{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T16:38:17Z","timestamp":1767026297438,"version":"3.48.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program","award":["22009"],"award-info":[{"award-number":["22009"]}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"crossref","award":["20212BAB206063"],"award-info":[{"award-number":["20212BAB206063"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-04006-9","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:54:23Z","timestamp":1763650463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of candidate susceptibility genes for cutaneous malignant melanoma through integrated multi-method analysis"],"prefix":"10.1007","volume":"16","author":[{"given":"Ping","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"4006_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cancergen.2024.06.002","volume":"286","author":"D Sonkin","year":"2024","unstructured":"Sonkin D, Thomas A, Teicher BA. Cancer treatments: past, present, and future. Cancer Genet. 2024;286:18\u201324. https:\/\/doi.org\/10.1016\/j.cancergen.2024.06.002.","journal-title":"Cancer Genet"},{"issue":"1","key":"4006_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00603-8","volume":"11","author":"A Tasdogan","year":"2025","unstructured":"Tasdogan A, Sullivan RJ, Katalinic A, et al. Cutaneous melanoma. Nat Rev Dis Primers. 2025;11(1):23. https:\/\/doi.org\/10.1038\/s41572-025-00603-8.","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"4006_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26051849","volume":"26","author":"D Mallardo","year":"2025","unstructured":"Mallardo D, Basile D, Vitale MG. Advances in melanoma and skin cancers. Int J Mol Sci. 2025;26(5):1849. https:\/\/doi.org\/10.3390\/ijms26051849.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"4006_CR4","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1001\/jamadermatol.2022.0160","volume":"158","author":"M Arnold","year":"2022","unstructured":"Arnold M, Singh D, Laversanne M, et al. Global burden of cutaneous melanoma in 2020 and projections to 2040. JAMA Dermatol. 2022;158(5):495\u2013503. https:\/\/doi.org\/10.1001\/jamadermatol.2022.0160.","journal-title":"JAMA Dermatol"},{"issue":"1","key":"4006_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12\u201349. https:\/\/doi.org\/10.3322\/caac.21820.","journal-title":"CA Cancer J Clin"},{"key":"4006_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104276","volume":"196","author":"A Boutros","year":"2024","unstructured":"Boutros A, Croce E, Ferrari M, et al. The treatment of advanced melanoma: current approaches and new challenges. Crit Rev Oncol Hematol. 2024;196:104276. https:\/\/doi.org\/10.1016\/j.critrevonc.2024.104276.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"21","key":"4006_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115881","volume":"24","author":"LM Gosman","year":"2023","unstructured":"Gosman LM, \u021a\u0103poi DA, Costache M. Cutaneous melanoma: a review of multifactorial pathogenesis, immunohistochemistry, and emerging biomarkers for early detection and management. Int J Mol Sci. 2023;24(21):15881. https:\/\/doi.org\/10.3390\/ijms242115881.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4006_CR8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1001\/jama.2015.17703","volume":"315","author":"LA Mucci","year":"2016","unstructured":"Mucci LA, Hjelmborg JB, Harris JR, et al. Familial risk and heritability of cancer among twins in nordic countries. JAMA. 2016;315(1):68\u201376. https:\/\/doi.org\/10.1001\/jama.2015.17703.","journal-title":"JAMA"},{"issue":"6","key":"4006_CR9","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.jid.2021.08.449","volume":"142","author":"UE Liyanage","year":"2022","unstructured":"Liyanage UE, MacGregor S, Bishop DT, et al. Multi-trait genetic analysis identifies autoimmune loci associated with cutaneous melanoma. J Invest Dermatol. 2022;142(6):1607\u201316. https:\/\/doi.org\/10.1016\/j.jid.2021.08.449.","journal-title":"J Invest Dermatol"},{"issue":"5","key":"4006_CR10","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41588-020-0611-8","volume":"52","author":"MT Landi","year":"2020","unstructured":"Landi MT, Bishop DT, MacGregor S, et al. Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. Nat Genet. 2020;52(5):494\u2013504. https:\/\/doi.org\/10.1038\/s41588-020-0611-8.","journal-title":"Nat Genet"},{"issue":"8","key":"4006_CR11","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","volume":"20","author":"V Tam","year":"2019","unstructured":"Tam V, Patel N, Turcotte M, Boss\u00e9 Y, Par\u00e9 G, Meyre D. Benefits and limitations of genome-wide association studies. Nat Rev Genet. 2019;20(8):467\u201384. https:\/\/doi.org\/10.1038\/s41576-019-0127-1.","journal-title":"Nat Rev Genet"},{"issue":"4","key":"4006_CR12","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/s41588-019-0385-z","volume":"51","author":"M Wainberg","year":"2019","unstructured":"Wainberg M, Sinnott-Armstrong N, Mancuso N, et al. Opportunities and challenges for transcriptome-wide association studies. Nat Genet. 2019;51(4):592\u20139. https:\/\/doi.org\/10.1038\/s41588-019-0385-z.","journal-title":"Nat Genet"},{"issue":"17","key":"4006_CR13","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1093\/hmg\/ddab119","volume":"30","author":"M Zhu","year":"2021","unstructured":"Zhu M, Fan J, Zhang C, et al. A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for lung cancer in Chinese populations. Hum Mol Genet. 2021;30(17):1666\u201376. https:\/\/doi.org\/10.1093\/hmg\/ddab119.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"4006_CR14","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1186\/s12885-025-14095-y","volume":"25","author":"J Liu","year":"2025","unstructured":"Liu J, Guan X, Gao S, et al. Novel insight of critical genes involved in breast cancer brain metastasis: evidence from a cross-tissue transcriptome association study and validation through external clinical cohorts. BMC Cancer. 2025;25(1):707. https:\/\/doi.org\/10.1186\/s12885-025-14095-y.","journal-title":"BMC Cancer"},{"key":"4006_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1244740","volume":"13","author":"GA Herrera-Quiterio","year":"2023","unstructured":"Herrera-Quiterio GA, Encarnaci\u00f3n-Guevara S. The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer. Front Oncol. 2023;13:1244740. https:\/\/doi.org\/10.3389\/fonc.2023.1244740.","journal-title":"Front Oncol"},{"issue":"10","key":"4006_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-021-01573-z","volume":"38","author":"A Arunachalam","year":"2021","unstructured":"Arunachalam A, Lakshmanan DK, Ravichandran G, et al. Regulatory mechanisms of heme regulatory protein BACH1: a potential therapeutic target for cancer. Med Oncol. 2021;38(10):122. https:\/\/doi.org\/10.1007\/s12032-021-01573-z.","journal-title":"Med Oncol"},{"issue":"1","key":"4006_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34426-y","volume":"13","author":"H Liu","year":"2023","unstructured":"Liu H, Xie R, Dai Q, Fang J, Xu Y, Li B. Exploring the mechanism underlying hyperuricemia using comprehensive research on multi-omics. Sci Rep. 2023;13(1):7161. https:\/\/doi.org\/10.1038\/s41598-023-34426-y.","journal-title":"Sci Rep"},{"key":"4006_CR18","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jad.2023.05.020","volume":"335","author":"H Liu","year":"2023","unstructured":"Liu H. Association between sleep duration and depression: a Mendelian randomization analysis. J Affect Disord. 2023;335:152\u20134. https:\/\/doi.org\/10.1016\/j.jad.2023.05.020.","journal-title":"J Affect Disord"},{"issue":"6","key":"4006_CR19","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/ng.2653","volume":"45","author":"GTEx Consortium","year":"2013","unstructured":"GTEx Consortium. The genotype-tissue expression (GTEx) project. Nat Genet. 2013;45(6):580\u20135. https:\/\/doi.org\/10.1038\/ng.2653.","journal-title":"Nat Genet"},{"issue":"3","key":"4006_CR20","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/s41588-019-0345-7","volume":"51","author":"Y Hu","year":"2019","unstructured":"Hu Y, Li M, Lu Q, et al. A statistical framework for cross-tissue transcriptome-wide association analysis. Nat Genet. 2019;51(3):568\u201376. https:\/\/doi.org\/10.1038\/s41588-019-0345-7.","journal-title":"Nat Genet"},{"issue":"1","key":"4006_CR21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s10194-023-01649-3","volume":"23","author":"Li Shuang-jie","year":"2023","unstructured":"Shuang-jie Li, Jing-jing Shi, Mao C, et al. Identifying causal genes for migraine by integrating the proteome and transcriptome. J Headache Pain. 2023;23(1):111. https:\/\/doi.org\/10.1186\/s10194-023-01649-3.","journal-title":"J Headache Pain"},{"issue":"1","key":"4006_CR22","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.1038\/s41467-019-12450-9","volume":"10","author":"C Liao","year":"2019","unstructured":"Liao C, Laporte AD, Spiegelman D, et al. Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes. Nat Commun. 2019;10(1):4450. https:\/\/doi.org\/10.1038\/s41467-019-12450-9.","journal-title":"Nat Commun"},{"issue":"4","key":"4006_CR23","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/ng.2213","volume":"44","author":"J Yang","year":"2012","unstructured":"Yang J, Ferreira T, Morris AP, et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet. 2012;44(4):369\u201375. https:\/\/doi.org\/10.1038\/ng.2213.","journal-title":"Nat Genet"},{"issue":"6","key":"4006_CR24","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nrg.2016.29","volume":"17","author":"CA de Leeuw","year":"2016","unstructured":"de Leeuw CA, Neale BM, Heskes T, Posthuma D. The statistical properties of gene-set analysis. Nat Rev Genet. 2016;17(6):353\u201364. https:\/\/doi.org\/10.1038\/nrg.2016.29.","journal-title":"Nat Rev Genet"},{"issue":"4","key":"4006_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004219","volume":"11","author":"CA de Leeuw","year":"2015","unstructured":"de Leeuw CA, Mooij JM, Heskes T, Posthuma D. Magma: generalized gene-set analysis of GWAS data. PLoS Comput Biol. 2015;11(4):e1004219. https:\/\/doi.org\/10.1371\/journal.pcbi.1004219.","journal-title":"PLoS Comput Biol"},{"issue":"4","key":"4006_CR26","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41588-019-0367-1","volume":"51","author":"N Mancuso","year":"2019","unstructured":"Mancuso N, Freund MK, Johnson R, et al. Probabilistic fine-mapping of transcriptome-wide association studies. Nat Genet. 2019;51(4):675\u201382. https:\/\/doi.org\/10.1038\/s41588-019-0367-1.","journal-title":"Nat Genet"},{"key":"4006_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1425370","volume":"15","author":"S Ren","year":"2024","unstructured":"Ren S, Sun C, Zhai W, Wei W, Liu J. Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study. Front Genet. 2024;15:1425370. https:\/\/doi.org\/10.3389\/fgene.2024.1425370.","journal-title":"Front Genet"},{"issue":"4","key":"4006_CR28","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1093\/gerona\/glac245","volume":"78","author":"S Zhou","year":"2023","unstructured":"Zhou S, Tian Y, Song X, Xiong J, Cheng G. Brain proteome-wide and transcriptome-wide asso-ciation studies, bayesian colocalization, and Mendelian randomization analyses reveal causal genes of Parkinson\u2019s disease. J Gerontol A Biol Sci Med Sci. 2023;78(4):563\u20138. https:\/\/doi.org\/10.1093\/gerona\/glac245.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"8","key":"4006_CR29","doi-asserted-by":"publisher","first-page":"4688","DOI":"10.1097\/JS9.0000000000001514","volume":"110","author":"Y Sun","year":"2024","unstructured":"Sun Y, Liu Y, Dian Y, Zeng F, Deng G, Lei S. Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials. Int J Surg. 2024;110(8):4688\u201394. https:\/\/doi.org\/10.1097\/JS9.0000000000001514.","journal-title":"Int J Surg"},{"key":"4006_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00092-5","volume":"2","author":"E Sanderson","year":"2022","unstructured":"Sanderson E, Glymour MM, Holmes MV, et al. Mendelian randomization. Nat Rev Methods Primers. 2022;2:6. https:\/\/doi.org\/10.1038\/s43586-021-00092-5.","journal-title":"Nat Rev Methods Primers"},{"issue":"5","key":"4006_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"C Giambartolomei","year":"2014","unstructured":"Giambartolomei C, Vukcevic D, Schadt EE, et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 2014;10(5):e1004383. https:\/\/doi.org\/10.1371\/journal.pgen.1004383.","journal-title":"PLoS Genet"},{"key":"4006_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00859-z","volume":"11","author":"Z Han","year":"2025","unstructured":"Han Z, Zhu Y, Xia Z, et al. Genetic analyses identify circulating genes related to brain structures associated with Parkinson\u2019s disease. NPJ Parkinsons Dis. 2025;11:17. https:\/\/doi.org\/10.1038\/s41531-024-00859-z.","journal-title":"NPJ Parkinsons Dis"},{"key":"4006_CR33","doi-asserted-by":"publisher","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"D Warde-Farley","year":"2010","unstructured":"Warde-Farley D, Donaldson SL, Comes O, et al. The genemania prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010;38:W214\u2013220. https:\/\/doi.org\/10.1093\/nar\/gkq537. Web Server issue).","journal-title":"Nucleic Acids Res"},{"issue":"17","key":"4006_CR34","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1523\/JNEUROSCI.2893-15.2016","volume":"36","author":"MRC Bhattacharya","year":"2016","unstructured":"Bhattacharya MRC, Geisler S, Pittman SK, et al. TMEM184b promotes axon degeneration and neuromuscular junction maintenance. J Neurosci. 2016;36(17):4681\u20139. https:\/\/doi.org\/10.1523\/JNEUROSCI.2893-15.2016.","journal-title":"J Neurosci"},{"issue":"5","key":"4006_CR35","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1093\/bib\/bbr042","volume":"12","author":"P Gaudet","year":"2011","unstructured":"Gaudet P, Livstone MS, Lewis SE, Thomas PD. Phylogenetic-based propagation of functional annotations within the gene ontology consortium. Brief Bioinform. 2011;12(5):449\u201362. https:\/\/doi.org\/10.1093\/bib\/bbr042.","journal-title":"Brief Bioinform"},{"issue":"21","key":"4006_CR36","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1038\/sj.onc.1206406","volume":"22","author":"A Matsuda","year":"2003","unstructured":"Matsuda A, Suzuki Y, Honda G, et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. 2003;22(21):3307\u201318. https:\/\/doi.org\/10.1038\/sj.onc.1206406.","journal-title":"Oncogene"},{"issue":"3","key":"4006_CR37","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.critrevonc.2015.08.021","volume":"96","author":"MS Carlino","year":"2015","unstructured":"Carlino MS, Long GV, Kefford RF, Rizos H. Targeting oncogenic BRAF and aberrant MAPK activation in the treatment of cutaneous melanoma. Crit Rev Oncol Hematol. 2015;96(3):385\u201398. https:\/\/doi.org\/10.1016\/j.critrevonc.2015.08.021.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"5","key":"4006_CR38","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/bjc.2015.19","volume":"112","author":"I Fukumoto","year":"2015","unstructured":"Fukumoto I, Hanazawa T, Kinoshita T, et al. Microrna expression signature of oral squamous cell carcinoma: functional role of microrna-26a\/b in the modulation of novel cancer pathways. Br J Cancer. 2015;112(5):891\u2013900. https:\/\/doi.org\/10.1038\/bjc.2015.19.","journal-title":"Br J Cancer"},{"key":"4006_CR39","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53308","volume":"9","author":"A Patkunarajah","year":"2020","unstructured":"Patkunarajah A, Stear JH, Moroni M, et al. TMEM87a\/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration. Elife. 2020;9:e53308. https:\/\/doi.org\/10.7554\/eLife.53308.","journal-title":"Elife"},{"key":"4006_CR40","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-24-0747","author":"M Matejcic","year":"2025","unstructured":"Matejcic M, Teer JK, Hoehn HJ, et al. Colorectal tumors in diverse patient populations feature a spectrum of somatic mutational profiles. Cancer Res. 2025. https:\/\/doi.org\/10.1158\/0008-5472.CAN-24-0747.","journal-title":"Cancer Res"},{"issue":"21","key":"4006_CR41","doi-asserted-by":"publisher","first-page":"5551","DOI":"10.1111\/jcmm.17572","volume":"26","author":"Y Lin","year":"2022","unstructured":"Lin Y, Liu D, Li X, Ma Y, Pan X. TMEM184B promotes proliferation, migration and invasion, and inhibits apoptosis in hypopharyngeal squamous cell carcinoma. J Cell Mol Med. 2022;26(21):5551\u201361. https:\/\/doi.org\/10.1111\/jcmm.17572.","journal-title":"J Cell Mol Med"},{"issue":"20","key":"4006_CR42","doi-asserted-by":"publisher","first-page":"7711","DOI":"10.1073\/pnas.86.20.7711","volume":"86","author":"M Nishizawa","year":"1989","unstructured":"Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S. V-maf, a viral oncogene that encodes a leucine zipper motif. Proc Natl Acad Sci U S A. 1989;86(20):7711\u20135. https:\/\/doi.org\/10.1073\/pnas.86.20.7711.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"4006_CR43","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/j.bbamcr.2012.06.012","volume":"1823","author":"MB Kannan","year":"2012","unstructured":"Kannan MB, Solovieva V, Blank V. The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives. Biochim Biophys Acta. 2012;1823(10):1841\u20136. https:\/\/doi.org\/10.1016\/j.bbamcr.2012.06.012.","journal-title":"Biochim Biophys Acta"},{"issue":"9","key":"4006_CR44","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nrc2460","volume":"8","author":"A Eych\u00e8ne","year":"2008","unstructured":"Eych\u00e8ne A, Rocques N, Pouponnot C. A new mafia in cancer. Nat Rev Cancer. 2008;8(9):683\u201393. https:\/\/doi.org\/10.1038\/nrc2460.","journal-title":"Nat Rev Cancer"},{"key":"4006_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114105","volume":"149","author":"F Cai","year":"2025","unstructured":"Cai F, Mao S, Peng S, et al. A comprehensive pan-cancer examination of transcription factor MAFF: oncogenic potential, prognostic relevance, and immune landscape dynamics. Int Immunopharmacol. 2025;149:114105. https:\/\/doi.org\/10.1016\/j.intimp.2025.114105.","journal-title":"Int Immunopharmacol"},{"key":"4006_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24631-6","volume":"12","author":"EJ Moon","year":"2021","unstructured":"Moon EJ, Mello SS, Li CG, et al. The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. Nat Commun. 2021;12:4308. https:\/\/doi.org\/10.1038\/s41467-021-24631-6.","journal-title":"Nat Commun"},{"issue":"5","key":"4006_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114176","volume":"43","author":"CDK Nguyen","year":"2024","unstructured":"Nguyen CDK, Col\u00f3n-Emeric BA, Murakami S, Shujath MNY, Yi C. PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer. Cell Rep. 2024;43(5):114176. https:\/\/doi.org\/10.1016\/j.celrep.2024.114176.","journal-title":"Cell Rep"},{"issue":"12","key":"4006_CR48","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1016\/j.ajhg.2022.11.006","volume":"109","author":"E Long","year":"2022","unstructured":"Long E, Yin J, Funderburk KM, et al. Massively parallel reporter assays and variant scoring identified functional variants and target genes for melanoma loci and highlighted cell-type specificity. Am J Hum Genet. 2022;109(12):2210\u201329. https:\/\/doi.org\/10.1016\/j.ajhg.2022.11.006.","journal-title":"Am J Hum Genet"},{"key":"4006_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1467052","volume":"15","author":"Y Wang","year":"2024","unstructured":"Wang Y, Wang X, Liu Y, et al. A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma. Front Immunol. 2024;15:1467052. https:\/\/doi.org\/10.3389\/fimmu.2024.1467052.","journal-title":"Front Immunol"},{"key":"4006_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101057","volume":"73","author":"J Liang","year":"2024","unstructured":"Liang J, Bi G, Huang Y, et al. MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinoma. Drug Resist Updat. 2024;73:101057. https:\/\/doi.org\/10.1016\/j.drup.2024.101057.","journal-title":"Drug Resist Updat"},{"issue":"6","key":"4006_CR51","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1002\/ana.24802","volume":"80","author":"R Inzelberg","year":"2016","unstructured":"Inzelberg R, Flash S, Friedman E, Azizi E. Cutaneous malignant melanoma and Parkinson disease: common pathways? Ann Neurol. 2016;80(6):811\u201320. https:\/\/doi.org\/10.1002\/ana.24802.","journal-title":"Ann Neurol"},{"issue":"1","key":"4006_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0314745","volume":"20","author":"H Liu","year":"2025","unstructured":"Liu H, Karsidag M, Chhatwal K, Wang P, Tang T. Single-cell and bulk RNA sequencing analysis reveals CENPA as a potential biomarker and therapeutic target in cancers. PLoS One. 2025;20(1):e0314745. https:\/\/doi.org\/10.1371\/journal.pone.0314745.","journal-title":"PLoS One"},{"key":"4006_CR53","doi-asserted-by":"publisher","first-page":"102042","DOI":"10.1016\/j.genrep.2024.102042","volume":"37","author":"H Liu","year":"2024","unstructured":"Liu H, Guo Z, Wang P. Genetic expression in cancer research: Challenges and complexity. Gene Rep. 2024;37:102042.","journal-title":"Gene Rep"},{"issue":"1","key":"4006_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70184-1","volume":"14","author":"H Liu","year":"2024","unstructured":"Liu H, Dong A, Rasteh AM, Wang P, Weng J. Identification of the novel exhausted T cell CD8\u2009+\u2009markers in breast cancer. Sci Rep. 2024;14(1):19142. https:\/\/doi.org\/10.1038\/s41598-024-70184-1.","journal-title":"Sci Rep"},{"issue":"4","key":"4006_CR55","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3233\/CBM-220143","volume":"35","author":"H Liu","year":"2022","unstructured":"Liu H, Li Y. Potential roles of Cornichon family AMPA receptor auxiliary protein 4 (CNIH4) in head and neck squamous cell carcinoma. Cancer Biomark. 2022;35(4):439\u201350. https:\/\/doi.org\/10.3233\/CBM-220143.","journal-title":"Cancer Biomark"},{"key":"4006_CR56","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cancergen.2024.09.001","volume":"288","author":"L Jahangiri","year":"2024","unstructured":"Jahangiri L. Updates on liquid biopsies in neuroblastoma for treatment response, relapse and recurrence assessment. Cancer Genet. 2024;288:32\u20139. https:\/\/doi.org\/10.1016\/j.cancergen.2024.09.001.","journal-title":"Cancer Genet"},{"issue":"16","key":"4006_CR57","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1016\/j.cell.2022.06.036","volume":"185","author":"RL Collins","year":"2022","unstructured":"Collins RL, Glessner JT, Porcu E, et al. A cross-disorder dosage sensitivity map of the human genome. Cell. 2022;185(16):3041-e305525. https:\/\/doi.org\/10.1016\/j.cell.2022.06.036.","journal-title":"Cell"},{"key":"4006_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104289","volume":"196","author":"RA Fischer","year":"2024","unstructured":"Fischer RA, Ryan I, De La Torre K, et al. US physician perspective on the use of biomarker and ctDNA testing in patients with melanoma. Crit Rev Oncol Hematol. 2024;196:104289. https:\/\/doi.org\/10.1016\/j.critrevonc.2024.104289.","journal-title":"Crit Rev Oncol Hematol"},{"key":"4006_CR59","doi-asserted-by":"publisher","DOI":"10.1002\/cso2.1050","author":"X Ai","year":"2023","unstructured":"Ai X, Smith MC, Feltus FA. Generative adversarial networks applied to gene expression analysis: an interdisciplinary perspective. Comput Syst Oncol. 2023. https:\/\/doi.org\/10.1002\/cso2.1050.","journal-title":"Comput Syst Oncol"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04006-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-04006-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04006-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T16:34:40Z","timestamp":1767026080000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-04006-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4006"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-04006-9","relation":{},"ISSN":["2730-6011"],"issn-type":[{"type":"electronic","value":"2730-6011"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"5 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This study used publicly available data and did not involve human participants or animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not available.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2250"}}