{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:23:59Z","timestamp":1793298239443,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBQN-0988"],"award-info":[{"award-number":["2024JC-YBQN-0988"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-04023-8","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:59:50Z","timestamp":1764169190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the carcinogenic potential and molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human stomach using organoids and bulk sequencing data: a multi-machine learning approach combined with computational simulation"],"prefix":"10.1007","volume":"16","author":[{"given":"Youfu","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dede","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"issue":"4","key":"4023_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12580","volume":"24","author":"C Peng","year":"2019","unstructured":"Peng C, Li NS, Hu Y, Lu NH. Impact factors that modulate gastric cancer risk in Helicobacter pylori-infected rodent models. Helicobacter. 2019;24(4): e12580.","journal-title":"Helicobacter"},{"issue":"1","key":"4023_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03824-z","volume":"25","author":"C Xia","year":"2025","unstructured":"Xia C, Liu Y, Qing X. Burden of gastrointestinal cancers in Asia, 1990\u20132019. BMC Gastroenterol. 2025;25(1):232.","journal-title":"BMC Gastroenterol"},{"key":"4023_CR3","first-page":"25","volume":"444","author":"LE Wroblewski","year":"2023","unstructured":"Wroblewski LE, Peek RM Jr. Clinical pathogenesis, molecular mechanisms of gastric cancer development. Curr Top Microbiol Immunol. 2023;444:25\u201352.","journal-title":"Curr Top Microbiol Immunol"},{"key":"4023_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1397656","volume":"15","author":"B Lu","year":"2024","unstructured":"Lu B, Shi J, Cheng T, Wang C, Xu M, Sun P, et al. Chemokine ligand 14 correlates with immune cell infiltration in the gastric cancer microenvironment in predicting unfavorable prognosis. Front Pharmacol. 2024;15:1397656.","journal-title":"Front Pharmacol"},{"issue":"6","key":"4023_CR5","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00826-21","volume":"6","author":"AS Lin","year":"2021","unstructured":"Lin AS, Shuman JHB, Kotnala A, Shaw JA, Beckett AC, Harvey JL, Tuck M, Dixon B, Reyzer ML, Algood HMS, et al. Loss of corpus-specific lipids in Helicobacter pylori-induced atrophic gastritis. mSphere. 2021;6(6): e0082621.","journal-title":"mSphere"},{"issue":"5","key":"4023_CR6","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.4251\/wjgo.v16.i5.1725","volume":"16","author":"YY Liu","year":"2024","unstructured":"Liu YY, Wu DK, Chen JB, Tang YM, Jiang F. Advances in the study of gastric organoids as disease models. World J Gastrointest Oncol. 2024;16(5):1725\u201336.","journal-title":"World J Gastrointest Oncol"},{"issue":"3","key":"4023_CR7","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2174\/1871530323666230824161901","volume":"24","author":"TV Jacob","year":"2024","unstructured":"Jacob TV, Doshi GM. A mini-review on Helicobacter pylori with gastric cancer and available treatments. Endocr Metab Immune Disord Drug Targets. 2024;24(3):277\u201390.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"2","key":"4023_CR8","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3892\/mmr.2016.6046","volume":"15","author":"C Ledda","year":"2017","unstructured":"Ledda C, Loreto C, Zammit C, Marconi A, Fago L, Matera S, et al. Non\u2013infective occupational risk factors for hepatocellular carcinoma: a review (Review). Mol Med Rep. 2017;15(2):511\u201333.","journal-title":"Mol Med Rep"},{"key":"4023_CR9","unstructured":"Institute of Medicine Committee on the Implications of Dioxin in the Food S. In: Dioxins and Dioxin-like Compounds in the Food Supply: Strategies to Decrease Exposure. Washington (DC): National Academies Press (US) Copyright 2003 by the National Academy of Sciences. All rights reserved.; 2003."},{"issue":"1","key":"4023_CR10","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1021\/acs.jproteome.0c00495","volume":"20","author":"A Keller","year":"2021","unstructured":"Keller A, Chavez JD, Tang X, Bruce JE. Leveraging the entirety of the protein data bank to enable improved structure prediction based on cross-link data. J Proteome Res. 2021;20(1):1087\u201395.","journal-title":"J Proteome Res"},{"issue":"1","key":"4023_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-98301-8","volume":"15","author":"C Wan","year":"2025","unstructured":"Wan C, Wang P, Xu Y, Zhu Y, Chen H, Cao X, et al. Mechanism and role of H. pylori CagA-induced NLRP3 inflammasome in gastric cancer immune cell infiltration. Sci Rep. 2025;15(1):14335.","journal-title":"Sci Rep"},{"issue":"1","key":"4023_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04047-5","volume":"23","author":"C Hu","year":"2025","unstructured":"Hu C, Liu H, Hong B, Wang L, Wu Z, Xie W, et al. Helicobacter pylori reversing the landscape of neoadjuvant immunotherapy for microsatellite stable gastric cancer: a multicenter cohort study. BMC Med. 2025;23(1):230.","journal-title":"BMC Med"},{"issue":"1","key":"4023_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03886-z","volume":"25","author":"Z Wu","year":"2025","unstructured":"Wu Z, Tang Y, Tang M, Wu Z, Xu Y. The relationship between the eradication of Helicobacter pylori and the occurrence of stomach cancer: an updated meta-analysis and systemic review. BMC Gastroenterol. 2025;25(1):278.","journal-title":"BMC Gastroenterol"},{"key":"4023_CR14","doi-asserted-by":"crossref","unstructured":"Jang J, Choi Y, Kim N. Sex differences in the effect of changes in body mass index on the risk of developing gastric cancer: findings from a nationwide retrospective cohort study. Gut Liver; 2025.","DOI":"10.5009\/gnl240555"},{"key":"4023_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/foods14061052","author":"A Avila-Nava","year":"2025","unstructured":"Avila-Nava A, Guti\u00e9rrez-Solis AL, Pacheco-Can OD, Sagols-Tanoira IY, Gonz\u00e1lez-Marenco R, Cabrera-Lizarraga AG, et al. Dietary components associated with the risk of gastric cancer in the Latin American population: a systematic review and meta-analysis. Foods. 2025. https:\/\/doi.org\/10.3390\/foods14061052.","journal-title":"Foods"},{"key":"4023_CR16","doi-asserted-by":"publisher","DOI":"10.5009\/gnl240440","author":"F Xue","year":"2025","unstructured":"Xue F, Xue J, Zhao B, Zhu S. The associations of tobacco, alcohol, and coffee consumption with upper and lower gastrointestinal disease risk: a Mendelian randomization study. Gut Liver. 2025. https:\/\/doi.org\/10.5009\/gnl240440.","journal-title":"Gut Liver"},{"issue":"2","key":"4023_CR17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.5230\/jgc.2025.25.e16","volume":"25","author":"S Kim","year":"2025","unstructured":"Kim S, Kim MS, Kwon Y, Min JS, Alromi A, Kim JY, et al. Environmental protective and risk factors for gastric cancer: an umbrella review and reanalysis of meta-analyses. J Gastric Cancer. 2025;25(2):285\u2013302.","journal-title":"J Gastric Cancer"},{"issue":"12","key":"4023_CR18","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1093\/oxfordjournals.aje.a009069","volume":"145","author":"M Kogevinas","year":"1997","unstructured":"Kogevinas M, Becher H, Benn T, Bertazzi PA, Boffetta P, Bueno-de-Mesquita HB, Coggon D, Colin D, Flesch-Janys D, Fingerhut M, et al. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study. Am J Epidemiol. 1997;145(12):1061\u201375.","journal-title":"Am J Epidemiol"},{"issue":"6","key":"4023_CR19","first-page":"646","volume":"8","author":"PA Bertazzi","year":"1997","unstructured":"Bertazzi PA, Zocchetti C, Guercilena S, Consonni D, Tironi A, Landi MT, et al. Dioxin exposure and cancer risk: a 15-year mortality study after the Seveso accident. Epidemiology. 1997;8(6):646\u201352.","journal-title":"Epidemiology"},{"issue":"23","key":"4023_CR20","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1002\/cncr.28961","volume":"120","author":"SW Yi","year":"2014","unstructured":"Yi SW, Ohrr H. Agent orange exposure and cancer incidence in Korean Vietnam veterans: a prospective cohort study. Cancer. 2014;120(23):3699\u2013706.","journal-title":"Cancer"},{"key":"4023_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081905","author":"M Perrot-Applanat","year":"2024","unstructured":"Perrot-Applanat M, Pimpie C, Vacher S, Pocard M, Baud V. High expression of AhR and environmental pollution as AhR-linked ligands impact on oncogenic signaling pathways in Western patients with gastric cancer-a pilot study. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12081905.","journal-title":"Biomedicines"},{"issue":"1","key":"4023_CR22","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1093\/toxsci\/kfq232","volume":"118","author":"S Chmill","year":"2010","unstructured":"Chmill S, Kadow S, Winter M, Weighardt H, Esser C. 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs stable establishment of oral tolerance in mice. Toxicol Sci. 2010;118(1):98\u2013107.","journal-title":"Toxicol Sci"},{"issue":"3","key":"4023_CR23","first-page":"269","volume":"17","author":"HJ Kim","year":"2003","unstructured":"Kim HJ, Jeong KS, Park SJ, Cho SW, Son HY, Kim SR, Kim SH, An MY, Ryu SY. Effects of benzo [alpha]pyrene, 2-bromopropane, phenol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on IL-6 production in mice after single or repeated exposure. In Vivo. 2003;17(3):269\u201375.","journal-title":"In Vivo"},{"key":"4023_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081912","author":"JL Wang","year":"2024","unstructured":"Wang JL, Yeh CH, Huang SH, Wu LS, Chen MC. Effects of resistant-starch-encapsulated probiotic cocktail on intestines damaged by 5-fluorouracil. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12081912.","journal-title":"Biomedicines"},{"key":"4023_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081913","author":"AC Damian-Buda","year":"2024","unstructured":"Damian-Buda AC, Matei DM, Ciobanu L, Damian-Buda DZ, Pop RM, Buzoianu AD, et al. Nesfatin-1: a novel diagnostic and prognostic biomarker in digestive diseases. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12081913.","journal-title":"Biomedicines"},{"issue":"3","key":"4023_CR26","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.cyto.2007.06.002","volume":"38","author":"Y Zhou","year":"2007","unstructured":"Zhou Y, Toh ML, Zrioual S, Miossec P. IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells. Cytokine. 2007;38(3):157\u201364.","journal-title":"Cytokine"},{"issue":"1","key":"4023_CR27","doi-asserted-by":"publisher","first-page":"2430421","DOI":"10.1080\/19490976.2024.2430421","volume":"16","author":"LC Brackman","year":"2024","unstructured":"Brackman LC, Jung MS, Green EH, Joshi N, Revetta FL, McClain MS, Markham NO, Piazuelo MB. Scott Algood HM: IL-17 signaling protects against Helicobacter pylori-induced gastric cancer. Gut Microbes. 2024;16(1):2430421.","journal-title":"Gut Microbes"},{"issue":"4","key":"4023_CR28","doi-asserted-by":"publisher","first-page":"339","DOI":"10.4049\/immunohorizons.2300078","volume":"8","author":"LC Brackman","year":"2024","unstructured":"Brackman LC, Jung MS, Ogaga EI, Joshi N, Wroblewski LE, Piazuelo MB, et al. IL-17RA-mediated epithelial cell activity prevents severe inflammatory response to Helicobacter pylori infection. Immunohorizons. 2024;8(4):339\u201353.","journal-title":"Immunohorizons"},{"key":"4023_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ncrna.2025.04.001","volume":"13","author":"Y Wang","year":"2025","unstructured":"Wang Y, Liu W, Zhao X, Li Y, Song C, Huo B, et al. LINC02679 regulates TRIML2 to promote gastric cancer proliferation and invasion via targeting miR-5004-3p. Non-coding RNA Res. 2025;13:1\u201314.","journal-title":"Non-coding RNA Res"},{"issue":"4","key":"4023_CR30","doi-asserted-by":"publisher","first-page":"990","DOI":"10.7150\/ijms.99920","volume":"22","author":"YY Feng","year":"2025","unstructured":"Feng YY, Jin X, Pan MX, Liao JM, Huang XZ, Kang CM. LRP5 enhances glioma cell proliferation by modulating the MAPK\/p53\/cdc2 pathway. Int J Med Sci. 2025;22(4):990\u20131001.","journal-title":"Int J Med Sci"},{"issue":"9","key":"4023_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.70004","volume":"12","author":"Q Guo","year":"2024","unstructured":"Guo Q, Wang XY, Zhai YC, Dong YW, He QS. Oxaliplatin activates P53\/miR-34a\/survivin axis in inhibiting the progression of gastric cancer cells. Immun Inflamm Dis. 2024;12(9):e70004.","journal-title":"Immun Inflamm Dis"},{"key":"4023_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081914","author":"J Nowak","year":"2024","unstructured":"Nowak J, Aronin J, Beg F, O\u2019Malley N, Ferrick M, Quattrin T, et al. The effects of chronic psychostimulant administration on bone health: a review. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12081914.","journal-title":"Biomedicines"},{"key":"4023_CR33","doi-asserted-by":"crossref","unstructured":"Anjum A, Yazid MD, Daud MF, Idris J, Ng AMH, Naicker AS, Rashidah Ismail OH, Athi Kumar RK, Lokanathan Y. NeuroAiD(TM)-II (MLC901) promoted neurogenesis by activating the PI3K\/AKT\/GSK-3\u03b2 signaling pathway in rat spinal cord injury models. Biomedicines. 2024;12(8).","DOI":"10.3390\/biomedicines12081920"},{"issue":"1","key":"4023_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-023-03187-3","volume":"21","author":"Z Cui","year":"2023","unstructured":"Cui Z, Zou F, Wang R, Wang L, Cheng F, Wang L, et al. Integrative bioinformatics analysis of WDHD1: a potential biomarker for pan-cancer prognosis, diagnosis, and immunotherapy. World J Surg Oncol. 2023;21(1):309.","journal-title":"World J Surg Oncol"},{"issue":"2","key":"4023_CR35","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1158\/0008-5472.CAN-09-2736","volume":"70","author":"J Kool","year":"2010","unstructured":"Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M, Matentzoglu K, Lagcher W, Krimpenfort P, et al. Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes. Cancer Res. 2010;70(2):520\u201331.","journal-title":"Cancer Res"},{"issue":"1","key":"4023_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54960-y","volume":"9","author":"S Wan","year":"2019","unstructured":"Wan S, Kim TH, Smith KJ, Delaney R, Park GS, Guo H, et al. New labyrinth microfluidic device detects circulating tumor cells expressing cancer stem cell marker and circulating tumor microemboli in hepatocellular carcinoma. Sci Rep. 2019;9(1):18575.","journal-title":"Sci Rep"},{"issue":"1","key":"4023_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-019-0924-7","volume":"19","author":"KD Wyatt","year":"2019","unstructured":"Wyatt KD, Jenkins SM, Plevak MF, Venegas Pont MR, Pruthi S. A personalized, web-based breast cancer decision making application: a pre-post survey. BMC Med Inform Decis Mak. 2019;19(1):196.","journal-title":"BMC Med Inform Decis Mak"},{"issue":"7","key":"4023_CR38","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.acap.2021.02.013","volume":"21","author":"T Hamner","year":"2021","unstructured":"Hamner T. A NICU fortress. Acad Pediatr. 2021;21(7):1095\u20136.","journal-title":"Acad Pediatr"},{"issue":"1","key":"4023_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77256-y","volume":"10","author":"GL Davidson","year":"2020","unstructured":"Davidson GL, Wiley N, Cooke AC, Johnson CN, Fouhy F, Reichert MS, et al. Diet induces parallel changes to the gut microbiota and problem solving performance in a wild bird. Sci Rep. 2020;10(1):20783.","journal-title":"Sci Rep"},{"key":"4023_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081921","author":"V Giusti","year":"2024","unstructured":"Giusti V, Miserocchi G, Sbanchi G, Pannella M, Hattinger CM, Cesari M, et al. Xenografting human musculoskeletal sarcomas in mice, chick embryo, and zebrafish: how to boost translational research. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12081921.","journal-title":"Biomedicines"},{"key":"4023_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081906","author":"S Issa","year":"2024","unstructured":"Issa S, Fayoud H, Shaimardanova A, Sufianov A, Sufianova G, Solovyeva V, et al. Growth factors and their application in the therapy of hereditary neurodegenerative diseases. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12081906.","journal-title":"Biomedicines"},{"key":"4023_CR42","doi-asserted-by":"crossref","unstructured":"Munguia-Galaviz FJ, Miranda-Diaz AG, Gutierrez-Mercado YK, Ku-Centurion M, Gonzalez-Gonzalez RA, Portilla-de Buen E, Echavarria R. The Sigma-1 receptor exacerbates cardiac dysfunction induced by obstructive nephropathy: a role for sexual dimorphism. Biomedicines 2024;12(8).","DOI":"10.3390\/biomedicines12081908"},{"key":"4023_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081910","author":"L Petramala","year":"2024","unstructured":"Petramala L, Circosta F, Marino L, Palombi E, Costanzo ML, Servello A, et al. Clinical evaluation of adrenal incidentaloma: the experience of a referral center. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12081910.","journal-title":"Biomedicines"},{"key":"4023_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12081919","author":"A Korpysz","year":"2024","unstructured":"Korpysz A, Jaworski M, Skorupa E, Szalecki M, Walczak M, Petriczko E. Bone turnover markers during growth hormone therapy for short stature children born small for gestational age. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12081919.","journal-title":"Biomedicines"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04023-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-04023-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04023-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:59:52Z","timestamp":1764169192000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-04023-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4023"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-04023-8","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"3 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2170"}}