{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:43:31Z","timestamp":1793648611034,"version":"4.5.1"},"reference-count":197,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shenyang Young and Middle aged Science and Technology Talents Cultivation Special Project for Returning Overseas Youth","award":["RC230088"],"award-info":[{"award-number":["RC230088"]}]},{"name":"Doctoral Research Start-up Projects of the Natural Science Foundation of Liaoning Province","award":["2024-BS-280"],"award-info":[{"award-number":["2024-BS-280"]}]},{"name":"Basic Research Projects of Liaoning Provincial Department of Education","award":["LJ222410164030"],"award-info":[{"award-number":["LJ222410164030"]}]},{"name":"Liaoning Provincial Science and Technology Department Science \uff0c Technology Plan General Project","award":["(2024JH2\/102600237"],"award-info":[{"award-number":["(2024JH2\/102600237"]}]},{"name":"Liaoning Provincial Department of Education","award":["LJ222410164024"],"award-info":[{"award-number":["LJ222410164024"]}]},{"name":"International Industrial Technology Research and Development Project of Liaoning Provincial Department of Science and Technology","award":["No.2025JH2\/101900023"],"award-info":[{"award-number":["No.2025JH2\/101900023"]}]},{"name":")Liaoning Provincial Department of Science and Technology Applied Basic Research Program Project","award":["2023JH2\/101300079"],"award-info":[{"award-number":["2023JH2\/101300079"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-04222-3","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T18:07:15Z","timestamp":1764958035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Research progress on carcinogenic factors and personalized treatment of oral cancer"],"prefix":"10.1007","volume":"17","author":[{"given":"Kebin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaozhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"4222_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2020.100988","author":"G Sarode","year":"2020","unstructured":"Sarode G, Maniyar N, Sarode SC, et al. Epidemiologic aspects of oral cancer. Dis Mon. 2020. https:\/\/doi.org\/10.1016\/j.disamonth.2020.100988.","journal-title":"Dis Mon"},{"issue":"3","key":"4222_CR2","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.soc.2015.03.006","volume":"24","author":"PH Montero","year":"2015","unstructured":"Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am. 2015;24(3):491\u2013508.","journal-title":"Surg Oncol Clin N Am"},{"issue":"5","key":"4222_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/app13053370","volume":"13","author":"SM Yang","year":"2023","unstructured":"Yang SM, Song B, Wink C, et al. Performance of automated oral cancer screening algorithm in tobacco users vs. non-tobacco users. Appl Sci. 2023;13(5):3370.","journal-title":"Appl Sci"},{"key":"4222_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-025-06098-w","author":"J Wu","year":"2025","unstructured":"Wu J, Chen H, Liu Y, Yang R, An N. The global, regional, and national burden of oral cancer, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021. J Cancer Res Clin Oncol. 2025. https:\/\/doi.org\/10.1007\/s00432-025-06098-w.","journal-title":"J Cancer Res Clin Oncol"},{"key":"4222_CR5","unstructured":"World Health Organization. (2024) Absolute numbers, mortality, both sexes, in 2022. https:\/\/gco.iarc.who.int. Accessed 2024-08-02."},{"key":"4222_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182111003","author":"N Ahmed","year":"2021","unstructured":"Ahmed N, Arshad S, Basheer SN, et al. Smoking a dangerous addiction: a systematic review on an underrated risk factor for oral diseases. Int J Environ Res Public Health. 2021. https:\/\/doi.org\/10.3390\/ijerph182111003.","journal-title":"Int J Environ Res Public Health"},{"issue":"9","key":"4222_CR7","doi-asserted-by":"publisher","first-page":"001417","DOI":"10.1099\/jmm.0.001417","volume":"70","author":"S Sawant","year":"2021","unstructured":"Sawant S, Dugad J, Parikh D, et al. Identification & correlation of bacterial diversity in oral cancer and long- term tobacco chewers- A case- control pilot study. J Med Microbiol. 2021;70(9):001417.","journal-title":"J Med Microbiol"},{"key":"4222_CR8","first-page":"1","volume":"44","author":"drinkingIARC Alcohol","year":"1988","unstructured":"Alcohol drinkingIARC. Monogr Eval Carcinog Risks Hum. 1988;44:1\u2013378.","journal-title":"Monogr Eval Carcinog Risks Hum"},{"key":"4222_CR9","first-page":"3","volume":"96","author":"IARC Working Group on the Evaluatio","year":"2010","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Alcohol consumption and Ethyl carbamate. IARC Monogr Eval Carcinog Risks Hum. 2010;96:3\u20131383.","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"issue":"24","key":"4222_CR10","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1093\/jnci\/djr483","volume":"103","author":"VJ Cogliano","year":"2011","unstructured":"Cogliano VJ, Baan R, Straif K, et al. Preventable exposures associated with human cancers. J Natl Cancer Inst. 2011;103(24):1827\u201339.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"4222_CR11","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.jds.2023.05.016","volume":"18","author":"H Liu","year":"2023","unstructured":"Liu H, Yu Z, Xu Z, et al. A scientometric study of tobacco and alcohol use as risk factors for oral cavity health. J Dent Sci. 2023;18(4):1883\u20138.","journal-title":"J Dent Sci"},{"key":"4222_CR12","doi-asserted-by":"publisher","DOI":"10.5334\/aogh.4174","author":"K Rieth","year":"2023","unstructured":"Rieth K, Sy A, McIntosh S, et al. Dental health utilization in Palau: feasibility of an oral cancer screening program. Ann Glob Health. 2023. https:\/\/doi.org\/10.5334\/aogh.4174.","journal-title":"Ann Glob Health"},{"issue":"1","key":"4222_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04501-5","volume":"24","author":"SAA Zaidi","year":"2024","unstructured":"Zaidi SAA, Chughtai N, Abbassi ZA, et al. TUSC3, p53 and p21 genetic association with development of oral submucous fibrosis and oral squamous cell carcinoma among addictive tobacco chewers of Pakistan. BMC Oral Health. 2024;24(1):780.","journal-title":"BMC Oral Health"},{"key":"4222_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106760","volume":"152","author":"RL Hong","year":"2024","unstructured":"Hong RL, Yen CJ, Lien MY, et al. Betel-nut chewing does not influence PD-L1 expression rates in recurrent\/metastatic head and neck squamous cell carcinoma (HNSCC): a prospective biomarker prevalence study. Oral Oncol. 2024;152:106760.","journal-title":"Oral Oncol"},{"issue":"13","key":"4222_CR15","doi-asserted-by":"publisher","first-page":"8290","DOI":"10.1002\/jsfa.13664","volume":"104","author":"Z Sun","year":"2024","unstructured":"Sun Z, Guo X, Li C, et al. Exploring the therapeutic mechanisms of resveratrol for treating arecoline-induced malignant transformation in oral epithelial cells: insights into hub targets. J Sci Food Agric. 2024;104(13):8290\u2013305.","journal-title":"J Sci Food Agric"},{"issue":"8","key":"4222_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12080996","volume":"12","author":"P Diwan","year":"2023","unstructured":"Diwan P, Nirwan M, Bahuguna M, et al. Evaluating alterations of the oral microbiome and its link to oral cancer among betel quid chewers: prospecting reversal through probiotic intervention. Pathogens. 2023;12(8):996.","journal-title":"Pathogens"},{"issue":"1","key":"4222_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278221","volume":"18","author":"M Bahuguna","year":"2023","unstructured":"Bahuguna M, Hooda S, Mohan L, et al. Identifying oral microbiome alterations in adult betel quid chewing population of Delhi, India. PLoS One. 2023;18(1):e0278221.","journal-title":"PLoS One"},{"key":"4222_CR18","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14943","author":"AG Singh","year":"2024","unstructured":"Singh AG, Chaturvedi P. Areca nut and oral cancer. Oral Dis. 2024. https:\/\/doi.org\/10.1111\/odi.14943.","journal-title":"Oral Dis"},{"issue":"1","key":"4222_CR19","first-page":"21","volume":"14","author":"FH Fauzi","year":"2019","unstructured":"Fauzi FH, Hamzan NI, Rahman NA, et al. Detection of human papillomavirus types 16 and 18 in oral squamous cell carcinoma samples in Malaysia. Archives Orofac Sci. 2019;14(1):21\u20139.","journal-title":"Archives Orofac Sci"},{"issue":"7","key":"4222_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11071838","volume":"11","author":"SE Moe","year":"2023","unstructured":"Moe SE, Erland FA, Fromreide S, et al. The TP53 codon 72 arginine polymorphism is found with increased TP53 somatic mutations in HPV (\u2212) and in an increased percentage among HPV (+) Norwegian HNSCC patients. Biomedicines. 2023;11(7):1838.","journal-title":"Biomedicines"},{"key":"4222_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.07.007","author":"K Hoppe-Seyler","year":"2017","unstructured":"Hoppe-Seyler K, Bossler F, Braun JA, et al. The HPV E6\/E7 oncogenes: key factors for viral carcinogenesis and therapeutic targets. Trends Microbiol 2017. https:\/\/doi.org\/10.1016\/j.tim.2017.07.007.","journal-title":"Trends Microbiol\u00a0"},{"issue":"1","key":"4222_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-023-00682-3","volume":"31","author":"Q Peng","year":"2024","unstructured":"Peng Q, Wang L, Zuo L, et al. HPV E6\/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor. Cancer Gene Ther. 2024;31(1):9. https:\/\/doi.org\/10.1038\/s41417-023-00682-3.","journal-title":"Cancer Gene Ther"},{"key":"4222_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.08.001","author":"S Mittal","year":"2017","unstructured":"Mittal S, Banks L. Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation. Mutation Research\/Reviews in Mutation Research. 2017. https:\/\/doi.org\/10.1016\/j.mrrev.2016.08.001.","journal-title":"Mutation Research\/Reviews in Mutation Research"},{"key":"4222_CR24","doi-asserted-by":"publisher","DOI":"10.1101\/gr.241141.118","author":"ML Gillison","year":"2018","unstructured":"Gillison ML, Akagi K, Xiao W, et al. Human papillomavirus and the landscape of secondary genetic alterations in oral cancers. Genome Res. 2018. https:\/\/doi.org\/10.1101\/gr.241141.118.","journal-title":"Genome Res"},{"issue":"4","key":"4222_CR25","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1158\/1940-6207.CAPR-14-0366","volume":"8","author":"EM Rettig","year":"2015","unstructured":"Rettig EM, Chung CH, Bishop JA, et al. Cleaved NOTCH1 expression pattern in head and neck squamous cell carcinoma is associated with NOTCH1 mutation, HPV status, and high-risk features. Cancer Prev Res. 2015;8(4):287.","journal-title":"Cancer Prev Res"},{"issue":"9","key":"4222_CR26","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1001\/jamaoto.2023.1573","volume":"149","author":"AR Giuliano","year":"2023","unstructured":"Giuliano AR, Felsher M, Waterboer T, et al. Oral human papillomavirus prevalence and genotyping among a healthy adult population in the US. Jama Otolaryngology-Head & Neck Surgery. 2023;149(9):783\u201395.","journal-title":"Jama Otolaryngology-Head & Neck Surgery"},{"issue":"6","key":"4222_CR27","doi-asserted-by":"publisher","first-page":"985","DOI":"10.5114\/ada.2020.97396","volume":"38","author":"J Oleszkiewicz-Spiolek","year":"2021","unstructured":"Oleszkiewicz-Spiolek J, Adamska P, Marvaso G, et al. Assessment of awareness of human papillomavirus infection impact on oral cavity among patients[J]. Postepy Dermatologii I Alergologii. 2021;38(6):985\u201393.","journal-title":"Postepy Dermatologii I Alergologii"},{"key":"4222_CR28","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2024-0392","author":"L Kavitha","year":"2025","unstructured":"Kavitha L, Kuzhalmozhi M, Vijayashree Priyadharsini J, et al. Microbial signatures in head and neck squamous cell carcinoma: an in silico study. J Appl Oral Sci. 2025. https:\/\/doi.org\/10.1590\/1678-7757-2024-0392.","journal-title":"J Appl Oral Sci"},{"issue":"17","key":"4222_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3206","volume":"9","author":"J Sun","year":"2020","unstructured":"Sun J, Tang Q, Yu S, et al. Role of the oral microbiota in cancer evolution and progression. Cancer Med. 2020;6348. https:\/\/doi.org\/10.1002\/cam4.3206.","journal-title":"Cancer Med"},{"key":"4222_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2023.105630","volume":"147","author":"X Shen","year":"2023","unstructured":"Shen X, Zhang Y, Zhu J, Xu B. Oral dysbiosis in the onset and carcinogenesis of oral epithelial dysplasia: a systematic review. Arch Oral Biol. 2023;147:105630.","journal-title":"Arch Oral Biol"},{"key":"4222_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26041424","author":"Q Xia","year":"2025","unstructured":"Xia Q, Pierson S. HPV infection and oral microbiota: interactions and future implications. Int J Mol Sci. 2025. https:\/\/doi.org\/10.3390\/ijms26041424.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4222_CR32","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1038\/s41598-024-81607-4","volume":"15","author":"D Marcillo","year":"2025","unstructured":"Marcillo D, Privitera G, Rollo F, Latini A, Giuliani E, Benevolo M, Giuliani M, Pichi B, Pellini R, Dona M. Microbiome analysis in individuals with human papillomavirus oral infection. Sci Rep. 2025;15(1):2953.","journal-title":"Sci Rep"},{"key":"4222_CR33","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae004","author":"X Feng","year":"2024","unstructured":"Feng X, Patel E, White J, Li S, Zhu X, Zhao N, et al. Association of oral microbiome with oral human papillomavirus infection: a population study of the National Health and Nutrition Examination Survey, 2009\u20132012. J Infect Dis. 2024. https:\/\/doi.org\/10.1093\/infdis\/jiae004.","journal-title":"J Infect Dis"},{"key":"4222_CR34","first-page":"1","volume":"31","author":"G Al-Qadami","year":"2023","unstructured":"Al-Qadami G, Bowen J, Van Sebille Y, Secombe K, Dorraki M, Verjans J, et al. Baseline gut microbiota composition is associated with oral mucositis and tumour recurrence in patients with head and neck cancer: a pilot study. Support Care Cancer. 2023;31:1\u201314.","journal-title":"Support Care Cancer"},{"key":"4222_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0409-1","author":"J Galloway-Pe\u00f1a","year":"2017","unstructured":"Galloway-Pe\u00f1a J, Smith D, Sahasrabhojane P, Wadsworth W, Fellman B, Ajami N, et al. Characterization of oral and gut microbiome temporal variability in hospitalized cancer patients. Genome Med. 2017. https:\/\/doi.org\/10.1186\/s13073-017-0409-1.","journal-title":"Genome Med"},{"issue":"21","key":"4222_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218171","volume":"21","author":"LY Huang","year":"2020","unstructured":"Huang LY, Hsieh YP, Wang YY, et al. Single-cell analysis of different stages of oral cancer carcinogenesis in a mouse model. Int J Mol Sci. 2020;21(21):8171.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"4222_CR37","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00335-021-09885-1","volume":"32","author":"A Nashef","year":"2021","unstructured":"Nashef A, Qahaz N, El-Naaj IA, et al. Systems genetics analysis of oral squamous cell carcinoma susceptibility using the mouse model: current position and new perspective. Mamm Genome. 2021;32(5):323\u201331.","journal-title":"Mamm Genome"},{"key":"4222_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.niox.2018.06.005","volume":"79","author":"CW Su","year":"2018","unstructured":"Su CW, Chien MH, Lin CW, et al. Associations of genetic variations of the endothelial nitric oxide synthase gene and environmental carcinogens with oral cancer susceptibility and development. Nitric Oxide. 2018;79:1\u20137.","journal-title":"Nitric Oxide"},{"issue":"5","key":"4222_CR39","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.7150\/jca.106426","volume":"16","author":"PJ Chen","year":"2025","unstructured":"Chen PJ, Lu YT, Yang WE, et al. The impact of MET variants in oral cancer progression and clinicopathological characteristics. J Cancer. 2025;16(5):1747\u201353.","journal-title":"J Cancer"},{"issue":"4","key":"4222_CR40","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.4103\/jcrt.JCRT_1057_20","volume":"18","author":"NH Tata","year":"2022","unstructured":"Tata NH, Kshirsagar A, Nangare N. Characterization of genetic polymorphisms in oral cancer-related genes pertaining to oxidative stress, carcinogen detoxifying, and DNA repair: a case\u2013control study. J Cancer Res Ther. 2022;18(4):1023\u20139.","journal-title":"J Cancer Res Ther"},{"issue":"7","key":"4222_CR41","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.7150\/jca.84470","volume":"14","author":"PJ Chen","year":"2023","unstructured":"Chen PJ, Lin CW, Lu HJ, et al. The impact of FOXP3 polymorphisms on oral cancer progression and clinicopathological characteristics. J Cancer. 2023;14(7):1195.","journal-title":"J Cancer"},{"issue":"3","key":"4222_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032789","volume":"24","author":"DT Bau","year":"2023","unstructured":"Bau DT, Liu TY, Tsai CW, et al. A genome-wide association study identified novel genetic susceptibility loci for oral cancer in Taiwan. Int J Mol Sci. 2023;24(3):2789.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"4222_CR43","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.1007\/s12094-023-03192-8","volume":"25","author":"MK Mishra","year":"2023","unstructured":"Mishra MK, Gupta S, Shivangi, et al. The repertoire of mutational signatures in tobacco-and non-tobacco-induced oral cancer[J]. Clin Transl Oncol. 2023;25(12):3332\u201344.","journal-title":"Clin Transl Oncol"},{"issue":"2","key":"4222_CR44","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-024-03907-y","volume":"74","author":"F Oliveri","year":"2025","unstructured":"Oliveri F, Neher L, Pscheid R, et al. Characterization of the adaptive immune response in a mouse model for HPV-positive head and neck squamous cell carcinoma with implications to human disease. Cancer Immunol Immunother. 2025;74(2):66.","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"4222_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03255-w","volume":"43","author":"C Liu","year":"2024","unstructured":"Liu C, Wu K, Li C, et al. SPP1\u2009+\u2009macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-\u03b1 and IL-1\u03b2. J Exp Clin Cancer Res. 2024;43(1):332.","journal-title":"J Exp Clin Cancer Res"},{"issue":"5","key":"4222_CR46","first-page":"466","volume":"33","author":"XQ Zhai","year":"2024","unstructured":"Zhai XQ, Liu B, Sheng CY, et al. Expression and clinical significance of USP20 in oral squamous cell carcinoma[J]. Shanghai J Stomatology. 2024;33(5):466.","journal-title":"Shanghai J Stomatology"},{"issue":"12","key":"4222_CR47","volume":"7","author":"Y Hibino","year":"2024","unstructured":"Hibino Y, Sakai R, Takahashi H, et al. Efficacy of combined Encorafenib and Binimetinib treatment for Erdheim\u2013Chester disease harboring concurrent BRAF V600E and KRAS G12R mutations: a case report. Cancer Rep. 2024;7(12):e70093.","journal-title":"Cancer Rep"},{"issue":"3","key":"4222_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/mmr.2026.13789","volume":"31","author":"YJ Chen","year":"2025","unstructured":"Chen YJ, Liao SW, Lai YL, et al. Epigenetic downregulation of the proapoptotic gene HOXA5 in oral squamous cell carcinoma[J]. Mol Med Rep. 2025;31(3):1\u201310.","journal-title":"Mol Med Rep"},{"issue":"2","key":"4222_CR49","doi-asserted-by":"publisher","first-page":"306","DOI":"10.21037\/tcr-21-1637","volume":"11","author":"Z Li","year":"2022","unstructured":"Li Z, Wang S, Fang S, et al. Adipose-derived stem cells promote the proliferation, migration, and invasion of oral squamous cell carcinoma cells by activating the Wnt\/planar cell polarity signaling pathway. Transl Cancer Res. 2022;11(2):306.","journal-title":"Transl Cancer Res"},{"issue":"12","key":"4222_CR50","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.2174\/1871530321666210421125231","volume":"21","author":"A Pandey","year":"2021","unstructured":"Pandey A, Bhuvanadas S, Joseph JP, et al. Notch signalling: a potential therapeutic pathway in oral squamous cell carcinoma. Endocrine, Metabolic & Immune Disorders. 2021;21(12):2159\u201368.","journal-title":"Endocrine, Metabolic & Immune Disorders"},{"issue":"3","key":"4222_CR51","doi-asserted-by":"publisher","first-page":"528","DOI":"10.4103\/jomfp.jomfp_8_23","volume":"27","author":"YP Kumar","year":"2023","unstructured":"Kumar YP, Muthukrishnan A, Rao GRR, et al. Role of desmosomal components in the initiation and metastasis of oral cancer\u2014a review. J Oral Maxillofac Pathol. 2023;27(3):528\u201332.","journal-title":"J Oral Maxillofac Pathol"},{"key":"4222_CR52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1485174","volume":"15","author":"C Li","year":"2024","unstructured":"Li C, Dong X, Li B. Tumor microenvironment in oral squamous cell carcinoma. Front Immunol. 2024;15:1485174.","journal-title":"Front Immunol"},{"issue":"1","key":"4222_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02193-7","volume":"23","author":"M Gan","year":"2024","unstructured":"Gan M, Liu N, Li W, et al. Metabolic targeting of regulatory T cells in oral squamous cell carcinoma: new horizons in immunotherapy. Mol Cancer. 2024;23(1):273.","journal-title":"Mol Cancer"},{"key":"4222_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-05330-2","volume":"24","author":"T Mousavi","year":"2024","unstructured":"Mousavi T, Shokoohy F, Moosazadeh M. Polyomaviruses and the risk of oral cancer: a systematic review and meta-analysis. BMC Oral Health. 2024;24:1490.","journal-title":"BMC Oral Health"},{"issue":"3","key":"4222_CR55","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","volume":"20","author":"E Sahai","year":"2020","unstructured":"Sahai E, Astsaturov I, Cukierman E, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020;20(3):174\u201386.","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"4222_CR56","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1111\/odi.13140","volume":"26","author":"D Graizel","year":"2020","unstructured":"Graizel D, Zlotogorski-Hurvitz A, Tsesis I, et al. Oral cancer\u2010associated fibroblasts predict poor survival: systematic review and meta\u2010analysis. Oral Dis. 2020;26(4):733\u201344.","journal-title":"Oral Dis"},{"issue":"7","key":"4222_CR57","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1593805","volume":"8","author":"MN Theodoraki","year":"2019","unstructured":"Theodoraki MN, Yerneni S, Gooding WE, et al. Circulating exosomes measure responses to therapy in head and neck cancer patients treated with cetuximab, ipilimumab, and IMRT. Oncoimmunology. 2019;8(7):e1593805.","journal-title":"Oncoimmunology"},{"issue":"3","key":"4222_CR58","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s12079-022-00693-z","volume":"17","author":"D Saha","year":"2023","unstructured":"Saha D, Mitra D, Alam N, et al. Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1\u03b1-EphA2-Laminin-5\u03b32 network in human oral cancer. J Cell Commun Signal. 2023;17(3):591\u2013608.","journal-title":"J Cell Commun Signal"},{"issue":"5\u20137","key":"4222_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2024.152174","volume":"126","author":"Q Ma","year":"2024","unstructured":"Ma Q, Xu X, Zhu Y, et al. Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 \u03b1\/VEGF\/PDGF pathway. Acta Histochem. 2024;126(5\u20137):152174.","journal-title":"Acta Histochem"},{"issue":"9","key":"4222_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200190","volume":"6","author":"C Doan","year":"2022","unstructured":"Doan C, Aouizerat BE, Ye Y, et al. Neurotrophin pathway receptors NGFR and TrkA control perineural invasion, metastasis, and pain in oral cancer. Adv Biol. 2022;6(9):2200190.","journal-title":"Adv Biol"},{"issue":"1","key":"4222_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-02924-8","volume":"23","author":"S Kim","year":"2023","unstructured":"Kim S, Park S, Moon EH, et al. Hypoxia disrupt tight junctions and promote metastasis of oral squamous cell carcinoma via loss of par3. Cancer Cell Int. 2023;23(1):79.","journal-title":"Cancer Cell Int"},{"issue":"3","key":"4222_CR62","first-page":"150","volume":"54","author":"AS Tsao","year":"2004","unstructured":"Tsao AS, Kim ES, Hong WK. Chemoprevention of cancer. CA Cancer J Clin. 2004;54(3):150\u201380.","journal-title":"CA Cancer J Clin"},{"issue":"10","key":"4222_CR63","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1600-0714.2007.00582.x","volume":"36","author":"S Warnakulasuriya","year":"2007","unstructured":"Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36(10):575\u201380.","journal-title":"J Oral Pathol Med"},{"issue":"3","key":"4222_CR64","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.oooo.2016.11.004","volume":"123","author":"JT Hwang","year":"2017","unstructured":"Hwang JT, Gu YR, Shen M, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):374\u201381.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"1","key":"4222_CR65","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05292-7","volume":"22","author":"W Xie","year":"2024","unstructured":"Xie W, Lu J, Chen Y, et al. TCL1A-expressing B cells are critical for tertiary lymphoid structure formation and the prognosis of oral squamous cell carcinoma. J Transl Med. 2024;22(1):477.","journal-title":"J Transl Med"},{"key":"4222_CR66","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27968","author":"A Alade","year":"2024","unstructured":"Alade A, Persad M, Bitar G, et al. A review of contemporary image guidance techniques in head and neck cancer. Head Neck. 2024. https:\/\/doi.org\/10.1002\/hed.27968.","journal-title":"Head Neck"},{"issue":"1","key":"4222_CR67","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ejrad.2008.06.018","volume":"72","author":"MA Momin","year":"2009","unstructured":"Momin MA, Okochi K, Watanabe H, et al. Diagnostic accuracy of cone-beam CT in the assessment of mandibular invasion of lower gingival carcinoma: comparison with conventional panoramic radiography. Eur J Radiol. 2009;72(1):75\u201381.","journal-title":"Eur J Radiol"},{"issue":"3","key":"4222_CR68","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.mric.2012.05.003","volume":"20","author":"M Hagiwara","year":"2012","unstructured":"Hagiwara M, Nusbaum A, Schmidt BL. MR assessment of oral cavity carcinomas. Magn Reson Imaging Clin N Am. 2012;20(3):473\u201394.","journal-title":"Magn Reson Imaging Clin N Am"},{"issue":"3","key":"4222_CR69","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0720-048X(99)00143-6","volume":"33","author":"M Lenz","year":"2000","unstructured":"Lenz M, Greess H, Baum U, Dobritz M, Kersting-Sommerhoff B. Oropharynx, oral cavity, floor of the mouth: CT and MRI. Eur J Radiol. 2000;33(3):203\u201315.","journal-title":"Eur J Radiol"},{"key":"4222_CR70","doi-asserted-by":"publisher","first-page":"92","DOI":"10.12659\/PJR.899352","volume":"82","author":"A Singh","year":"2017","unstructured":"Singh A, Thukral CL, Gupta K, et al. Role of MRI in evaluation of malignant lesions of tongue and oral cavity. Pol J Radiol. 2017;82:92\u20139.","journal-title":"Pol J Radiol"},{"issue":"32","key":"4222_CR71","first-page":"1520","volume":"144","author":"EF Comans","year":"2000","unstructured":"Comans EF, Hoekstra OS, Hoekman K, et al. [Added value of positron emission tomography with fluoro-18-deoxyglucose as the tracer (FDG-PET) in clinical problem cases in oncology][J]. Ned Tijdschr Geneeskd. 2000;144(32):1520\u20138.","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"2","key":"4222_CR72","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1148\/radiol.2382041977","volume":"238","author":"GK von Schulthess","year":"2006","unstructured":"von Schulthess GK, Steinert HC, Hany TF. Integrated PET\/CT: current applications and future directions. Radiology. 2006;238(2):405\u201322.","journal-title":"Radiology"},{"issue":"15","key":"4222_CR73","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1200\/JCO.2008.19.3300","volume":"27","author":"BJ Moeller","year":"2009","unstructured":"Moeller BJ, Rana V, Cannon BA, et al. Prospective risk-adjusted [18F] fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer. J Clin Oncol. 2009;27(15):2509\u201315.","journal-title":"J Clin Oncol"},{"issue":"2","key":"4222_CR74","doi-asserted-by":"publisher","first-page":"W1","DOI":"10.2214\/AJR.14.13830","volume":"205","author":"MA Pasha","year":"2015","unstructured":"Pasha MA, Marcus C, Fakhry C, et al. FDG PET\/CT for management and assessing outcomes of squamous cell cancer of the oral Cavity[J]. Am J Roentgenol. 2015;205(2):W1\u201312.","journal-title":"Am J Roentgenol"},{"key":"4222_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.107148","volume":"161","author":"N Kaorey","year":"2025","unstructured":"Kaorey N, Dickinson K, Agnihotram VR, et al. The role of ctDNA from liquid biopsy in predicting survival outcomes in HPV-negative head and neck cancer: a meta-analysis. Oral Oncol. 2025;161:107148.","journal-title":"Oral Oncol"},{"issue":"1","key":"4222_CR76","doi-asserted-by":"publisher","DOI":"10.3390\/biotech11010005","volume":"11","author":"G Yang","year":"2022","unstructured":"Yang G, Wei L, Thong BKS, et al. A systematic review of oral biopsies, sample types, and detection techniques applied in relation to oral cancer detection. BioTech. 2022;11(1):5.","journal-title":"BioTech"},{"issue":"11","key":"4222_CR77","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1039\/D3AY02250A","volume":"16","author":"L Li","year":"2024","unstructured":"Li L, Yu M, Li X, et al. A deep learning method for multi-task intelligent detection of oral cancer based on optical fiber Raman spectroscopy. Anal Methods. 2024;16(11):1659\u201373.","journal-title":"Anal Methods"},{"key":"4222_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105588","volume":"123","author":"SB Mali","year":"2021","unstructured":"Mali SB, Dahivelkar S. Liquid biopsy\u2009=\u2009individualized cancer management: diagnosis, monitoring treatment and checking recurrence and metastasis. Oral Oncol. 2021;123:105588.","journal-title":"Oral Oncol"},{"issue":"5","key":"4222_CR79","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ijom.2021.08.017","volume":"51","author":"NT Baby","year":"2022","unstructured":"Baby NT, Abdullah A, Kannan S. The scope of liquid biopsy in the clinical management of oral cancer. Int J Oral Maxillofac Surg. 2022;51(5):591\u2013601.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4222_CR80","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.e18054","author":"H Fang","year":"2024","unstructured":"Fang H, Mou Y, Zhang W, Bao H, Wu M, Chen X, et al. Multi-dimensional cell-free DNA-based liquid biopsy for sensitive detection of head and neck squamous cell carcinomas. J Clin Oncol. 2024. https:\/\/doi.org\/10.1200\/JCO.2024.42.16_suppl.e18054.","journal-title":"J Clin Oncol"},{"key":"4222_CR81","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1038\/s41416-022-01716-7","volume":"126","author":"S Flach","year":"2022","unstructured":"Flach S, Howarth K, Hackinger S, Pipinikas C, Ellis P, McLay K, et al. Liquid biopsy for minimal residual disease detection in head and neck squamous cell carcinoma (LIONESS)\u2014a personalised circulating tumour DNA analysis in head and neck squamous cell carcinoma. Br J Cancer. 2022;126:1186\u201395.","journal-title":"Br J Cancer"},{"key":"4222_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104631","volume":"104","author":"R Galot","year":"2020","unstructured":"Galot R, Van Marcke C, Helaers R, Mendola A, Goebbels R, Caignet X, et al. Liquid biopsy for mutational profiling of locoregional recurrent and\/or metastatic head and neck squamous cell carcinoma. Oral Oncol. 2020;104:104631.","journal-title":"Oral Oncol"},{"key":"4222_CR83","doi-asserted-by":"publisher","first-page":"108477","DOI":"10.1016\/j.mrrev.2023.108477","volume":"793","author":"X Huang","year":"2023","unstructured":"Huang X, Leo P, Jones L, Duijf P, Hartel G, Kenny L, Vasani S, Punyadeera C. A comparison between mutational profiles in tumour tissue DNA and Circulating tumour DNA in head and neck squamous cell carcinoma\u2014s systematic review. Mutat Res Rev Mutat Res. 2023;793:108477.","journal-title":"Mutat Res Rev Mutat Res"},{"issue":"40","key":"4222_CR84","doi-asserted-by":"publisher","first-page":"69162","DOI":"10.18632\/oncotarget.19942","volume":"8","author":"M Peng","year":"2017","unstructured":"Peng M, Chen C, Hulbert A, et al. Non-blood circulating tumor DNA detection in cancer. Oncotarget. 2017;8(40):69162.","journal-title":"Oncotarget"},{"key":"4222_CR85","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061704","author":"F Lousada-Fernandez","year":"2018","unstructured":"Lousada-Fernandez F, Rapado-Gonzalez O, Lopez-Cedrun JL, et al. Liquid biopsy in oral cancer. Int J Mol Sci. 2018. https:\/\/doi.org\/10.3390\/ijms19061704.","journal-title":"Int J Mol Sci"},{"key":"4222_CR86","doi-asserted-by":"publisher","DOI":"10.1177\/17588359221112696","author":"D Ezeife","year":"2022","unstructured":"Ezeife D, Spackman E, Juergens R, Laskin J, Agulnik J, Hao D, et al. The economic value of liquid biopsy for genomic profiling in advanced non-small cell lung cancer. Ther Adv Med Oncol. 2022. https:\/\/doi.org\/10.1177\/17588359221112696.","journal-title":"Ther Adv Med Oncol"},{"key":"4222_CR87","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s00432-022-04034-w","volume":"149","author":"F Englmeier","year":"2022","unstructured":"Englmeier F, Bleckmann A, Br\u00fcckl W, Griesinger F, Fleitz A, Nagels K. Clinical benefit and cost-effectiveness analysis of liquid biopsy application in patients with advanced non-small cell lung cancer (NSCLC): a modelling approach. J Cancer Res Clin Oncol. 2022;149:1495\u2013511.","journal-title":"J Cancer Res Clin Oncol"},{"key":"4222_CR88","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/CEOR.S220726","volume":"12","author":"D S\u00e1nchez-Calder\u00f3n","year":"2020","unstructured":"S\u00e1nchez-Calder\u00f3n D, Pedraza A, Urrego C, Mej\u00eda-Mej\u00eda A, Montealegre-P\u00e1ez A, Perdomo S. Analysis of the cost-effectiveness of liquid biopsy to determine treatment change in patients with Her2-Positive advanced breast cancer in Colombia. ClinicoEconomics Outcomes Research: CEOR. 2020;12:115\u201322.","journal-title":"ClinicoEconomics Outcomes Research: CEOR"},{"key":"4222_CR89","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1007\/s40273-023-01292-5","volume":"41","author":"M Fagery","year":"2023","unstructured":"Fagery M, Khorshidi H, Wong S, Vu M, IJzerman M. Health economic evidence and modeling challenges for liquid biopsy assays in cancer management: a systematic literature review. Pharmacoeconomics. 2023;41:1229\u201348.","journal-title":"Pharmacoeconomics"},{"key":"4222_CR90","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1016\/j.jval.2023.08.010","volume":"26","author":"J Jansen","year":"2023","unstructured":"Jansen J, Ragavan M, Chen C, Douglas M, Phillips K. The health inequality impact of liquid biopsy to inform first-line treatment of advanced non\u2013small cell lung cancer: a distributional cost-effectiveness analysis. Value Health: J Int Soc Pharmacoeconomics Outcomes Res. 2023;26:1697\u2013710.","journal-title":"Value Health: J Int Soc Pharmacoeconomics Outcomes Res"},{"issue":"11","key":"4222_CR91","first-page":"e74381","volume":"16","author":"G Suragimath","year":"2024","unstructured":"Suragimath G, Patil S, Suragimath DG, et al. Salivaomics: A revolutionary Non-invasive approach for oral cancer Detection[J]. Cureus. 2024;16(11):e74381.","journal-title":"Cureus"},{"issue":"1","key":"4222_CR92","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-024-01745-z","volume":"19","author":"D Heguedusch","year":"2025","unstructured":"Heguedusch D, Carvalho GL, Tomo S, et al. The patterns of P53, E-cadherin, \u03b2-catenin, CXCR4 and podoplanin expression in oral squamous cell carcinoma suggests a hybrid invasion model: an immunohistochemical study on tissue microarrays. Head Neck Pathol. 2025;19(1):6.","journal-title":"Head Neck Pathol"},{"issue":"1","key":"4222_CR93","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03559-w","volume":"22","author":"N Jin","year":"2024","unstructured":"Jin N, An Y, Tian Y, et al. Multispectral fluorescence imaging of EGFR and PD-L1 for precision detection of oral squamous cell carcinoma: a preclinical and clinical study. BMC Med. 2024;22(1):342.","journal-title":"BMC Med"},{"issue":"4","key":"4222_CR94","doi-asserted-by":"publisher","DOI":"10.1088\/2050-6120\/acf6ac","volume":"11","author":"P Thapa","year":"2023","unstructured":"Thapa P, Singh V, Bhatt S, et al. Multimodal fluorescence imaging and spectroscopic techniques for oral cancer screening: a real-time approach. Methods Appl Fluoresc. 2023;11(4):045008.","journal-title":"Methods Appl Fluoresc"},{"issue":"5","key":"4222_CR95","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s11307-023-01828-3","volume":"25","author":"X Hui","year":"2023","unstructured":"Hui X, Wang Y, Li W, et al. Nd-Mn molecular cluster with searched targets for oral cancer imaging. Mol Imaging Biol. 2023;25(5):875\u201386.","journal-title":"Mol Imaging Biol"},{"issue":"6","key":"4222_CR96","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1007\/s11307-023-01858-x","volume":"25","author":"M Lawaetz","year":"2023","unstructured":"Lawaetz M, Binderup T, Christensen A, et al. Urokinase-type plasminogen activator receptor (uPAR) expression and [64Cu] Cu-DOTA-AE105 uPAR-PET\/CT in patient-derived xenograft models of oral squamous cell carcinoma. Mol Imaging Biol. 2023;25(6):1034\u201344.","journal-title":"Mol Imaging Biol"},{"issue":"1","key":"4222_CR97","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.identj.2024.09.032","volume":"75","author":"M Al-Raeei","year":"2024","unstructured":"Al-Raeei M. The future of oral oncology: how artificial intelligence is redefining surgical procedures and patient management. Int Dental J. 2024;75(1):109\u201316.","journal-title":"Int Dental J"},{"issue":"5","key":"4222_CR98","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050987","volume":"16","author":"B Song","year":"2024","unstructured":"Song B, Kc DR, Yang RY, et al. Classification of mobile-based oral cancer images using the vision transformer and the Swin transformer. Cancers. 2024;16(5):987.","journal-title":"Cancers"},{"key":"4222_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2024.104584","volume":"150","author":"Z Guo","year":"2024","unstructured":"Guo Z, Ao S, Ao B. Few-shot learning based oral cancer diagnosis using a dual feature extractor prototypical network. J Biomed Inform. 2024;150:104584.","journal-title":"J Biomed Inform"},{"issue":"1","key":"4222_CR100","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-024-00624-8","volume":"8","author":"AJ Shephard","year":"2024","unstructured":"Shephard AJ, Bashir RMS, Mahmood H, et al. A fully automated and explainable algorithm for predicting malignant transformation in oral epithelial dysplasia. NPJ Precis Oncol. 2024;8(1):137.","journal-title":"NPJ Precis Oncol"},{"key":"4222_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106946","volume":"156","author":"NS Piyarathne","year":"2024","unstructured":"Piyarathne NS, Liyanage SN, Rasnayaka R, et al. A comprehensive dataset of annotated oral cavity images for diagnosis of oral cancer and oral potentially malignant disorders. Oral Oncol. 2024;156:106946.","journal-title":"Oral Oncol"},{"key":"4222_CR102","doi-asserted-by":"publisher","first-page":"103777","DOI":"10.1016\/j.critrevonc.2022.103777","volume":"178","author":"I Elmakaty","year":"2022","unstructured":"Elmakaty I, Elmarasi M, Amarah A, Abdo R, Malki M. Accuracy of artificial intelligence-assisted detection of oral squamous cell carcinoma: a systematic review and meta-analysis. Critical Review Oncol\/Hematol. 2022;178:103777.","journal-title":"Critical Review Oncol\/Hematol"},{"key":"4222_CR103","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.identj.2022.03.001","volume":"72","author":"M Alnajjar","year":"2022","unstructured":"Alnajjar M, Alketbi M, Mohammad Y, Shetty S, Mashrah M. The effectiveness of artificial intelligence in detection of oral cancer. Int Dent J. 2022;72:436\u201347.","journal-title":"Int Dent J"},{"key":"4222_CR104","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11061612","author":"S Khanagar","year":"2023","unstructured":"Khanagar S, Alkadi L, Alghilan M, Kalagi S, Awawdeh M, Bijai L, et al. Application and performance of artificial intelligence (AI) in oral cancer diagnosis and prediction using histopathological images: a systematic review. Biomedicines. 2023. https:\/\/doi.org\/10.3390\/biomedicines11061612.","journal-title":"Biomedicines"},{"key":"4222_CR105","doi-asserted-by":"publisher","DOI":"10.22541\/au.167398391.14269279\/v1","author":"C Liu","year":"2024","unstructured":"Liu C, Guan C, Li Y, et al. Advances in electrochemical biosensors for the detection of common oral diseases. Crit Rev Anal Chem. 2024. https:\/\/doi.org\/10.22541\/au.167398391.14269279\/v1.","journal-title":"Crit Rev Anal Chem"},{"key":"4222_CR106","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110671","volume":"131","author":"M Jafari","year":"2020","unstructured":"Jafari M, Hasanzadeh M. Non-invasive bioassay of Cytokeratin Fragment 21.1 (Cyfra 21.1) protein in human saliva samples using immunoreaction method: an efficient platform for early-stage diagnosis of oral cancer based on biomedicine. Biomed Pharmacother. 2020;131:110671.","journal-title":"Biomed Pharmacother"},{"issue":"47","key":"4222_CR107","doi-asserted-by":"publisher","first-page":"12207","DOI":"10.1039\/D4TB01216J","volume":"12","author":"P Kapil","year":"2024","unstructured":"Kapil P, Verma D, Pradhan R, et al. A bioinspired porous and electroactive reduced graphene oxide hydrogel based biosensing platform for efficient detection of tumor necrosis factor-\u03b1. J Mater Chem B. 2024;12(47):12207\u201319.","journal-title":"J Mater Chem B"},{"issue":"5","key":"4222_CR108","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202001205","volume":"5","author":"Z Xiao","year":"2021","unstructured":"Xiao Z, Huang C, Jiang S, et al. Ultra-sensitive and selective electrochemical bio\u2010fluid biopsy for oral cancer screening. Small Methods. 2021;5(5):2001205.","journal-title":"Small Methods"},{"issue":"5","key":"4222_CR109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0285214","volume":"18","author":"PJ Brooks","year":"2023","unstructured":"Brooks PJ, Malkin EZ, De Michino S, et al. Isolation of salivary cell-free DNA for cancer detection. PLoS One. 2023;18(5):e0285214.","journal-title":"PLoS One"},{"issue":"12","key":"4222_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2024.100614","volume":"37","author":"TYY Lin","year":"2024","unstructured":"Lin TYY, Liu KYP, Novack R, et al. Abnormal p53 immunohistochemical patterns are associated with regional lymph node metastasis in oral cavity squamous cell carcinoma at time of surgery. Mod Pathol. 2024;37(12):100614.","journal-title":"Mod Pathol"},{"issue":"14","key":"4222_CR111","doi-asserted-by":"publisher","first-page":"6249","DOI":"10.1021\/ac301392g","volume":"84","author":"R Malhotra","year":"2012","unstructured":"Malhotra R, Patel V, Chikkaveeraiah BV, et al. Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array. Anal Chem. 2012;84(14):6249\u201355.","journal-title":"Anal Chem"},{"issue":"8","key":"4222_CR112","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1080\/03091902.2020.1831633","volume":"44","author":"S Emran","year":"2020","unstructured":"Emran S, Laitinen K, Lappalainen R, et al. Novel 3D printing-based probe for impedance spectroscopic examination of oral mucosa: design and preliminary testing with phantom models. J Med Eng Technol. 2020;44(8):517\u201326.","journal-title":"J Med Eng Technol"},{"issue":"12","key":"4222_CR113","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.2932","volume":"34","author":"FB Tofighi","year":"2021","unstructured":"Tofighi FB, Saadati A, Kholafazad-kordasht H, et al. Electrochemical immunoplatform to assist in the diagnosis of oral cancer through the determination of CYFRA 21.1 biomarker in human saliva samples: preparation of a novel portable biosensor toward non\u2010invasive diagnosis of oral cancer. J Mol Recognit. 2021;34(12):e2932.","journal-title":"J Mol Recognit"},{"issue":"1","key":"4222_CR114","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1021\/acsabm.4c01379","volume":"8","author":"S Vasu","year":"2025","unstructured":"Vasu S, Verma D, Souraph SOS, et al. In situ Ag Seeded lamellar Ti3C2 nanosheets an electroactive interface for noninvasive diagnosis of oral carcinoma via salivary TNF\u03b1 Sensing. ACS Appl Bio Mat. 2025;8(1):420\u201334.","journal-title":"ACS Appl Bio Mat"},{"key":"4222_CR115","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.aca.2018.04.025","volume":"1027","author":"CK Song","year":"2018","unstructured":"Song CK, Oh E, Kang MS, et al. Fluorescence-based immunosensor using three-dimensional CNT network structure for sensitive and reproducible detection of oral squamous cell carcinoma biomarker. Anal Chim Acta. 2018;1027:101\u20138.","journal-title":"Anal Chim Acta"},{"key":"4222_CR116","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bios.2017.11.004","volume":"102","author":"S Kumar","year":"2018","unstructured":"Kumar S, Kumar S, Augustine S, et al. Effect of brownian motion on reduced agglomeration of nanostructured metal oxide towards development of efficient cancer biosensor[J]. Biosens Bioelectron. 2018;102:247\u201355.","journal-title":"Biosens Bioelectron"},{"issue":"29","key":"4222_CR117","doi-asserted-by":"publisher","first-page":"4938","DOI":"10.1039\/D4AY01048E","volume":"16","author":"M Choramle","year":"2024","unstructured":"Choramle M, Verma D, Kalkal A, et al. l-Cysteine functionalized magnetite nanoparticle adorned Ti 3 C 2-MXene nanohybrid based screen printed immunosensor for oral cancer biomarker detection. Anal Methods. 2024;16(29):4938\u201350.","journal-title":"Anal Methods"},{"key":"4222_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116936","volume":"269","author":"J Li","year":"2025","unstructured":"Li J, Zhang W, Chang R, et al. A magnetic separation-assisted auto-cyclic primer extension for OSCC-associated salivary miRNA detection. Biosens Bioelectron. 2025;269:116936.","journal-title":"Biosens Bioelectron"},{"issue":"12","key":"4222_CR119","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129990","volume":"24","author":"S Christodoulou","year":"2023","unstructured":"Christodoulou S, Sotiropoulou CD, Vassiliu P, et al. MicroRNA-675-5p overexpression is an independent prognostic molecular biomarker of short-term relapse and poor overall survival in colorectal cancer. Int J Mol Sci. 2023;24(12):9990.","journal-title":"Int J Mol Sci"},{"key":"4222_CR120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-018-0378-6","volume":"16","author":"XJ Chen","year":"2018","unstructured":"Chen XJ, Zhang XQ, Liu Q, et al. Nanotechnology: a promising method for oral cancer detection and diagnosis[J]. J Nanobiotechnol. 2018;16:1\u201317.","journal-title":"J Nanobiotechnol"},{"key":"4222_CR121","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.927595","volume":"10","author":"GM Zhang","year":"2022","unstructured":"Zhang GM, Nie SC, Xu ZY, et al. Advanced polymeric nanoagents for oral cancer theranostics: a mini review. Front Chem. 2022;10:927595.","journal-title":"Front Chem"},{"key":"4222_CR122","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00256","volume":"8","author":"Y Li","year":"2020","unstructured":"Li Y, Cao X, Li H. Identification and validation of novel long non-coding RNA biomarkers for early diagnosis of oral squamous cell carcinoma. Front Bioeng Biotechnol. 2020;8:256.","journal-title":"Front Bioeng Biotechnol"},{"issue":"11","key":"4222_CR123","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/dc.25400","volume":"52","author":"S Wang","year":"2024","unstructured":"Wang S, Zheng Z. Advances in oral exfoliative cytology: from cancer diagnosis to systemic disease detection. Diagn Cytopathol. 2024;52(11):697\u2013706.","journal-title":"Diagn Cytopathol"},{"issue":"4","key":"4222_CR124","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna8040060","volume":"8","author":"G Gattuso","year":"2022","unstructured":"Gattuso G, Crimi S, Lavoro A, et al. Liquid biopsy and circulating biomarkers for the diagnosis of precancerous and cancerous oral lesions. Non-coding RNA. 2022;8(4):60.","journal-title":"Non-coding RNA"},{"issue":"1","key":"4222_CR125","first-page":"4616682","volume":"2023","author":"Y Lu","year":"2023","unstructured":"Lu Y, Yang J, Zhu J, et al. Advances in the histone acetylation modification in the oral squamous cell carcinoma[J]. J Oncol. 2023;2023(1):4616682.","journal-title":"J Oncol"},{"issue":"2","key":"4222_CR126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/CritRevOncog.2023046835","volume":"28","author":"R Shah","year":"2023","unstructured":"Shah R, Shah H, Thakkar K, et al. Conventional therapies of oral cancers: highlights on chemotherapeutic agents and radiotherapy, their adverse effects, and the cost burden of conventional therapies. Critical Reviews\u2122 in Oncogenesis. 2023;28(2):1\u201310.","journal-title":"Critical Reviews\u2122 in Oncogenesis"},{"issue":"6","key":"4222_CR127","first-page":"e15723","volume":"13","author":"SHA Ali","year":"2021","unstructured":"Ali SHA, Hafeez A, Javed A, et al. Induction Chemotherapy Followed by Radiation Therapy Versus Surgery Followed by Concurrent Chemo-Radiation Therapy in Locally Advanced Squamous Cell Carcinoma of the Oral Cavity[J]. Cureus J Med Sci. 2021;13(6):e15723.","journal-title":"Cureus J Med Sci"},{"issue":"11","key":"4222_CR128","doi-asserted-by":"publisher","first-page":"5314","DOI":"10.1097\/MS9.0000000000001357","volume":"85","author":"WE Bernaola-Paredes","year":"2023","unstructured":"Bernaola-Paredes WE, Rodrigues ML, Carvalho HP, et al. Reconstructive surgery and adjuvant radiotherapy for the multimodal approach in oral cancer: a single cancer centre experience. Ann Med Surg. 2023;85(11):5314\u201322.","journal-title":"Ann Med Surg"},{"key":"4222_CR129","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00835-4","author":"C Liu","year":"2022","unstructured":"Liu C, Wang M, Zhang H, et al. Tumor microenvironment and immunotherapy of oral cancer. Eur J Med Res. 2022. https:\/\/doi.org\/10.1186\/s40001-022-00835-4.","journal-title":"Eur J Med Res"},{"issue":"14","key":"4222_CR130","doi-asserted-by":"publisher","first-page":"5413","DOI":"10.7150\/thno.97269","volume":"14","author":"H Jang","year":"2024","unstructured":"Jang H, Choi J, Park D, et al. Milk-derived extracellular vesicles enable gut-to-tumor oral delivery of tumor-activated doxorubicin prodrugs. Theranostics. 2024;14(14):5413.","journal-title":"Theranostics"},{"issue":"8","key":"4222_CR131","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s11864-023-01095-y","volume":"24","author":"K Janssens","year":"2023","unstructured":"Janssens K, Lambrechts C, Geerinckx B, et al. New developments in treating RAS-mutated metastatic colorectal cancer. Curr Treat Options Oncol. 2023;24(8):965\u201387.","journal-title":"Curr Treat Options Oncol"},{"issue":"4","key":"4222_CR132","doi-asserted-by":"publisher","first-page":"113","DOI":"10.15430\/JCP.24.027","volume":"29","author":"L Ma","year":"2024","unstructured":"Ma L, Kim MO. Advances in preventive and therapeutic strategies for oral cancer: a short review. J Cancer Prev. 2024;29(4):113.","journal-title":"J Cancer Prev"},{"issue":"10","key":"4222_CR133","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1248\/bpb.b24-00408","volume":"47","author":"C Sun","year":"2024","unstructured":"Sun C, Bai S, Chen S, et al. Insufficient effective time of Suberanilohydroxamic acid, a deacetylase inhibitor, treatment promotes PC3 cell growth. Biol Pharm Bull. 2024;47(10):1708\u201316.","journal-title":"Biol Pharm Bull"},{"issue":"6","key":"4222_CR134","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15061653","volume":"15","author":"JPN Silva","year":"2023","unstructured":"Silva JPN, Pinto B, Monteiro L, et al. Combination therapy as a promising way to fight oral cancer. Pharmaceutics. 2023;15(6):1653.","journal-title":"Pharmaceutics"},{"issue":"14","key":"4222_CR135","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27144638","volume":"27","author":"K Luo","year":"2022","unstructured":"Luo K, Li N, Ye W, et al. Activation of stimulation of interferon genes (STING) signal and cancer immunotherapy. Molecules. 2022;27(14):4638.","journal-title":"Molecules"},{"key":"4222_CR136","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S272031","author":"GIY Rocha","year":"2023","unstructured":"Rocha GIY, Gomes JEM, Leite ML, et al. Epigenome-driven strategies for personalized cancer immunotherapy. Cancer Manage Res. 2023. https:\/\/doi.org\/10.2147\/CMAR.S272031.","journal-title":"Cancer Manage Res"},{"issue":"1","key":"4222_CR137","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41392-024-02075-w","volume":"10","author":"J Zheng","year":"2025","unstructured":"Zheng J, Wang S, **a L, et al. Hepatocellular carcinoma: signaling pathways and therapeutic advances. Signal Transduct Target Therapy. 2025;10(1):35.","journal-title":"Signal Transduct Target Therapy"},{"issue":"1","key":"4222_CR138","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15010117","volume":"15","author":"M W\u0142odarczyk","year":"2022","unstructured":"W\u0142odarczyk M, Pyrzynska B. CAR-NK as a rapidly developed and efficient immunotherapeutic strategy against cancer. Cancers. 2022;15(1):117.","journal-title":"Cancers"},{"key":"4222_CR139","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.suronc.2019.09.001","volume":"31","author":"L Liu","year":"2019","unstructured":"Liu L, Chen J, Cai X, et al. Progress in targeted therapeutic drugs for oral squamous cell carcinoma. Surg Oncol. 2019;31:90\u20137. https:\/\/doi.org\/10.1016\/j.suronc.2019.09.001.","journal-title":"Surg Oncol"},{"key":"4222_CR140","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00572-w","author":"L Zhong","year":"2021","unstructured":"Zhong L, Li Y, Xiong L, et al. Small molecules in targeted cancer therapy: advances, challenges, and future perspectives. Signal Transduct Target Ther. 2021(1). https:\/\/doi.org\/10.1038\/s41392-021-00572-w.","journal-title":"Signal Transduct Target Ther"},{"key":"4222_CR141","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ejphar.2018.07.034","volume":"834","author":"LY Ting","year":"2018","unstructured":"Ting LY, Jer TY, Ein OC. Molecular targeted therapy: treating cancer with specificity. Eur J Pharmacol. 2018;834:188\u201396.","journal-title":"Eur J Pharmacol"},{"key":"4222_CR142","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1801278","author":"NC Aziz","year":"2025","unstructured":"Aziz NC, Alahmad BEM, Kashmoola MA, et al. Oral cancers new enemy: Goniothalamus umbrosus targets oral squamous cell carcinoma and spare human gingival fibroblast cells. Eur J Dent. 2025. https:\/\/doi.org\/10.1055\/s-0044-1801278.","journal-title":"Eur J Dent"},{"issue":"8","key":"4222_CR143","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1007\/s10147-023-02327-9","volume":"28","author":"H Shigeishi","year":"2023","unstructured":"Shigeishi H. Association between human papillomavirus and oral cancer: a literature review. Int J Clin Oncol. 2023;28(8):982\u20139.","journal-title":"Int J Clin Oncol"},{"issue":"4","key":"4222_CR144","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1200\/JCO.22.01408","volume":"41","author":"AL Ho","year":"2023","unstructured":"Ho AL. Immunotherapy, chemotherapy, or both: options for first-line therapy for patients with recurrent or metastatic head and neck squamous cell carcinoma. J Clin Oncol. 2023;41(4):736\u201341.","journal-title":"J Clin Oncol"},{"issue":"2","key":"4222_CR145","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2024.14486","volume":"28","author":"L Cheng","year":"2024","unstructured":"Cheng L, Chai C, Liu Y, et al. First\u2011line programmed cell death 1 inhibitor plus chemotherapy vs. standard treatment in patients with recurrent or metastatic oral squamous cell carcinoma: a retrospective cohort study. Oncol Lett. 2024;28(2):352.","journal-title":"Oncol Lett"},{"key":"4222_CR146","doi-asserted-by":"publisher","DOI":"10.1111\/eos.13034","author":"AP Shan","year":"2025","unstructured":"Shan AP, Hlaing KS, Leelahavanichkul A, et al. Efficacy of metformin and verteporfin treatment alone or in combination in a murine head and neck cancer xenograft model. Eur J Oral Sci. 2025. https:\/\/doi.org\/10.1111\/eos.13034.","journal-title":"Eur J Oral Sci"},{"issue":"2","key":"4222_CR147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000302","volume":"8","author":"S Amarnath","year":"2010","unstructured":"Amarnath S, Costanzo CM, Mariotti J, et al. Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1. PLoS Biol. 2010;8(2):e1000302.","journal-title":"PLoS Biol"},{"issue":"19","key":"4222_CR148","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/j.seminoncol.2014.09.004","volume":"41","author":"MaryL Disis","year":"2014","unstructured":"Disis Mary L. Mechanism of action of immunotherapy. Semin Oncol. 2014;41(19):3\u201313. https:\/\/doi.org\/10.1053\/j.seminoncol.2014.09.004.","journal-title":"Semin Oncol"},{"issue":"1","key":"4222_CR149","doi-asserted-by":"publisher","DOI":"10.1186\/s12575-024-00252-3","volume":"26","author":"KS Kazemi","year":"2024","unstructured":"Kazemi KS, Kazemi P, Mivehchi H, et al. Photodynamic therapy: a novel approach for head and neck cancer treatment with focusing on oral cavity. Biol Proced Online. 2024;26(1):25.","journal-title":"Biol Proced Online"},{"issue":"2","key":"4222_CR150","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jds.2022.10.026","volume":"18","author":"YF Huang","year":"2023","unstructured":"Huang YF, Yang HW, Lin-Shiau SY. Synergistic antibacterial effects of 5-fluorouracil or thioridazine in combination with phytopolyphenols on cultured Porphyromonas gingivalis. J Dent Sci. 2023;18(2):709\u201314.","journal-title":"J Dent Sci"},{"issue":"15","key":"4222_CR151","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1158\/1078-0432.CCR-22-3929","volume":"29","author":"CT Letson","year":"2023","unstructured":"Letson CT, Balasis ME, Newman H, et al. Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML. Clin Cancer Res. 2023;29(15):2919\u201332.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"4222_CR152","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052925","volume":"25","author":"C Pampeno","year":"2024","unstructured":"Pampeno C, Opp S, Hurtado A, et al. Sindbis virus vaccine platform: a promising oncolytic virus-mediated approach for ovarian cancer treatment. Int J Mol Sci. 2024;25(5):2925.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"4222_CR153","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1002\/jat.4408","volume":"43","author":"A Rasa","year":"2023","unstructured":"Rasa A, Alberts P. Oncolytic virus preclinical toxicology studies. J Appl Toxicol. 2023;43(5):620\u201348.","journal-title":"J Appl Toxicol"},{"key":"4222_CR154","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.682911","volume":"11","author":"I Giacomini","year":"2021","unstructured":"Giacomini I, Gianfanti F, Desbats MA, et al. Cholesterol metabolic reprogramming in cancer and its pharmacological modulation as therapeutic strategy. Front Oncol. 2021;11:682911.","journal-title":"Front Oncol"},{"key":"4222_CR155","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115581","volume":"167","author":"L Martinez-Ruiz","year":"2023","unstructured":"Martinez-Ruiz L, L\u00f3pez-Rodr\u00edguez A, Florido J, et al. Patient-derived tumor models in cancer research: evaluation of the oncostatic effects of melatonin. Biomed Pharmacother. 2023;167:115581.","journal-title":"Biomed Pharmacother"},{"key":"4222_CR156","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114183","volume":"159","author":"Y Ye","year":"2023","unstructured":"Ye Y, Huang Z, Zhang M, et al. Synergistic therapeutic potential of alpelisib in cancers (excluding breast cancer): preclinical and clinical evidences. Biomed Pharmacother. 2023;159:114183.","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"4222_CR157","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062179","volume":"12","author":"DG Lynch","year":"2023","unstructured":"Lynch DG, Narayan RK, Li C. Multi-mechanistic approaches to the treatment of traumatic brain injury: a review. J Clin Med. 2023;12(6):2179.","journal-title":"J Clin Med"},{"key":"4222_CR158","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110068","author":"AK Adebayo","year":"2024","unstructured":"Adebayo AK, Bhat-Nakshatri P, Davis C, et al. Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies. iScience. 2024. https:\/\/doi.org\/10.1016\/j.isci.2024.110068.","journal-title":"iScience"},{"key":"4222_CR159","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1440764","volume":"15","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Xie J, Wu H, et al. NK cell based immunotherapy against oral squamous cell carcinoma. Front Immunol. 2024;15:1440764.","journal-title":"Front Immunol"},{"issue":"2","key":"4222_CR160","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16020224","volume":"16","author":"WT Liao","year":"2024","unstructured":"Liao WT, Chang DM, Lin MX, et al. Indocyanine-green-loaded liposomes for photodynamic and photothermal therapies: inducing apoptosis and ferroptosis in cancer cells with implications beyond oral cancer. Pharmaceutics. 2024;16(2):224.","journal-title":"Pharmaceutics"},{"key":"4222_CR161","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1183766","volume":"13","author":"KS Satish","year":"2024","unstructured":"Satish KS, Saravanan KS, Augustine D, et al. Leveraging technology-driven strategies to untangle omics big data: circumventing roadblocks in clinical facets of oral cancer. Front Oncol. 2024;13:1183766.","journal-title":"Front Oncol"},{"issue":"3","key":"4222_CR162","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"4222_CR163","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1515\/jtim-2024-0038","volume":"12","author":"Y Zou","year":"2025","unstructured":"Zou Y, Zhang H, Liu F, et al. Intratumoral microbiota in orchestrating cancer immunotherapy response. Journal of Translational Internal Medicine. 2025;12(6):540\u20132.","journal-title":"Journal of Translational Internal Medicine"},{"key":"4222_CR164","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1158\/1055-9965.EPI-21-0513","volume":"30","author":"C Harvey","year":"2021","unstructured":"Harvey C, Gapstur S, Pottinger C, Elena J, Helzlsouer K. Applying the strategic planning process to a large research consortium: the example of the National Cancer Institute Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2021;30:1769\u201374.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"4222_CR165","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12032-025-02694-5","volume":"42","author":"H Mivehchi","year":"2025","unstructured":"Mivehchi H, Eskandari-Yaghbastlo A, Ghazanfarpour M, et al. Microenvironment-based immunotherapy in oral cancer: a comprehensive review[J]. Med Oncol. 2025;42(5):1\u201329.","journal-title":"Med Oncol"},{"key":"4222_CR166","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25895","author":"Y Cheng","year":"2024","unstructured":"Cheng Y, Song Z, Chen J, et al. Molecular basis, potential biomarkers, and future prospects of OSCC and PD-1\/PD-L1 related immunotherapy methods. Heliyon. 2024. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e25895.","journal-title":"Heliyon"},{"key":"4222_CR167","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.961805","volume":"13","author":"C Liu","year":"2022","unstructured":"Liu C, Yang M, Zhang D, et al. Clinical cancer immunotherapy: current progress and prospects. Front Immunol. 2022;13:961805.","journal-title":"Front Immunol"},{"issue":"03","key":"4222_CR168","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1055\/s-0042-1756663","volume":"9","author":"H Singh","year":"2022","unstructured":"Singh H, Patel V. Role of molecular targeted therapeutic drugs in treatment of oral squamous cell carcinoma: development and current strategies\u2014a review article. Glob Med Genet. 2022;9(03):242\u20136.","journal-title":"Glob Med Genet"},{"issue":"9","key":"4222_CR169","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098188","volume":"24","author":"A Villa","year":"2023","unstructured":"Villa A, Kuten-Shorrer M. Pathogenesis of oral toxicities associated with targeted therapy and immunotherapy. Int J Mol Sci. 2023;24(9):8188.","journal-title":"Int J Mol Sci"},{"issue":"16","key":"4222_CR170","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1097\/CM9.0000000000002768","volume":"136","author":"H Yang","year":"2023","unstructured":"Yang H, Li X, Yang W. Advances in targeted therapy and immunotherapy for esophageal cancer. Chin Med J. 2023;136(16):1910\u201322.","journal-title":"Chin Med J"},{"key":"4222_CR171","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1127349","volume":"14","author":"W Zhang","year":"2023","unstructured":"Zhang W, Zhang K, Liu C, et al. Hepatic arterial infusion chemotherapy combined with anti-PD-1\/PD-L1 immunotherapy and molecularly targeted agents for advanced hepatocellular carcinoma: a real world study. Front Immunol. 2023;14:1127349.","journal-title":"Front Immunol"},{"issue":"21","key":"4222_CR172","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1056\/NEJMsr2210097","volume":"387","author":"IARC Perspective on Oral Cancer Prevention[J]","year":"2022","unstructured":"IARC Perspective on Oral Cancer Prevention[J]. N Engl J Med. 2022;387(21):1999\u20132005.","journal-title":"N Engl J Med"},{"issue":"6","key":"4222_CR173","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1002\/cncr.34620","volume":"129","author":"JJW Lee","year":"2023","unstructured":"Lee JJW, Kunaratnam V, Kim CJH, et al. Cigarette smoking cessation, duration of smoking abstinence, and head and neck squamous cell carcinoma prognosis. Cancer. 2023;129(6):867\u201377.","journal-title":"Cancer"},{"issue":"10","key":"4222_CR174","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1600-0714.1992.tb00970.x","volume":"21","author":"PC Gupta","year":"2010","unstructured":"Gupta PC, Mehta FS, Pindborg JJ, et al. Primary prevention trial of oral cancer in india: a 10\u2013year follow-up study[J]. J Oral Pathol Med. 2010;21(10):433\u20139.","journal-title":"J Oral Pathol Med"},{"issue":"2","key":"4222_CR175","first-page":"241","volume":"5","author":"R Ravishankar","year":"2020","unstructured":"Ravishankar R. Combination of smoking and alcoholism has high risk on oral cancer. Int J Sci Dev Res. 2020;5(2):241\u20135.","journal-title":"Int J Sci Dev Res"},{"key":"4222_CR176","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18168738","author":"P Worakhajit","year":"2021","unstructured":"Worakhajit P, Fuangtharnthip P, Khovidhunkit S-OP, et al. The relationship of tobacco, alcohol, and betel quid with the formation of oral potentially malignant disorders: a community-based study from northeastern Thailand. Int J Environ Res Public Health. 2021. https:\/\/doi.org\/10.3390\/ijerph18168738.","journal-title":"Int J Environ Res Public Health"},{"key":"4222_CR177","doi-asserted-by":"publisher","DOI":"10.5334\/aogh.3643","author":"R Gupta","year":"2022","unstructured":"Gupta R, Mariano LC, Nethan ST, et al. Risk reversal of oral, pharyngeal and oesophageal cancers after cessation of betel quid users: a systematic review and meta-analysis. Ann Glob Health. 2022. https:\/\/doi.org\/10.5334\/aogh.3643.","journal-title":"Ann Glob Health"},{"issue":"1","key":"4222_CR178","doi-asserted-by":"publisher","first-page":"105","DOI":"10.30829\/adzkia.v4i1.17996","volume":"4","author":"C Ngadilah","year":"2023","unstructured":"Ngadilah C, Eluama M, Eky Y, Baunsele N. Preventing parental behavior regarding childhood chewing betel habits in preschool children. J Abdi Mas Adzkia. 2023;4(1):105\u20135.","journal-title":"J Abdi Mas Adzkia"},{"key":"4222_CR179","first-page":"760","volume":"5","author":"S Pintauli","year":"2020","unstructured":"Pintauli S, Situmorang H, Nainggolan M. Development Program for Culturally Betel Nut Chewing Into A Healthy Behavior of Chewing Through Empowerment of Posyandu Cadres at Puskesmas Tiga Panah Karo Regency. J Pengabdian Kepada Masyarakat. 2020;5:760\u20136.","journal-title":"\u00a0J Pengabdian Kepada Masyarakat"},{"key":"4222_CR180","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.5004","author":"C Bramati","year":"2021","unstructured":"Bramati C, Abati S, Bondi S, et al. Early diagnosis of oral squamous cell carcinoma may ensure better prognosis: a case series. Clin Case Rep. 2021. https:\/\/doi.org\/10.1002\/ccr3.5004.","journal-title":"Clin Case Rep"},{"issue":"9475","key":"4222_CR181","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1016\/S0140-6736(05)66658-5","volume":"365","author":"R Sankaranarayanan","year":"2005","unstructured":"Sankaranarayanan R, Ramadas K, Thomas G, et al. Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet. 2005;365(9475):1927\u201333.","journal-title":"Lancet"},{"issue":"4","key":"4222_CR182","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.oraloncology.2012.11.004","volume":"49","author":"R Sankaranarayanan","year":"2013","unstructured":"Sankaranarayanan R, Ramadas K, Thara S, et al. Long term effect of visual screening on oral cancer incidence and mortality in a randomized trial in Kerala, India. Oral Oncol. 2013;49(4):314\u201321.","journal-title":"Oral Oncol"},{"key":"4222_CR183","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105656","author":"JD Cramer","year":"2022","unstructured":"Cramer JD, Grauer J. Modeling oral cancer screening in the United States population. Oral Oncol. 2022. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105656.","journal-title":"Oral Oncol"},{"key":"4222_CR184","volume":"16","author":"SS Kumararama","year":"2024","unstructured":"Kumararama SS, Patel S, Parekh NH, et al. Investigate how frequently dental professionals conduct oral cancer screenings during routine dental check-ups and the methods they use. J Pharm Bioallied Sci. 2024;16:S783-S785.","journal-title":"J Pharm Bioallied Sci"},{"key":"4222_CR185","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155574","author":"D Aden","year":"2024","unstructured":"Aden D, Zaheer S, Khan S, et al. Navigating the landscape of HPV-associated cancers: from epidemiology to prevention. Pathology. 2024. https:\/\/doi.org\/10.1016\/j.prp.2024.155574.","journal-title":"Pathology"},{"key":"4222_CR186","doi-asserted-by":"publisher","DOI":"10.3390\/v13071339","author":"KJ Nielsen","year":"2021","unstructured":"Nielsen KJ, Jakobsen KK, Jensen JS, et al. The effect of prophylactic HPV vaccines on oral and oropharyngeal HPV infection-a systematic review. Viruses. 2021. https:\/\/doi.org\/10.3390\/v13071339.","journal-title":"Viruses"},{"issue":"6","key":"4222_CR187","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ijom.2024.12.006","volume":"54","author":"EA Prostakishina","year":"2024","unstructured":"Prostakishina EA, Sidenko EA, Kolegova ES, et al. Premalignant lesions of the oral cavity: a narrative review of factors and mechanisms of transformation into cancer. Int J Oral Maxillofacial Surg. 2024;54(6):479\u201393.","journal-title":"Int J Oral Maxillofacial Surg"},{"issue":"5","key":"4222_CR188","first-page":"509","volume":"36","author":"SB Griner","year":"2025","unstructured":"Griner SB, Digbeu B, Farris AN, et al. Oral cavity and oropharyngeal cancers in Texas: examining incidence rates in dental health professional shortage areas. Cancer Causes Control. 2025;36(5):509\u201320.","journal-title":"Cancer Causes Control"},{"issue":"15","key":"4222_CR189","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15153779","volume":"15","author":"VCA Caponio","year":"2023","unstructured":"Caponio VCA, Zhurakivska K, Lo Muzio L, et al. The immune cells in the development of oral squamous cell carcinoma. Cancers. 2023;15(15):3779.","journal-title":"Cancers"},{"key":"4222_CR190","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02398-6","author":"XH Zhou","year":"2022","unstructured":"Zhou XH, Huang Y, Yuan C, et al. A survey of the awareness and knowledge of oral cancer among residents in Beijing. BMC Oral Health. 2022. https:\/\/doi.org\/10.1186\/s12903-022-02398-6.","journal-title":"BMC Oral Health"},{"issue":"4","key":"4222_CR191","volume":"26","author":"P Varela-Centelles","year":"2021","unstructured":"Varela-Centelles P, Seoane J, Ulloa-Morales Y, et al. Oral cancer awareness in North-Western Spain: a population-based study. Medicina Oral Patologia Oral Y Cirugia Bucal. 2021;26(4):E518-E525.","journal-title":"Medicina Oral Patologia Oral Y Cirugia Bucal"},{"issue":"2","key":"4222_CR192","doi-asserted-by":"publisher","first-page":"282","DOI":"10.4103\/jomfp.jomfp_420_21","volume":"27","author":"V Agaraj","year":"2023","unstructured":"Agaraj V, Priya S, Muthanandam S, et al. Self-negligence and awareness among oral precancerous and cancer patients - A cross-sectional questionnaire study[J]. J Oral Maxillofacial Pathology: JOMFP. 2023;27(2):282\u20136.","journal-title":"J Oral Maxillofacial Pathology: JOMFP"},{"key":"4222_CR193","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-09015-y","author":"A Yokoi","year":"2024","unstructured":"Yokoi A, Maruyama T, Yamanaka R, et al. Relationship among cancer treatment, quality of life, and oral function in head and neck cancer survivors: a cross-sectional study. Support Care Cancer. 2024. https:\/\/doi.org\/10.1007\/s00520-024-09015-y.","journal-title":"Support Care Cancer"},{"key":"4222_CR194","doi-asserted-by":"publisher","first-page":"177222","DOI":"10.1016\/j.ejphar.2024.177222","volume":"989","author":"PJ Nagarathna","year":"2025","unstructured":"Nagarathna PJ, Patil SR, Veeraraghavan VP, et al. Oral cancer stem cells: a comprehensive review of key drivers of treatment resistance and tumor recurrence. Eur J Pharmacol. 2025;989:177222.","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"4222_CR195","first-page":"189","volume":"38","author":"HA Hirna","year":"2024","unstructured":"Hirna HA, Maltsev DV, Kostyshyn ID, et al. Results of the study of factors predicting the risk of the development of grade III radiation-induced mucositis during radiation or chemoradiation therapy in patients with oral cavity and oropharynx cancer[J]. Klinick\u00e1 Onkologie. 2024;38(3):189\u2013201.","journal-title":"Klinick\u00e1 Onkologie"},{"issue":"2","key":"4222_CR196","first-page":"1","volume":"33","author":"V Mercadante","year":"2025","unstructured":"Mercadante V, Smith DK, Abdalla-Aslan R, et al. A systematic review of salivary gland hypofunction and\/or Xerostomia induced by non-surgical cancer therapies: prevention strategies[J]. Support Care Cancer. 2025;33(2):1\u201325.","journal-title":"Support Care Cancer"},{"issue":"4","key":"4222_CR197","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.job.2024.09.002","volume":"66","author":"R Chakraborty","year":"2024","unstructured":"Chakraborty R, Khodlan P, Tay A, Liu F. STAT3 interactome predicts presence of proteins that regulate immune system in oral squamous cell carcinoma. J Oral Biosci. 2024;66(4):67\u201373. https:\/\/doi.org\/10.1016\/j.job.2024.09.002.","journal-title":"J Oral Biosci"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04222-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-04222-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04222-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:04:19Z","timestamp":1768341859000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-04222-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":197,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4222"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-04222-3","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]},"assertion":[{"value":"16 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is a review article that only synthesizes and analyzes data from previously published studies. No original human or animal experiments were conducted, so ethical approval was not required.\u00a0This review does not involve human participants or collection of original individual data, so consent to participate is not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This review relies on publicly available published data and does not contain any unpublished individual information or personal data. Thus, consent to publish is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"59"}}