{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:53:58Z","timestamp":1770166438593,"version":"3.49.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-04291-4","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T07:04:49Z","timestamp":1767510289000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The potential of cytokine polymorphisms as biomarkers for oral squamous cell carcinoma: a systematic review"],"prefix":"10.1007","volume":"17","author":[{"given":"Mvuyisi O. M.","family":"Mfengu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance R.","family":"Sewani-Rusike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannibal T.","family":"Musarurwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nomagugu","family":"Ndlovu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"issue":"1","key":"4291_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12957-021-02423-y","volume":"19","author":"J Pillai","year":"2021","unstructured":"Pillai J, Chincholkar T, Dixit R, Pandey M. A systematic review of proteomic biomarkers in oral squamous cell cancer. World J Surg Oncol. 2021;19(1):315. https:\/\/doi.org\/10.1186\/s12957-021-02423-y.","journal-title":"World J Surg Oncol"},{"issue":"1","key":"4291_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41432-022-0243-1","volume":"23","author":"L Xie","year":"2022","unstructured":"Xie L, Z. S. Oral cancer\u2014the fight must go on against all odds. Evid-Based Dent. 2022;23(1):4\u20135. https:\/\/doi.org\/10.1038\/s41432-022-0243-1.","journal-title":"Evid-Based Dent"},{"key":"4291_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2020.00003","author":"RD Coletta","year":"2020","unstructured":"Coletta RD, Yeudall WA, Salo T. Grand challenges in oral Cancers. Front Oral Health. 2020. (Specialty grand Challenge). https:\/\/doi.org\/10.3389\/froh.2020.00003.","journal-title":"Front Oral Health"},{"issue":"3","key":"4291_CR4","doi-asserted-by":"publisher","first-page":"e305","DOI":"10.4317\/medoral.20347","volume":"20","author":"C Carreras-Torras","year":"2015","unstructured":"Carreras-Torras C, Gay-Escoda C. Techniques for early diagnosis of oral squamous cell carcinoma: systematic review. Med Oral Patol Oral Cir Bucal. 2015;20(3):e305\u2013315. https:\/\/doi.org\/10.4317\/medoral.20347.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"4291_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2024.1426507","author":"A Pal","year":"2024","unstructured":"Pal A, Ghoshal S, Chauhan A, Kaur R, Boora GS, Suri S. Recent advances in minimally invasive biomarkers of OSCC: from generalized to personalized approach. Front Oral Health. 2024. https:\/\/doi.org\/10.3389\/froh.2024.1426507 (Mini Review).","journal-title":"Front Oral Health"},{"key":"4291_CR6","doi-asserted-by":"publisher","unstructured":"Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, et al. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 2023. https:\/\/doi.org\/10.1038\/s41368-023-00249-w.","DOI":"10.1038\/s41368-023-00249-w"},{"issue":"9","key":"4291_CR7","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.3390\/jcm9092866","volume":"9","author":"A Roi","year":"2020","unstructured":"Roi A, Roi CI, Negru\u021biu ML, Rivi\u0219 M, Sinescu C, Rusu L-C. The challenges of OSCC diagnosis: salivary cytokines as potential biomarkers. J Clin Med. 2020;9(9):2866.","journal-title":"J Clin Med"},{"key":"4291_CR8","doi-asserted-by":"publisher","unstructured":"Huang L, Luo F, Deng M, Zhang J. The relationship between salivary cytokines and oral cancer and their diagnostic capability for oral cancer: a systematic review and network meta-analysis. BMC Oral Health. 2024. https:\/\/doi.org\/10.1186\/s12903-024-04840-3.","DOI":"10.1186\/s12903-024-04840-3"},{"issue":"4","key":"4291_CR9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1089\/jir.2020.0251","volume":"41","author":"V Ruhanya","year":"2021","unstructured":"Ruhanya V, Jacobs GB, Paul R, Joska J, Seedat S, Nyandoro G, et al. Plasma cytokine levels as predictors of global and Domain-Specific human immunodeficiency Virus-Associated neurocognitive impairment in Treatment-Naive individuals. J Interferon Cytokine Res. 2021;41(4):153\u201360. https:\/\/doi.org\/10.1089\/jir.2020.0251.","journal-title":"J Interferon Cytokine Res"},{"key":"4291_CR10","doi-asserted-by":"publisher","unstructured":"Castro F, Cardoso AP, Gon\u00e7alves RM, Serre K, Oliveira MJ. Interferon-Gamma at the crossroads of tumor immune surveillance or evasion. Front Immunol. 2018. https:\/\/doi.org\/10.3389\/fimmu.2018.00847.","DOI":"10.3389\/fimmu.2018.00847"},{"key":"4291_CR11","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028530","author":"J Yan","year":"2018","unstructured":"Yan J, Smyth MJ, Teng MWL. Interleukin (IL)-12 and IL-23 and their conflicting roles in cancer. Cold Spring Harb Perspect Biol. 2018. https:\/\/doi.org\/10.1101\/cshperspect.a028530.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"4291_CR12","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/978-1-61779-842-9_31","volume":"882","author":"G Kaur","year":"2012","unstructured":"Kaur G, Mehra N. Cytokine gene polymorphisms: methods of detection and biological significance. Methods Mol Biol. 2012;882:549\u201368. https:\/\/doi.org\/10.1007\/978-1-61779-842-9_31.","journal-title":"Methods Mol Biol"},{"key":"4291_CR13","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.mgene.2015.03.002","volume":"4","author":"PK Singh","year":"2015","unstructured":"Singh PK, Chandra G, Bogra J, Gupta R, Kumar V, Jain A, et al. Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population. Meta Gene. 2015;4:142\u201351. https:\/\/doi.org\/10.1016\/j.mgene.2015.03.002.","journal-title":"Meta Gene"},{"key":"4291_CR14","doi-asserted-by":"publisher","first-page":"100969","DOI":"10.1016\/j.mgene.2021.100969","volume":"30","author":"V Unamuno","year":"2021","unstructured":"Unamuno V, Brunotto M, Zarate AM. An update of cytokine polymorphisms in head and neck cancer: a systematic review and meta-analysis. Meta Gene. 2021;30:100969. https:\/\/doi.org\/10.1016\/j.mgene.2021.100969.","journal-title":"Meta Gene"},{"key":"4291_CR15","unstructured":"Bouckaert, Munzhelele TI, Feller L, Lemmer JJ, Rag K. The clinical characteristics of oral squamous cell carcinoma in patients attending the Medunsa oral health Centre, South Africa. 2016."},{"issue":"4","key":"4291_CR16","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/iji.12037","volume":"40","author":"NK Carneiro","year":"2013","unstructured":"Carneiro NK, Oda JM, Guembarovski L, Ramos R, Oliveira G, Cavalli BV, I. J., et al. Possible association between TGF-\u03b21 polymorphism and oral cancer. Int J Immunogenet. 2013;40(4):292\u20138. https:\/\/doi.org\/10.1111\/iji.12037.","journal-title":"Int J Immunogenet"},{"issue":"6","key":"4291_CR17","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1002\/ijc.31530","volume":"143","author":"Y Tao","year":"2018","unstructured":"Tao Y, Sturgis EM, Huang Z, Sun Y, Dahlstrom KR, Wei Q, et al. A TGF-\u03b21 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer. Int J Cancer. 2018;143(6):1327\u201334. https:\/\/doi.org\/10.1002\/ijc.31530.","journal-title":"Int J Cancer"},{"issue":"11","key":"4291_CR18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.kjms.2014.09.003","volume":"30","author":"H-J Hsu","year":"2014","unstructured":"Hsu H-J, Yang Y-H, Shieh T-Y, Chen C-H, Kao Y-H, Yang C-F, et al. Role of cytokine gene (interferon-\u03b3, transforming growth factor-\u03b21, tumor necrosis factor-\u03b1, interleukin-6, and interleukin-10) polymorphisms in the risk of oral precancerous lesions in Taiwanese. Kaohsiung J Med Sci. 2014;30(11):551\u20138.","journal-title":"Kaohsiung J Med Sci"},{"key":"4291_CR19","doi-asserted-by":"crossref","unstructured":"Hsu HanJen HH, Yang YiHsin YY, Shieh TienYu ST, Chen ChungHo CC, Kao YuHsun KY, Yang ChiaFu YC, et al. TGF-\u03b21 and IL-10 single nucleotide polymorphisms as risk factors for oral cancer in Taiwanese. 2015.","DOI":"10.1016\/j.kjms.2014.12.003"},{"issue":"5","key":"4291_CR20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/00016357.2020.1850856","volume":"79","author":"ITS Santana","year":"2021","unstructured":"Santana ITS, Dos Santos JNA, de Almeida VL, Ferreira WNS, Santos EM, de Freitas A, R., et al. Association of PON1, TNF-\u03b1 and TGF-\u03b2 gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma. Acta Odontol Scand. 2021;79(5):327\u201334.","journal-title":"Acta Odontol Scand"},{"key":"4291_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-4598-12-80","volume":"12","author":"L Jin","year":"2013","unstructured":"Jin L, Sturgis EM, Zhang Y, Huang Z, Song X, Li C, et al. Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. Mol Cancer. 2013;12:1\u20139.","journal-title":"Mol Cancer"},{"issue":"1","key":"4291_CR22","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12903-024-03939-x","volume":"24","author":"MH Marabi","year":"2024","unstructured":"Marabi MH, Mozaffari HR, Ghasemi H, Hatami M, Yari K. Evaluation of the association between TNF-\u03b1-1031 T\/C polymorphism with oral lichen planus disease. BMC Oral Health. 2024;24(1):189.","journal-title":"BMC Oral Health"},{"issue":"4","key":"4291_CR23","doi-asserted-by":"publisher","first-page":"e2014","DOI":"10.1002\/hsr2.2014","volume":"7","author":"MH Marabi","year":"2024","unstructured":"Marabi MH, Yari K, Mozaffari HR, Hatami M. Assessment of TNF-\u03b1 (\u2010857\u00a0C\/T) gene polymorphism in oral lichen planus disease: a case\u2013control study. Health Sci Rep. 2024;7(4):e2014.","journal-title":"Health Sci Rep"},{"key":"4291_CR24","first-page":"531","volume":"28","author":"R Mlak","year":"2020","unstructured":"Mlak R, Powr\u00f3zek T, Brzozowska A, Homa-Mlak I, Mazurek M, Go\u0142\u0119biowski P, et al. The relationship between TNF-\u03b1 gene promoter polymorphism (\u2013\u20091211 T\u2009>\u2009C), the plasma concentration of TNF-\u03b1, and risk of oral mucositis and shortening of overall survival in patients subjected to intensity-modulated radiation therapy due to head and neck cancer. Support Care Cancer. 2020;28:531\u201340.","journal-title":"Support Care Cancer"},{"key":"4291_CR25","doi-asserted-by":"publisher","first-page":"100525","DOI":"10.1016\/j.genrep.2019.100525","volume":"17","author":"Y Shahi","year":"2019","unstructured":"Shahi Y, Samadi F, Mukherjee S. The influence of tumor necrosis factor-alpha gene polymorphism on oxidative stress in patients with oral precancerous lesions and oral cancer. Gene Rep. 2019;17:100525.","journal-title":"Gene Rep"},{"issue":"4","key":"4291_CR26","doi-asserted-by":"publisher","first-page":"371","DOI":"10.5505\/tjo.2022.3624","volume":"37","author":"\u00d6 G\u00fcm\u00fc\u015fay","year":"2022","unstructured":"G\u00fcm\u00fc\u015fay \u00d6, Yi\u011fit S, Nursal AF, Tekcan A, Dagmura H, Kuruca N. Role of Interleukin-6 gene variants in the development of oral squamous cell carcinoma. Turk Onkoloji Dergisi. 2022;37(4):371\u20138. https:\/\/doi.org\/10.5505\/tjo.2022.3624.","journal-title":"Turk Onkoloji Dergisi"},{"key":"4291_CR27","first-page":"13","volume":"8","author":"S Gupta","year":"2016","unstructured":"Gupta S, Kumud N, Bhatt M, Abbas A. The interleukin-6-174 G\/C and 572 G\/C promoter polymorphism associated with high risk of oral pre cancer and cancer in North Indians population. Int J Inn Bio Chem Sci. 2016;8:13\u201324.","journal-title":"Int J Inn Bio Chem Sci"},{"key":"4291_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00405-021-06620-z","volume":"278","author":"Y Shahi","year":"2021","unstructured":"Shahi Y, Mukherjee S, Samadi FM. Interaction of tobacco chewing and smoking habit with Interleukin 6 promoter polymorphism in oral precancerous lesions and oral cancer. Eur Arch Otorhinolaryngol. 2021;278:1\u20139.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"4291_CR29","doi-asserted-by":"publisher","unstructured":"Chien MH, Liu YF, Hsin CH, Lin CH, Shih CH, Yang SF, et al. Impact of VEGF-C gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan. PLoS ONE. 2013;8(4):e60283. https:\/\/doi.org\/10.1371\/journal.pone.0060283.","DOI":"10.1371\/journal.pone.0060283"},{"issue":"11","key":"4291_CR30","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.oraloncology.2012.05.023","volume":"48","author":"G Supic","year":"2012","unstructured":"Supic G, Jovic N, Zeljic K, Kozomara R, Magic Z. Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients. Oral Oncol. 2012;48(11):1171\u20137. https:\/\/doi.org\/10.1016\/j.oraloncology.2012.05.023.","journal-title":"Oral Oncol"},{"issue":"4","key":"4291_CR31","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/jicd.12103","volume":"6","author":"AP Borase","year":"2015","unstructured":"Borase AP, Ganvir SM, Hazarey VK, Gosavi SR, Mohatta AA, Singh J. Estimation of vascular endothelial growth factor gene\u2013460\u00a0C\/T polymorphism as a biomarker in oral squamous cell carcinoma patients from the Indian Subcontinent. J Invest Clin Dent. 2015;6(4):267\u201372.","journal-title":"J Invest Clin Dent"},{"issue":"2","key":"4291_CR32","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.joms.2014.09.009","volume":"73","author":"N Li","year":"2015","unstructured":"Li N, Zhang C, Chen Z, Bai L, Nie M, Zhou B, et al. Interleukin 17A and Interleukin 17F polymorphisms are associated with oral squamous cell carcinoma susceptibility in a Chinese population. J Oral Maxillofac Surg. 2015;73(2):267\u201373.","journal-title":"J Oral Maxillofac Surg"},{"key":"4291_CR33","doi-asserted-by":"publisher","first-page":"102024","DOI":"10.1016\/j.genrep.2024.102024","volume":"37","author":"D Prasad","year":"2024","unstructured":"Prasad D, Shahi Y, Tiwari V, Agarwal A, Mukherjee S. Genetic variants of interleukin-1\u03b1, interleukin-12\u03b2 and matrix metalloproteinase-9 in oral cancer risk and progression. Gene Rep. 2024;37:102024.","journal-title":"Gene Rep"},{"key":"4291_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10528-015-9704-y","volume":"54","author":"PK Singh","year":"2016","unstructured":"Singh PK, Chandra G, Bogra J, Gupta R, Kumar V, Hussain SR, et al. Association of genetic polymorphism in the interleukin-8 gene with risk of oral cancer and its correlation with pain. Biochem Genet. 2016;54:95\u2013106.","journal-title":"Biochem Genet"},{"issue":"4","key":"4291_CR35","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.21873\/invivo.11969","volume":"34","author":"L-C Shih","year":"2020","unstructured":"Shih L-C, Chang W-S, Lee H-T, Wang Y-C, Wang Z-H, Chao C-Y, et al. Interaction of interleukin-16 genotypes with betel quid chewing behavior on oral cancer in Taiwan. Vivo. 2020;34(4):1759\u201364.","journal-title":"Vivo"},{"issue":"12","key":"4291_CR36","doi-asserted-by":"publisher","first-page":"12275","DOI":"10.1007\/s13277-014-2538-0","volume":"35","author":"PK Singh","year":"2014","unstructured":"Singh PK, Ahmad MK, Kumar V, Hussain SR, Gupta R, Jain A, et al. Effects of interleukin-18 promoter (C607A and G137C) gene polymorphisms and their association with oral squamous cell carcinoma (OSCC) in Northern India. Tumour Biol. 2014;35(12):12275\u201384. https:\/\/doi.org\/10.1007\/s13277-014-2538-0.","journal-title":"Tumour Biol"},{"issue":"3","key":"4291_CR37","doi-asserted-by":"publisher","first-page":"935","DOI":"10.31557\/apjcp.2019.20.3.935","volume":"20","author":"E Goud","year":"2019","unstructured":"Goud E, Malleedi S, Ramanathan A, Wong GR, Ern H, Yean BT, G. Y., et al. Association of Interleukin-10 genotypes and oral cancer susceptibility in selected Malaysian population: a Case-control study. Asian Pac J Cancer Prev. 2019;20(3):935\u201341. https:\/\/doi.org\/10.31557\/apjcp.2019.20.3.935.","journal-title":"Asian Pac J Cancer Prev"},{"key":"4291_CR38","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.archoralbio.2016.12.011","volume":"77","author":"PK Singh","year":"2017","unstructured":"Singh PK, Ahmad MK, Kumar V, Gupta R, Kohli M, Jain A, et al. Genetic polymorphism of interleukin-10 (-A592C) among oral cancer with squamous cell carcinoma. Arch Oral Biol. 2017;77:18\u201322. https:\/\/doi.org\/10.1016\/j.archoralbio.2016.12.011.","journal-title":"Arch Oral Biol"},{"issue":"6","key":"4291_CR39","doi-asserted-by":"publisher","first-page":"730","DOI":"10.4103\/ijmr.IJMR_1949_15","volume":"146","author":"PK Singh","year":"2017","unstructured":"Singh PK, Kumar V, Ahmad MK, Gupta R, Mahdi AA, Jain A, et al. Association of \u2013\u2009330 interleukin-2 gene polymorphism with oral cancer. Indian J Med Res. 2017;146(6):730\u20137.","journal-title":"Indian J Med Res"},{"issue":"1","key":"4291_CR40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.archoralbio.2013.09.010","volume":"59","author":"C-M Yang","year":"2014","unstructured":"Yang C-M, Chen H-C, Hou Y-Y, Lee M-C, Liou H-H, Huang S-J, et al. A high IL-4 production diplotype is associated with an increased risk but better prognosis of oral and pharyngeal carcinomas. Arch Oral Biol. 2014;59(1):35\u201346.","journal-title":"Arch Oral Biol"},{"issue":"11","key":"4291_CR41","doi-asserted-by":"publisher","first-page":"e79187","DOI":"10.1371\/journal.pone.0079187","volume":"8","author":"E Erdei","year":"2013","unstructured":"Erdei E, Luo L, Sheng H, Maestas E, White KA, Mackey A, et al. Cytokines and tumor metastasis gene variants in oral cancer and precancer in Puerto Rico. PLoS ONE. 2013;8(11):e79187. https:\/\/doi.org\/10.1371\/journal.pone.0079187.","journal-title":"PLoS ONE"},{"issue":"1a","key":"4291_CR42","first-page":"309","volume":"28","author":"E Vairaktaris","year":"2008","unstructured":"Vairaktaris E, Yapijakis C, Serefoglou Z, Derka S, Vassiliou S, Nkenke E, et al. The interleukin-10 (-1082A\/G) polymorphism is strongly associated with increased risk for oral squamous cell carcinoma. Anticancer Res. 2008;28(1a):309\u201314.","journal-title":"Anticancer Res"},{"key":"4291_CR43","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s12041-016-0626-1","volume":"95","author":"SR Hussain","year":"2016","unstructured":"Hussain SR, Ahmad MK, Mahdi AA, Naqvi H, Ahmad MW, Srivastava S, et al. Association of interleukin-10 (A1082G) gene polymorphism with oral squamous cell carcinoma in North Indian population. J Genet. 2016;95:249\u201355.","journal-title":"J Genet"},{"issue":"1","key":"4291_CR44","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2298\/ABS1301387K","volume":"65","author":"M Kosti\u0107","year":"2013","unstructured":"Kosti\u0107 M, Nikoli\u0107 N, Ili\u0107 B, Jelovac D, Trakilovi\u0107 S, Bo\u017eovi\u0107 M, et al. Association of TNF-R2 (676T\u2009>\u2009G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population. Archives Biol Sci. 2013;65(1):387\u201393.","journal-title":"Archives Biol Sci"},{"issue":"6","key":"4291_CR45","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.oraloncology.2012.01.008","volume":"48","author":"Y-C Lin","year":"2012","unstructured":"Lin Y-C, Yeh C-J, Wang L-H, Lee C-W, Chen C-H. The effect of CCND1\u2009+\u2009870A\u2009>\u2009G and VEGF\u2009+\u2009936C\u2009>\u2009T polymorphisms on oral cancer development and disease-free survival in a Taiwan population. Oral Oncol. 2012;48(6):535\u201340.","journal-title":"Oral Oncol"},{"issue":"8","key":"4291_CR46","doi-asserted-by":"publisher","first-page":"4847","DOI":"10.1111\/odi.14906","volume":"30","author":"AM Filho","year":"2024","unstructured":"Filho AM, Warnakulasuriya S. Epidemiology of oral cancer in South and South-East asia: incidence and mortality. Oral Dis. 2024;30(8):4847\u201354. https:\/\/doi.org\/10.1111\/odi.14906.","journal-title":"Oral Dis"},{"issue":"1","key":"4291_CR47","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1038\/s41598-019-39249-4","volume":"9","author":"S Wu","year":"2019","unstructured":"Wu S, Wang M-G, Wang Y, He J-Q. Polymorphisms of cytokine genes and tuberculosis in two independent studies. Sci Rep. 2019;9(1):2507. https:\/\/doi.org\/10.1038\/s41598-019-39249-4.","journal-title":"Sci Rep"},{"issue":"7","key":"4291_CR48","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.31557\/apjcp.2023.24.7.2353","volume":"24","author":"R Pandey","year":"2023","unstructured":"Pandey R, Nema R, Vishwakarma S, Singh AP, Mohan S, Patel P, et al. Single nucleotide polymorphisms in cytokine genes are associated with the susceptibility to oral squamous cell carcinoma. Asian Pac J Cancer Prev. 2023;24(7):2353\u201360. https:\/\/doi.org\/10.31557\/apjcp.2023.24.7.2353.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"9","key":"4291_CR49","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1158\/1055-9965.1547.13.9","volume":"13","author":"SA Savage","year":"2004","unstructured":"Savage SA, Abnet CC, Haque K, Mark SD, Qiao YL, Dong ZW, et al. Polymorphisms in Interleukin \u2013\u20092, \u2013\u20096, and \u2013\u200910 are not associated with gastric cardia or esophageal cancer in a high-risk Chinese population. Cancer Epidemiol Biomarkers Prev. 2004;13(9):1547\u20139.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"4291_CR50","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3892\/or.2020.7863","volume":"45","author":"C Li","year":"2021","unstructured":"Li C, Zhu M, Zhu J, Lu Q, Shi B, Sun B, et al. SOX12 contributes to the activation of the JAK2\/STAT3 pathway and malignant transformation of esophageal squamous cell carcinoma. Oncol Rep. 2021;45(1):129\u201338. https:\/\/doi.org\/10.3892\/or.2020.7863.","journal-title":"Oncol Rep"},{"key":"4291_CR51","doi-asserted-by":"publisher","unstructured":"Xiao L, Li X, Cao P, Fei W, Zhou H, Tang N, et al. Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2\/STAT3\/Sox4\/NLRP3 signaling pathway. J Exp Clin Cancer Res. 2022. https:\/\/doi.org\/10.1186\/s13046-022-02376-4.","DOI":"10.1186\/s13046-022-02376-4"},{"issue":"5","key":"4291_CR52","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.3892\/or.2015.3838","volume":"33","author":"T Jinno","year":"2015","unstructured":"Jinno T, Kawano S, Maruse Y, Matsubara R, Goto Y, Sakamoto T, et al. Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma. Oncol Rep. 2015;33(5):2161\u20138. https:\/\/doi.org\/10.3892\/or.2015.3838.","journal-title":"Oncol Rep"},{"issue":"3","key":"4291_CR53","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.ygyno.2006.10.014","volume":"104","author":"E Ioana Braicu","year":"2007","unstructured":"Ioana Braicu E, Mustea A, Toliat MR, Pirvulescu C, K\u00f6nsgen D, Sun P, et al. Polymorphism of IL-1alpha, IL-1beta and IL-10 in patients with advanced ovarian cancer: results of a prospective study with 147 patients. Gynecol Oncol. 2007;104(3):680\u20135. https:\/\/doi.org\/10.1016\/j.ygyno.2006.10.014.","journal-title":"Gynecol Oncol"},{"key":"4291_CR54","doi-asserted-by":"publisher","unstructured":"L\u00f3pez-Anglada E, Collazos J, Montes AH, P\u00e9rez-Is L, P\u00e9rez-Hevia I, Jim\u00e9nez-Tostado S, et al. IL-1 \u03b2 gene (+\u20093954\u00a0C\/T, exon 5, rs1143634) and NOS2 (exon 22) polymorphisms associate with early aseptic loosening of arthroplasties. Sci Rep. 2022. https:\/\/doi.org\/10.1038\/s41598-022-22693-0.","DOI":"10.1038\/s41598-022-22693-0"},{"key":"4291_CR55","doi-asserted-by":"publisher","unstructured":"Niklander SE. Inflammatory mediators in oral cancer: pathogenic mechanisms and diagnostic Potential. Front Oral Health. 2021. (Mini Review). https:\/\/doi.org\/10.3389\/froh.2021.642238.","DOI":"10.3389\/froh.2021.642238"},{"key":"4291_CR56","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.2147\/ott.S71420","volume":"7","author":"D Cheng","year":"2014","unstructured":"Cheng D, Hao Y, Zhou W. IL-1\u03b1 -889\u00a0C\/T polymorphism and cancer susceptibility: a meta-analysis. Onco Targets Ther. 2014;7:2067\u201374. https:\/\/doi.org\/10.2147\/ott.S71420.","journal-title":"Onco Targets Ther"},{"key":"4291_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00177","author":"E Voronov","year":"2013","unstructured":"Voronov E, Dotan S, Krelin Y, Song X, Elkabets M, Carmi Y, et al. Unique versus redundant functions of IL-1\u03b1 and IL-1\u03b2 in the tumor Microenvironment. Front Immunol. 2013. https:\/\/doi.org\/10.3389\/fimmu.2013.00177. (Review).","journal-title":"Front Immunol"},{"key":"4291_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.722676","author":"SE Niklander","year":"2021","unstructured":"Niklander SE, Murdoch C, Hunter KD. IL-1\/IL-1R signaling in head and neck Cancer. Front Oral Health. 2021. https:\/\/doi.org\/10.3389\/froh.2021.722676. (Review).","journal-title":"Front Oral Health"},{"key":"4291_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030867","author":"K Babiuch","year":"2020","unstructured":"Babiuch K, Ku\u015bnierz-Cabala B, K\u0119sek B, Oko\u0144 K, Darczuk D, Chomyszyn-Gajewska M. Evaluation of Proinflammatory, NF-kappaB dependent cytokines: IL-1\u03b1, IL-6, IL-8, and TNF-\u03b1 in tissue specimens and saliva of patients with oral squamous cell carcinoma and oral potentially malignant disorders. J Clin Med. 2020. https:\/\/doi.org\/10.3390\/jcm9030867.","journal-title":"J Clin Med"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-04291-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04291-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04291-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:01:54Z","timestamp":1770120114000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-04291-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,4]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4291"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-04291-4","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,4]]},"assertion":[{"value":"12 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Clinical trial number is not applicable in this manuscript since it is a systematic review. Ethics, Consent to Participate, and Consent to Publish declarations are not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that this manuscript has not been submitted to another Journal for consideration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Dual publications"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"219"}}