{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:25:58Z","timestamp":1788488758576,"version":"build-2803163510"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-025-04343-9","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:26:13Z","timestamp":1767014773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioinformatics-based screening and prediction of compounds and antigen epitopes for immune targets with point mutations in colitis-associated colorectal cancer"],"prefix":"10.1007","volume":"17","author":[{"given":"Xinyi","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"4343_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cancergen.2024.06.002","volume":"286\u2013287","author":"D Sonkin","year":"2024","unstructured":"Sonkin D, Thomas A, Teicher BA. Cancer treatments: Past, present, and future. Cancer Genet. 2024;286\u2013287:18\u201324.","journal-title":"Cancer Genet"},{"issue":"3","key":"4343_CR2","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"4343_CR3","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1136\/gutjnl-2020-321661","volume":"70","author":"H Chen","year":"2021","unstructured":"Chen H, Zheng X, Zong X, Li Z, Li N, Hur J, Fritz CD, Chapman W Jr, Nickel KB, Tipping A, Colditz GA, Giovannucci EL, Olsen MA, Fields RC, Cao Y. Metabolic syndrome, metabolic comorbid conditions and risk of early-onset colorectal cancer. Gut. 2021;70(6):1147\u201354.","journal-title":"Gut"},{"issue":"3","key":"4343_CR4","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1053\/j.gastro.2021.10.035","volume":"162","author":"SC Shah","year":"2022","unstructured":"Shah SC, Itzkowitz SH. Colorectal cancer in inflammatory bowel disease: mechanisms and management. Gastroenterology. 2022;162(3):715\u2013e7303.","journal-title":"Gastroenterology"},{"key":"4343_CR5","doi-asserted-by":"publisher","first-page":"103269","DOI":"10.1016\/j.eclinm.2025.103269","volume":"84","author":"L Zhang","year":"2025","unstructured":"Zhang L, Zhang X, Su T, Xiao T, Xu H, Zhao S. Colorectal cancer risk in ulcerative colitis: an updated population-based systematic review and meta-analysis. EClinicalMedicine. 2025;84:103269.","journal-title":"EClinicalMedicine"},{"issue":"1","key":"4343_CR6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12893-023-02160-x","volume":"23","author":"R Kuwahara","year":"2023","unstructured":"Kuwahara R, Ikeuchi H, Kusunoki K, Minagawa T, Horio Y, Kimura K, Kataoka K, Beppu N, Ikeda M, Uchino M. Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis. BMC Surg. 2023;23(1):256.","journal-title":"BMC Surg"},{"issue":"6","key":"4343_CR7","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cgh.2021.01.037","volume":"20","author":"DE O\u2019Sullivan","year":"2022","unstructured":"O\u2019Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR. Risk factors for Early-Onset colorectal cancer: A systematic review and Meta-analysis. Clin Gastroenterol Hepatol. 2022;20(6):1229\u2013e12405.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"4343_CR8","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1080\/15384047.2018.1529108","volume":"20","author":"SQ Wang","year":"2019","unstructured":"Wang SQ, Cui SX, Qu XJ. Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice. Cancer Biol Ther. 2019;20(3):338\u201348.","journal-title":"Cancer Biol Ther"},{"key":"4343_CR9","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.semcancer.2020.10.003","volume":"73","author":"S Ocvirk","year":"2021","unstructured":"Ocvirk S, O\u2019Keefe SJD. Dietary fat, bile acid metabolism and colorectal cancer. Semin Cancer Biol. 2021;73:347\u201355.","journal-title":"Semin Cancer Biol"},{"key":"4343_CR10","doi-asserted-by":"publisher","first-page":"105884","DOI":"10.1016\/j.intimp.2019.105884","volume":"76","author":"K Amirshahrokhi","year":"2019","unstructured":"Amirshahrokhi K. Febuxostat attenuates ulcerative colitis by the Inhibition of NF-\u03baB, Proinflammatory cytokines, and oxidative stress in mice. Int Immunopharmacol. 2019;76:105884.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4343_CR11","doi-asserted-by":"publisher","first-page":"e1375640","DOI":"10.1080\/2162402X.2017.1375640","volume":"6","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Sun Y, Fan D, et al. Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy. Oncoimmunology. 2017;6(1):e1375640.","journal-title":"Oncoimmunology"},{"issue":"3","key":"4343_CR12","first-page":"105","volume":"10","author":"RM Joshi","year":"2024","unstructured":"Joshi RM, Telang B, Soni G, Khalife A. Overview of perspectives on cancer,newer therapies,and future directions. Oncol Translational Med. 2024;10(3):105\u20139.","journal-title":"Oncol Translational Med"},{"issue":"6230","key":"4343_CR13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1126\/science.aaa4971","volume":"348","author":"TN Schumacher","year":"2015","unstructured":"Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015;348(6230):69\u201374. https:\/\/doi.org\/10.1126\/science.aaa4971.","journal-title":"Science"},{"issue":"19","key":"4343_CR14","doi-asserted-by":"publisher","first-page":"5597","DOI":"10.1158\/0008-5472.CAN-16-0431","volume":"76","author":"P Tsou","year":"2016","unstructured":"Tsou P, Katayama H, Ostrin EJ, Hanash SM. The emerging role of B cells in tumor immunity. Cancer Res. 2016;76(19):5597\u2013601.","journal-title":"Cancer Res"},{"issue":"2","key":"4343_CR15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cell.2013.03.034","volume":"153","author":"R Nussinov","year":"2013","unstructured":"Nussinov R, Tsai CJ. Allostery in disease and in drug discovery. Cell. 2013;153(2):293\u2013305.","journal-title":"Cell"},{"issue":"11","key":"4343_CR16","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1002\/ajmg.a.62407","volume":"185","author":"A Hamosh","year":"2021","unstructured":"Hamosh A, Amberger JS, Bocchini C, Scott AF, Rasmussen SA. Online Mendelian inheritance in man (OMIM\u00ae): victor mckusick\u2019s magnum opus. Am J Med Genet A. 2021;185(11):3259\u201365.","journal-title":"Am J Med Genet A"},{"key":"4343_CR17","doi-asserted-by":"crossref","unstructured":"Stelzer G, Rosen N, Plaschkes I, Zimmerman S, Twik M, Fishilevich S, Stein TI, Nudel R, Lieder I, Mazor Y, Kaplan S, Dahary D, Warshawsky D, Guan-Golan Y, Kohn A, Rappaport N, Safran M, Lancet D. The genecards suite: from gene data mining to disease genome sequence analyses. Curr Protoc Bioinform. 2016;54:1.30.1\u20131.30.33.","DOI":"10.1002\/cpbi.5"},{"issue":"4","key":"4343_CR18","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/clpt.2012.96","volume":"92","author":"M Whirl-Carrillo","year":"2012","unstructured":"Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012;92(4):414\u20137.","journal-title":"Clin Pharmacol Ther"},{"issue":"D1","key":"4343_CR19","doi-asserted-by":"publisher","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","volume":"51","author":"AP Davis","year":"2023","unstructured":"Davis AP, Wiegers TC, Johnson RJ, Sciaky D, Wiegers J, Mattingly CJ. Comparative toxicogenomics database (CTD): update 2023. Nucleic Acids Res. 2023;51(D1):D1257\u201362.","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"4343_CR20","first-page":"D991","volume":"41","author":"T Barrett","year":"2013","unstructured":"Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, Yefanov A, Lee H, Zhang N, Robertson CL, Serova N, Davis S, Soboleva A. NCBI GEO: archive for functional genomics data sets\u2013update. Nucleic Acids Res. 2013;41(Database issue):D991\u20135.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"4343_CR21","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2105-15-293","volume":"15","author":"P Bardou","year":"2014","unstructured":"Bardou P, Mariette J, Escudi\u00e9 F, Djemiel C, Klopp C. Jvenn: an interactive Venn diagram viewer. BMC Bioinformatics. 2014;15(1):293.","journal-title":"BMC Bioinformatics"},{"key":"4343_CR22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","volume":"1711","author":"B Chen","year":"2018","unstructured":"Chen B, Khodadoust MS, Liu CL, Newman AM, Alizadeh AA. Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol Biol. 2018;1711:243\u201359.","journal-title":"Methods Mol Biol"},{"issue":"W1","key":"4343_CR23","doi-asserted-by":"publisher","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","volume":"48","author":"T Li","year":"2020","unstructured":"Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B, Liu XS. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 2020;48(W1):W509\u201314.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"4343_CR24","first-page":"100625","volume":"5","author":"B Gy\u0151rffy","year":"2024","unstructured":"Gy\u0151rffy B. Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors. Innov (Camb). 2024;5(3):100625.","journal-title":"Innov (Camb)"},{"key":"4343_CR25","doi-asserted-by":"publisher","unstructured":"Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2(5):401-4. https:\/\/doi.org\/10.1158\/2159-8290.CD-12-0095. Erratum in: Cancer Discov. 2012;2(10):960.","DOI":"10.1158\/2159-8290.CD-12-0095"},{"issue":"23","key":"4343_CR26","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1158\/0008-5472.CAN-23-0816","volume":"83","author":"I de Bruijn","year":"2023","unstructured":"de Bruijn I, Kundra R, Mastrogiacomo B, Tran TN, Sikina L, Mazor T, Li X, Ochoa A, Zhao G, Lai B, Abeshouse A, Baiceanu D, Ciftci E, Dogrusoz U, Dufilie A, Erkoc Z, Garcia Lara E, Fu Z, Gross B, Haynes C, Heath A, Higgins D, Jagannathan P, Kalletla K, Kumari P, Lindsay J, Lisman A, Leenknegt B, Lukasse P, Madela D, Madupuri R, van Nierop P, Plantalech O, Quach J, Resnick AC, Rodenburg SYA, Satravada BA, Schaeffer F, Sheridan R, Singh J, Sirohi R, Sumer SO, van Hagen S, Wang A, Wilson M, Zhang H, Zhu K, Rusk N, Brown S, Lavery JA, Panageas KS, Rudolph JE, LeNoue-Newton ML, Warner JL, Guo X, Hunter-Zinck H, Yu TV, Pilai S, Nichols C, Gardos SM, Philip J, AACR Project GENIE BPC Core Team, AACR Project GENIE Consortium, Kehl KL, Riely GJ, Schrag D, Lee J, Fiandalo MV, Sweeney SM, Pugh TJ, Sander C, Cerami E, Gao J, Schultz N. Analysis and visualization of longitudinal genomic and clinical data from the AACR project GENIE biopharma collaborative in cBioPortal. Cancer Res. 2023;83(23):3861\u20137.","journal-title":"Cancer Res"},{"issue":"W1","key":"4343_CR27","doi-asserted-by":"publisher","first-page":"W315","DOI":"10.1093\/nar\/gkz350","volume":"47","author":"K Song","year":"2019","unstructured":"Song K, Li Q, Gao W, Lu S, Shen Q, Liu X, Wu Y, Wang B, Lin H, Chen G, Zhang J. AlloDriver: a method for the identification and analysis of cancer driver targets. Nucleic Acids Res. 2019;47(W1):W315\u201321.","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"4343_CR28","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","volume":"61","author":"J Eberhardt","year":"2021","unstructured":"Eberhardt J, Santos-Martins D, Tillack AF, Forli S, AutoDock. Vina 1.2.0: new Docking Methods, expanded force Field, and python bindings. J Chem Inf Model. 2021;61(8):3891\u20138.","journal-title":"J Chem Inf Model"},{"issue":"2","key":"4343_CR29","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott O, Olson AJ. AutoDock vina: improving the speed and accuracy of Docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010;31(2):455\u201361.","journal-title":"J Comput Chem"},{"key":"4343_CR30","doi-asserted-by":"publisher","unstructured":"Helen M, Berman J, Westbrook Z, Feng G, Gilliland TN, Bhat H, Weissig IN, Shindyalov PE, Bourne. The protein data Bank. Nucleic Acids Res. 2000;28(1):235\u201342. https:\/\/doi.org\/10.1093\/nar\/28.1.235.","DOI":"10.1093\/nar\/28.1.235"},{"key":"4343_CR31","doi-asserted-by":"crossref","unstructured":"Stephen K, Burley R, Bhatt C, Bhikadiya C, Bi A, Biester P, Biswas S, Bittrich S, Blaumann R, Brown H, Chao VR, Chithari PA, Craig, Gregg V, Crichlow, Jose M, Duarte S, Dutta Z, Feng JW, Flatt S, Ghosh DS, Goodsell RK, Green V, Guranovic J, Henry, Brian P, Hudson M, Joy, Jason T, Kaelber I, Khokhriakov J-S, Lai CL, Lawson I, Persikova, Dennis W, Piehl A, Pingale Y, Rose Y, Young. Arthur Zalevsky, Christine Zardecki. Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank. Nucleic Acids Res. 2025;53(D1):D564\u2013D74.","DOI":"10.1093\/nar\/gkae1091"},{"issue":"13","key":"4343_CR32","doi-asserted-by":"publisher","first-page":"134110","DOI":"10.1063\/5.0018516","volume":"153","author":"S P\u00e1ll","year":"2020","unstructured":"P\u00e1ll S, Zhmurov A, Bauer P, Abraham M, Lundborg M, Gray A, Hess B, Lindahl E. Heterogeneous parallelization and acceleration of molecular dynamics simulations in GROMACS. J Chem Phys. 2020;153(13):134110.","journal-title":"J Chem Phys"},{"issue":"7","key":"4343_CR33","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1021\/ci500020m","volume":"54","author":"R Kumari","year":"2014","unstructured":"Kumari R, Kumar R, Open Source Drug Discovery Consortium, Lynn A. g_mmpbsa\u2013a GROMACS tool for high-throughput MM-PBSA calculations. J Chem Inf Model. 2014;54(7):1951\u201362.","journal-title":"J Chem Inf Model"},{"issue":"-","key":"4343_CR34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1008763014207","volume":"18","author":"Massova Irina","year":"2000","unstructured":"Massova, I., Kollman, P.A. Combined molecular mechanical and continuum solvent approach (MM-PBSA\/GBSA) to predict ligand binding. Perspectives in Drug Discovery and Design 18, 113\u2013135 (2000). https:\/\/doi.org\/10.1023\/A:1008763014207","journal-title":"Perspectives in Drug Discovery and Design"},{"issue":"W1","key":"4343_CR35","doi-asserted-by":"publisher","first-page":"W449","DOI":"10.1093\/nar\/gkaa379","volume":"48","author":"B Reynisson","year":"2020","unstructured":"Reynisson B, Alvarez B, Paul S, Peters B, Nielsen M. NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif Deconvolution and integration of MS MHC eluted ligand data. Nucleic Acids Res. 2020;48(W1):W449\u201354.","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"4343_CR36","doi-asserted-by":"publisher","first-page":"W24","DOI":"10.1093\/nar\/gkx346","volume":"45","author":"MC Jespersen","year":"2017","unstructured":"Jespersen MC, Peters B, Nielsen M, Marcatili P. BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes. Nucleic Acids Res. 2017;45(W1):W24\u20139.","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"4343_CR37","doi-asserted-by":"publisher","first-page":"btad590","DOI":"10.1093\/bioinformatics\/btad590","volume":"39","author":"Z Khatooni","year":"2023","unstructured":"Khatooni Z, Teymourian N, Wilson HL. Using a novel structure\/function approach to select diverse swine major histocompatibility complex 1 alleles to predict epitopes for vaccine development. Bioinformatics. 2023;39(10):btad590.","journal-title":"Bioinformatics"},{"key":"4343_CR38","doi-asserted-by":"publisher","first-page":"108613","DOI":"10.1016\/j.pharmthera.2024.108613","volume":"256","author":"E Splendiani","year":"2024","unstructured":"Splendiani E, Besharat ZM, Covre A, Maio M, Di Giacomo AM, Ferretti E. Immunotherapy in melanoma: can we predict response to treatment with Circulating biomarkers? Pharmacol Ther. 2024;256:108613.","journal-title":"Pharmacol Ther"},{"key":"4343_CR39","doi-asserted-by":"publisher","first-page":"108667","DOI":"10.1016\/j.pharmthera.2024.108667","volume":"259","author":"R Ramapriyan","year":"2024","unstructured":"Ramapriyan R, Vykunta VS, Vandecandelaere G, Richardson LGK, Sun J, Curry WT, Choi BD. Altered cancer metabolism and implications for next-generation CAR T-cell therapies. Pharmacol Ther. 2024;259:108667.","journal-title":"Pharmacol Ther"},{"issue":"1","key":"4343_CR40","doi-asserted-by":"publisher","first-page":"166881","DOI":"10.1016\/j.bbadis.2023.166881","volume":"1870","author":"X Yu","year":"2024","unstructured":"Yu X, Zhai X, Wu J, Feng Q, Hu C, Zhu L, Zhou Q. Evolving perspectives regarding the role of the PD-1\/PD-L1 pathway in gastric cancer immunotherapy. Biochim Biophys Acta Mol Basis Dis. 2024;1870(1):166881.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"2","key":"4343_CR41","doi-asserted-by":"publisher","first-page":"166917","DOI":"10.1016\/j.bbadis.2023.166917","volume":"1870","author":"L Niu","year":"2024","unstructured":"Niu L, Wang Q, Feng F, Yang W, Xie Z, Zheng G, Zhou W, Duan L, Du K, Li Y, Tian Y, Chen J, Xie Q, Fan A, Dan H, Liu J, Fan D, Hong L, Zhang J, Zheng J. Small extracellular vesicles-mediated cellular interactions between tumor cells and tumor-associated macrophages: implication for immunotherapy. Biochim Biophys Acta Mol Basis Dis. 2024;1870(2):166917.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4343_CR42","doi-asserted-by":"publisher","first-page":"1103617","DOI":"10.3389\/fimmu.2023.1103617","volume":"14","author":"M Zhang","year":"2023","unstructured":"Zhang M, Li X, Zhang Q, Yang J, Liu G. Roles of macrophages on ulcerative colitis and colitis-associated colorectal cancer. Front Immunol. 2023;14:1103617.","journal-title":"Front Immunol"},{"issue":"19","key":"4343_CR43","doi-asserted-by":"publisher","first-page":"4743","DOI":"10.3390\/cancers15194743","volume":"15","author":"J Schardey","year":"2023","unstructured":"Schardey J, Lu C, Neumann J, Wirth U, Li Q, Jiang T, Zimmermann P, Andrassy J, Bazhin AV, Werner J, K\u00fchn F. Differential immune infiltration profiles in Colitis-Associated colorectal cancer versus sporadic colorectal cancer. Cancers (Basel). 2023;15(19):4743.","journal-title":"Cancers (Basel)"},{"issue":"3","key":"4343_CR44","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41401-023-01188-2","volume":"45","author":"E Cho","year":"2024","unstructured":"Cho E, Mun SJ, Kim HK, Ham YS, Gil WJ, Yang CS. Colon-targeted S100A8\/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models. Acta Pharmacol Sin. 2024;45(3):581\u201393.","journal-title":"Acta Pharmacol Sin"},{"issue":"12","key":"4343_CR45","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.7150\/thno.32126","volume":"9","author":"ZY Liu","year":"2019","unstructured":"Liu ZY, Zheng M, Li YM, Fan XY, Wang JC, Li ZC, Yang HJ, Yu JM, Cui J, Jiang JL, Tang J, Chen ZN. RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression. Theranostics. 2019;9(12):3659\u201373.","journal-title":"Theranostics"},{"issue":"5","key":"4343_CR46","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1053\/j.gastro.2022.07.016","volume":"163","author":"DN Hanna","year":"2022","unstructured":"Hanna DN, Smith PM, Novitskiy SV, Washington MK, Zi J, Weaver CJ, Hamaamen JA, Lewis KB, Zhu J, Yang J, Liu Q, Beauchamp RD, Means AL. SMAD4 suppresses Colitis-associated carcinoma through Inhibition of CCL20\/CCR6-mediated inflammation. Gastroenterology. 2022;163(5):1334\u2013e135014.","journal-title":"Gastroenterology"},{"issue":"9","key":"4343_CR47","doi-asserted-by":"publisher","first-page":"6091","DOI":"10.3390\/curroncol29090479","volume":"29","author":"W Li","year":"2022","unstructured":"Li W, Zhao T, Wu D, Li J, Wang M, Sun Y, Hou S. Colorectal cancer in ulcerative colitis: Mechanisms, surveillance and chemoprevention. Curr Oncol. 2022;29(9):6091\u2013114.","journal-title":"Curr Oncol"},{"issue":"5","key":"4343_CR48","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1053\/j.gastro.2022.01.023","volume":"162","author":"N Krugliak Cleveland","year":"2022","unstructured":"Krugliak Cleveland N, Torres J, Rubin DT. What does disease progression look like in ulcerative Colitis, and how might it be prevented? Gastroenterology. 2022;162(5):1396\u2013408.","journal-title":"Gastroenterology"},{"issue":"3","key":"4343_CR49","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cell.2019.06.029","volume":"178","author":"CS Smillie","year":"2019","unstructured":"Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, Herbst RH, Rogel N, Slyper M, Waldman J, Sud M, Andrews E, Velonias G, Haber AL, Jagadeesh K, Vickovic S, Yao J, Stevens C, Dionne D, Nguyen LT, Villani AC, Hofree M, Creasey EA, Huang H, Rozenblatt-Rosen O, Garber JJ, Khalili H, Desch AN, Daly MJ, Ananthakrishnan AN, Shalek AK, Xavier RJ, Regev A. Intra- and Inter-cellular rewiring of the human colon during ulcerative colitis. Cell. 2019;178(3):714\u2013e73022.","journal-title":"Cell"},{"issue":"1","key":"4343_CR50","doi-asserted-by":"publisher","first-page":"5820","DOI":"10.1038\/s41467-022-33331-8","volume":"13","author":"P Pavlidis","year":"2022","unstructured":"Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby-Bell J, Yang F, Lo JW, Alberts E, Sa ACC, Niazi U, Friedman J, Long AK, Ding Y, Carey CD, Lamb C, Saqi M, Madgwick M, Gul L, Treveil A, Korcsmaros T, Macdonald TT, Lord GM, Bewick G, Powell N. Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy. Nat Commun. 2022;13(1):5820.","journal-title":"Nat Commun"},{"issue":"26","key":"4343_CR51","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1056\/NEJMoa1500596","volume":"372","author":"DT Le","year":"2015","unstructured":"Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Duffy SM, Goldberg RM, de la Chapelle A, Koshiji M, Bhaijee F, Huebner T, Hruban RH, Wood LD, Cuka N, Pardoll DM, Papadopoulos N, Kinzler KW, Zhou S, Cornish TC, Taube JM, Anders RA, Eshleman JR, Vogelstein B, Diaz LA Jr. PD-1 Blockade in tumors with Mismatch-Repair deficiency. N Engl J Med. 2015;372(26):2509\u201320.","journal-title":"N Engl J Med"},{"issue":"13","key":"4343_CR52","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1158\/1078-0432.CCR-18-4070","volume":"25","author":"L Marcus","year":"2019","unstructured":"Marcus L, Lemery SJ, Keegan P, Pazdur R. FDA approval summary: pembrolizumab for the treatment of microsatellite Instability-High solid tumors. Clin Cancer Res. 2019;25(13):3753\u20138.","journal-title":"Clin Cancer Res"},{"issue":"9","key":"4343_CR53","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S1470-2045(17)30422-9","volume":"18","author":"MJ Overman","year":"2017","unstructured":"Overman MJ, McDermott R, Leach JL, Lonardi S, Lenz HJ, Morse MA, Desai J, Hill A, Axelson M, Moss RA, Goldberg MV, Cao ZA, Ledeine JM, Maglinte GA, Kopetz S, Andr\u00e9 T. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol. 2017;18(9):1182\u201391. https:\/\/doi.org\/10.1016\/S1470-2045(17)30422-9.","journal-title":"Lancet Oncol"},{"key":"4343_CR54","first-page":"1","volume":"3","author":"X Ai","year":"2023","unstructured":"Ai X, Smith MC, Feltus FA. Generative adversarial networks applied to gene expression analysis: an interdisciplinary perspective. Comput Syst Oncol. 2023;3:1\u201317.","journal-title":"Comput Syst Oncol"},{"key":"4343_CR55","doi-asserted-by":"publisher","first-page":"968165","DOI":"10.3389\/fimmu.2022.968165","volume":"13","author":"M Khan","year":"2022","unstructured":"Khan M, Lin J, Wang B, Chen C, Huang Z, Tian Y, Yuan Y, Bu J. A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma. Front Immunol. 2022;13:968165.","journal-title":"Front Immunol"},{"key":"4343_CR56","doi-asserted-by":"publisher","first-page":"1213891","DOI":"10.3389\/fphar.2023.1213891","volume":"14","author":"L Li","year":"2023","unstructured":"Li L, Li F, Xu Z, Li L, Hu H, Li Y, Yu S, Wang M, Gao L. Identification and validation of SERPINE1 as a prognostic and immunological biomarker in pan-cancer and in CcRCC. Front Pharmacol. 2023;14:1213891.","journal-title":"Front Pharmacol"},{"key":"4343_CR57","doi-asserted-by":"publisher","first-page":"goad041","DOI":"10.1093\/gastro\/goad041","volume":"11","author":"C Zhan","year":"2023","unstructured":"Zhan C, Zhou Z, Huang Y, Huang S, Lin Z, He F, Song Z. Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease: evidence from transcriptome data. Gastroenterol Rep (Oxf). 2023;11:goad041.","journal-title":"Gastroenterol Rep (Oxf)"},{"issue":"4","key":"4343_CR58","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.ccell.2022.02.013","volume":"40","author":"Y Liu","year":"2022","unstructured":"Liu Y, Zhang Q, Xing B, Luo N, Gao R, Yu K, Hu X, Bu Z, Peng J, Ren X, Zhang Z. Immune phenotypic linkage between colorectal cancer and liver metastasis. Cancer Cell. 2022;40(4):424\u2013e4375.","journal-title":"Cancer Cell"},{"issue":"6657","key":"4343_CR59","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1126\/science.ade2292","volume":"381","author":"R Bill","year":"2023","unstructured":"Bill R, Wirapati P, Messemaker M, Roh W, Zitti B, Duval F, Kiss M, Park JC, Saal TM, Hoelzl J, Tarussio D, Benedetti F, Tissot S, Kandalaft L, Varrone M, Ciriello G, McKee TA, Monnier Y, Mermod M, Blaum EM, Gushterova I, Gonye ALK, Hacohen N, Getz G, Mempel TR, Klein AM, Weissleder R, Faquin WC, Sadow PM, Lin D, Pai SI, Sade-Feldman M, Pittet MJ. CXCL9:SPP1 macrophage Polarity identifies a network of cellular programs that control human cancers. Science. 2023;381(6657):515\u201324.","journal-title":"Science"},{"issue":"6654","key":"4343_CR60","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1126\/science.abq3061","volume":"381","author":"M Hulsmans","year":"2023","unstructured":"Hulsmans M, Schloss MJ, Lee IH, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous FE, Keller D, Bening C, Green U, Lennerz JK, Mitchell RN, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong CS, Pierson RN, Aster JC, Rohde D, Wojtkiewicz GR, Weissleder R, Swirski FK, Tellides G, Tolis G Jr, Melnitchouk S, Milan DJ, Ellinor PT, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science. 2023;381(6654):231\u20139.","journal-title":"Science"},{"key":"4343_CR61","doi-asserted-by":"publisher","first-page":"728062","DOI":"10.3389\/fimmu.2021.728062","volume":"12","author":"D Chen","year":"2021","unstructured":"Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X. Development and verification of the Hypoxia- and Immune-Associated prognostic signature for pancreatic ductal adenocarcinoma. Front Immunol. 2021;12:728062.","journal-title":"Front Immunol"},{"issue":"2","key":"4343_CR62","doi-asserted-by":"publisher","first-page":"166965","DOI":"10.1016\/j.bbadis.2023.166965","volume":"1870","author":"K Shi","year":"2024","unstructured":"Shi K, Zhou J, Li M, Yan W, Zhang J, Zhang X, Jiang L. Pan-cancer analysis of PLAU indicates its potential prognostic value and correlation with neutrophil infiltration in BLCA. Biochim Biophys Acta Mol Basis Dis. 2024;1870(2):166965.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"19","key":"4343_CR63","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.1158\/0008-5472.CAN-22-1417","volume":"82","author":"G Wang","year":"2022","unstructured":"Wang G, Xie Z, Su J, Chen M, Du Y, Gao Q, Zhang G, Zhang H, Chen X, Liu H, Han L, Ye Y. Characterization of Immune-Related alternative polyadenylation events in cancer immunotherapy. Cancer Res. 2022;82(19):3474\u201385.","journal-title":"Cancer Res"},{"issue":"8","key":"4343_CR64","doi-asserted-by":"publisher","first-page":"7304","DOI":"10.3390\/ijms24087304","volume":"24","author":"D Murthy","year":"2023","unstructured":"Murthy D, Attri KS. PTGES expression is associated with metabolic and immune reprogramming in pancreatic ductal adenocarcinoma. Int J Mol Sci. 2023;24(8):7304.","journal-title":"Int J Mol Sci"},{"issue":"15","key":"4343_CR65","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1038\/s41388-020-1207-6","volume":"39","author":"T Wang","year":"2020","unstructured":"Wang T, Jing B, Xu D, Liao Y, Song H, Sun B, Guo W, Xu J, Li K, Hu M, Liu S, Ling J, Kuang Y, Zhang T, Zhang S, Yao F, Zhou BP, Deng J. PTGES\/PGE2 signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model. Oncogene. 2020;39(15):3179\u201394.","journal-title":"Oncogene"},{"key":"4343_CR66","doi-asserted-by":"publisher","first-page":"106891","DOI":"10.1016\/j.phrs.2023.106891","volume":"195","author":"L Hidalgo-Garc\u00eda","year":"2023","unstructured":"Hidalgo-Garc\u00eda L, Ruiz-Malagon AJ, Huertas F, Rodr\u00edguez-Sojo MJ, Molina-Tijeras JA, Diez-Echave P, Becerra P, Mir\u00f3n B, Mor\u00f3n R, Rodr\u00edguez-Nogales A, G\u00e1lvez J, Rodr\u00edguez-Cabezas ME, Anderson P. Administration of intestinal mesenchymal stromal cells reduces colitis-associated cancer in C57BL\/6J mice modulating the immune response and gut dysbiosis. Pharmacol Res. 2023;195:106891.","journal-title":"Pharmacol Res"},{"issue":"8","key":"4343_CR67","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1038\/s41591-022-01868-2","volume":"28","author":"AX Zhu","year":"2022","unstructured":"Zhu AX, Abbas AR, de Galarreta MR, Guan Y, Lu S, Koeppen H, Zhang W, Hsu CH, He AR, Ryoo BY, Yau T, Kaseb AO, Burgoyne AM, Dayyani F, Spahn J, Verret W, Finn RS, Toh HC, Lujambio A, Wang Y. Molecular correlates of clinical response and resistance to Atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma. Nat Med. 2022;28(8):1599\u2013611.","journal-title":"Nat Med"},{"issue":"1","key":"4343_CR68","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/s41467-023-36892-4","volume":"14","author":"X Bai","year":"2023","unstructured":"Bai X, Guo ZQ, Zhang YP, Fan ZZ, Liu LJ, Liu L, Long LL, Ma SC, Wang J, Fang Y, Tang XR, Zeng YJ, Pan X, Wu DH, Dong ZY. CDK4\/6 Inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy. Nat Commun. 2023;14(1):1247.","journal-title":"Nat Commun"},{"issue":"13","key":"4343_CR69","doi-asserted-by":"publisher","first-page":"e23802","DOI":"10.1096\/fj.202302176R","volume":"38","author":"C Yang","year":"2024","unstructured":"Yang C, Ni B, Shen L, Li Z, Zhou L, Wu H, Zhang Y, Liu L, Liu J, Tian L, Yan L, Jin X. Systematic pan-cancer analysis insights into ICAM1 as an immunological and prognostic biomarker. FASEB J. 2024;38(13):e23802.","journal-title":"FASEB J"},{"issue":"11","key":"4343_CR70","doi-asserted-by":"publisher","first-page":"e23242","DOI":"10.1096\/fj.202300462RR","volume":"37","author":"CH Chu","year":"2023","unstructured":"Chu CH, Chen JS, Chan YL, Lu WJ, Huang YT, Mao PC, Sze CI, Sun HS. TIAM2S-positive microglia enhance inflammation and neurotoxicity through soluble ICAM-1-mediated immune priming. FASEB J. 2023;37(11):e23242.","journal-title":"FASEB J"},{"issue":"4","key":"4343_CR71","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.ccell.2020.03.013","volume":"37","author":"M Drosten","year":"2020","unstructured":"Drosten M, Barbacid M. Targeting the MAPK pathway in KRAS-Driven tumors. Cancer Cell. 2020;37(4):543\u201350.","journal-title":"Cancer Cell"},{"issue":"2","key":"4343_CR72","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/joim.13057","volume":"288","author":"JG Christensen","year":"2020","unstructured":"Christensen JG, Olson P, Briere T, Wiel C, Bergo MO. Targeting Krasg12c -mutant cancer with a mutation-specific inhibitor. J Intern Med. 2020;288(2):183\u201391.","journal-title":"J Intern Med"},{"issue":"8","key":"4343_CR73","doi-asserted-by":"publisher","first-page":"e173205","DOI":"10.1172\/jci.insight.173205","volume":"9","author":"H Deng","year":"2024","unstructured":"Deng H, Liang WY, Chen LQ, Yuen TH, Sahin B, Vasilescu DM, Trinder M, Walley K, Rensen PCN, Boyd JH, Brunham LR. CETP Inhibition enhances monocyte activation and bacterial clearance and reduces Streptococcus pneumonia-associated mortality in mice. JCI Insight. 2024;9(8):e173205.","journal-title":"JCI Insight"},{"issue":"5","key":"4343_CR74","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1053\/j.gastro.2024.01.026","volume":"166","author":"AO Bamidele","year":"2024","unstructured":"Bamidele AO, Mishra SK, Piovezani Ramos G, Hirsova P, Klatt EE, Abdelrahman LM, Sagstetter MR, Davidson HM, Fehrenbach PJ, Valenzuela-P\u00e9rez L, Kim Lee HS, Zhang S, Aguirre Lopez A, Kurdi AT, Westphal MS, Gonzalez MM, Gaballa JM, Kosinsky RL, Lee HE, Smyrk TC, Bantug G, Gades NM, Faubion WA Jr. Interleukin 21 drives a hypermetabolic state and CD4\u2009+\u2009T-Cell-Associated pathogenicity in chronic intestinal inflammation. Gastroenterology. 2024;166(5):826\u2013e84119.","journal-title":"Gastroenterology"},{"issue":"6","key":"4343_CR75","doi-asserted-by":"publisher","first-page":"101073","DOI":"10.1016\/j.jhepr.2024.101073","volume":"6","author":"M Khoury","year":"2024","unstructured":"Khoury M, Guo Q, Furuta K, Correia C, Meroueh C, Kim Lee HS, Warasnhe K, Valenzuela-P\u00e9rez L, Mazar AP, Kim I, Noh YK, Holmes H, Romero MF, Sussman CR, Pavelko KD, Islam S, Bamidele AO, Hirsova P, Li H, Ibrahim SH. Glycogen synthase kinase 3 activity enhances liver inflammation in MASH. JHEP Rep. 2024;6(6):101073.","journal-title":"JHEP Rep"},{"issue":"1","key":"4343_CR76","doi-asserted-by":"publisher","first-page":"4365","DOI":"10.1038\/s41467-021-24562-2","volume":"12","author":"AS Bear","year":"2021","unstructured":"Bear AS, Blanchard T, Cesare J, Ford MJ, Richman LP, Xu C, Baroja ML, McCuaig S, Costeas C, Gabunia K, Scholler J, Posey AD Jr, O\u2019Hara MH, Smole A, Powell DJ Jr, Garcia BA, Vonderheide RH, Linette GP, Carreno BM. Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting. Nat Commun. 2021;12(1):4365.","journal-title":"Nat Commun"},{"issue":"1","key":"4343_CR77","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1038\/s41467-020-16755-y","volume":"11","author":"D Wu","year":"2020","unstructured":"Wu D, Gallagher DT, Gowthaman R, Pierce BG, Mariuzza RA. Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen. Nat Commun. 2020;11(1):2908.","journal-title":"Nat Commun"},{"issue":"5","key":"4343_CR78","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/s41591-022-01786-3","volume":"28","author":"SS Chandran","year":"2022","unstructured":"Chandran SS, Ma J, Klatt MG, D\u00fcndar F, Bandlamudi C, Razavi P, Wen HY, Weigelt B, Zumbo P, Fu SN, Banks LB, Yi F, Vercher E, Etxeberria I, Bestman WD, Da Cruz Paula A, Aricescu IS, Drilon A, Betel D, Scheinberg DA, Baker BM, Klebanoff CA. Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nat Med. 2022;28(5):946\u201357.","journal-title":"Nat Med"},{"issue":"11","key":"4343_CR79","doi-asserted-by":"publisher","first-page":"e1461","DOI":"10.1002\/ctm2.1461","volume":"13","author":"YJ Zhu","year":"2023","unstructured":"Zhu YJ, Li X, Chen TT, Wang JX, Zhou YX, Mu XL, Du Y, Wang JL, Tang J, Liu JY. Personalised neoantigen-based therapy in colorectal cancer. Clin Transl Med. 2023;13(11):e1461.","journal-title":"Clin Transl Med"},{"issue":"4","key":"4343_CR80","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nrc.2016.154","volume":"17","author":"M Yarchoan","year":"2017","unstructured":"Yarchoan M, Johnson BA 3rd, Lutz ER, Laheru DA, Jaffee EM. Targeting neoantigens to augment antitumour immunity. Nat Rev Cancer. 2017;17(4):209\u201322.","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"4343_CR81","doi-asserted-by":"publisher","first-page":"166941","DOI":"10.1016\/j.bbadis.2023.166941","volume":"1870","author":"ZR Kang","year":"2024","unstructured":"Kang ZR, Jiang S, Han JX, Gao Y, Xie Y, Chen J, Liu Q, Yu J, Zhao X, Hong J, Chen H, Chen YX, Chen H, Fang JY. Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development. Biochim Biophys Acta Mol Basis Dis. 2024;1870(2):166941.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"6","key":"4343_CR82","doi-asserted-by":"publisher","first-page":"167250","DOI":"10.1016\/j.bbadis.2024.167250","volume":"1870","author":"SJ Lee","year":"2024","unstructured":"Lee SJ, Jeon SH, Cho S, Kim CM, Yoo JK, Oh SH, Kim JH, Yang YD, Kim JK. hsa-miR-CHA2, a novel microRNA, exhibits anticancer effects by suppressing Cyclin E1 in human non-small cell lung cancer cells. Biochim Biophys Acta Mol Basis Dis. 2024;1870(6):167250.","journal-title":"Biochim Biophys Acta Mol Basis Dis"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-04343-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04343-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04343-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T16:03:24Z","timestamp":1769789004000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-04343-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":82,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4343"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-04343-9","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"189"}}