","year":"2023","unstructured":"Li G, Zhang J, Chen B, et al. Racial and ethnic subgroup reporting in diabetes randomized controlled trials published from 2000 to 2020: A survey. Diabetes Metab Res Rev. 2023;39(1):e3588.","journal-title":"Diabetes Metab Res Rev"},{"doi-asserted-by":"crossref","unstructured":"Pliszka M, Szablewski L. Associations between diabetes mellitus and selected cancers. Int J Mol Sci. 2024;25(13).","key":"3476_CR6","DOI":"10.3390\/ijms25137476"},{"key":"3476_CR7","doi-asserted-by":"publisher","first-page":"173805","DOI":"10.1016\/j.ejphar.2020.173805","volume":"893","author":"S Gajjar","year":"2021","unstructured":"Gajjar S, Patel BM. Common targets for a deadly duo of diabetes mellitus and colon cancer: catching two fish with one worm. Eur J Pharmacol. 2021;893:173805.","journal-title":"Eur J Pharmacol"},{"doi-asserted-by":"crossref","unstructured":"Shahid RK, Ahmed S, Le D, et al. Diabetes and cancer: risk, challenges, management and outcomes. Cancers. 2021;13(22).","key":"3476_CR8","DOI":"10.3390\/cancers13225735"},{"key":"3476_CR9","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ejca.2022.02.005","volume":"166","author":"N Christou","year":"2022","unstructured":"Christou N, Bergen ES, Canton C, et al. Impact of diabetes and Metformin use on recurrence and outcome in stage II-III colon cancer patients-A pooled analysis of three adjuvant trials. Eur J Cancer. 2022;166:100\u201311.","journal-title":"Eur J Cancer"},{"issue":"2","key":"3476_CR10","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/DCR.0000000000002323","volume":"65","author":"JD Vogel","year":"2022","unstructured":"Vogel JD, Felder SI, Bhama AR, et al. The American society of colon and rectal surgeons clinical practice guidelines for the management of colon cancer. Dis Colon Rectum. 2022;65(2):148\u201377.","journal-title":"Dis Colon Rectum"},{"issue":"4","key":"3476_CR11","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/1878-0261.12438","volume":"13","author":"L Del Puerto-Nevado","year":"2019","unstructured":"Del Puerto-Nevado L, Minguez P, Corton M, et al. Molecular evidence of field cancerization initiated by diabetes in colon cancer patients. Mol Oncol. 2019;13(4):857\u201372.","journal-title":"Mol Oncol"},{"issue":"2","key":"3476_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1530\/ERC-11-0329","volume":"19","author":"B Gyorffy","year":"2012","unstructured":"Gyorffy B, L\u00e1nczky A, Sz\u00e1ll\u00e1si Z. Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr Relat Cancer. 2012;19(2):197\u2013208.","journal-title":"Endocr Relat Cancer"},{"unstructured":"Subramanian A, Narayan R, Corsello SM, et al. A next generation connectivity map: L1000 platform and the first 1,000,000 profiles. Cell. 2017;171(6).","key":"3476_CR13"},{"issue":"1","key":"3476_CR14","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12967-023-03983-1","volume":"21","author":"H Li","year":"2023","unstructured":"Li H, Li C, Zhang B, et al. Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP\/m6A\/NT5DC3\/HKDC1 axis. J Transl Med. 2023;21(1):156.","journal-title":"J Transl Med"},{"issue":"1","key":"3476_CR15","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12964-023-01193-2","volume":"21","author":"Q Wu","year":"2023","unstructured":"Wu Q, Du X, Cheng J, et al. PECAM-1 drives \u03b2-catenin-mediated EndMT via internalization in colon cancer with diabetes mellitus. Cell Commun Signal. 2023;21(1):203.","journal-title":"Cell Commun Signal"},{"issue":"9","key":"3476_CR16","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s00018-022-04485-x","volume":"79","author":"M Noureldein","year":"2022","unstructured":"Noureldein M, Nawfal R, Bitar S, et al. Intestinal microbiota regulates diabetes and cancer progression by IL-1\u03b2 and NOX4 dependent signaling cascades. Cell Mol Life Sci. 2022;79(9):502.","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"3476_CR17","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1002\/1878-0261.12531","volume":"13","author":"L Del Puerto-Nevado","year":"2019","unstructured":"Del Puerto-Nevado L, Santiago-Hernandez A, Solanes-Casado S, et al. Diabetes-mediated promotion of colon mucosa carcinogenesis is associated with mitochondrial dysfunction. Mol Oncol. 2019;13(9):1887\u201397.","journal-title":"Mol Oncol"},{"issue":"12","key":"3476_CR18","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/nrc2536","volume":"8","author":"M Pollak","year":"2008","unstructured":"Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer. 2008;8(12):915\u201328.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"3476_CR19","doi-asserted-by":"publisher","first-page":"399","DOI":"10.5534\/wjmh.210146","volume":"40","author":"T Vezza","year":"2022","unstructured":"Vezza T, D\u00edaz-Pozo P, Canet F, et al. The role of mitochondrial dynamic dysfunction in Age-Associated type 2 diabetes. World J Mens Health. 2022;40(3):399\u2013411.","journal-title":"World J Mens Health"},{"issue":"1","key":"3476_CR20","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/s41467-024-44843-w","volume":"15","author":"Y-C Shih","year":"2024","unstructured":"Shih Y-C, Chen H-F, Wu C-Y, et al. The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling. Nat Commun. 2024;15(1):532.","journal-title":"Nat Commun"},{"issue":"1","key":"3476_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1021\/acs.jproteome.7b00550","volume":"17","author":"H-F Hu","year":"2018","unstructured":"Hu H-F, Xu WW, Wang Y, et al. Comparative proteomics analysis identifies Cdc42-Cdc42BPA signaling as prognostic biomarker and therapeutic target for colon cancer invasion. J Proteome Res. 2018;17(1):265\u201375.","journal-title":"J Proteome Res"},{"issue":"10","key":"3476_CR22","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1080\/15548627.2020.1851492","volume":"17","author":"P Luo","year":"2021","unstructured":"Luo P, Yan H, Du J, et al. PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). Autophagy. 2021;17(10):3221\u201337.","journal-title":"Autophagy"},{"issue":"43","key":"3476_CR23","doi-asserted-by":"publisher","first-page":"22442","DOI":"10.1074\/jbc.M116.754069","volume":"291","author":"CP Wigington","year":"2016","unstructured":"Wigington CP, Morris KJ, Newman LE, et al. The Polyadenosine RNA-binding protein, zinc finger Cys3His protein 14 (ZC3H14), regulates the Pre-mRNA processing of a key ATP synthase subunit mRNA. J Biol Chem. 2016;291(43):22442\u201359.","journal-title":"J Biol Chem"},{"issue":"3","key":"3476_CR24","first-page":"198","volume":"21","author":"JC Fabregas","year":"2022","unstructured":"Fabregas JC, Ramnaraign B, George TJ. Clinical updates for colon cancer care in 2022. Clin Colorectal Cancer. 2022;21(3):198\u2013203.","journal-title":"Clin Colorectal Cancer"},{"issue":"13","key":"3476_CR25","doi-asserted-by":"publisher","first-page":"11995","DOI":"10.1007\/s00432-023-05033-1","volume":"149","author":"J Liu","year":"2023","unstructured":"Liu J, Dou M, Liu X, et al. A novel m6A\/m5C\/m1A score signature to evaluate prognosis and its immunotherapy value in colon cancer patients. J Cancer Res Clin Oncol. 2023;149(13):11995\u20132012.","journal-title":"J Cancer Res Clin Oncol"},{"doi-asserted-by":"crossref","unstructured":"Stefani C, Miricescu D, Stanescu-Spinu I-I, et al. Growth factors, PI3K\/AKT\/mTOR and MAPK signaling pathways in colorectal cancer pathogenesis: where are we now? Int J Mol Sci. 2021;22(19).","key":"3476_CR26","DOI":"10.3390\/ijms221910260"},{"doi-asserted-by":"crossref","unstructured":"Subtil FSB, Gr\u00f6bner C, Recknagel N, et al. Dual PI3K\/mTOR inhibitor NVP-BEZ235 leads to a synergistic enhancement of cisplatin and radiation in both HPV-Negative and -Positive HNSCC cell lines. Cancers. 2022;14(13).","key":"3476_CR27","DOI":"10.3390\/cancers14133160"},{"key":"3476_CR28","doi-asserted-by":"publisher","first-page":"781623","DOI":"10.3389\/fphar.2021.781623","volume":"12","author":"B Li","year":"2021","unstructured":"Li B, Zhang X, Ren Q, et al. NVP-BEZ235 inhibits renal cell carcinoma by targeting TAK1 and PI3K\/Akt\/mTOR pathways. Front Pharmacol. 2021;12:781623.","journal-title":"Front Pharmacol"},{"issue":"1","key":"3476_CR29","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","volume":"22","author":"A Glaviano","year":"2023","unstructured":"Glaviano A, Foo ASC, Lam HY, et al. PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer. Mol Cancer. 2023;22(1):138.","journal-title":"Mol Cancer"},{"issue":"6","key":"3476_CR30","first-page":"3798","volume":"19","author":"H Cheng","year":"2020","unstructured":"Cheng H, Jiang X, Zhang Q, et al. Naringin inhibits colorectal cancer cell growth by repressing the PI3K\/AKT\/mTOR signaling pathway. Exp Ther Med. 2020;19(6):3798\u2013804.","journal-title":"Exp Ther Med"},{"issue":"1","key":"3476_CR31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3892\/ijo.2020.5151","volume":"58","author":"J Wang","year":"2021","unstructured":"Wang J, Liang D, Zhang X-P, et al. Novel PI3K\/Akt\/mTOR signaling inhibitor, W922, prevents colorectal cancer growth via the regulation of autophagy. Int J Oncol. 2021;58(1):70\u201382.","journal-title":"Int J Oncol"},{"issue":"5","key":"3476_CR32","doi-asserted-by":"publisher","first-page":"4797","DOI":"10.1007\/s11033-021-06458-y","volume":"48","author":"Z Moafian","year":"2021","unstructured":"Moafian Z, Maghrouni A, Soltani A, et al. Cross-talk between non-coding RNAs and PI3K\/AKT\/mTOR pathway in colorectal cancer. Mol Biol Rep. 2021;48(5):4797\u2013811.","journal-title":"Mol Biol Rep"},{"issue":"3","key":"3476_CR33","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1007\/s11033-020-05327-4","volume":"47","author":"MW Helmy","year":"2020","unstructured":"Helmy MW, Ghoneim AI, Katary MA, et al. The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through Inhibition of the PI3K\/Akt\/mTOR\/NF-\u03baB axis. Mol Biol Rep. 2020;47(3):2217\u201330.","journal-title":"Mol Biol Rep"},{"issue":"3","key":"3476_CR34","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/d41573-021-00023-9","volume":"20","author":"MP East","year":"2021","unstructured":"East MP, Asquith CRM. CDC42BPA\/MRCK\u03b1: a kinase target for brain, ovarian and skin cancers. Nat Rev Drug Discov. 2021;20(3):167.","journal-title":"Nat Rev Drug Discov"},{"doi-asserted-by":"crossref","unstructured":"Kumar A, Karuppagounder SS, Chen Y, et al. 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer\u2019s resilience. Neuron. 2023;111(18).","key":"3476_CR35","DOI":"10.1016\/j.neuron.2023.06.013"},{"doi-asserted-by":"crossref","unstructured":"Zhao J, Ye L, Liu Z, et al. Protective effects of resveratrol on adolescent social isolation-induced anxiety-like behaviors via modulating nucleus accumbens spine plasticity and mitochondrial function in female rats. Nutrients. 2022;14(21).","key":"3476_CR36","DOI":"10.3390\/nu14214542"},{"key":"3476_CR37","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.semcancer.2017.11.013","volume":"56","author":"T Bacchetti","year":"2019","unstructured":"Bacchetti T, Ferretti G, Sahebkar A. The role of paraoxonase in cancer. Semin Cancer Biol. 2019;56:72\u201386.","journal-title":"Semin Cancer Biol"},{"doi-asserted-by":"crossref","unstructured":"Hagmann H, Khayyat NH, Matin M, et al. Capsazepine (CPZ) inhibits TRPC6 conductance and is protective in adriamycin-induced nephropathy and diabetic glomerulopathy. Cells. 2023;12(2).","key":"3476_CR38","DOI":"10.3390\/cells12020271"},{"issue":"Pt 1","key":"3476_CR39","first-page":"128899","volume":"258","author":"R Ravi","year":"2023","unstructured":"Ravi R, Nagarajan H, Muralikumar S, et al. Unveiling the therapeutic potential of a mutated paraoxonase 2 in diabetic retinopathy: defying glycation, mitigating oxidative stress, ER stress and inflammation. Int J Biol Macromol. 2023;258(Pt 1):128899.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"3476_CR40","doi-asserted-by":"publisher","first-page":"15327","DOI":"10.1038\/s41598-018-33527-3","volume":"8","author":"CR Clark","year":"2018","unstructured":"Clark CR, Maile M, Blaney P, et al. Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. Sci Rep. 2018;8(1):15327.","journal-title":"Sci Rep"},{"issue":"43","key":"3476_CR41","doi-asserted-by":"publisher","first-page":"e2200215119","DOI":"10.1073\/pnas.2200215119","volume":"119","author":"S Gao","year":"2022","unstructured":"Gao S, Zhang G, Zhang Z, et al. UBR2 targets myosin heavy chain IIb and IIx for degradation: molecular mechanism essential for cancer-induced muscle wasting. Proc Natl Acad Sci U S A. 2022;119(43):e2200215119.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"3476_CR42","doi-asserted-by":"publisher","first-page":"210","DOI":"10.2337\/db22-0362","volume":"72","author":"J Xu","year":"2023","unstructured":"Xu J, Liu Z, Zhang J, et al. N-end Rule-Mediated proteasomal degradation of ATGL promotes lipid storage. Diabetes. 2023;72(2):210\u201322.","journal-title":"Diabetes"},{"issue":"12","key":"3476_CR43","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/s41419-020-03258-3","volume":"11","author":"E Villa","year":"2020","unstructured":"Villa E, Paul R, Meynet O, et al. The E3 ligase UBR2 regulates cell death under caspase deficiency via erk\/mapk pathway. Cell Death Dis. 2020;11(12):1041.","journal-title":"Cell Death Dis"},{"issue":"1","key":"3476_CR44","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12885-023-10779-5","volume":"23","author":"K Hong","year":"2023","unstructured":"Hong K, Yang Q, Yin H, et al. Comprehensive analysis of ZNF family genes in prognosis, immunity, and treatment of esophageal cancer. BMC Cancer. 2023;23(1):301.","journal-title":"BMC Cancer"},{"key":"3476_CR45","doi-asserted-by":"publisher","first-page":"100118","DOI":"10.1074\/jbc.RA120.015389","volume":"296","author":"S Alqawlaq","year":"2021","unstructured":"Alqawlaq S, Livne-Bar I, Williams D, et al. An endogenous PI3K interactome promoting astrocyte-mediated neuroprotection identifies a novel association with RNA-binding protein ZC3H14. J Biol Chem. 2021;296:100118.","journal-title":"J Biol Chem"},{"key":"3476_CR46","doi-asserted-by":"publisher","first-page":"115669","DOI":"10.1016\/j.biopha.2023.115669","volume":"168","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Suo W, Zhang X, et al. Targeting mitochondrial quality control for diabetic cardiomyopathy: therapeutic potential of hypoglycemic drugs. Biomed Pharmacother. 2023;168:115669.","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"3476_CR47","doi-asserted-by":"publisher","first-page":"e781","DOI":"10.1097\/SLA.0000000000004312","volume":"275","author":"FF Van Den Berg","year":"2022","unstructured":"Van Den Berg FF, Issa Y, Vreijling JP, et al. Whole-exome sequencing identifies SLC52A1 and ZNF106 variants as novel genetic risk factors for (Early) Multiple-organ failure in acute pancreatitis. Ann Surg. 2022;275(6):e781\u20138.","journal-title":"Ann Surg"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03476-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-03476-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03476-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T12:16:40Z","timestamp":1757420200000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-03476-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,24]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3476"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-03476-1","relation":{},"ISSN":["2730-6011"],"issn-type":[{"type":"electronic","value":"2730-6011"}],"subject":[],"published":{"date-parts":[[2025,8,24]]},"assertion":[{"value":"2 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors are aware of and have consented to publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1604"}}