{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T18:30:34Z","timestamp":1779042634625,"version":"3.51.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2025-1037"],"award-info":[{"award-number":["ORF-2025-1037"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-03904-2","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:18:57Z","timestamp":1762877937000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lablab purpureus bioactive fractions as potent anticancer agents: an in vitro and in Silico study"],"prefix":"10.1007","volume":"16","author":[{"given":"Smitha S.","family":"Bhat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushma","family":"Jahagirdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarana Rose","family":"Sommano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rashmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Matam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh F.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haneen A.","family":"Al-Mazroua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamaleldin I.","family":"Harisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva Prasad","family":"Kollur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan","family":"Shivamallu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashanka K.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"issue":"3","key":"3904_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0378-8741(00)00341-X","volume":"73","author":"JG Graham","year":"2000","unstructured":"Graham JG, Quinn ML, Fabricant DS, Farnsworth NR. Plants used against cancer\u2013an extension of the work of Jonathan Hartwell. J Ethnopharmacol. 2000;73(3):347\u201377.","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"3904_CR2","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1177\/2156587214533346","volume":"19","author":"H Khan","year":"2014","unstructured":"Khan H. Medicinal plants in light of history: recognized therapeutic modality. J Evid Based Complement Altern Med. 2014;19(3):216\u20139.","journal-title":"J Evid Based Complement Altern Med"},{"key":"3904_CR3","doi-asserted-by":"publisher","first-page":"100040","DOI":"10.1016\/j.oor.2023.100040","volume":"6","author":"SB Mali","year":"2023","unstructured":"Mali SB. Cancer treatment: role of natural products. Time to have a serious rethink. Oral Oncol Rep. 2023;6:100040.","journal-title":"Oral Oncol Rep"},{"issue":"3","key":"3904_CR4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"AG Atanasov","year":"2021","unstructured":"Atanasov AG, Zotchev SB, Dirsch VM, Supuran CT. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021;20(3):200\u201316.","journal-title":"Nat Rev Drug Discov"},{"issue":"24","key":"3904_CR5","doi-asserted-by":"publisher","first-page":"6203","DOI":"10.3390\/cancers14246203","volume":"14","author":"ST Asma","year":"2022","unstructured":"Asma ST, Acaroz U, Imre K, Morar A, Shah SRA, Hussain SZ, et al. Natural products\/bioactive compounds as a source of anticancer drugs. Cancers (Basel). 2022;14(24):6203.","journal-title":"Cancers (Basel)"},{"key":"3904_CR6","doi-asserted-by":"publisher","unstructured":"Bhat SS, Shivamallu C, Prasad KS, Prasad SK. Biomedical importance of Lablab purpureus: A review. Medicinal Plants. 2022;14(1):20\u20139. https:\/\/doi.org\/10.5958\/0975-6892.2022.00003.X","DOI":"10.5958\/0975-6892.2022.00003.X"},{"key":"3904_CR7","doi-asserted-by":"publisher","unstructured":"Bhat SS, Jahagirdar S, Dharmashekar C, Lumsangkul C, Sommano SR, Ahmad SF et al. Lablab purpureus phytochemicals demonstrate potential anticancer activity as evidenced through experimental and computational analysis. Sci Rep [Internet]. 2025;15(1):23033. Available from: https:\/\/doi.org\/10.1038\/s41598-025-06992-w","DOI":"10.1038\/s41598-025-06992-w"},{"key":"3904_CR8","doi-asserted-by":"publisher","first-page":"22684","DOI":"10.1021\/acsomega.3c01478","volume":"8","author":"SS Bhat","year":"2023","unstructured":"Bhat SS, Pradeep S, Patil SS, Flores-Holgu\u00edn N, Glossman-Mitnik D, Frau J, et al. Preliminary evaluation of lablab purpureus phytochemicals for Anti-BoHV-1 activity using in vitro and in Silico approaches. ACS Omega. 2023;8:22684\u201397.","journal-title":"ACS Omega"},{"issue":"3","key":"3904_CR9","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.3390\/cimb43030106","volume":"43","author":"SS Bhat","year":"2021","unstructured":"Bhat SS, Prasad SK, Shivamallu C, Prasad KS, Syed A, Reddy P, et al. Genistein: A potent Anti-Breast cancer agent. Curr Issues Mol Biol. 2021;43(3):1502\u201317.","journal-title":"Curr Issues Mol Biol"},{"key":"3904_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/plants11212886","volume":"11","author":"J Mani","year":"2022","unstructured":"Mani J, Johnson J, Hosking H, Hoyos BE, Walsh KB, Neilsen P, et al. Bioassay guided fractionation protocol for determining novel active compounds in selected Australian flora. Plants. 2022;11:21.","journal-title":"Plants"},{"key":"3904_CR11","doi-asserted-by":"crossref","unstructured":"Malviya N, Malviya D. Bioassay guided fractionation-an emerging technique influence the isolation, identification and characterization of lead phytomolecules. Int J Hosp Pharm. 2017;2(5):1\u20136.","DOI":"10.28933\/ijhp-2017-07-0901"},{"issue":"1","key":"3904_CR12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.9734\/ajacr\/2023\/v13i1237","volume":"13","author":"IA Amoo","year":"2023","unstructured":"Amoo IA, Balogun TM, Ibeto AU, Adeboye OO, Phytochemicals. Antioxidants and glycemic index assessment of lablab purpureus (Lablab Bean) and phaseolus lunatus (Lima Bean) seeds. Asian J Appl Chem Res. 2023;13(1):54\u201363.","journal-title":"Asian J Appl Chem Res"},{"key":"3904_CR13","doi-asserted-by":"crossref","unstructured":"Ho KL, Tan CG, Yong PH, Wang CW, Lim SH, Kuppusamy UR et al. Extraction of phytochemicals with health benefit from Peperomia pellucida (L.) Kunth through liquid-liquid partitioning. J Appl Res Med Aromat Plants. 2022;30:100392. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2214786122000249","DOI":"10.1016\/j.jarmap.2022.100392"},{"issue":"3","key":"3904_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.sjbs.2013.02.003","volume":"20","author":"L Aksoy","year":"2013","unstructured":"Aksoy L, Kolay E, A\u011f\u0131l\u00f6n\u00fc Y, Aslan Z, Karg\u0131o\u011flu M. Free radical scavenging activity, total phenolic content, total antioxidant status, and total oxidant status of endemic thermopsis turcica. Saudi J Biol Sci. 2013;20(3):235\u20139.","journal-title":"Saudi J Biol Sci"},{"key":"3904_CR15","doi-asserted-by":"crossref","unstructured":"Benzie IFF, Strain JJ. Ferric reducing\/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods in enzymology. Elsevier; 1999. pp. 15\u201327.","DOI":"10.1016\/S0076-6879(99)99005-5"},{"issue":"11","key":"3904_CR16","doi-asserted-by":"publisher","first-page":"e02762","DOI":"10.1016\/j.heliyon.2019.e02762","volume":"5","author":"S Adusei","year":"2019","unstructured":"Adusei S, Otchere JK, Oteng P, Mensah RQ, Tei-Mensah E. Phytochemical analysis, antioxidant and metal chelating capacity of tetrapleura tetraptera. Heliyon. 2019;5(11):e02762.","journal-title":"Heliyon"},{"issue":"9\u201310","key":"3904_CR17","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999;26(9\u201310):1231\u20137.","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"3904_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3233\/MGC-130117","volume":"13","author":"N Morsy","year":"2014","unstructured":"Morsy N. Phytochemical analysis of biologically active constituents of medicinal plants. Main Group Chem. 2014;13(1):7\u201321.","journal-title":"Main Group Chem"},{"key":"3904_CR19","doi-asserted-by":"crossref","unstructured":"Levine VE. A General Test for Carbohydrates. Proc Soc Exp Biol Med. 1930;27(8):830\u20131.","DOI":"10.3181\/00379727-27-4992"},{"key":"3904_CR20","unstructured":"Auwal MS, Saka S, Mairiga IA, Sanda KA, Shuaibu A, Ibrahim A. Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa). In: Veterinary research forum: an international quarterly journal. 2014. p. 95."},{"issue":"1","key":"3904_CR21","first-page":"5873648","volume":"2017","author":"R Gul","year":"2017","unstructured":"Gul R, Jan SU, Faridullah S, Sherani S, Jahan N. Preliminary phytochemical screening, quantitative analysis of alkaloids, and antioxidant activity of crude plant extracts from ephedra intermedia Indigenous to Balochistan. Sci World J. 2017;2017(1):5873648.","journal-title":"Sci World J"},{"issue":"6","key":"3904_CR22","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1093\/jaoac\/86.6.1124","volume":"86","author":"N Sreevidya","year":"2003","unstructured":"Sreevidya N, Mehrotra S. Spectrophotometric method for Estimation of alkaloids precipitable with dragendorff\u2019s reagent in plant materials. J AOAC Int. 2003;86(6):1124\u20137.","journal-title":"J AOAC Int"},{"issue":"6","key":"3904_CR23","first-page":"571","volume":"76","author":"BK Das","year":"2014","unstructured":"Das BK, Al-Amin MM, Russel SM, Kabir S, Bhattacherjee R, Hannan JMA. Phytochemical screening and evaluation of analgesic activity of oroxylum indicum. Indian J Pharm Sci. 2014;76(6):571.","journal-title":"Indian J Pharm Sci"},{"key":"3904_CR24","unstructured":"Evans WC. Trease and evans\u2019 pharmacognosy. Elsevier Health Sciences; 2009."},{"key":"3904_CR25","doi-asserted-by":"publisher","first-page":"517","DOI":"10.54085\/ap.2022.11.1.59","volume":"11","author":"I Amin","year":"2022","unstructured":"Amin I, Shubeena S, Rashid SM, Gull G, Rasool S, Razak R, et al. Biochemical Estimation of Artemesia absinthium L. powder and qualitative phytochemical screening of its hexanic and ethanolic extracts for assessment of purity. Ann Phytomed. 2022;11:517\u201322.","journal-title":"Ann Phytomed"},{"issue":"8","key":"3904_CR26","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S2221-1691(13)60126-4","volume":"3","author":"F Alhakmani","year":"2013","unstructured":"Alhakmani F, Kumar S, Khan SA. Estimation of total phenolic content, in\u2013vitro antioxidant and anti\u2013inflammatory activity of flowers of Moringa Oleifera. Asian Pac J Trop Biomed. 2013;3(8):623\u20137.","journal-title":"Asian Pac J Trop Biomed"},{"key":"3904_CR27","doi-asserted-by":"crossref","unstructured":"Wahab R, Khan F, A.Siddiqui M, Ahmad J, Saquib Q, Al-Khedhairy AA. Cytotoxic assessment of liver cancer cells (HepG2) with raw, functionalized multiwalled carbon nanotubes and their comparison with nanohydroxyapatite. J King Saud Univ Sci [Internet]. 2021;33(5):101444. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1018364721001051","DOI":"10.1016\/j.jksus.2021.101444"},{"key":"3904_CR28","doi-asserted-by":"crossref","unstructured":"Jahagirdar S, Bhat SS, Ahmad SF, Attia SM, Prasad SK. Elucidating the anticancer properties of Clinacanthus nutans: an in Silico and in vitro based approach targeting breast and lung cancer. J Comput Biophys Chem. 2025;25(1):147\u201365.","DOI":"10.1142\/S2737416525500413"},{"issue":"2","key":"3904_CR29","first-page":"121","volume":"41","author":"JH Zhang","year":"1998","unstructured":"Zhang JH, Yu J, Li WX, Cheng CP. Inhibited apoptosis in rat corpus luteal cells by flow cytometry and fluorochromes. Chin J Physiol. 1998;41(2):121\u20136.","journal-title":"Chin J Physiol"},{"issue":"1","key":"3904_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep. 2017;7(1):1\u201313.","journal-title":"Sci Rep"},{"key":"3904_CR31","volume-title":"Release 2024-3, Glide, Schr\u00f6dinger","author":"Schr\u00f6dinger","year":"2024","unstructured":"Schr\u00f6dinger. Release 2024-3, Glide, Schr\u00f6dinger. New York, NY: LLC; 2024."},{"key":"3904_CR32","doi-asserted-by":"crossref","unstructured":"Bhat SS, Mahapatra SD, Sommano RS, Prasad SR. SK. Virtual screening and quantitative structure-activity relationship of Moringa oleifera with melanoma antigen A (MAGE-A) genes against the therapeutics of non-small cell lung cancers (NSCLCs). Cancers. 2022: 14.","DOI":"10.3390\/cancers14205052"},{"key":"3904_CR33","doi-asserted-by":"crossref","unstructured":"Prasad SK, Bhat SS, Koskowska O, Sangta J, Ahmad SF, Nadeem A et al. Naringin from coffee inhibits foodborne Aspergillus fumigatus via the NDK pathway: evidence from an in Silico study. Molecules. 2023;28(13):5189.","DOI":"10.3390\/molecules28135189"},{"issue":"1","key":"3904_CR34","doi-asserted-by":"publisher","first-page":"6","DOI":"10.55691\/2278-344X.1007","volume":"11","author":"SS Bhat","year":"2022","unstructured":"Bhat SS, Prasad SK. In Silico screening of Violacein as an epidermal growth factor receptor inhibitor. Int J Health Allied Sci. 2022;11(1):6.","journal-title":"Int J Health Allied Sci"},{"key":"3904_CR35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1201\/9781003354437-2","volume-title":"Computational approaches in biotechnology and bioinformatics","author":"SS Bhat","year":"2024","unstructured":"Bhat SS, Prasad RS. A bioinformatics approach towards Plant-Based anticancer drug discovery. In: Pathak PD, Raut R, Jaramillo-Isaza S, Borkar P, Jhaveri RH, editors. Computational approaches in biotechnology and bioinformatics. 1st ed. Boca Raton: CRC; 2024.","edition":"1"},{"key":"3904_CR36","doi-asserted-by":"crossref","unstructured":"Jahagirdar S, Praveen Kumar H, Bhat SS, Poddar A, Chattaraj PK, Ahmad SF et al. In Silico evaluations of phytochemicals from Withania somnifera exhibiting anticancer activity against NAD[P]H-quinone oxidoreductase. Hum Exp Toxicol. 2024;43:09603271241291399.","DOI":"10.1177\/09603271241291399"},{"key":"3904_CR37","doi-asserted-by":"crossref","unstructured":"Bhat SS, Pradeep S, Jadhav G, Devegowda D, Sommano SR, Shivamallu C et al. In Silico examination of peptides containing selenium and Ebselen backbone to assess their tumoricidal potential. Int J Health Allied Sci. 2022;11(2):9.","DOI":"10.55691\/2278-344X.1029"},{"key":"3904_CR38","doi-asserted-by":"crossref","unstructured":"Shiragannavar VD, Sannappa Gowda NG, Puttahanumantharayappa LD, Karunakara SH, Bhat S, Prasad SK et al. The ameliorating effect of Withaferin A on high-fat diet-induced non-alcoholic fatty liver disease by acting as an LXR\/FXR dual receptor activator. Front Pharmacol. 2023;14:1135952.","DOI":"10.3389\/fphar.2023.1135952"},{"key":"3904_CR39","doi-asserted-by":"crossref","unstructured":"Sannappa Gowda NG, Shiragannavar VD, Puttahanumantharayappa LD, Shivakumar AT, Dallavalasa S, Basavaraju CG et al. Quercetin activates vitamin D receptor and ameliorates breast cancer induced hepatic inflammation and fibrosis. Front Nutr. 2023;10:1158633.","DOI":"10.3389\/fnut.2023.1158633"},{"issue":"1","key":"3904_CR40","doi-asserted-by":"publisher","first-page":"29905","DOI":"10.1038\/s41598-024-81471-2","volume":"14","author":"R Sindhu","year":"2024","unstructured":"Sindhu R, Bhat SS, Sangta J, Dharmashekar C, Shreevatsa B, Shivamallu C, et al. Gaining molecular insights towards Inhibition of foodborne fungi Aspergillus fumigatus by a food colourant Violacein via computational approach. Sci Rep. 2024;14(1):29905.","journal-title":"Sci Rep"},{"key":"3904_CR41","doi-asserted-by":"crossref","unstructured":"Mandal M, Mandal S. Metadynamics approach elucidating the free energy landscape and binding modes of vomicine with virulence factor towards anti-mpox drug discovery. Chem Phys Lett. 2024;846:141355. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0009261424002926","DOI":"10.1016\/j.cplett.2024.141355"},{"issue":"6","key":"3904_CR42","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.4103\/jcrt.JCRT_494_19","volume":"16","author":"SK Prasad","year":"2020","unstructured":"Prasad SK, Veeresh PM, Ramesh PS, Natraj SM, Madhunapantula SV, Devegowda D. Phytochemical fractions from Annona muricata seeds and fruit pulp inhibited the growth of breast cancer cells through cell cycle arrest at G0\/G1 phase. J Cancer Res Ther. 2020;16(6):1235\u201349.","journal-title":"J Cancer Res Ther"},{"key":"3904_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jchromb.2013.04.006","volume":"929","author":"X Cao","year":"2013","unstructured":"Cao X, li, Xu J, Bai G, Zhang H, Liu Y, Xiang J, feng, et al. Isolation of anti-tumor compounds from the stem bark of Zanthoxylum ailanthoides Sieb. & Zucc. By silica gel column and counter-current chromatography. J Chromatogr B. 2013;929:6\u201310.","journal-title":"J Chromatogr B"},{"key":"3904_CR44","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1472-6882-10-42","volume":"10","author":"N Yaacob","year":"2010","unstructured":"Yaacob N, Hamzah N, Kamal N, Zainal Abidin SA, Lai C, Navaratnam V, et al. Anticancer activity of a sub-fraction of dichloromethane extract of strobilanthes Crispus on human breast and prostate cancer cells in vitro. BMC Complement Altern Med. 2010;10:42.","journal-title":"BMC Complement Altern Med"},{"issue":"2","key":"3904_CR45","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jep.2004.04.017","volume":"93","author":"JY Lee","year":"2004","unstructured":"Lee JY, Hwang WI, Lim ST. Antioxidant and anticancer activities of organic extracts from platycodon grandiflorum A. De Candolle roots. J Ethnopharmacol. 2004;93(2):409\u201315.","journal-title":"J Ethnopharmacol"},{"key":"3904_CR46","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jep.2017.10.029","volume":"213","author":"N Sahu","year":"2018","unstructured":"Sahu N, Meena S, Shukla V, Chaturvedi P, Kumar B, Datta D, et al. Extraction, fractionation and re-fractionation of Artemisia nilagirica for anticancer activity and HPLC-ESI-QTOF-MS\/MS determination. J Ethnopharmacol. 2018;213:72\u201380.","journal-title":"J Ethnopharmacol"},{"key":"3904_CR47","doi-asserted-by":"crossref","unstructured":"Siphali S, Dwarka D, Amonsou E, Mellem J. In vitro apoptotic activity of lablab purpureus (L.) sweet low-molecular-weight peptides. Food Sci Technol. 2023;43.","DOI":"10.5327\/fst.124922"},{"key":"3904_CR48","doi-asserted-by":"publisher","first-page":"115849","DOI":"10.1016\/j.jep.2022.115849","volume":"302","author":"S Kumar","year":"2023","unstructured":"Kumar S, Verma PK, Shukla A, Singh RK, Patel AK, Yadav L, et al. Moringa Oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in dalton\u2019s lymphoma: an in vitro and in vivo study. J Ethnopharmacol. 2023;302:115849.","journal-title":"J Ethnopharmacol"},{"key":"3904_CR49","doi-asserted-by":"publisher","first-page":"115729","DOI":"10.1016\/j.jep.2022.115729","volume":"300","author":"S Das","year":"2023","unstructured":"Das S, Rahaman A, Nath R, Das Talukdar A, Nath D, Bhattacharjee S, et al. Effect of acetone fraction of ottelia alismoides on the G2\/M cell cycle arrest and apoptosis in the human carcinoma cell lines. J Ethnopharmacol. 2023;300:115729.","journal-title":"J Ethnopharmacol"},{"key":"3904_CR50","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.52711\/0974-360X.2022.00542","volume":"15","author":"E Purwanti","year":"2022","unstructured":"Purwanti E, Hermanto F, Prihanta W, Permana T. Unfolding biomechanism of Dolichos lablab bean as A dietary supplement in type 2 diabetes mellitus management through computational simulation. Res J Pharm Technol. 2022;15:3233\u201340.","journal-title":"Res J Pharm Technol"},{"issue":"9","key":"3904_CR51","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1089\/cmb.2019.0323","volume":"27","author":"X Chen","year":"2020","unstructured":"Chen X, Li H, Tian L, Li Q, Luo J, Zhang Y. Analysis of the physicochemical properties of acaricides based on lipinski\u2019s rule of five. J Comput Biol. 2020;27(9):1397\u2013406.","journal-title":"J Comput Biol"},{"key":"3904_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2407-8-391","volume":"8","author":"I Androic","year":"2008","unstructured":"Androic I, Kr\u00e4mer A, Yan R, R\u00f6del F, G\u00e4tje R, Kaufmann M, et al. Targeting Cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol. BMC Cancer. 2008;8:1\u201311.","journal-title":"BMC Cancer"},{"issue":"10","key":"3904_CR53","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.3390\/ijms18102111","volume":"18","author":"L Wang","year":"2017","unstructured":"Wang L, Liang C, Li F, Guan D, Wu X, Fu X, et al. PARP1 in carcinomas and PARP1 inhibitors as antineoplastic drugs. Int J Mol Sci. 2017;18(10):2111.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3904_CR54","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.drudis.2019.12.001","volume":"25","author":"S Tadesse","year":"2020","unstructured":"Tadesse S, Anshabo AT, Portman N, Lim E, Tilley W, Caldon CE, et al. Targeting CDK2 in cancer: challenges and opportunities for therapy. Drug Discov Today. 2020;25(2):406\u201313.","journal-title":"Drug Discov Today"},{"issue":"22","key":"3904_CR55","doi-asserted-by":"publisher","first-page":"7210","DOI":"10.1021\/acs.jcim.3c01453","volume":"63","author":"A Saar","year":"2023","unstructured":"Saar A, Ghahremanpour MM, Tirado-Rives J, Jorgensen WL. Assessing metadynamics and Docking for absolute binding free energy calculations using severe acute respiratory syndrome coronavirus 2 main protease inhibitors. J Chem Inf Model. 2023;63(22):7210\u20138.","journal-title":"J Chem Inf Model"},{"issue":"12","key":"3904_CR56","doi-asserted-by":"publisher","first-page":"5465","DOI":"10.1080\/07391102.2022.2087736","volume":"41","author":"V Chahal","year":"2023","unstructured":"Chahal V, Kakkar R. A combination strategy of structure-based virtual screening, MM-GBSA, cross docking, molecular dynamics and metadynamics simulations used to investigate natural compounds as potent and specific inhibitors of tumor linked human carbonic anhydrase IX. J Biomol Struct Dyn. 2023;41(12):5465\u201380.","journal-title":"J Biomol Struct Dyn"},{"key":"3904_CR57","doi-asserted-by":"crossref","unstructured":"Soni D, Wahi D, Verma S. In vitro study on anti-proliferative and anti-cancer activity of Picrosides in triple-negative breast cancer. Med Oncol. 2024;41(6):143.","DOI":"10.1007\/s12032-024-02397-3"},{"issue":"1","key":"3904_CR58","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.arabjc.2011.01.011","volume":"6","author":"D Rathee","year":"2013","unstructured":"Rathee D, Thanki M, Bhuva S, Anandjiwala S, Agrawal R. Iridoid glycosides-Kutkin, Picroside I, and Kutkoside from picrorrhiza Kurroa Benth inhibits the invasion and migration of MCF-7 breast cancer cells through the down regulation of matrix metalloproteinases: 1st cancer update. Arab J Chem. 2013;6(1):49\u201358.","journal-title":"Arab J Chem"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03904-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-03904-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03904-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:19:01Z","timestamp":1762877941000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-03904-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3904"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-03904-2","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,11]]},"assertion":[{"value":"3 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable as the article does not contain any studies with human participants or animals performed by any of the authors. The human cancer cell lines- MCF-7 and A549 were procured from National Centre for Cell Science (NCCS), Pune, India. These are commercially available cell lines and do not require ethics committee approval. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have reviewed the manuscript and agreed to publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2092"}}