{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:47:06Z","timestamp":1785822426035,"version":"3.56.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-04070-1","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:46:04Z","timestamp":1763135164000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal association between inflammatory markers and malignant neoplasms of bone and articular cartilage using Mendelian randomization"],"prefix":"10.1007","volume":"16","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"4070_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117427","volume":"288","author":"W Liu","year":"2025","unstructured":"Liu W, Guo M, Hu Y, Chen Y, Wang Y, Nezamzadeh-Ejhieh A, et al. Recent advances in metal-based nanomaterials for malignant bone tumor therapy. Eur J Med Chem. 2025;288:117427.","journal-title":"Eur J Med Chem"},{"key":"4070_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/jfb16020062","author":"CJ Yon","year":"2025","unstructured":"Yon CJ, Choi BC, Lee JM, Lee SW. Personalized 3D-printed prostheses for bone defect reconstruction after tumor resection in the foot and ankle. J Funct Biomater. 2025. https:\/\/doi.org\/10.3390\/jfb16020062.","journal-title":"J Funct Biomater"},{"key":"4070_CR3","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-009367","author":"EM Zawidzka","year":"2025","unstructured":"Zawidzka EM, Biavati L, Thomas A, Zanettini C, Marchionni L, Leone R, et al. Tumor-specific CD8(+) T cells from the bone marrow resist exhaustion and exhibit increased persistence in tumor-bearing hosts as compared with tumor-infiltrating lymphocytes. J Immunother Cancer. 2025. https:\/\/doi.org\/10.1136\/jitc-2024-009367.","journal-title":"J Immunother Cancer"},{"key":"4070_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214237","volume":"172","author":"Q Zhao","year":"2025","unstructured":"Zhao Q, Xu X, Zheng T, He B, Zhang N, Wang D, et al. Magnesium-phosphorus gel containing oxygen vacancy niobium oxide with photothermal property for treating tumor, preventing infection and facilitating bone generation. Biomaterials Advances. 2025;172:214237.","journal-title":"Biomaterials Advances"},{"issue":"1","key":"4070_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-025-01564-8","volume":"25","author":"S Alavimanesh","year":"2025","unstructured":"Alavimanesh S, Nayerain Jazi N, Choubani M, Saeidi F, Afkhami H, Yarahmadi A, et al. Cellular senescence in the tumor with a bone niche microenvironment: friend or foe? Clin Exp Med. 2025;25(1):44.","journal-title":"Clin Exp Med"},{"issue":"1","key":"4070_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02161-1","volume":"23","author":"Y Guan","year":"2024","unstructured":"Guan Y, Zhang W, Mao Y, Li S. Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment. Mol Cancer. 2024;23(1):246.","journal-title":"Mol Cancer"},{"key":"4070_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.2147\/CMAR.S495169","volume":"17","author":"H Jiang","year":"2025","unstructured":"Jiang H. Prostate cancer bone metastasis: molecular mechanisms of tumor and bone microenvironment. Cancer Manag Res. 2025;17:219\u201337.","journal-title":"Cancer Manag Res"},{"issue":"33","key":"4070_CR8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2402903121","volume":"121","author":"G Yu","year":"2024","unstructured":"Yu G, Corn PG, Mak CS, Liang X, Zhang M, Troncoso P, et al. Prostate cancer-induced endothelial-cell-to-osteoblast transition drives immunosuppression in the bone-tumor microenvironment through Wnt pathway-induced M2 macrophage polarization. Proc Natl Acad Sci U S A. 2024;121(33):e2402903121.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4070_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1462531","volume":"16","author":"Z Feng","year":"2025","unstructured":"Feng Z, Fu J, Wang K, Yang J, Jiang X, Wu Q. Causal relationship between hormone levels and lung cancer: a Mendelian randomization study. Front Endocrinol (Lausanne). 2025;16:1462531.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"4070_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13774-0","volume":"25","author":"Q Wang","year":"2025","unstructured":"Wang Q, Lv D, Wen J, Zhou H, Jia M, Li J, et al. Relationship of obesity, body fat, benign adrenal tumors and the mediating mechanism: a two-step Mendelian randomization study. BMC Cancer. 2025;25(1):360.","journal-title":"BMC Cancer"},{"issue":"9","key":"4070_CR11","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41590-023-01588-w","volume":"24","author":"JH Zhao","year":"2023","unstructured":"Zhao JH, Stacey D, Eriksson N, Macdonald-Dunlop E, Hedman \u00c5K, Kalnapenkis A, et al. Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets. Nat Immunol. 2023;24(9):1540\u201351.","journal-title":"Nat Immunol"},{"key":"4070_CR12","doi-asserted-by":"crossref","unstructured":"Markowska A, Antoszczak M, Markowska J, Huczynski A. Role of Epigallocatechin gallate in selected malignant neoplasms in women. Nutrients. 2025;17(2).","DOI":"10.3390\/nu17020212"},{"issue":"1","key":"4070_CR13","first-page":"55","volume":"34","author":"P Nikolova","year":"2025","unstructured":"Nikolova P, Hadzhiyska V, Gramatikov Y, Veneva S, Gaydarov G, Raycheva E, et al. A rare case of triple primary malignant neoplasms (RCC and colon Cancer) detected by (18)F-FDG PET\/CT. Mol Imaging Radionucl Ther. 2025;34(1):55\u20137.","journal-title":"Mol Imaging Radionucl Ther"},{"key":"4070_CR14","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000002900","author":"AF Tadrosse","year":"2025","unstructured":"Tadrosse AF, Tadrosse MF, Lotfalla ME, Messiha PA, Eloy JA, Langer PD. Squamous cell carcinoma of the conjunctiva: a population-based study on epidemiologic trends, cancer-specific survival patterns, and the risk of second malignant neoplasms, 1975 to 2016. Ophthalmic Plast Reconstr Surg. 2025. https:\/\/doi.org\/10.1097\/IOP.0000000000002900.","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"1","key":"4070_CR15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11307-025-01982-w","volume":"27","author":"M Xiong","year":"2025","unstructured":"Xiong M, You H, Feng J, Liu Y, Luo X, Liu Y, et al. (18)F-FAPI-42 PET\/CT and (18)F-FDG PET\/CT in patients with malignant digestive system neoplasms: a head-to-head comparative study. Mol Imaging Biol. 2025;27(1):131\u201341.","journal-title":"Mol Imaging Biol"},{"issue":"1","key":"4070_CR16","first-page":"665","volume":"104","author":"SE Abd El-Ghani","year":"2025","unstructured":"Abd El-Ghani SE, Abido HY, Tawfik NM, Shaheen G, Ellithy HN. A study of the relationship between circulating cytokines (interleukin-2 receptor and tumor necrosis factor receptor 2) and risk of B-cell nonhodgkin lymphoma. Ann Hematol. 2025;104(1):665\u201373.","journal-title":"Ann Hematol"},{"issue":"1","key":"4070_CR17","first-page":"e77734","volume":"17","author":"H Fukuda","year":"2025","unstructured":"Fukuda H, Sakuma Y, Inage K, Takahashi K, Yamaura I, Shiratsuchi H, et al. Tumor necrosis Factor-Alpha (TNF-alpha) and Interleukin-6 (IL-6) cytokines in the injured meniscus of patients with knee subchondral insufficiency fractures: A potential association with preoperative pain. Cureus. 2025;17(1):e77734.","journal-title":"Cureus"},{"key":"4070_CR18","doi-asserted-by":"crossref","unstructured":"Gkiokas A, Papadatou-Gigante M, Gkioka AI, Koudouna A, Tryfou TM, Alexandropoulos A et al. Tumor-associated macrophage (TAM)-related cytokines, sCD163, CCL2, and CCL4, as novel biomarkers for overall survival and time to treatment in Waldenstrom\u2019s macroglobulinemia: emphasis on asymptomatic WM. Cells. 2025;14(4).","DOI":"10.3390\/cells14040275"},{"key":"4070_CR19","doi-asserted-by":"publisher","first-page":"e2503009","DOI":"10.1002\/advs.202503009","volume":"2025","author":"T He","year":"2025","unstructured":"He T, Wang ZY, Xu B, Zhong CJ, Wang LN, Shi HC, et al. CXCL6 reshapes lipid metabolism and induces neutrophil extracellular trap formation in cholangiocarcinoma progression and immunotherapy resistance. Adv Sci (Weinh). 2025;2025:e2503009.","journal-title":"Adv Sci (Weinh)"},{"issue":"12","key":"4070_CR20","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1016\/j.ccell.2024.10.008","volume":"42","author":"C Yang","year":"2024","unstructured":"Yang C, Geng H, Yang X, Ji S, Liu Z, Feng H, et al. Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy. Cancer Cell. 2024;42(12):2064\u201381. e2019.","journal-title":"Cancer Cell"},{"issue":"19","key":"4070_CR21","doi-asserted-by":"publisher","first-page":"4505","DOI":"10.1158\/1078-0432.CCR-24-0385","volume":"30","author":"E Bonfill-Teixidor","year":"2024","unstructured":"Bonfill-Teixidor E, Neva-Alejo A, Arias A, Cuartas I, Iurlaro R, Planas-Rigol E, et al. Cervical cancer evades the host immune system through the inhibition of type I interferon and CXCL9 by LIF. Clin Cancer Res. 2024;30(19):4505\u201316.","journal-title":"Clin Cancer Res"},{"key":"4070_CR22","volume":"9","author":"Z Li","year":"2019","unstructured":"Li Z, Jin C, Lu X, Zhang Y, Zhang Y, Wen J, et al. Activation of CXCL6\/CXCR1\/2 axis promotes the growth and metastasis of osteosarcoma cells in vitro and in vivo. Front Oncol. 2019;9:217.","journal-title":"Front Oncol"},{"key":"4070_CR23","first-page":"77","volume":"145","author":"K Singh","year":"2020","unstructured":"Singh K, Deshpande P, Pryma DA, Bushman FD, Zhang L. Ccl4 signaling in the tumor microenvironment. Adv Cancer Res. 2020;145:77\u201392.","journal-title":"Adv Cancer Res"},{"key":"4070_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1394284","volume":"15","author":"S Orrapin","year":"2024","unstructured":"Orrapin S, Moonmuang S, Udomruk S, Yongpitakwattana P, Pruksakorn D, Chaiyawat P. Unlocking the tumor-immune microenvironment in osteosarcoma: insights into the immune landscape and mechanisms. Front Immunol. 2024;15:1394284.","journal-title":"Front Immunol"},{"key":"4070_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1295257","volume":"14","author":"U Basak","year":"2023","unstructured":"Basak U, Sarkar T, Mukherjee S, Chakraborty S, Dutta A, Dutta S, et al. Tumor-associated macrophages: an effective player of the tumor microenvironment. Front Immunol. 2023;14:1295257.","journal-title":"Front Immunol"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04070-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-04070-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04070-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T13:03:27Z","timestamp":1766149407000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-04070-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4070"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-04070-1","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"15 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors agreed to publish this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2210"}}