{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:17:08Z","timestamp":1788243428490,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-04086-7","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:24:56Z","timestamp":1764332696000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case study of gastritis cystica profunda mimicking a submucosal tumor treated with endoscopic submucosal dissection"],"prefix":"10.1007","volume":"16","author":[{"given":"Ya-Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Fei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Li","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"issue":"11","key":"4086_CR1","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1080\/00365529850172610","volume":"33","author":"H Mitomi","year":"1998","unstructured":"Mitomi H, Iwabuchi K, Amemiya A, et al. Immunohistochemical analysis of a case of gastritis cystica profunda associated with carcinoma development. Scand J Gastroenterol. 1998;33(11):1226\u20139.","journal-title":"Scand J Gastroenterol"},{"issue":"6","key":"4086_CR2","first-page":"459","volume":"81","author":"EC Fonde","year":"1986","unstructured":"Fonde EC, Rodning CB. Gastritis cystica profunda. Am J Gastroenterol. 1986;81(6):459\u201364.","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"4086_CR3","doi-asserted-by":"publisher","first-page":"3668","DOI":"10.21037\/apm-20-1253","volume":"9","author":"Y Du","year":"2020","unstructured":"Du Y, Zhang W, Ma Y, Qiu Z. Gastritis cystica profunda: a case report and literature review. Ann Palliat Med. 2020;9(5):3668\u201377.","journal-title":"Ann Palliat Med"},{"issue":"S 01","key":"4086_CR4","doi-asserted-by":"publisher","first-page":"E1180","DOI":"10.1055\/a-2197-9115","volume":"55","author":"L Zeng","year":"2023","unstructured":"Zeng L, Zheng L, Hu B, Ye L. Gastritis cystica profunda mimicking submucosal tumor. Endoscopy. 2023;55(S 01):E1180\u20131.","journal-title":"Endoscopy"},{"key":"4086_CR5","doi-asserted-by":"crossref","unstructured":"Okada M, Iizuka Y, Oh K, et al. Gastritis cystica profunda presenting as giant gastric mucosal folds: the role of endoscopic ultrasonography and mucosectomy in the diagnostic work-up. Gastrointest Endosc. 1994 Sep-Oct;40(5):640\u20134.","DOI":"10.1016\/S0016-5107(94)70272-1"},{"issue":"1","key":"4086_CR6","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/1097-0142(197201)29:1<205::AID-CNCR2820290130>3.0.CO;2-J","volume":"29","author":"ER Littler","year":"1972","unstructured":"Littler ER, Gleibermann E. Gastritis cystica polyposa. (Gastric mucosal prolapse at gastroenterostomy site, with cystic and infiltrative epithelial hyperplasia). Cancer. 1972;29(1):205\u20139.","journal-title":"Cancer"},{"issue":"3","key":"4086_CR7","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1159\/000368076","volume":"8","author":"N Ogasawara","year":"2014","unstructured":"Ogasawara N, Noda H, Kondo Y, Yoshimine T, et al. A case of early gastric cancer arising from gastritis cystica profunda treated by endoscopic submucosal dissection. Case Rep Gastroenterol. 2014;8(3):270\u20135.","journal-title":"Case Rep Gastroenterol"},{"issue":"3","key":"4086_CR8","first-page":"347","volume":"29","author":"H Yamagiwa","year":"1979","unstructured":"Yamagiwa H, Matsuzaki O, Ishihara A, Yoshimura H. Heterotopic gastric glands in the submucosa of the stomach. Acta Pathol Jpn. 1979;29(3):347\u201350.","journal-title":"Acta Pathol Jpn"},{"issue":"Suppl 1","key":"4086_CR9","doi-asserted-by":"publisher","first-page":"E80","DOI":"10.1055\/s-2006-945070","volume":"39","author":"D B\u00e9chade","year":"2007","unstructured":"B\u00e9chade D, Desram\u00e9 J, Algayres JP. Gastritis cystica profunda in a patient with no history of gastric surgery. Endoscopy. 2007;39(Suppl 1):E80-1.","journal-title":"Endoscopy"},{"issue":"5","key":"4086_CR10","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/j.1365-2559.1981.tb01817.x","volume":"5","author":"G Franzin","year":"1981","unstructured":"Franzin G, Novelli P. Gastritis cystica profunda. Histopathology. 1981;5(5):535\u201347.","journal-title":"Histopathology"},{"issue":"10","key":"4086_CR11","first-page":"004845","volume":"11","author":"GC Haddad","year":"2024","unstructured":"Haddad GC, Moussallem N, Sbeih S, et al. Double the trouble: a rare finding of gastritis cystica profunda in a previously unoperated young female with concomitant Helicobacter pyloriinfection. Eur J Case Rep Intern Med. 2024;11(10):004845.","journal-title":"Eur J Case Rep Intern Med"},{"issue":"1","key":"4086_CR12","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/S0016-5085(00)70412-4","volume":"118","author":"TC Wang","year":"2000","unstructured":"Wang TC, Dangler CA, Chen D, et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology. 2000;118(1):36\u201347.","journal-title":"Gastroenterology"},{"issue":"7","key":"4086_CR13","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3748\/wjg.v30.i7.673","volume":"30","author":"ZH Geng","year":"2024","unstructured":"Geng ZH, Zhu Y, Fu PY, Qu YF, Chen WF, Yang X, Zhou PH, Li QL. Endoscopic features and treatments of gastric cystica profunda. World J Gastroenterol. 2024;30(7):673\u201384.","journal-title":"World J Gastroenterol"},{"key":"4086_CR14","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.3748\/wjg.v19.i8.1314","volume":"19","author":"N Kuwahara","year":"2013","unstructured":"Kuwahara N, Kitazawa R, Fujiishi K, Nagai Y, Haraguchi R, Kitazawa S. Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression. World J Gastroenterol. 2013;19:1314\u20137.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"4086_CR15","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.gie.2014.11.017","volume":"81","author":"G Xu","year":"2015","unstructured":"Xu G, Peng C, Li X, Zhang W, et al. Endoscopic resection of gastritis cystica profunda: preliminary experience with 34 patients from a single center in China. Gastrointest Endosc. 2015;81(6):1493\u20138.","journal-title":"Gastrointest Endosc"},{"issue":"13","key":"4086_CR16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037652","volume":"103","author":"S Shimizu","year":"2024","unstructured":"Shimizu S, Hara H, Muto Y, et al. Gastritis cystica profunda in an unoperated stomach mimicking a pyloric submucosal tumor and causing anorexia: a case report and literature review. Medicine. 2024;103(13):e37652.","journal-title":"Medicine"},{"issue":"2","key":"4086_CR17","first-page":"261","volume":"14","author":"C Li","year":"2021","unstructured":"Li C, Song S, Wu G, Zhang Z. Gastritis cystica profunda: clinical and pathologic study of seven cases and review of literature. Int J Clin Exp Pathol. 2021;14(2):261\u20136.","journal-title":"Int J Clin Exp Pathol"},{"issue":"7","key":"4086_CR18","doi-asserted-by":"publisher","first-page":"e29349","DOI":"10.1016\/j.heliyon.2024.e29349","volume":"10","author":"W Jiang","year":"2024","unstructured":"Jiang W, Bai L, Zhang S, Cheng R. Endoscopic submucosal dissection (ESD) for gastritis cystica profunda (GCP) with early gastric cancer: a propensity score matching analysis. Heliyon. 2024;10(7):e29349.","journal-title":"Heliyon"}],"updated-by":[{"DOI":"10.1007\/s12672-026-04557-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04086-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-04086-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04086-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:11:21Z","timestamp":1788243081000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-04086-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4086"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-04086-7","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"12 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12672-026-04557-5","URL":"https:\/\/doi.org\/10.1007\/s12672-026-04557-5","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki (as was revised in 2013). The study was approved by Ethics Committee of the First Hospital of Tsinghua University. The written, informed consent was obtained from the participant for the publication of this case report.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was taken from patient for publication of this case report.\u00a0","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"2344"}}