{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:21:54Z","timestamp":1763738514737,"version":"3.45.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National TCM Advantageous Specialty Construction-Hematology","award":["2024327"],"award-info":[{"award-number":["2024327"]}]},{"name":"Science and Technology Development Program of Shanghai University of Traditional Chinese Medicine","award":["No.24BZH15"],"award-info":[{"award-number":["No.24BZH15"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-03987-x","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T14:40:29Z","timestamp":1763736029000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the molecular mechanisms of histological transformation in follicular lymphoma via bioinformatics analysis"],"prefix":"10.1007","volume":"16","author":[{"given":"Ming","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-7939","authenticated-orcid":false,"given":"Yirong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqing","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"2","key":"3987_CR1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/1097-0142(197908)44:2<645::AID-CNCR2820440234>3.0.CO;2-Y","volume":"44","author":"MH Cullen","year":"1979","unstructured":"Cullen MH, Lister TA, Brearley RI, Shand WS, Stansfeld AG. Histological transformation of non-Hodgkin\u2019s lymphoma: a prospective study. Cancer. 1979;44(2):645\u201351.","journal-title":"Cancer"},{"issue":"12","key":"3987_CR2","doi-asserted-by":"publisher","first-page":"3835","DOI":"10.1200\/JCO.1999.17.12.3835","volume":"17","author":"NL Harris","year":"1999","unstructured":"Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol. 1999;17(12):3835\u201349.","journal-title":"J Clin Oncol"},{"issue":"14","key":"3987_CR3","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1200\/JCO.2010.32.7577","volume":"29","author":"S Montoto","year":"2011","unstructured":"Montoto S, Fitzgibbon J. Transformation of indolent B-cell lymphomas. J Clin Oncol. 2011;29(14):1827\u201334.","journal-title":"J Clin Oncol"},{"issue":"5","key":"3987_CR4","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","volume":"84","author":"NL Harris","year":"1994","unstructured":"Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84(5):1361\u201392.","journal-title":"Blood"},{"issue":"9873","key":"3987_CR5","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/S0140-6736(12)61763-2","volume":"381","author":"MJ Rummel","year":"2013","unstructured":"Rummel MJ, Niederle N, Maschmeyer G, et al. Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial. Lancet. 2013;381(9873):1203\u201310.","journal-title":"Lancet"},{"issue":"4","key":"3987_CR6","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1182\/blood-2014-04-571786","volume":"125","author":"C Correia","year":"2015","unstructured":"Correia C, Schneider PA, Dai H, et al. Bcl2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma. Blood. 2015;125(4):658\u201367.","journal-title":"Blood"},{"issue":"22","key":"3987_CR7","doi-asserted-by":"publisher","first-page":"9166","DOI":"10.1158\/0008-5472.CAN-10-2460","volume":"70","author":"KJ Cheung","year":"2010","unstructured":"Cheung KJ, Johnson NA, Affleck JG, et al. Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis. Cancer Res. 2010;70(22):9166\u201374.","journal-title":"Cancer Res"},{"issue":"26","key":"3987_CR8","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1200\/JCO.2012.48.3990","volume":"31","author":"BK Link","year":"2013","unstructured":"Link BK, Maurer MJ, Nowakowski GS, et al. Rates and outcomes of follicular lymphoma transformation in the immunochemotherapy era: a report from the University of Iowa\/MayoClinic specialized program of research excellence molecular epidemiology resource. J Clin Oncol. 2013;31(26):3272\u20138.","journal-title":"J Clin Oncol"},{"issue":"3","key":"3987_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S1044-579X(03)00015-4","volume":"13","author":"IS Lossos","year":"2003","unstructured":"Lossos IS, Levy R. Higher grade transformation of follicular lymphoma: phenotypic tumor progression associated with diverse genetic lesions. Semin Cancer Biol. 2003;13(3):191\u2013202.","journal-title":"Semin Cancer Biol"},{"issue":"7","key":"3987_CR10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1182\/blood-2015-01-621375","volume":"126","author":"ND Wagner-Johnston","year":"2015","unstructured":"Wagner-Johnston ND, Link BK, Byrtek M, et al. Outcomes of transformed follicular lymphoma in the modern era: a report from the National LymphoCare Study (NLCS). Blood. 2015;126(7):851\u20137.","journal-title":"Blood"},{"issue":"4","key":"3987_CR11","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/bjh.12570","volume":"163","author":"M Ban-Hoefen","year":"2013","unstructured":"Ban-Hoefen M, Vanderplas A, Crosby-Thompson AL, et al. Transformed non-Hodgkin lymphoma in the rituximab era: analysis of the NCCN outcomes database. Br J Haematol. 2013;163(4):487\u201395.","journal-title":"Br J Haematol"},{"issue":"3","key":"3987_CR12","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2519\/jospt.2004.34.3.116","volume":"34","author":"MA Sherry","year":"2004","unstructured":"Sherry MA, Best TM. A comparison of 2 rehabilitation programs in the treatment of acute hamstring strains. J Orthop Sports Phys Ther. 2004;34(3):116\u201325.","journal-title":"J Orthop Sports Phys Ther"},{"issue":"1","key":"3987_CR13","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.celrep.2013.12.027","volume":"6","author":"L Pasqualucci","year":"2014","unstructured":"Pasqualucci L, Khiabanian H, Fangazio M, et al. Genetics of follicular lymphoma transformation. Cell Rep. 2014;6(1):130\u201340.","journal-title":"Cell Rep"},{"issue":"1","key":"3987_CR14","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","volume":"8","author":"WE Johnson","year":"2007","unstructured":"Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical bayes methods. Biostatistics. 2007;8(1):118\u201327. https:\/\/doi.org\/10.1093\/biostatistics\/kxj037.","journal-title":"Biostatistics"},{"issue":"18","key":"3987_CR15","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1182\/blood-2015-06-649905","volume":"126","author":"R Kridel","year":"2015","unstructured":"Kridel R, Mottok A, Farinha P, et al. Cell of origin of transformed follicular lymphoma. Blood. 2015;126(18):2118\u201327.","journal-title":"Blood"},{"issue":"7277","key":"3987_CR16","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature08638","volume":"463","author":"RE Davis","year":"2010","unstructured":"Davis RE, Ngo VN, Lenz G, et al. Chronic active b-cell-receptor signalling in diffuse large b-cell lymphoma. Nature. 2010;463(7277):88\u201392.","journal-title":"Nature"},{"issue":"17","key":"3987_CR17","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1200\/JCO.2006.09.3260","volume":"25","author":"S Montoto","year":"2007","unstructured":"Montoto S, Davies AJ, Matthews J, et al. Risk and clinical implications of transformation of follicular lymphoma to diffuse large B-cell lymphoma. J Clin Oncol. 2007;25(17):2426\u201333.","journal-title":"J Clin Oncol"},{"issue":"32","key":"3987_CR18","doi-asserted-by":"publisher","first-page":"5165","DOI":"10.1200\/JCO.2008.16.0283","volume":"26","author":"AJ Al-Tourah","year":"2008","unstructured":"Al-Tourah AJ, Gill KK, Chhanabhai M, et al. Population-based analysis of incidence and outcome of transformed non-Hodgkin\u2019s lymphoma. J Clin Oncol. 2008;26(32):5165\u20139.","journal-title":"J Clin Oncol."},{"issue":"10","key":"3987_CR19","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1093\/annonc\/mdl162","volume":"17","author":"E Gine","year":"2006","unstructured":"Gine E, Montoto S, Bosch F, et al. The follicular lymphoma international prognostic index (FLIPI)and the histological subtype are the most important factors to predict histological transformation in follicular lymphoma. Ann Oncol. 2006;17(10):1539\u201345.","journal-title":"Ann Oncol"},{"issue":"10","key":"3987_CR20","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1002\/ijc.25236","volume":"127","author":"D Venetz","year":"2010","unstructured":"Venetz D, Ponzoni M, Schiraldi M, et al. Perivascular expression of CXCL9 and CXCL12 in primary central nervous system lymphoma: t-cell infiltration and positioning of malignant B cells. Int J Cancer. 2010;127(10):2300\u201312.","journal-title":"Int J Cancer"},{"issue":"7","key":"3987_CR21","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jcms.2021.02.027","volume":"49","author":"Q Wang","year":"2021","unstructured":"Wang Q, Zou H, Wang Y, et al. Ccr7-ccl21 axis promotes the cervical lymph node metastasis of tongue squamous cell carcinoma by up-regulating MUC1. J Craniomaxillofac Surg. 2021;49(7):562\u20139.","journal-title":"J Craniomaxillofac Surg"},{"issue":"10","key":"3987_CR22","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.7150\/jca.49707","volume":"12","author":"Y Qin","year":"2021","unstructured":"Qin Y, Wang F, Ni H, et al. Cancer-associated fibroblasts in gastric cancer affect malignant progression via the CXCL12-CXCR4 axis. J Cancer. 2021;12(10):3011\u201323.","journal-title":"J Cancer"},{"issue":"12","key":"3987_CR23","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1158\/1078-0432.CCR-11-2417","volume":"18","author":"HJ Lee","year":"2012","unstructured":"Lee HJ, Lee K, Lee DG, et al. Chemokine (C-X-C motif) ligand 12 is associated with gallbladder carcinoma progression and is a novel independent poor prognostic factor. Clin Cancer Res. 2012;18(12):3270\u201380.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3987_CR24","first-page":"5","volume":"23","author":"M Silva","year":"2010","unstructured":"Silva M, Azenha D, Pereira C, et al. Carcinoma g\u00e1strico e gastrite cr\u00f3nica: regula\u00e7\u00e3o epigen\u00e9tica por metila\u00e7\u00e3o dos genes CDH1 (Caderina-E), CDKN2A (p16INK4A), PTGS2 (COX2) e EGFR [Gastric carcinoma and chronic gastritis: epigenetic regulation of CDH1 (E-Cadherin), CDKN2A (p16INK4A), PTGS2 (COX-2) and EGFR genes through methylation]. Acta Med Port. 2010;23(1):5\u201314.","journal-title":"Acta Med Port"},{"issue":"51","key":"3987_CR25","doi-asserted-by":"publisher","first-page":"18538","DOI":"10.1073\/pnas.0509182102","volume":"102","author":"E Sato","year":"2005","unstructured":"Sato E, Olson SH, Ahn J, Bundy B, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+\/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 2005;102(51):18538\u201343.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3987_CR26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/sj.leu.2404426","volume":"21","author":"RJ Bende","year":"2007","unstructured":"Bende RJ, Smit LA, van Noesel CJ. Molecular pathways in follicular lymphoma. Leukemia. 2007;21(1):18\u201329.","journal-title":"Leukemia"},{"issue":"6","key":"3987_CR27","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.ccell.2024.05.011","volume":"42","author":"C Sarkozy","year":"2024","unstructured":"Sarkozy C, Wu S, Takata K, Aoki T, Neriah SB, Milne K, et al. Integrated single cell analysis reveals co-evolution of malignant B cells and tumor micro-environment in transformed follicular lymphoma. Cancer Cell. 2024;42(6):1003-1017.e6. https:\/\/doi.org\/10.1016\/j.ccell.2024.05.011.","journal-title":"Cancer Cell"},{"issue":"10","key":"3987_CR28","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1093\/annonc\/mdl162","volume":"17","author":"E Gin\u00e9","year":"2006","unstructured":"Gin\u00e9 E, Montoto S, Bosch F, Arenillas L, et al. The follicular lymphoma international prognostic index (FLIPI) and the histological subtype are the most important factors to predict histological transformation in follicular lymphoma. Ann Oncol. 2006;17(10):1539\u201345.","journal-title":"Ann Oncol"},{"issue":"11","key":"3987_CR29","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1158\/1078-0432.CCR-13-2367","volume":"20","author":"JP Smeltzer","year":"2014","unstructured":"Smeltzer JP, Jones JM, Ziesmer SC, Grote DM, Xiu B, Ristow KM, et al. Pattern of CD14+ follicular dendritic cells and PD1+ T cells independently predicts time to transformation in follicular lymphoma. Clin Cancer Res. 2014;20(11):2862\u201372.","journal-title":"Clin Cancer Res"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03987-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-03987-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-03987-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T14:40:29Z","timestamp":1763736029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-03987-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3987"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-03987-x","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"assertion":[{"value":"12 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This study involved only the secondary analysis of publicly available, anonymized data and did not require ethical approval.Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2140"}}