{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:10:14Z","timestamp":1788480614101,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Key Discipline Fund of Clinical Laboratory Medicine at Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","award":["YJZDXK202208"],"award-info":[{"award-number":["YJZDXK202208"]}]},{"name":"the Key Discipline Fund of Clinical Laboratory Medicine at Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","award":["YJZDXK202208"],"award-info":[{"award-number":["YJZDXK202208"]}]},{"name":"the Key Discipline Fund of Clinical Laboratory Medicine at Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University","award":["YJZDXK202208"],"award-info":[{"award-number":["YJZDXK202208"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-03693-8","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:56:45Z","timestamp":1759921005000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a novel 4-protein signature for prognostic prediction in hepatitis B virus-induced hepatocellular carcinoma"],"prefix":"10.1007","volume":"16","author":[{"given":"HaiFeng","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heran","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"issue":"9","key":"3693_CR1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41568-021-00383-9","volume":"21","author":"X Li","year":"2021","unstructured":"Li X, Ramadori P, Pfister D, Seehawer M, Zender L, Heikenwalder M. The immunological and metabolic landscape in primary and metastatic liver cancer. Nat Rev Cancer. 2021;21(9):541\u201357.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"3693_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"Cancer J Clin"},{"issue":"10","key":"3693_CR3","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","volume":"16","author":"JD Yang","year":"2019","unstructured":"Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Reviews Gastroenterol Hepatol. 2019;16(10):589\u2013604.","journal-title":"Nat Reviews Gastroenterol Hepatol"},{"issue":"3","key":"3693_CR4","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.bpg.2017.04.011","volume":"31","author":"W Xu","year":"2017","unstructured":"Xu W, Yu J, Wong VW. Mechanism and prediction of HCC development in HBV infection. Best Pract Res Clin Gastroenterol. 2017;31(3):291\u20138.","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"3693_CR5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fgene.2018.00261","volume":"9","author":"P An","year":"2018","unstructured":"An P, Xu J, Yu Y, Winkler CA. Host and viral genetic variation in HBV-Related hepatocellular carcinoma. Front Genet. 2018;9:261.","journal-title":"Front Genet"},{"issue":"1","key":"3693_CR6","doi-asserted-by":"publisher","first-page":"e28436","DOI":"10.1002\/jmv.28436","volume":"95","author":"A Kar","year":"2023","unstructured":"Kar A, Samanta A, Mukherjee S, Barik S, Biswas A. The HBV web: an insight into molecular interactomes between the hepatitis B virus and its host En route to hepatocellular carcinoma. J Med Virol. 2023;95(1):e28436.","journal-title":"J Med Virol"},{"key":"3693_CR7","doi-asserted-by":"crossref","unstructured":"Liu YC, Yeh CT, Lin KH. Cancer stem cell functions in hepatocellular carcinoma and comprehensive therapeutic strategies. Cells. 2020;9(6):1331.","DOI":"10.3390\/cells9061331"},{"issue":"10360","key":"3693_CR8","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","volume":"400","author":"A Vogel","year":"2022","unstructured":"Vogel A, Meyer T, Sapisochin G, Salem R, Saborowski A. Hepatocellular carcinoma. Lancet. 2022;400(10360):1345\u201362.","journal-title":"Lancet"},{"issue":"2","key":"3693_CR9","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.cell.2019.08.052","volume":"179","author":"Q Gao","year":"2019","unstructured":"Gao Q, Zhu H, Dong L, Shi W, Chen R, Song Z, et al. Integrated proteogenomic characterization of HBV-Related hepatocellular carcinoma. Cell. 2019;179(2):561\u2013e7722.","journal-title":"Cell"},{"issue":"7409","key":"3693_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/nature11213","volume":"488","author":"G Robinson","year":"2012","unstructured":"Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, et al. Novel mutations target distinct subgroups of Medulloblastoma. Nature. 2012;488(7409):43\u20138.","journal-title":"Nature"},{"key":"3693_CR11","doi-asserted-by":"crossref","unstructured":"Ali SR, Jordan M, Nagarajan P, Amit M. Nerve density and neuronal biomarkers in cancer. Cancers (Basel). 2022;14(19):4817.","DOI":"10.3390\/cancers14194817"},{"issue":"6","key":"3693_CR12","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.ccell.2017.05.005","volume":"31","author":"FMG Cavalli","year":"2017","unstructured":"Cavalli FMG, Remke M, Rampasek L, Peacock J, Shih DJH, Luu B, et al. Intertumoral heterogeneity within Medulloblastoma subgroups. Cancer Cell. 2017;31(6):737\u2013e546.","journal-title":"Cancer Cell"},{"key":"3693_CR13","first-page":"37","volume":"1869","author":"V Ramaswamy","year":"2019","unstructured":"Ramaswamy V, Taylor MD. Bioinformatic strategies for the genomic and epigenomic characterization of brain Tumors. Methods in molecular biology. (Clifton NJ). 2019;1869:37\u201356.","journal-title":"(Clifton NJ)"},{"issue":"7605","key":"3693_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature18003","volume":"534","author":"P Mertins","year":"2016","unstructured":"Mertins P, Mani DR, Ruggles KV, Gillette MA, Clauser KR, Wang P, et al. Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016;534(7605):55\u201362.","journal-title":"Nature"},{"issue":"Suppl 4","key":"3693_CR15","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","volume":"8","author":"CH Chin","year":"2014","unstructured":"Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY. CytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 2014;8(Suppl 4):S11.","journal-title":"BMC Syst Biol"},{"issue":"1","key":"3693_CR16","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41575-022-00688-6","volume":"20","author":"DQ Huang","year":"2023","unstructured":"Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R. Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors. Nat Reviews Gastroenterol Hepatol. 2023;20(1):37\u201349.","journal-title":"Nat Reviews Gastroenterol Hepatol"},{"key":"3693_CR17","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.2147\/JHC.S462168","volume":"11","author":"YK Li","year":"2024","unstructured":"Li YK, Wu S, Wu YS, Zhang WH, Wang Y, Li YH, et al. Portal venous and hepatic arterial coefficients predict Post-Hepatectomy overall and Recurrence-Free survival in patients with hepatocellular carcinoma: A retrospective study. J Hepatocellular Carcinoma. 2024;11:1389\u2013402.","journal-title":"J Hepatocellular Carcinoma"},{"key":"3693_CR18","doi-asserted-by":"crossref","unstructured":"Xiang J, Li Y, Mei S, Ou Z, Wang L, Ke Y, et al. Novel diagnostic and therapeutic strategies based on PANoptosis for hepatocellular carcinoma. Cancer biology & medicine; 2025.","DOI":"10.20892\/j.issn.2095-3941.2025.0150"},{"key":"3693_CR19","doi-asserted-by":"publisher","first-page":"5291","DOI":"10.2147\/CMAR.S178579","volume":"10","author":"K Ke","year":"2018","unstructured":"Ke K, Chen G, Cai Z, Huang Y, Zhao B, Wang Y, et al. Evaluation and prediction of hepatocellular carcinoma prognosis based on molecular classification. Cancer Manag Res. 2018;10:5291\u2013302.","journal-title":"Cancer Manag Res"},{"key":"3693_CR20","doi-asserted-by":"publisher","first-page":"4051192","DOI":"10.1155\/2021\/4051192","volume":"2021","author":"Y Yu","year":"2021","unstructured":"Yu Y, Chen X, Zhang W, Liu J. Abnormal expression of centromere protein U is associated with hepatocellular cancer progression. Biomed Res Int. 2021;2021:4051192.","journal-title":"Biomed Res Int"},{"issue":"1","key":"3693_CR21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13048-020-00632-9","volume":"13","author":"G Gong","year":"2020","unstructured":"Gong G, Lin T, Yuan Y. Integrated analysis of gene expression and DNA methylation profiles in ovarian cancer. J Ovarian Res. 2020;13(1):30.","journal-title":"J Ovarian Res"},{"issue":"3","key":"3693_CR22","first-page":"978","volume":"52","author":"H Arai","year":"2018","unstructured":"Arai H, Wada R, Ishino K, Kudo M, Uchida E, Naito Z. Expression of DNA damage response proteins in gastric cancer: comprehensive protein profiling and histological analysis. Int J Oncol. 2018;52(3):978\u201388.","journal-title":"Int J Oncol"},{"issue":"6","key":"3693_CR23","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.jtha.2023.02.029","volume":"21","author":"A Falanga","year":"2023","unstructured":"Falanga A, Marchetti M. Cancer-associated thrombosis: enhanced awareness and pathophysiologic complexity. J Thromb Haemostasis: JTH. 2023;21(6):1397\u2013408.","journal-title":"J Thromb Haemostasis: JTH"},{"issue":"47","key":"3693_CR24","doi-asserted-by":"publisher","first-page":"7561","DOI":"10.3748\/wjg.v12.i47.7561","volume":"12","author":"M Minagawa","year":"2006","unstructured":"Minagawa M, Makuuchi M. Treatment of hepatocellular carcinoma accompanied by portal vein tumor thrombus. World J Gastroenterol. 2006;12(47):7561\u20137.","journal-title":"World J Gastroenterol"},{"issue":"8","key":"3693_CR25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrclinonc.2012.106","volume":"9","author":"A Young","year":"2012","unstructured":"Young A, Chapman O, Connor C, Poole C, Rose P, Kakkar AK. Thrombosis and cancer. Nat Reviews Clin Oncol. 2012;9(8):437\u201349.","journal-title":"Nat Reviews Clin Oncol"},{"issue":"5","key":"3693_CR26","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1080\/14737140.2025.2489651","volume":"25","author":"QB Wang","year":"2025","unstructured":"Wang QB, Li J, Zhang ZJ, Li YK, Liang YB, Chen XM, et al. The effectiveness and safety of therapies for hepatocellular carcinoma with tumor thrombus in the hepatic vein, inferior Vena cave and\/or right atrium: a systematic review and single-arm meta-analysis. Expert Rev Anticancer Ther. 2025;25(5):561\u201370.","journal-title":"Expert Rev Anticancer Ther"},{"issue":"17","key":"3693_CR27","first-page":"8119","volume":"27","author":"ZB Tan","year":"2023","unstructured":"Tan ZB, Zhang J. Recent advances in treatment strategies for hepatocellular carcinoma with portal vein cancer thrombus. Eur Rev Med Pharmacol Sci. 2023;27(17):8119\u201334.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"8","key":"3693_CR28","first-page":"3977","volume":"11","author":"X Yang","year":"2018","unstructured":"Yang X, Ran R, Du J, Qiu Z, Cui L, Jiang X, et al. CCL20 is overexpressed in hepatocellular carcinoma with bile duct tumor thrombus and correlates negatively with surgical outcome. Int J Clin Exp Pathol. 2018;11(8):3977\u201383.","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"3693_CR29","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/1756-9966-29-156","volume":"29","author":"N Li","year":"2010","unstructured":"Li N, Guo W, Shi J, Xue J, Hu H, Xie D, et al. Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus. J Experimental Clin Cancer Research: CR. 2010;29(1):156.","journal-title":"J Experimental Clin Cancer Research: CR"},{"issue":"1","key":"3693_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1756-9966-33-55","volume":"33","author":"B Zhou","year":"2014","unstructured":"Zhou B, Chen H, Wei D, Kuang Y, Zhao X, Li G, et al. A novel miR-219-SMC4-JAK2\/Stat3 regulatory pathway in human hepatocellular carcinoma. J Experimental Clin Cancer Research: CR. 2014;33(1):55.","journal-title":"J Experimental Clin Cancer Research: CR"},{"issue":"6","key":"3693_CR31","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.tig.2018.03.003","volume":"34","author":"MS van Ruiten","year":"2018","unstructured":"van Ruiten MS, Rowland BD. SMC complexes: universal DNA looping machines with distinct regulators. Trends Genet. 2018;34(6):477\u201387.","journal-title":"Trends Genet"},{"key":"3693_CR32","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1146\/annurev-genet-112618-043633","volume":"53","author":"S Yatskevich","year":"2019","unstructured":"Yatskevich S, Rhodes J, Nasmyth K. Organization of chromosomal DNA by SMC complexes. Annu Rev Genet. 2019;53:445\u201382.","journal-title":"Annu Rev Genet"},{"issue":"9","key":"3693_CR33","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1016\/j.molcel.2022.04.006","volume":"82","author":"R Oldenkamp","year":"2022","unstructured":"Oldenkamp R, Rowland BD. A walk through the SMC cycle: from catching DNAs to shaping the genome. Mol Cell. 2022;82(9):1616\u201330.","journal-title":"Mol Cell"},{"key":"3693_CR34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40104-016-0061-4","volume":"7","author":"L Zhang","year":"2016","unstructured":"Zhang L, Zhang L, Zhan X, Zeng X, Zhou L, Cao G, et al. Effects of dietary supplementation of probiotic, clostridium butyricum, on growth performance, immune response, intestinal barrier function, and digestive enzyme activity in broiler chickens challenged with Escherichia coli K88. J Anim Sci Biotechnol. 2016;7:3.","journal-title":"J Anim Sci Biotechnol"},{"issue":"4","key":"3693_CR35","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.3892\/or.2012.1929","volume":"28","author":"B Zhou","year":"2012","unstructured":"Zhou B, Yuan T, Liu M, Liu H, Xie J, Shen Y, et al. Overexpression of the structural maintenance of chromosome 4 protein is associated with tumor de-differentiation, advanced stage and vascular invasion of primary liver cancer. Oncol Rep. 2012;28(4):1263\u20138.","journal-title":"Oncol Rep"},{"issue":"3","key":"3693_CR36","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2217\/fon-2016-0223","volume":"13","author":"H Kim","year":"2017","unstructured":"Kim H, Skowronski J, Den RB. Prognostic outlier genes for enhanced prostate cancer treatment. Future Oncol (London England). 2017;13(3):249\u201361.","journal-title":"Future Oncol (London England)"},{"issue":"1","key":"3693_CR37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10549-010-0825-z","volume":"125","author":"H Chang","year":"2011","unstructured":"Chang H, Jeung HC, Jung JJ, Kim TS, Rha SY, Chung HC. Identification of genes associated with chemosensitivity to SAHA\/taxane combination treatment in taxane-resistant breast cancer cells. Breast Cancer Res Treat. 2011;125(1):55\u201363.","journal-title":"Breast Cancer Res Treat"},{"issue":"13","key":"3693_CR38","doi-asserted-by":"publisher","first-page":"21733","DOI":"10.18632\/oncotarget.15562","volume":"8","author":"J P\u00e9rez-Pe\u00f1a","year":"2017","unstructured":"P\u00e9rez-Pe\u00f1a J, Alcaraz-Sanabria A, Nieto-Jim\u00e9nez C, P\u00e1ez R, Corrales-S\u00e1nchez V, Serrano-Oviedo L, et al. Mitotic read-out genes confer poor outcome in luminal A breast cancer tumors. Oncotarget. 2017;8(13):21733\u201340.","journal-title":"Oncotarget"},{"key":"3693_CR39","doi-asserted-by":"publisher","first-page":"107385","DOI":"10.1016\/j.biotechadv.2019.04.007","volume":"38","author":"H Khan","year":"2020","unstructured":"Khan H, Reale M, Ullah H, Sureda A, Tejada S, Wang Y, et al. Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions. Biotechnol Adv. 2020;38:107385.","journal-title":"Biotechnol Adv"},{"issue":"1","key":"3693_CR40","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s12859-021-04256-8","volume":"22","author":"L Yuan","year":"2021","unstructured":"Yuan L, Zhao J, Sun T, Shen Z. A machine learning framework that integrates multi-omics data predicts cancer-related LncRNAs. BMC Bioinformatics. 2021;22(1):332.","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"3693_CR41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1083\/jcb.200906147","volume":"188","author":"JH van Ree","year":"2010","unstructured":"van Ree JH, Jeganathan KB, Malureanu L, van Deursen JM. Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. J Cell Biol. 2010;188(1):83\u2013100.","journal-title":"J Cell Biol"},{"issue":"14","key":"3693_CR42","first-page":"4167","volume":"63","author":"Y Okamoto","year":"2003","unstructured":"Okamoto Y, Ozaki T, Miyazaki K, Aoyama M, Miyazaki M, Nakagawara A. UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme. Cancer Res. 2003;63(14):4167\u201373.","journal-title":"Cancer Res"},{"key":"3693_CR43","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3389\/fphar.2018.00847","volume":"9","author":"J Zhang","year":"2018","unstructured":"Zhang J, Liu X, Yu G, Liu L, Wang J, Chen X, et al. UBE2C is a potential biomarker of Intestinal-Type gastric cancer with chromosomal instability. Front Pharmacol. 2018;9:847.","journal-title":"Front Pharmacol"},{"issue":"6","key":"3693_CR44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41389-018-0054-6","volume":"7","author":"J Guo","year":"2018","unstructured":"Guo J, Wu Y, Du J, Yang L, Chen W, Gong K, et al. Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression. Oncogenesis. 2018;7(6):49.","journal-title":"Oncogenesis"},{"issue":"10","key":"3693_CR45","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.7150\/jca.32731","volume":"10","author":"G Liu","year":"2019","unstructured":"Liu G, Zhao J, Pan B, Ma G, Liu L. UBE2C overexpression in melanoma and its essential role in G2\/M transition. J Cancer. 2019;10(10):2176\u201384.","journal-title":"J Cancer"},{"issue":"6","key":"3693_CR46","first-page":"5409","volume":"17","author":"Z Wei","year":"2019","unstructured":"Wei Z, Liu Y, Qiao S, Li X, Li Q, Zhao J, et al. Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: an investigation based on GEO and TCGA databases. Oncol Lett. 2019;17(6):5409\u201318.","journal-title":"Oncol Lett"},{"key":"3693_CR47","doi-asserted-by":"crossref","unstructured":"Ashraf W, Ahmad T, Reynoird N, Hamiche A, M\u00e9ly Y, Bronner C et al. Natural and synthetic anticancer epidrugs targeting the epigenetic integrator UHRF1. Molecules. 2023;28(16):5997.","DOI":"10.3390\/molecules28165997"},{"issue":"1","key":"3693_CR48","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13046-016-0453-5","volume":"35","author":"M Alhosin","year":"2016","unstructured":"Alhosin M, Omran Z, Zamzami MA, Al-Malki AL, Choudhry H, Mousli M, et al. Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer. J Experimental Clin Cancer Research: CR. 2016;35(1):174.","journal-title":"J Experimental Clin Cancer Research: CR"},{"issue":"6","key":"3693_CR49","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1128\/MCB.01191-12","volume":"33","author":"H Chen","year":"2013","unstructured":"Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi YG, et al. DNA damage regulates UHRF1 stability via the SCF(\u03b2-TrCP) E3 ligase. Mol Cell Biol. 2013;33(6):1139\u201348.","journal-title":"Mol Cell Biol"},{"issue":"12","key":"3693_CR50","doi-asserted-by":"publisher","first-page":"4929","DOI":"10.1096\/fj.13-233387","volume":"27","author":"L Zhou","year":"2013","unstructured":"Zhou L, Zhao X, Han Y, Lu Y, Shang Y, Liu C, et al. Regulation of UHRF1 by miR-146a\/b modulates gastric cancer invasion and metastasis. FASEB Journal: Official Publication Federation Am Soc Experimental Biology. 2013;27(12):4929\u201339.","journal-title":"FASEB Journal: Official Publication Federation Am Soc Experimental Biology"},{"issue":"46","key":"3693_CR51","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1038\/onc.2011.641","volume":"31","author":"F Babbio","year":"2012","unstructured":"Babbio F, Pistore C, Curti L, Castiglioni I, Kunderfranco P, Brino L, et al. The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression. Oncogene. 2012;31(46):4878\u201387.","journal-title":"Oncogene"},{"issue":"6","key":"3693_CR52","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.3892\/or.2012.2064","volume":"28","author":"Y Kofunato","year":"2012","unstructured":"Kofunato Y, Kumamoto K, Saitou K, Hayase S, Okayama H, Miyamoto K, et al. UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer. Oncol Rep. 2012;28(6):1997\u20132002.","journal-title":"Oncol Rep"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03693-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-03693-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03693-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:04:52Z","timestamp":1759925092000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-03693-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3693"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-03693-8","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"4 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board of Institutional Ethics Committee of Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University (approval No. 2025KLL162), and conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Written informed consent was obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1835"}}