{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T01:59:40Z","timestamp":1770083980154,"version":"3.49.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Datta Meghe Institute of Higher Education and Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hodgkin lymphoma is a rare lymph node malignancy that has the presence of Reed-Sternberg cells. We describe a case of a 72-year-old male with progressive bilateral cervical and inguinal lymphadenopathy with the absence of constitutional symptoms. Primary clinical and radiographic assessment was in favor of an infectious or metastatic etiology. Classical Hodgkin lymphoma was confirmed by excisional biopsy of the lymph nodes that demonstrated classic Reed-Sternberg cells in a polymorphous inflammatory background. Additional support to the diagnosis was provided by immunohistochemistry. The patient was staged at Ann Arbor stage IIIB disease and sent to oncologic care, where he was placed on systemic chemotherapy. The case demonstrates that persistent lymphadenopathy can be a hard-to-detect disease, particularly in tuberculosis-endemic regions, and that a timely biopsy and comprehensive evaluation are necessary to avoid diagnostic lag time and offer treatment before it is too late.<\/jats:p>","DOI":"10.1007\/s12672-025-04371-5","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:33:34Z","timestamp":1767206014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual bilateral lymphadenopathy revealing Hodgkin\u2019s lymphoma: a case report"],"prefix":"10.1007","volume":"17","author":[{"given":"Vaishnavi D.","family":"Rajurkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshao","family":"Hiwale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahitya","family":"Vodithala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha D.","family":"Barole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prajakta","family":"Nimbalkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"4371_CR1","unstructured":"Kaseb H, Babiker HM. Hodgkin Lymphoma. Treasure Island (FL): StatPearls Publishing; 2024. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499969\/. Accessed 11 Nov 2024."},{"issue":"2","key":"4371_CR2","first-page":"116","volume":"68","author":"S Shanbhag","year":"2018","unstructured":"Shanbhag S, Ambinder R. Hodgkin lymphoma: a review and update on recent progress. CA Cancer J Clin. 2018;68(2):116\u201332.","journal-title":"CA Cancer J Clin"},{"key":"4371_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fpubh.2016.00031","volume":"4","author":"K Thakkar","year":"2016","unstructured":"Thakkar K, Ghaisas SM, Singh M, Lymphadenopathy. Differentiation between tuberculosis and other Non-Tuberculosis causes like follicular lymphoma. Front Public Health. 2016;4:31.","journal-title":"Front Public Health"},{"key":"4371_CR4","unstructured":"Maini R, Nagalli S. Adenopathy. Treasure Island (FL): StatPearls Publishing; 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK558918\/. 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Int J Mol Sci. 2023;24(12):10095.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"4371_CR7","doi-asserted-by":"publisher","first-page":"5644","DOI":"10.4081\/hr.2015.5644","volume":"7","author":"N G\u00f6knar","year":"2015","unstructured":"G\u00f6knar N, \u00c7ak\u0131r E, \u00c7ak\u0131r FB, Kasapcopur O, Yegen G, Gedik AH, et al. A difficult case of hodgkin lymphoma with differential diagnosis of tuberculosis and sarcoidosis. Hematol Rep. 2015;7(2):5644.","journal-title":"Hematol Rep"},{"issue":"3","key":"4371_CR8","doi-asserted-by":"publisher","first-page":"e155","DOI":"10.15190\/d.2022.14","volume":"10","author":"G Yadav","year":"2022","unstructured":"Yadav G, Singh A, Jain M, Kushwaha R, Verma SP. Reed sternberg-like cells in non-Hodgkin lymphoma: a diagnostic challenge. Discoveries. 2022;10(3):e155.","journal-title":"Discoveries"},{"issue":"5","key":"4371_CR9","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s00277-022-04789-9","volume":"101","author":"T Husby","year":"2022","unstructured":"Husby T, Johansen H, Bogsrud T, Hustad KV, Evensen BV, Boellard R, et al. A comparison of FDG PET\/MR and PET\/CT for staging, response assessment, and prognostic imaging biomarkers in lymphoma. Ann Hematol. 2022;101(5):1077\u201388.","journal-title":"Ann Hematol"},{"key":"4371_CR10","doi-asserted-by":"publisher","first-page":"1017787","DOI":"10.3389\/fonc.2022.1017787","volume":"12","author":"A Barrett","year":"2023","unstructured":"Barrett A, Collins GP. Older patients with hodgkin lymphoma: walking the tightrope of efficacy and toxicity. Front Oncol. 2023;12:1017787.","journal-title":"Front Oncol"},{"issue":"1","key":"4371_CR11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.17998\/jlc.2024.02.27","volume":"24","author":"JH Oh","year":"2024","unstructured":"Oh JH, Sinn DH. Multidisciplinary approach for hepatocellular carcinoma patients: current evidence and future perspectives. J Liver Cancer. 2024;24(1):47\u201356.","journal-title":"J Liver Cancer"},{"issue":"1","key":"4371_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/ejh.13863","volume":"110","author":"AR Paquin","year":"2023","unstructured":"Paquin AR, Oyogoa E, McMurry HS, Kartika T, West M, Shatzel JJ. The diagnosis and management of suspected lymphoma in general practice. Eur J Haematol. 2023;110(1):3\u201313.","journal-title":"Eur J Haematol"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-025-04371-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04371-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-025-04371-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:54:24Z","timestamp":1770036864000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-025-04371-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4371"],"URL":"https:\/\/doi.org\/10.1007\/s12672-025-04371-5","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]},"assertion":[{"value":"6 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was reviewed and approved by the Institutional Ethics Committee of DMIHER. All experiments involving human participants, human data, or tissue samples were conducted in full accordance with relevant guidelines and regulations. Written informed consent was obtained from the patient before their involvement in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained for the publication of images\/ identifying information in an open access journal from the participant. Written informed consent was obtained from the patient for publication of this case report and any accompanying images or potentially identifying information in an open-access journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"202"}}