{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:54:16Z","timestamp":1793933656721,"version":"4.8.0"},"reference-count":273,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University","award":["grant number IMSIU-DDRSP2601"],"award-info":[{"award-number":["grant number IMSIU-DDRSP2601"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-026-04687-w","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:36:59Z","timestamp":1771508219000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The emerging role of exosomal circRNAs in modulating apoptotic pathways and overcoming cancer therapy resistance"],"prefix":"10.1007","volume":"17","author":[{"given":"Mokhtar","family":"Rejili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najma","family":"Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"4687_CR1","doi-asserted-by":"crossref","unstructured":"Simeone P, Bologna G, Lanuti P, Pierdomenico L, Guagnano MT, Pieragostino D et al. Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers. Int J Mol Sci. 2020;21(7):2514.","DOI":"10.3390\/ijms21072514"},{"issue":"1","key":"4687_CR2","doi-asserted-by":"publisher","first-page":"11585","DOI":"10.1038\/s41598-021-91129-y","volume":"11","author":"S Allelein","year":"2021","unstructured":"Allelein S, Medina-Perez P, Lopes ALH, Rau S, Hause G, K\u00f6lsch A, et al. Potential and challenges of specifically isolating extracellular vesicles from heterogeneous populations. Sci Rep. 2021;11(1):11585.","journal-title":"Sci Rep"},{"issue":"9","key":"4687_CR3","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1093\/stcltm\/szae052","volume":"13","author":"D Upadhya","year":"2024","unstructured":"Upadhya D, Shetty AK. MISEV2023 provides an updated and key reference for researchers studying the basic biology and applications of extracellular vesicles. Stem Cells Translational Med. 2024;13(9):848\u201350.","journal-title":"Stem Cells Translational Med"},{"issue":"4","key":"4687_CR4","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/ijms20040953","volume":"20","author":"S Kagota","year":"2019","unstructured":"Kagota S, Taniguchi K, Lee S-W, Ito Y, Kuranaga Y, Hashiguchi Y, et al. Analysis of extracellular vesicles in gastric juice from gastric cancer patients. Int J Mol Sci. 2019;20(4):953.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4687_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"C He","year":"2018","unstructured":"He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8(1):237.","journal-title":"Theranostics"},{"key":"4687_CR6","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1007\/s00018-014-1811-0","volume":"72","author":"N Nishida-Aoki","year":"2015","unstructured":"Nishida-Aoki N, Ochiya T. Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles. Cell Mol Life Sci. 2015;72:1849\u201361.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"4687_CR7","doi-asserted-by":"publisher","first-page":"6494","DOI":"10.1038\/s41598-020-62920-0","volume":"10","author":"P Reclusa","year":"2020","unstructured":"Reclusa P, Verstraelen P, Taverna S, Gunasekaran M, Pucci M, Pintelon I, et al. Improving extracellular vesicles visualization: From static to motion. Sci Rep. 2020;10(1):6494.","journal-title":"Sci Rep"},{"issue":"2","key":"4687_CR8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1083\/jcb.201506084","volume":"213","author":"W Heusermann","year":"2016","unstructured":"Heusermann W, Hean J, Trojer D, Steib E, Von Bueren S, Graff-Meyer A, et al. Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER. J Cell Biol. 2016;213(2):173\u201384.","journal-title":"J Cell Biol"},{"key":"4687_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10456-011-9241-1","volume":"15","author":"M Mineo","year":"2012","unstructured":"Mineo M, Garfield SH, Taverna S, Flugy A, De Leo G, Alessandro R, et al. Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion. Angiogenesis. 2012;15:33\u201345.","journal-title":"Angiogenesis"},{"issue":"6","key":"4687_CR10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.gendis.2020.12.004","volume":"8","author":"H Nie","year":"2021","unstructured":"Nie H, Liao Z, Wang Y, Zhou J, He X, Ou C. Exosomal long non-coding RNAs: Emerging players in cancer metastasis and potential diagnostic biomarkers for personalized oncology. Genes Dis. 2021;8(6):769\u201380.","journal-title":"Genes Dis"},{"issue":"14","key":"4687_CR11","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.3390\/cancers14143404","volume":"14","author":"G Cammarata","year":"2022","unstructured":"Cammarata G, Barraco N, Giusti I, Gristina V, Dolo V, Taverna S. Extracellular vesicles-ceRNAs as ovarian cancer biomarkers: looking into circRNA-miRNA-mRNA code. Cancers. 2022;14(14):3404.","journal-title":"Cancers"},{"key":"4687_CR12","doi-asserted-by":"publisher","first-page":"175755","DOI":"10.1016\/j.ejphar.2023.175755","volume":"950","author":"A Mafi","year":"2023","unstructured":"Mafi A, Keshavarzmotamed A, Hedayati N, Yeganeh Boroujeni Z, Reiter RJ, Mousavi Dehmordi R, et al. Melatonin targeting non-coding RNAs in cancer: Focus on mechanisms and potential therapeutic targets. Eur J Pharmacol. 2023;950:175755.","journal-title":"Eur J Pharmacol"},{"key":"4687_CR13","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.envpol.2019.01.014","volume":"247","author":"R Huang","year":"2019","unstructured":"Huang R, Zhou P. Double-edged effects of noncoding RNAs in responses to environmental genotoxic insults: Perspectives with regards to molecule-ecology network. Environ Pollut. 2019;247:64\u201371.","journal-title":"Environ Pollut"},{"issue":"2","key":"4687_CR14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2174\/1566524023666230110151155","volume":"24","author":"S Mazloomi","year":"2024","unstructured":"Mazloomi S, Mousavi V, Aghadavod E, Mafi A. Circular RNAs: Emerging Modulators in the Pathophysiology of Polycystic Ovary Syndrome and their Clinical Implications. Curr Mol Med. 2024;24(2):153\u201366.","journal-title":"Curr Mol Med"},{"issue":"1","key":"4687_CR15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.molcel.2017.02.021","volume":"66","author":"NR Pamudurti","year":"2017","unstructured":"Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, et al. Translation of circRNAs. Mol Cell. 2017;66(1):9\u201321. e7.","journal-title":"Mol Cell"},{"issue":"6","key":"4687_CR16","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.3390\/cancers12061445","volume":"12","author":"A Abramowicz","year":"2020","unstructured":"Abramowicz A, Story MD. The Long and Short of It: The Emerging Roles of Non-Coding RNA in Small Extracellular Vesicles. Cancers. 2020;12(6):1445.","journal-title":"Cancers"},{"key":"4687_CR17","first-page":"2021","volume":"11","author":"Y Qiu","year":"2021","unstructured":"Qiu Y, Li P, Zhang Z, Wu M. Corrigendum: Insights Into Exosomal Non-Coding RNAs Sorting Mechanism and Clinical Application. Front Oncol. 2021;11:2021.","journal-title":"Front Oncol"},{"issue":"48","key":"4687_CR18","doi-asserted-by":"publisher","first-page":"34389","DOI":"10.1074\/jbc.274.48.34389","volume":"274","author":"TP Munro","year":"1999","unstructured":"Munro TP, Magee RJ, Kidd GJ, Carson JH, Barbarese E, Smith LM, et al. Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking. J Biol Chem. 1999;274(48):34389\u201395.","journal-title":"J Biol Chem"},{"issue":"1","key":"4687_CR19","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1038\/ncomms3980","volume":"4","author":"C Villarroya-Beltri","year":"2013","unstructured":"Villarroya-Beltri C, Guti\u00e9rrez-V\u00e1zquez C, S\u00e1nchez-Cabo F, P\u00e9rez-Hern\u00e1ndez D, V\u00e1zquez J, Martin-Cofreces N, et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun. 2013;4(1):2980.","journal-title":"Nat Commun"},{"issue":"1","key":"4687_CR20","doi-asserted-by":"publisher","first-page":"14448","DOI":"10.1038\/ncomms14448","volume":"8","author":"Y Teng","year":"2017","unstructured":"Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, et al. MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nat Commun. 2017;8(1):14448.","journal-title":"Nat Commun"},{"key":"4687_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-021-01396-6","volume":"20","author":"X-H Tang","year":"2021","unstructured":"Tang X-H, Guo T, Gao X-Y, Wu X-L, Xing X-F, Ji J-F, et al. Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications. Mol Cancer. 2021;20:1\u201315.","journal-title":"Mol Cancer"},{"issue":"13","key":"4687_CR22","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.3390\/cancers17132186","volume":"17","author":"Y-W Luo","year":"2025","unstructured":"Luo Y-W, Liu C-G, Kirby JA, Chu C, Zang D, Chen J. The Emerging Role of Extracellular Vesicle-Derived lncRNAs and circRNAs in Tumor and Mesenchymal Stem Cells: The Biological Functions and Potential for Clinical Application. Cancers. 2025;17(13):2186.","journal-title":"Cancers"},{"issue":"6","key":"4687_CR23","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/s41419-022-04949-9","volume":"13","author":"B Tuo","year":"2022","unstructured":"Tuo B, Chen Z, Dang Q, Chen C, Zhang H, Hu S, et al. Roles of exosomal circRNAs in tumour immunity and cancer progression. Cell Death Dis. 2022;13(6):539.","journal-title":"Cell Death Dis"},{"key":"4687_CR24","unstructured":"Kerr J. Definition and incidence of apoptosis: an historical perspective. Apoptosis: Mol basis cell death. 1991;3:5\u201329."},{"key":"4687_CR25","doi-asserted-by":"publisher","first-page":"1224151","DOI":"10.3389\/fphar.2023.1224151","volume":"14","author":"A Mafi","year":"2023","unstructured":"Mafi A, Rismanchi H, Gholinezhad Y, Mohammadi MM, Mousavi V, Hosseini SA, et al. Melatonin as a regulator of apoptosis in leukaemia: molecular mechanism and therapeutic perspectives. Front Pharmacol. 2023;14:1224151.","journal-title":"Front Pharmacol"},{"key":"4687_CR26","doi-asserted-by":"crossref","unstructured":"Tian X, Srinivasan PR, Tajiknia V, Sanchez Sevilla Uruchurtu AF, Seyhan AA, Carneiro BA et al. Targeting apoptotic pathways for cancer therapy. J Clin Invest. 2024;134(14).","DOI":"10.1172\/JCI179570"},{"key":"4687_CR27","doi-asserted-by":"crossref","unstructured":"Mustafa M, Ahmad R, Tantry IQ, Ahmad W, Siddiqui S, Alam M et al. Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications. Cells. 2024;13(22):1838.","DOI":"10.3390\/cells13221838"},{"issue":"8","key":"4687_CR28","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1038\/sj.cdd.4401963","volume":"13","author":"JE Chipuk","year":"2006","unstructured":"Chipuk JE, Bouchier-Hayes L, Green DR. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 2006;13(8):1396\u2013402.","journal-title":"Cell Death Differ"},{"issue":"6","key":"4687_CR29","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1038\/cddis.2010.26","volume":"1","author":"L Flanagan","year":"2010","unstructured":"Flanagan L, Sebasti\u00e0 J, Tuffy LP, Spring A, Lichawska A, Devocelle M, et al. XIAP impairs Smac release from the mitochondria during apoptosis. Cell Death Dis. 2010;1(6):e49.","journal-title":"Cell Death Dis"},{"key":"4687_CR30","doi-asserted-by":"crossref","unstructured":"Green DR. The Death Receptor Pathway of Apoptosis. Cold Spring Harb Perspect Biol. 2022;14(2):a041053.","DOI":"10.1101\/cshperspect.a041053"},{"issue":"10","key":"4687_CR31","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","volume":"24","author":"PE Czabotar","year":"2023","unstructured":"Czabotar PE, Garcia-Saez AJ. Mechanisms of BCL-2 family proteins in mitochondrial apoptosis. Nat Rev Mol Cell Biol. 2023;24(10):732\u201348.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4687_CR32","doi-asserted-by":"crossref","unstructured":"Qian S, Wei Z, Yang W, Huang J, Yang Y, Wang J. The role of BCL-2 family proteins in regulating apoptosis and cancer therapy. Front Oncol. 2022;12:985363.","DOI":"10.3389\/fonc.2022.985363"},{"issue":"1","key":"4687_CR33","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s43042-024-00485-7","volume":"25","author":"M Saddam","year":"2024","unstructured":"Saddam M, Paul SK, Habib MA, Fahim MA, Mimi A, Islam S, et al. Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context. Egypt J Med Hum Genet. 2024;25(1):12.","journal-title":"Egypt J Med Hum Genet"},{"key":"4687_CR34","doi-asserted-by":"crossref","unstructured":"King LE, Hohorst L, Garc\u00eda-S\u00e1ez AJ. Expanding roles of BCL-2 proteins in apoptosis execution and beyond. J Cell Sci. 2023;136(22):jcs260790.","DOI":"10.1242\/jcs.260790"},{"issue":"12","key":"4687_CR35","doi-asserted-by":"publisher","first-page":"e443","DOI":"10.1038\/cddis.2012.178","volume":"3","author":"G Rautureau","year":"2012","unstructured":"Rautureau G, Yabal M, Yang H, Huang D, Kvansakul M, Hinds M. The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist. Cell Death Dis. 2012;3(12):e443\u2013e.","journal-title":"Cell Death Dis"},{"issue":"1","key":"4687_CR36","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.devcel.2011.06.017","volume":"21","author":"J-C Martinou","year":"2011","unstructured":"Martinou J-C, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 2011;21(1):92\u2013101.","journal-title":"Dev Cell"},{"issue":"268","key":"4687_CR37","doi-asserted-by":"publisher","first-page":"ra20","DOI":"10.1126\/scisignal.2003483","volume":"6","author":"GR Bean","year":"2013","unstructured":"Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, et al. PUMA and BIM are required for oncogene inactivation\u2013induced apoptosis. Sci Signal. 2013;6(268):ra20\u2013ra.","journal-title":"Sci Signal"},{"issue":"3","key":"4687_CR38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1083\/jcb.200904049","volume":"187","author":"JK Brunelle","year":"2009","unstructured":"Brunelle JK, Ryan J, Yecies D, Opferman JT, Letai A. MCL-1\u2013dependent leukemia cells are more sensitive to chemotherapy than BCL-2\u2013dependent counterparts. J Cell Biol. 2009;187(3):429\u201342.","journal-title":"J Cell Biol"},{"issue":"9","key":"4687_CR39","first-page":"3226","volume":"92","author":"P Zhou","year":"1998","unstructured":"Zhou P, Qian L, Bieszczad CK, Noelle R, Binder M, Levy NB, et al. Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage. Blood J Am Soc Hematol. 1998;92(9):3226\u201339.","journal-title":"Blood J Am Soc Hematol"},{"issue":"6189","key":"4687_CR40","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/335440a0","volume":"335","author":"DL Vaux","year":"1988","unstructured":"Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature. 1988;335(6189):440\u20132.","journal-title":"Nature"},{"issue":"12","key":"4687_CR41","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.tcb.2013.07.006","volume":"23","author":"K Fernald","year":"2013","unstructured":"Fernald K, Kurokawa M. Evading apoptosis in cancer. Trends Cell Biol. 2013;23(12):620\u201333.","journal-title":"Trends Cell Biol"},{"key":"4687_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/bcr426","volume":"4","author":"M Gasco","year":"2002","unstructured":"Gasco M, Shami S, Crook T. The p53 pathway in breast cancer. Breast Cancer Res. 2002;4:1\u20137.","journal-title":"Breast Cancer Res"},{"key":"4687_CR43","doi-asserted-by":"crossref","unstructured":"Rodrigues NR, Rowan A, Smith M, Kerr IB, Bodmer WF, Gannon JV et al. p53 mutations in colorectal cancer. Proceedings of the National Academy of Sciences. 1990;87(19):7555-9.","DOI":"10.1073\/pnas.87.19.7555"},{"key":"4687_CR44","doi-asserted-by":"crossref","unstructured":"Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B et al. Mutant p53 drives metastasis and overcomes growth arrest\/senescence in pancreatic cancer. Proceedings of the National Academy of Sciences. 2010;107(1):246\u2009\u2013\u200951.","DOI":"10.1073\/pnas.0908428107"},{"key":"4687_CR45","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10637-007-9106-z","volume":"26","author":"M Jensen","year":"2008","unstructured":"Jensen M, Engert A, Weissinger F, Knauf W, Kimby E, Poynton C, et al. Phase I study of a novel pro-apoptotic drug R-etodolac in patients with B-cell chronic lymphocytic leukemia. Investig New Drugs. 2008;26:139\u201349.","journal-title":"Investig New Drugs"},{"issue":"6","key":"4687_CR46","first-page":"1683","volume":"38","author":"S Baritaki","year":"2011","unstructured":"Baritaki S, Militello L, Malaponte G, Spandidos DA, Salcedo M, Bonavida B. The anti-CD20 mAb LFB-R603 interrupts the dysregulated NF-\u03baB\/Snail\/RKIP\/PTEN resistance loop in B-NHL cells: role in sensitization to TRAIL apoptosis. Int J Oncol. 2011;38(6):1683\u201394.","journal-title":"Int J Oncol"},{"key":"4687_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-9966-30-87","volume":"30","author":"RS Wong","year":"2011","unstructured":"Wong RS. Apoptosis in cancer: from pathogenesis to treatment. J experimental Clin cancer Res. 2011;30:1\u201314.","journal-title":"J experimental Clin cancer Res"},{"key":"4687_CR48","doi-asserted-by":"crossref","unstructured":"Minciacchi VR, Freeman MR, Di Vizio D, editors. Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Seminars in cell & developmental biology. Elsevier; 2015.","DOI":"10.1016\/j.semcdb.2015.02.010"},{"issue":"5","key":"4687_CR50","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.placenta.2014.02.009","volume":"35","author":"M Record","year":"2014","unstructured":"Record M. Intercellular communication by exosomes in placenta: a possible role in cell fusion? Placenta. 2014;35(5):297\u2013302.","journal-title":"Placenta"},{"issue":"2","key":"4687_CR51","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1161\/CIRCRESAHA.113.300636","volume":"114","author":"DM Yellon","year":"2014","unstructured":"Yellon DM, Davidson SM. Exosomes: nanoparticles involved in cardioprotection? Circul Res. 2014;114(2):325\u201332.","journal-title":"Circul Res"},{"issue":"12","key":"4687_CR52","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1111\/j.1600-0854.2011.01225.x","volume":"12","author":"A Bobrie","year":"2011","unstructured":"Bobrie A, Colombo M, Raposo G, Th\u00e9ry C. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic. 2011;12(12):1659\u201368.","journal-title":"Traffic"},{"issue":"19","key":"4687_CR53","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.15252\/embj.201592484","volume":"34","author":"JH Hurley","year":"2015","unstructured":"Hurley JH. ESCRT s are everywhere. EMBO J. 2015;34(19):2398\u2013407.","journal-title":"EMBO J"},{"key":"4687_CR54","doi-asserted-by":"crossref","unstructured":"Villarroya-Beltri C, Baixauli F, Guti\u00e9rrez-V\u00e1zquez C, S\u00e1nchez-Madrid F, Mittelbrunn M, editors. Sorting it out: regulation of exosome loading. Seminars in cancer biology. Elsevier; 2014.","DOI":"10.1016\/j.semcancer.2014.04.009"},{"issue":"17","key":"4687_CR55","doi-asserted-by":"publisher","first-page":"11649","DOI":"10.1074\/jbc.M112.445304","volume":"288","author":"D Perez-Hernandez","year":"2013","unstructured":"Perez-Hernandez D, Guti\u00e9rrez-V\u00e1zquez C, Jorge I, L\u00f3pez-Mart\u00edn S, Ursa A, S\u00e1nchez-Madrid F, et al. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. J Biol Chem. 2013;288(17):11649\u201361.","journal-title":"J Biol Chem"},{"issue":"8","key":"4687_CR56","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1194\/jlr.R083915","volume":"59","author":"C Verderio","year":"2018","unstructured":"Verderio C, Gabrielli M, Giussani P. Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles. J Lipid Res. 2018;59(8):1325\u201340.","journal-title":"J Lipid Res"},{"issue":"1","key":"4687_CR57","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bpj.2014.05.028","volume":"107","author":"Y Homsi","year":"2014","unstructured":"Homsi Y, Schloetel J-G, Scheffer Konstanze D, Schmidt Thomas H, Destainville N, Florin L, et al. The Extracellular \u03b4-Domain is Essential for the Formation of CD81 Tetraspanin Webs. Biophys J. 2014;107(1):100\u201313.","journal-title":"Biophys J"},{"issue":"3","key":"4687_CR58","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.addr.2012.06.011","volume":"65","author":"JG van den Boorn","year":"2013","unstructured":"van den Boorn JG, Da\u00dfler J, Coch C, Schlee M, Hartmann G. Exosomes as nucleic acid nanocarriers. Adv Drug Deliv Rev. 2013;65(3):331\u20135.","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"4687_CR59","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","volume":"19","author":"G van Niel","year":"2018","unstructured":"van Niel G, D\u2019Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213\u201328.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"4687_CR61","doi-asserted-by":"publisher","first-page":"7309","DOI":"10.4049\/jimmunol.166.12.7309","volume":"166","author":"C Th\u00e9ry","year":"2001","unstructured":"Th\u00e9ry C, Boussac M, V\u00e9ron P, Ricciardi-Castagnoli P, Raposo G, Garin J, et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol. 2001;166(12):7309\u201318.","journal-title":"J Immunol"},{"key":"4687_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13578-019-0282-2","volume":"9","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Liu Y, Liu H, Tang WH. Exosomes: biogenesis, biologic function and clinical potential. Cell bioscience. 2019;9:1\u201318.","journal-title":"Cell bioscience"},{"issue":"4","key":"4687_CR63","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3390\/cancers17040579","volume":"17","author":"\u00c9 M\u00e1rton","year":"2025","unstructured":"M\u00e1rton \u00c9, Varga A, Domoszlai D, Bugly\u00f3 G, Bal\u00e1zs A, Penyige A, et al. Non-Coding RNAs in Cancer: Structure, Function, and Clinical Application. Cancers. 2025;17(4):579.","journal-title":"Cancers"},{"issue":"4","key":"4687_CR64","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/7734","volume":"21","author":"J Lee","year":"1999","unstructured":"Lee J, Davidow LS, Warshawsky D. Tsix, a gene antisense to Xist at the X-inactivation centre. Nat Genet. 1999;21(4):400\u20134.","journal-title":"Nat Genet"},{"issue":"6772","key":"4687_CR65","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/35002607","volume":"403","author":"BJ Reinhart","year":"2000","unstructured":"Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403(6772):901\u20136.","journal-title":"Nature"},{"key":"4687_CR66","first-page":"1","volume":"19","author":"AA Bhat","year":"2020","unstructured":"Bhat AA, Younes SN, Raza SS, Zarif L, Nisar S, Ahmed I, et al. Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance. Mol Cancer. 2020;19:1\u201321.","journal-title":"Mol Cancer"},{"issue":"6","key":"4687_CR67","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, Ekstr\u00f6m K, Bossios A, Sj\u00f6strand M, Lee JJ, L\u00f6tvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654\u20139.","journal-title":"Nat Cell Biol"},{"issue":"10","key":"4687_CR68","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1172\/JCI129193","volume":"129","author":"S Kita","year":"2019","unstructured":"Kita S, Maeda N, Shimomura I. Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome. J Clin Investig. 2019;129(10):4041\u20139.","journal-title":"J Clin Investig"},{"key":"4687_CR69","doi-asserted-by":"publisher","first-page":"106880","DOI":"10.1016\/j.phrs.2023.106880","volume":"195","author":"B Xia","year":"2023","unstructured":"Xia B, Liu Y, Wang J, Lu Q, Lv X, Deng K, et al. Emerging role of exosome-shuttled noncoding RNAs in gastrointestinal cancers: From intercellular crosstalk to clinical utility. Pharmacol Res. 2023;195:106880.","journal-title":"Pharmacol Res"},{"issue":"1","key":"4687_CR70","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41392-021-00779-x","volume":"6","author":"C Li","year":"2021","unstructured":"Li C, Ni Y-Q, Xu H, Xiang Q-Y, Zhao Y, Zhan J-K, et al. Roles and mechanisms of exosomal non-coding RNAs in human health and diseases. Signal Transduct Target therapy. 2021;6(1):383.","journal-title":"Signal Transduct Target therapy"},{"issue":"8","key":"4687_CR71","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/cr.2015.82","volume":"25","author":"Y Li","year":"2015","unstructured":"Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 2015;25(8):981\u20134.","journal-title":"Cell Res"},{"key":"4687_CR72","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.omtn.2019.11.023","volume":"19","author":"X Shi","year":"2020","unstructured":"Shi X, Wang B, Feng X, Xu Y, Lu K, Sun M. circRNAs and exosomes: a mysterious frontier for human cancer. Mol Therapy-Nucleic Acids. 2020;19:384\u201392.","journal-title":"Mol Therapy-Nucleic Acids"},{"issue":"1","key":"4687_CR73","doi-asserted-by":"publisher","first-page":"37982","DOI":"10.1038\/srep37982","volume":"6","author":"Y Dou","year":"2016","unstructured":"Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, et al. Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Sci Rep. 2016;6(1):37982.","journal-title":"Sci Rep"},{"issue":"1","key":"4687_CR74","doi-asserted-by":"publisher","first-page":"1887552","DOI":"10.1080\/2162402X.2021.1887552","volume":"10","author":"C Han","year":"2021","unstructured":"Han C, Zhang C, Wang H, Zhao L. Exosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironment. Oncoimmunology. 2021;10(1):1887552.","journal-title":"Oncoimmunology"},{"issue":"4","key":"4687_CR75","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/cas.12896","volume":"107","author":"Y Fujita","year":"2016","unstructured":"Fujita Y, Yoshioka Y, Ochiya T. Extracellular vesicle transfer of cancer pathogenic components. Cancer Sci. 2016;107(4):385\u201390.","journal-title":"Cancer Sci"},{"issue":"9","key":"4687_CR76","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41580-019-0158-7","volume":"20","author":"G Raposo","year":"2019","unstructured":"Raposo G, Stahl PD. Extracellular vesicles: a new communication paradigm? Nat Rev Mol Cell Biol. 2019;20(9):509\u201310.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"4687_CR77","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.bbcan.2019.04.004","volume":"1871","author":"L Zhang","year":"2019","unstructured":"Zhang L, Yu D. Exosomes in cancer development, metastasis, and immunity. Biochim et Biophys Acta (BBA)-Reviews Cancer. 2019;1871(2):455\u201368.","journal-title":"Biochim et Biophys Acta (BBA)-Reviews Cancer"},{"key":"4687_CR78","doi-asserted-by":"publisher","first-page":"619939","DOI":"10.3389\/fmed.2021.619939","volume":"8","author":"R Rezaei","year":"2021","unstructured":"Rezaei R, Baghaei K, Hashemi SM, Zali MR, Ghanbarian H, Amani D. Tumor-derived exosomes enriched by miRNA-124 promote anti-tumor immune response in CT-26 tumor-bearing mice. Front Med. 2021;8:619939.","journal-title":"Front Med"},{"key":"4687_CR79","doi-asserted-by":"publisher","first-page":"1453786","DOI":"10.3389\/fonc.2025.1453786","volume":"15","author":"C Lv","year":"2025","unstructured":"Lv C, Chen J, Wang Y, Lin Y. Immunoregulatory role of exosomal circRNAs in the tumor microenvironment. Front Oncol. 2025;15:1453786.","journal-title":"Front Oncol"},{"key":"4687_CR80","doi-asserted-by":"publisher","first-page":"155316","DOI":"10.1016\/j.prp.2024.155316","volume":"257","author":"S Kahkesh","year":"2024","unstructured":"Kahkesh S, Khoshnazar SM, Gholinezhad Y, Esmailzadeh S, Hosseini SA, Alimohammadi M, et al. The potential role of circular RNAs -regulated PI3K signaling in non-small cell lung cancer: Molecular insights and clinical perspective. Pathol Res Pract. 2024;257:155316.","journal-title":"Pathol Res Pract"},{"issue":"13","key":"4687_CR81","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1080\/15384101.2020.1772545","volume":"19","author":"G Chen","year":"2020","unstructured":"Chen G, Liu T, Yu B, Wang B, Peng Q. CircRNA-UBE2G1 regulates LPS-induced osteoarthritis through miR-373\/HIF-1a axis. Cell Cycle. 2020;19(13):1696\u2013705.","journal-title":"Cell Cycle"},{"issue":"7","key":"4687_CR82","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1093\/cvr\/cvz215","volume":"116","author":"H Li","year":"2020","unstructured":"Li H, Xu J-D, Fang X-H, Zhu J-N, Yang J, Pan R, et al. Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4. Cardiovascular Res. 2020;116(7):1323\u201334.","journal-title":"Cardiovascular Res"},{"key":"4687_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-020-1529-9","volume":"39","author":"X-Y Huang","year":"2020","unstructured":"Huang X-Y, Huang Z-L, Huang J, Xu B, Huang X-Y, Xu Y-H, et al. Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis. J Experimental Clin Cancer Res. 2020;39:1\u201316.","journal-title":"J Experimental Clin Cancer Res"},{"key":"4687_CR84","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.canlet.2018.04.035","volume":"432","author":"Z Li","year":"2018","unstructured":"Li Z, Yanfang W, Li J, Jiang P, Peng T, Chen K, et al. Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338\/MACC1\/MET pathway in pancreatic cancer. Cancer Lett. 2018;432:237\u201350.","journal-title":"Cancer Lett"},{"issue":"18","key":"4687_CR85","doi-asserted-by":"publisher","first-page":"8211","DOI":"10.7150\/thno.44419","volume":"10","author":"H Yang","year":"2020","unstructured":"Yang H, Zhang H, Yang Y, Wang X, Deng T, Liu R, et al. Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1\/RhoA axis. Theranostics. 2020;10(18):8211.","journal-title":"Theranostics"},{"key":"4687_CR86","doi-asserted-by":"publisher","first-page":"568366","DOI":"10.3389\/fcell.2020.568366","volume":"8","author":"T Seimiya","year":"2020","unstructured":"Seimiya T, Otsuka M, Iwata T, Shibata C, Tanaka E, Suzuki T, et al. Emerging roles of exosomal circular RNAs in cancer. Front cell Dev biology. 2020;8:568366.","journal-title":"Front cell Dev biology"},{"issue":"18","key":"4687_CR87","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1042\/CS20190589","volume":"133","author":"S Wang","year":"2019","unstructured":"Wang S, Hu Y, Lv X, Li B, Gu D, Li Y, et al. Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication. Clin Sci (Lond). 2019;133(18):1935\u201353.","journal-title":"Clin Sci (Lond)"},{"issue":"4","key":"4687_CR88","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1158\/1078-0432.CCR-18-1447","volume":"25","author":"L Li","year":"2019","unstructured":"Li L, Li W, Chen N, Zhao H, Xu G, Zhao Y, et al. FLI1 exonic circular RNAs as a novel oncogenic driver to promote tumor metastasis in small cell lung cancer. Clin Cancer Res. 2019;25(4):1302\u201317.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"4687_CR89","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s10038-020-00826-5","volume":"66","author":"T Seimiya","year":"2021","unstructured":"Seimiya T, Otsuka M, Iwata T, Tanaka E, Sekiba K, Shibata C, et al. Aberrant expression of a novel circular RNA in pancreatic cancer. J Hum Genet. 2021;66(2):181\u201391.","journal-title":"J Hum Genet"},{"issue":"3","key":"4687_CR90","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1002\/jcb.28239","volume":"121","author":"T Li","year":"2020","unstructured":"Li T, Sun X, Chen L. Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker. J Cell Biochem. 2020;121(3):2118\u201326.","journal-title":"J Cell Biochem"},{"issue":"24","key":"4687_CR91","doi-asserted-by":"publisher","first-page":"6319","DOI":"10.1158\/1078-0432.CCR-18-1270","volume":"24","author":"X Chen","year":"2018","unstructured":"Chen X, Chen R-X, Wei W-S, Li Y-H, Feng Z-H, Tan L, et al. PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial\u2013mesenchymal transition. Clin Cancer Res. 2018;24(24):6319\u201330.","journal-title":"Clin Cancer Res"},{"key":"4687_CR92","first-page":"1","volume":"18","author":"X Zhang","year":"2019","unstructured":"Zhang X, Wang S, Wang H, Cao J, Huang X, Chen Z, et al. Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1\/mTOR pathway. Mol Cancer. 2019;18:1\u201324.","journal-title":"Mol Cancer"},{"key":"4687_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-019-1437-z","volume":"38","author":"Z-H Zong","year":"2019","unstructured":"Zong Z-H, Du Y-P, Guan X, Chen S, Zhao Y. CircWHSC1 promotes ovarian cancer progression by regulating MUC1 and hTERT through sponging miR-145 and miR-1182. J Experimental Clin Cancer Res. 2019;38:1\u201310.","journal-title":"J Experimental Clin Cancer Res"},{"issue":"3","key":"4687_CR94","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/1878-0261.12629","volume":"14","author":"X Wang","year":"2020","unstructured":"Wang X, Zhang H, Yang H, Bai M, Ning T, Deng T, et al. Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer. Mol Oncol. 2020;14(3):539\u201355.","journal-title":"Mol Oncol"},{"key":"4687_CR95","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.canlet.2020.01.022","volume":"475","author":"W Chen","year":"2020","unstructured":"Chen W, Quan Y, Fan S, Wang H, Liang J, Huang L, et al. Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression. Cancer Lett. 2020;475:119\u201328.","journal-title":"Cancer Lett"},{"key":"4687_CR96","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1007\/s12253-019-00716-y","volume":"26","author":"Y Shao","year":"2020","unstructured":"Shao Y, Tao X, Lu R, Zhang H, Ge J, Xiao B, et al. Hsa_circ_0065149 is an indicator for early gastric cancer screening and prognosis prediction. Pathol Oncol Res. 2020;26:1475\u201382.","journal-title":"Pathol Oncol Res"},{"key":"4687_CR97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-018-0888-8","volume":"17","author":"W Tang","year":"2018","unstructured":"Tang W, Fu K, Sun H, Rong D, Wang H, Cao H. CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer. Mol Cancer. 2018;17:1\u20136.","journal-title":"Mol Cancer"},{"issue":"1","key":"4687_CR98","doi-asserted-by":"publisher","first-page":"152763","DOI":"10.1016\/j.prp.2019.152763","volume":"216","author":"X Tao","year":"2020","unstructured":"Tao X, Shao Y, Lu R, Ye Q, Xiao B, Ye G, et al. Clinical significance of hsa_circ_0000419 in gastric cancer screening and prognosis estimation. Pathology-Research Pract. 2020;216(1):152763.","journal-title":"Pathology-Research Pract"},{"key":"4687_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-018-0822-3","volume":"37","author":"J Li","year":"2018","unstructured":"Li J, Li Z, Jiang P, Peng M, Zhang X, Chen K, et al. Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis. J Experimental Clin Cancer Res. 2018;37:1\u201316.","journal-title":"J Experimental Clin Cancer Res"},{"issue":"22","key":"4687_CR101","doi-asserted-by":"publisher","first-page":"2309857","DOI":"10.1002\/advs.202309857","volume":"11","author":"D Wang","year":"2024","unstructured":"Wang D, Wang S, Jin M, Zuo Y, Wang J, Niu Y, et al. Hypoxic Exosomal circPLEKHM1-Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis. Adv Sci. 2024;11(22):2309857.","journal-title":"Adv Sci"},{"issue":"4","key":"4687_CR102","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.ncrna.2024.05.005","volume":"9","author":"M Malek Mohammadi","year":"2024","unstructured":"Malek Mohammadi M, Rismanchi H, Esmailzadeh S, Farahani A, Hedayati N, Alimohammadi M, et al. The emerging role of circular RNAs in cisplatin resistance in ovarian cancer: From molecular mechanism to future potential. Non-coding RNA Res. 2024;9(4):1280\u201391.","journal-title":"Non-coding RNA Res"},{"issue":"12","key":"4687_CR103","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","volume":"185","author":"C-X Liu","year":"2022","unstructured":"Liu C-X, Chen L-L. Circular RNAs: Characterization, cellular roles, and applications. Cell. 2022;185(12):2016\u201334.","journal-title":"Cell"},{"key":"4687_CR104","doi-asserted-by":"crossref","unstructured":"Xu Y, Kong S, Qin S, Shen X, Ju S. Exosomal circRNAs: Sorting Mechanisms, Roles and Clinical Applications in Tumors. Front Cell Dev Biology. 2020; 8:581558.","DOI":"10.3389\/fcell.2020.581558"},{"issue":"1","key":"4687_CR105","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/s41392-020-00261-0","volume":"5","author":"J Dai","year":"2020","unstructured":"Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, et al. Exosomes: key players in cancer and potential therapeutic strategy. Signal Transduct Target Therapy. 2020;5(1):145.","journal-title":"Signal Transduct Target Therapy"},{"issue":"1","key":"4687_CR106","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12943-019-1041-z","volume":"18","author":"Y Wang","year":"2019","unstructured":"Wang Y, Liu J, Ma J, Sun T, Zhou Q, Wang W, et al. Exosomal circRNAs: biogenesis, effect and application in human diseases. Mol Cancer. 2019;18(1):116.","journal-title":"Mol Cancer"},{"issue":"12","key":"4687_CR108","doi-asserted-by":"publisher","first-page":"e70019","DOI":"10.1002\/mco2.70019","volume":"5","author":"J Li","year":"2024","unstructured":"Li J, Zhou W, Wang H, Huang M, Deng H. Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities. MedComm. 2024;5(12):e70019.","journal-title":"MedComm"},{"issue":"10","key":"4687_CR109","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","volume":"16","author":"JD Yang","year":"2019","unstructured":"Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat reviews Gastroenterol Hepatol. 2019;16(10):589\u2013604.","journal-title":"Nat reviews Gastroenterol Hepatol"},{"issue":"10","key":"4687_CR110","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1097\/CM9.0000000000002641","volume":"136","author":"Z Wang","year":"2023","unstructured":"Wang Z, Qin H, Liu S, Sheng J, Zhang X. Precision diagnosis of hepatocellular carcinoma. Chin Med J. 2023;136(10):1155\u201365.","journal-title":"Chin Med J"},{"issue":"1","key":"4687_CR111","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13046-020-1529-9","volume":"39","author":"XY Huang","year":"2020","unstructured":"Huang XY, Huang ZL, Huang J, Xu B, Huang XY, Xu YH, et al. Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis. J experimental Clin cancer research: CR. 2020;39(1):20.","journal-title":"J experimental Clin cancer research: CR"},{"issue":"1","key":"4687_CR112","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12943-023-01759-1","volume":"22","author":"Z Hu","year":"2023","unstructured":"Hu Z, Chen G, Zhao Y, Gao H, Li L, Yin Y, et al. Exosome-derived circCCAR1 promotes CD8\u2009+\u2009T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma. Mol Cancer. 2023;22(1):55.","journal-title":"Mol Cancer"},{"issue":"1","key":"4687_CR113","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1186\/s12885-022-10367-z","volume":"22","author":"P Yuan","year":"2022","unstructured":"Yuan P, Song J, Wang F, Chen B. Exosome-transmitted circ_002136 promotes hepatocellular carcinoma progression by miR-19a-3p\/RAB1A pathway. BMC Cancer. 2022;22(1):1284.","journal-title":"BMC Cancer"},{"key":"4687_CR114","doi-asserted-by":"publisher","first-page":"154276","DOI":"10.1016\/j.prp.2022.154276","volume":"241","author":"C Liu","year":"2023","unstructured":"Liu C, Ren C, Guo L, Yang C, Yu Q. Exosome-mediated circTTLL5 transfer promotes hepatocellular carcinoma malignant progression through miR-136-5p\/KIAA1522 axis. Pathol - Res Pract. 2023;241:154276.","journal-title":"Pathol - Res Pract"},{"key":"4687_CR115","doi-asserted-by":"publisher","first-page":"5657","DOI":"10.2147\/OTT.S251157","volume":"13","author":"S Jiang","year":"2020","unstructured":"Jiang S, Zhang Y, Li Q, Qiu L, Bian B. KIAA1522 Promotes the Progression of Hepatocellular Carcinoma via the Activation of the Wnt\/\u03b2-Catenin Signaling Pathway. Onco Targets Ther. 2020;13:5657\u201368.","journal-title":"Onco Targets Ther"},{"issue":"46","key":"4687_CR116","doi-asserted-by":"publisher","first-page":"6060","DOI":"10.3748\/wjg.v29.i46.6060","volume":"29","author":"ZZ Lyu","year":"2023","unstructured":"Lyu ZZ, Li M, Yang MY, Han MH, Yang Z. Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p\/metal-regulatory transcription factor-1 pathway. World J Gastroenterol. 2023;29(46):6060\u201375.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"4687_CR117","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41419-021-04345-9","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Zhang J, Li P, Li T, Zhou Z, Wu H. Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p\/JAM3. Cell Death Dis. 2022;13(1):32.","journal-title":"Cell Death Dis"},{"issue":"4","key":"4687_CR118","doi-asserted-by":"publisher","first-page":"267","DOI":"10.5582\/bst.2022.01281","volume":"16","author":"L Liu","year":"2022","unstructured":"Liu L, Liao R, Wu Z, Du C, You Y, Que K, et al. Hepatic stellate cell exosome-derived circWDR25 promotes the progression of hepatocellular carcinoma\u2009<\u2009i>via\u2009the miRNA-4474-3P-ALOX-15 and EMT axes. Biosci Trends. 2022;16(4):267\u201381.","journal-title":"Biosci Trends"},{"issue":"3","key":"4687_CR120","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.3390\/curroncol30030239","volume":"30","author":"F Petrella","year":"2023","unstructured":"Petrella F, Rizzo S, Attili I, Passaro A, Zilli T, Martucci F, et al. Stage III non-small-cell lung cancer: an overview of treatment options. Curr Oncol. 2023;30(3):3160\u201375.","journal-title":"Curr Oncol"},{"issue":"1","key":"4687_CR121","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12935-023-02974-y","volume":"23","author":"S-L Wei","year":"2023","unstructured":"Wei S-L, Ye J-J, Sun L, Hu L, Wei Y-Y, Zhang D-W, et al. Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer. Cancer Cell Int. 2023;23(1):129.","journal-title":"Cancer Cell Int"},{"issue":"1","key":"4687_CR122","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1080\/10717544.2022.2057617","volume":"29","author":"H Xie","year":"2022","unstructured":"Xie H, Yao J, Wang Y, Ni B. Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3\/SOX2 axis. Drug Delivery. 2022;29(1):1257\u201371.","journal-title":"Drug Delivery"},{"issue":"1","key":"4687_CR123","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1186\/s12935-020-01642-9","volume":"20","author":"X Xu","year":"2020","unstructured":"Xu X, Tao R, Sun L, Ji X. Exosome-transferred hsa_circ_0014235 promotes DDP chemoresistance and deteriorates the development of non-small cell lung cancer by mediating the miR-520a-5p\/CDK4 pathway. Cancer Cell Int. 2020;20(1):552.","journal-title":"Cancer Cell Int"},{"key":"4687_CR124","doi-asserted-by":"crossref","unstructured":"Yang B, Teng F, Chang L, Wang J, Liu D-L, Cui Y-S et al. Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p\/ROR1 axis in non-small cell lung cancer. Aging, 202113(9):13264\u201386.","DOI":"10.18632\/aging.203011"},{"issue":"1","key":"4687_CR125","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/s41420-024-02239-1","volume":"10","author":"A-B Tigu","year":"2024","unstructured":"Tigu A-B, Munteanu R, Moldovan C, Rares D, Kegyes D, Tomai R, et al. Therapeutic advances in the targeting of ROR1 in hematological cancers. Cell Death Discovery. 2024;10(1):471.","journal-title":"Cell Death Discovery"},{"issue":"10251","key":"4687_CR126","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","volume":"396","author":"EC Smyth","year":"2020","unstructured":"Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet (London England). 2020;396(10251):635\u201348.","journal-title":"Lancet (London England)"},{"key":"4687_CR127","doi-asserted-by":"crossref","unstructured":"Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R. Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies. Int J Mol Sci. 2020;21(11):4012.","DOI":"10.3390\/ijms21114012"},{"key":"4687_CR128","doi-asserted-by":"publisher","first-page":"155457","DOI":"10.1016\/j.prp.2024.155457","volume":"260","author":"A Mafi","year":"2024","unstructured":"Mafi A, Hedayati N, Milasi YE, Kahkesh S, Daviran M, Farahani N, et al. The function and mechanism of circRNAs in 5-fluorouracil resistance in tumors: Biological mechanisms and future potential. Pathol Res Pract. 2024;260:155457.","journal-title":"Pathol Res Pract"},{"issue":"1","key":"4687_CR129","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s12967-022-03527-z","volume":"20","author":"Z Guo","year":"2022","unstructured":"Guo Z, Zhang Y, Xu W, Zhang X, Jiang J. Engineered exosome-mediated delivery of circDIDO1 inhibits gastric cancer progression via regulation of MiR-1307-3p\/SOCS2 Axis. J Translational Med. 2022;20(1):326.","journal-title":"J Translational Med"},{"issue":"2","key":"4687_CR130","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3390\/cells13020159","volume":"13","author":"A F\u00fctterer","year":"2024","unstructured":"F\u00fctterer A, Rodriguez-Acebes S, M\u00e9ndez J, Guti\u00e9rrez J, Mart\u00ednez- AC. PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation. Cells. 2024;13(2):159.","journal-title":"Cells"},{"issue":"1","key":"4687_CR131","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12943-021-01390-y","volume":"20","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Jiang J, Zhang J, Shen H, Wang M, Guo Z, et al. CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability. Mol Cancer. 2021;20(1):101.","journal-title":"Mol Cancer"},{"issue":"4","key":"4687_CR132","first-page":"347","volume":"36","author":"W Yao","year":"2021","unstructured":"Yao W, Guo P, Mu Q, Wang Y. Exosome-Derived Circ-PVT1 Contributes to Cisplatin Resistance by Regulating Autophagy, Invasion, and Apoptosis Via miR-30a-5p\/YAP1 Axis in Gastric Cancer Cells. Cancer Biother Radiopharm. 2021;36(4):347\u201359.","journal-title":"Cancer Biother Radiopharm"},{"issue":"8","key":"4687_CR133","first-page":"2145","volume":"9","author":"M Sudol","year":"1994","unstructured":"Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene. 1994;9(8):2145\u201352.","journal-title":"Oncogene"},{"issue":"3","key":"4687_CR134","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","volume":"122","author":"J Huang","year":"2005","unstructured":"Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122(3):421\u201334.","journal-title":"Cell"},{"issue":"33","key":"4687_CR135","doi-asserted-by":"publisher","first-page":"12405","DOI":"10.1073\/pnas.0605579103","volume":"103","author":"M Overholtzer","year":"2006","unstructured":"Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA. 2006;103(33):12405\u201310.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"4687_CR136","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1089\/cbr.2020.3578","volume":"36","author":"W Yao","year":"2020","unstructured":"Yao W, Guo P, Mu Q, Wang Y. Exosome-Derived Circ-PVT1 Contributes to Cisplatin Resistance by Regulating Autophagy, Invasion, and Apoptosis Via miR-30a-5p\/YAP1 Axis in Gastric Cancer Cells. Cancer Biotherapy Radiopharmaceuticals. 2020;36(4):347\u201359.","journal-title":"Cancer Biotherapy Radiopharmaceuticals"},{"issue":"1","key":"4687_CR137","first-page":"55","volume":"51","author":"S Mai","year":"2021","unstructured":"Mai S, Zhang Z, Mi W. Upregulation of circ_PVT1 and circ_001569 Indicate Unfavorable Prognosis in Colorectal Cancer. Ann Clin Lab Sci. 2021;51(1):55\u201360.","journal-title":"Ann Clin Lab Sci"},{"issue":"4","key":"4687_CR138","first-page":"1736","volume":"44","author":"H Sui","year":"2020","unstructured":"Sui H, Zhu C, Li Z, Yang J. Propofol suppresses gastric cancer tumorigenesis by modulating the circular RNA\u2013PVT1\/miR\u2013195\u20135p\/E26 oncogene homolog 1 axis. Oncol Rep. 2020;44(4):1736\u201346.","journal-title":"Oncol Rep"},{"key":"4687_CR139","doi-asserted-by":"crossref","unstructured":"Liu YY, Zhang LY, Du WZ. Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through the regulation of ZEB1 expression by sponging miR-124-3p. Biosci Rep. 2019;39(12):BSR20193045.","DOI":"10.1042\/BSR20193045"},{"key":"4687_CR140","first-page":"1791","volume-title":"Identification of a zinc finger protein that inhibits IL-2 gene expression","author":"TM Williams","year":"1991","unstructured":"Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, et al. Identification of a zinc finger protein that inhibits IL-2 gene expression. Volume 254. New York, NY: Science; 1991. pp. 1791\u20134. 5039."},{"issue":"3","key":"4687_CR141","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00412-015-0543-8","volume":"125","author":"TR B\u00fcrglin","year":"2016","unstructured":"B\u00fcrglin TR, Affolter M. Homeodomain proteins: an update. Chromosoma. 2016;125(3):497\u2013521.","journal-title":"Chromosoma"},{"issue":"23","key":"4687_CR142","doi-asserted-by":"publisher","first-page":"13316","DOI":"10.1039\/C9RA01820D","volume":"9","author":"L Tao","year":"2019","unstructured":"Tao L, Yang L, Tian P, Guo X, Chen Y. Knockdown of circPVT1 inhibits progression of papillary thyroid carcinoma by sponging miR-126. RSC Adv. 2019;9(23):13316\u201324.","journal-title":"RSC Adv"},{"key":"4687_CR143","doi-asserted-by":"publisher","first-page":"104865","DOI":"10.1016\/j.yexmp.2023.104865","volume":"132\u2013133","author":"E Abdollahi","year":"2023","unstructured":"Abdollahi E, Mozdarani H. Epigenetic regulation of circ-HIPK3, circ-PVT1, miR-25, and miR-149 in radiosensitivity of breast cancer. Exp Mol Pathol. 2023;132\u2013133:104865.","journal-title":"Exp Mol Pathol"},{"issue":"10","key":"4687_CR144","first-page":"688","volume":"25","author":"E Abdollahi","year":"2023","unstructured":"Abdollahi E, Mozdarani H. Role of The circ-HIPK3, circ-PVT1, miR-25, and miR-149 in Response of Breast Cancer Cells to Ionizing Radiation. Cell J. 2023;25(10):688\u201395.","journal-title":"Cell J"},{"issue":"20","key":"4687_CR145","doi-asserted-by":"publisher","first-page":"20139","DOI":"10.18632\/aging.103679","volume":"12","author":"H Wang","year":"2020","unstructured":"Wang H, Wei M, Kang Y, Xing J, Zhao Y. Circular RNA circ_PVT1 induces epithelial-mesenchymal transition to promote metastasis of cervical cancer. Aging. 2020;12(20):20139\u201351.","journal-title":"Aging"},{"issue":"1\u20132","key":"4687_CR146","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11010-020-03840-5","volume":"474","author":"X Zhu","year":"2020","unstructured":"Zhu X, Du J, Gu Z. Circ-PVT1\/miR-106a-5p\/HK2 axis regulates cell growth, metastasis and glycolytic metabolism of oral squamous cell carcinoma. Mol Cell Biochem. 2020;474(1\u20132):147\u201358.","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"4687_CR147","first-page":"1018","volume":"26","author":"T Chen","year":"2021","unstructured":"Chen T, Chen F. The role of circular RNA plasmacytoma variant translocation 1 as a biomarker for prognostication of acute myeloid leukemia. Hematol (Amsterdam Netherlands). 2021;26(1):1018\u201324.","journal-title":"Hematol (Amsterdam Netherlands)"},{"key":"4687_CR148","doi-asserted-by":"crossref","unstructured":"Cao L, Zhou X, Ding X, Gao D. Knockdown of circ\u2013PVT1 inhibits the progression of lung adenocarcinoma and enhances the sensitivity to cisplatin via the miR\u2013429\/FOXK1 signaling axis. Mol Med Rep. 2021;24(4):684.","DOI":"10.3892\/mmr.2021.12323"},{"key":"4687_CR149","doi-asserted-by":"publisher","first-page":"10505","DOI":"10.2147\/CMAR.S272324","volume":"12","author":"S Liu","year":"2020","unstructured":"Liu S, Wu M, Peng M. Circ_0000260 Regulates the Development and Deterioration of Gastric Adenocarcinoma with Cisplatin Resistance by Upregulating MMP11 via Targeting MiR-129-5p. Cancer Manag Res. 2020;12:10505\u201319.","journal-title":"Cancer Manag Res"},{"issue":"6","key":"4687_CR150","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1080\/15384101.2022.2146839","volume":"22","author":"D Yu","year":"2023","unstructured":"Yu D, Chang Z, Liu X, Chen P, Zhang H, Qin Y. Macrophage-derived exosomes regulate gastric cancer cell oxaliplatin resistance by wrapping circ 0008253. Cell Cycle. 2023;22(6):705\u201317.","journal-title":"Cell Cycle"},{"issue":"3","key":"4687_CR151","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s10620-023-08254-z","volume":"69","author":"T Jiang","year":"2024","unstructured":"Jiang T, Xu L, Qu X, Li R, Cheng Y, He H. Hsa_circ_0014606 Derived from Exosomes Promotes Gastric Carcinoma Tumorigenesis and Proliferation by Sponging miR-514b-3p to Upregulate HNRNPC. Dig Dis Sci. 2024;69(3):811\u201320.","journal-title":"Dig Dis Sci"},{"issue":"11\u201312","key":"4687_CR152","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1101\/gad.348226.120","volume":"35","author":"J Li","year":"2021","unstructured":"Li J, Ma X, Chakravarti D, Shalapour S, DePinho RA. Genetic and biological hallmarks of colorectal cancer. Genes Dev. 2021;35(11\u201312):787\u2013820.","journal-title":"Genes Dev"},{"issue":"6","key":"4687_CR153","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41419-023-05881-2","volume":"14","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Luo J, Yang W, Ye WC. CircRNAs in colorectal cancer: potential biomarkers and therapeutic targets. Cell Death Dis. 2023;14(6):353.","journal-title":"Cell Death Dis"},{"issue":"14","key":"4687_CR155","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.7150\/thno.25541","volume":"8","author":"J Ren","year":"2018","unstructured":"Ren J, Ding L, Zhang D, Shi G, Xu Q, Shen S, et al. Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19. Theranostics. 2018;8(14):3932\u201348.","journal-title":"Theranostics"},{"issue":"4","key":"4687_CR156","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41419-019-1435-2","volume":"10","author":"R Zhang","year":"2019","unstructured":"Zhang R, Qi F, Zhao F, Li G, Shao S, Zhang X, et al. Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer. Cell Death Dis. 2019;10(4):273.","journal-title":"Cell Death Dis"},{"issue":"11","key":"4687_CR157","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/s41419-018-1104-x","volume":"9","author":"L Wei","year":"2018","unstructured":"Wei L, Ye H, Li G, Lu Y, Zhou Q, Zheng S, et al. Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1\/SATB-1 pathway in pancreatic cancer. Cell Death Dis. 2018;9(11):1065.","journal-title":"Cell Death Dis"},{"key":"4687_CR158","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12967-016-0788-x","volume":"14","author":"J Wang","year":"2016","unstructured":"Wang J, Zhang G, Wang J, Wang L, Huang X, Cheng Y. The role of cancer-associated fibroblasts in esophageal cancer. J Transl Med. 2016;14:30.","journal-title":"J Transl Med"},{"issue":"1","key":"4687_CR159","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12885-023-11791-5","volume":"24","author":"C Yang","year":"2024","unstructured":"Yang C, Zhang Y, Yan M, Wang J, Wang J, Wang M, et al. Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28. BMC Cancer. 2024;24(1):64.","journal-title":"BMC Cancer"},{"key":"4687_CR160","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fgene.2017.00031","volume":"8","author":"J Balzeau","year":"2017","unstructured":"Balzeau J, Menezes MR, Cao S, Hagan JP. The LIN28\/let-7 Pathway in Cancer. Front Genet. 2017;8:31.","journal-title":"Front Genet"},{"issue":"9","key":"4687_CR161","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1002\/1878-0261.12694","volume":"14","author":"J Dou","year":"2020","unstructured":"Dou J, Zhang H, Chen R, Shu Z, Yuan H, Zhao X, et al. SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells. Mol Oncol. 2020;14(9):2288\u2013312.","journal-title":"Mol Oncol"},{"issue":"5","key":"4687_CR162","doi-asserted-by":"publisher","first-page":"e00517","DOI":"10.1128\/MCB.00517-20","volume":"41","author":"K Zhao","year":"2021","unstructured":"Zhao K, Cheng X, Ye Z, Li Y, Peng W, Wu Y, et al. Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p. Mol Cell Biol. 2021;41(5):e00517\u201320.","journal-title":"Mol Cell Biol"},{"key":"4687_CR163","doi-asserted-by":"crossref","unstructured":"Zhao K, Cheng X, Ye Z, Li Y, Peng W, Wu Y et al. Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p. Mol Cell Biol. 2021;41(5):e00517-20.","DOI":"10.1128\/MCB.00517-20"},{"issue":"6","key":"4687_CR164","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.3892\/or.2020.7783","volume":"44","author":"J He","year":"2020","unstructured":"He J, Zhao H, Liu X, Wang D, Wang Y, Ai Y, et al. Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome\u2013mediated circ\u2013HMGCS1 via the miR\u201334a\u20135p\/SGPP1 axis. Oncol Rep. 2020;44(6):2429\u201342.","journal-title":"Oncol Rep"},{"issue":"3","key":"4687_CR165","doi-asserted-by":"publisher","first-page":"900","DOI":"10.7150\/thno.29515","volume":"9","author":"N Zhen","year":"2019","unstructured":"Zhen N, Gu S, Ma J, Zhu J, Yin M, Xu M, et al. CircHMGCS1 Promotes Hepatoblastoma Cell Proliferation by Regulating the IGF Signaling Pathway and Glutaminolysis. Theranostics. 2019;9(3):900\u201319.","journal-title":"Theranostics"},{"issue":"7","key":"4687_CR166","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41575-021-00457-x","volume":"18","author":"AP Klein","year":"2021","unstructured":"Klein AP. Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. Nat reviews Gastroenterol Hepatol. 2021;18(7):493\u2013502.","journal-title":"Nat reviews Gastroenterol Hepatol"},{"key":"4687_CR167","doi-asserted-by":"publisher","first-page":"7630894","DOI":"10.1155\/2019\/7630894","volume":"2019","author":"J Yang","year":"2019","unstructured":"Yang J, Cong X, Ren M, Sun H, Liu T, Chen G, et al. Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma. J Oncol. 2019;2019:7630894.","journal-title":"J Oncol"},{"key":"4687_CR168","doi-asserted-by":"publisher","first-page":"9859","DOI":"10.2147\/IJN.S279258","volume":"15","author":"Z Ye","year":"2020","unstructured":"Ye Z, Zhu Z, Xie J, Feng Z, Li Y, Xu X, et al. Hsa_circ_0000069 Knockdown Inhibits Tumorigenesis and Exosomes with Downregulated hsa_circ_0000069 Suppress Malignant Transformation via Inhibition of STIL in Pancreatic Cancer. Int J Nanomed. 2020;15:9859\u201373.","journal-title":"Int J Nanomed"},{"issue":"3","key":"4687_CR170","doi-asserted-by":"publisher","first-page":"3780","DOI":"10.1002\/jcb.27658","volume":"120","author":"L Hao","year":"2019","unstructured":"Hao L, Rong W, Bai L, Cui H, Zhang S, Li Y, et al. Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b. J Cell Biochem. 2019;120(3):3780\u20139.","journal-title":"J Cell Biochem"},{"issue":"1","key":"4687_CR171","doi-asserted-by":"publisher","first-page":"2218514","DOI":"10.1080\/15384047.2023.2218514","volume":"24","author":"L Wang","year":"2023","unstructured":"Wang L, Wu X, Ruan Y, Zhang X, Zhou X. Exosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b\/HIPK2 axis. Cancer Biol Ther. 2023;24(1):2218514.","journal-title":"Cancer Biol Ther"},{"issue":"20","key":"4687_CR172","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1080\/15384101.2023.2281768","volume":"22","author":"Z Chen","year":"2023","unstructured":"Chen Z, Xu Z, Wang Q, Wang L, Zhang H, Wang W, et al. Exosome-delivered circRNA circSYT15 contributes to cisplatin resistance in cervical cancer cells through the miR-503-5p\/RSF1 axis. Cell Cycle. 2023;22(20):2211\u201328.","journal-title":"Cell Cycle"},{"key":"4687_CR173","doi-asserted-by":"crossref","unstructured":"Du Z, Jia Z, Lin Y, Zhao X, Cao G, Wang H. Chromatin Remodeler RSF1 as an Oncogenic Driver and Therapeutic Target in Esophageal Squamous Cell Carcinoma. Cells. 2025;14(16):1262.","DOI":"10.3390\/cells14161262"},{"issue":"8","key":"4687_CR174","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1007\/s43032-022-00855-9","volume":"29","author":"J Chen","year":"2022","unstructured":"Chen J, Wu S, Wang J, Sha Y, Ji Y. Hsa_circ_0074269-mediated Upregulation of TUFT1 Through miR-485-5p Increases Cisplatin Resistance in Cervical Cancer. Reproductive Sci. 2022;29(8):2236\u201350.","journal-title":"Reproductive Sci"},{"key":"4687_CR175","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.bbrc.2021.03.020","volume":"551","author":"Z Chen","year":"2021","unstructured":"Chen Z, Ling K, Zhu Y, Deng L, Li Y, Liang Z. circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426. Biochem Biophys Res Commun. 2021;551:114\u201320.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"4687_CR176","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1007\/s10528-023-10494-7","volume":"62","author":"Z Gong","year":"2024","unstructured":"Gong Z, Ge L, Ye S, Xu Y. Hsa_circ_0000069 Accelerates Cervical Cancer Progression by Sponging miR-1270 to Facilitate CPEB4 Expression. Biochem Genet. 2024;62(3):1638\u201356.","journal-title":"Biochem Genet"},{"key":"4687_CR177","doi-asserted-by":"crossref","unstructured":"Liu J, Shang G. The Roles of Noncoding RNAs in the Development of Osteosarcoma Stem Cells and Potential Therapeutic Targets. Front Cell Dev Biology. 2022;10:773038.","DOI":"10.3389\/fcell.2022.773038"},{"issue":"1","key":"4687_CR178","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1186\/s40001-023-01309-x","volume":"28","author":"S Qin","year":"2023","unstructured":"Qin S, Wang Y, Ma C, Lv Q. Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance. Eur J Med Res. 2023;28(1):354.","journal-title":"Eur J Med Res"},{"issue":"1","key":"4687_CR179","doi-asserted-by":"publisher","first-page":"2343450","DOI":"10.1080\/15384047.2024.2343450","volume":"25","author":"A Luo","year":"2024","unstructured":"Luo A, Liu H, Huang C, Wei S. Exosome-transmitted circular RNA circ-LMO7 facilitates the progression of osteosarcoma by regulating miR-21-5p\/ARHGAP24 axis. Cancer Biol Ther. 2024;25(1):2343450.","journal-title":"Cancer Biol Ther"},{"issue":"5","key":"4687_CR180","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/carcin\/bgz144","volume":"41","author":"L Wang","year":"2019","unstructured":"Wang L, Shen S, Xiao H, Ding F, Wang M, Li G, et al. ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-p27 axis. Carcinogenesis. 2019;41(5):711\u201321.","journal-title":"Carcinogenesis"},{"issue":"3","key":"4687_CR181","first-page":"3517","volume":"16","author":"S Zhang","year":"2018","unstructured":"Zhang S, Sui L, Zhuang J, He S, Song Y, Ye Y, et al. ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53. Oncol Lett. 2018;16(3):3517\u201324.","journal-title":"Oncol Lett"},{"issue":"4","key":"4687_CR182","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1002\/cbin.11532","volume":"45","author":"Y Pan","year":"2021","unstructured":"Pan Y, Lin Y, Mi C. Cisplatin-resistant osteosarcoma cell-derived exosomes confer cisplatin resistance to recipient cells in an exosomal circ_103801-dependent manner. Cell Biol Int. 2021;45(4):858\u201368.","journal-title":"Cell Biol Int"},{"key":"4687_CR183","doi-asserted-by":"publisher","first-page":"673237","DOI":"10.3389\/fcell.2021.673237","volume":"9","author":"R Zang","year":"2021","unstructured":"Zang R, Qiu X, Song Y, Wang Y. Exosomes mediated transfer of Circ_0000337 contributes to cisplatin (CDDP) resistance of esophageal cancer by regulating JAK2 via miR-377-3p. Front Cell Dev Biology. 2021;9:673237.","journal-title":"Front Cell Dev Biology"},{"issue":"5","key":"4687_CR184","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2174\/1566524020666201015144702","volume":"21","author":"M Sopjani","year":"2021","unstructured":"Sopjani M, Morina R, Uka V, Xuan NT, D\u00ebrmaku-Sopjani M. JAK2-mediated intracellular signaling. Curr Mol Med. 2021;21(5):417\u201325.","journal-title":"Curr Mol Med"},{"key":"4687_CR185","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.biopha.2016.09.040","volume":"84","author":"Y Xu","year":"2016","unstructured":"Xu Y, Lv S-X. The effect of JAK2 knockout on inhibition of liver tumor growth by inducing apoptosis, autophagy and anti-proliferation via STATs and PI3K\/AKT signaling pathways. Biomed Pharmacother. 2016;84:1202\u201312.","journal-title":"Biomed Pharmacother"},{"key":"4687_CR186","doi-asserted-by":"publisher","first-page":"104774","DOI":"10.1016\/j.phrs.2020.104774","volume":"156","author":"L Huang","year":"2020","unstructured":"Huang L, Liu Z, Hu J, Luo Z, Zhang C, Wang L, et al. MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt\/\u03b2-catenin signaling by targeting XIAP and ZEB2. Pharmacol Res. 2020;156:104774.","journal-title":"Pharmacol Res"},{"issue":"1","key":"4687_CR187","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12935-020-01310-y","volume":"20","author":"L Li","year":"2020","unstructured":"Li L, Zhang Q, Lian K. Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion. Cancer Cell Int. 2020;20(1):247.","journal-title":"Cancer Cell Int"},{"key":"4687_CR188","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.2147\/CMAR.S195546","volume":"11","author":"H Song","year":"2019","unstructured":"Song H, Xu D, Shi P, He B, Li Z, Ji Y, et al. Upregulated circ RNA hsa_circ_0000337 promotes cell proliferation, migration, and invasion of esophageal squamous cell carcinoma. Cancer Manag Res. 2019;11:1997\u20132006.","journal-title":"Cancer Manag Res"},{"issue":"3","key":"4687_CR189","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1007\/s10528-023-10534-2","volume":"62","author":"J Xu","year":"2024","unstructured":"Xu J, Xue B, Gong M, Ling L, Nie S, Li F, et al. circ_0000337 Promotes the Progression of Cervical Cancer by miR-155-5p\/RAB3B Axis. Biochem Genet. 2024;62(3):2195\u2013209.","journal-title":"Biochem Genet"},{"key":"4687_CR190","doi-asserted-by":"publisher","first-page":"7635","DOI":"10.2147\/CMAR.S258340","volume":"12","author":"C Li","year":"2020","unstructured":"Li C, Liu H, Niu Q, Gao J. Circ_0000376, a Novel circRNA, Promotes the Progression of Non-Small Cell Lung Cancer Through Regulating the miR-1182\/NOVA2 Network. Cancer Manag Res. 2020;12:7635\u201347.","journal-title":"Cancer Manag Res"},{"key":"4687_CR191","doi-asserted-by":"crossref","unstructured":"Fang Y, Long F. Circular RNA circ_0000337 contributes to osteosarcoma via the miR-4458\/BACH1 pathway. Cancer biomarkers: section A of Disease markers. 2020;28(4):411\u20139.","DOI":"10.3233\/CBM-190647"},{"issue":"2","key":"4687_CR192","doi-asserted-by":"publisher","first-page":"e23659","DOI":"10.1002\/jbt.23659","volume":"38","author":"T Chai","year":"2024","unstructured":"Chai T, Liu J, Liu Z, Fan R. Exosome-transported of circ_0081069 induces SPIN1 production by binding to miR-195-5p to inhibit radiosensitivity in esophageal squamous cell carcinoma. J Biochem Mol Toxicol. 2024;38(2):e23659.","journal-title":"J Biochem Mol Toxicol"},{"key":"4687_CR193","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.biopha.2017.06.058","volume":"93","author":"Y Li","year":"2017","unstructured":"Li Y, Ma X, Wang Y, Li G. miR-489 inhibits proliferation, cell cycle progression and induces apoptosis of glioma cells via targeting SPIN1-mediated PI3K\/AKT pathway. Biomed Pharmacother. 2017;93:435\u201343.","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"4687_CR195","doi-asserted-by":"publisher","first-page":"6556","DOI":"10.1007\/s12035-024-04002-0","volume":"61","author":"N Zhang","year":"2024","unstructured":"Zhang N, Wu P, Mu M, Niu C, Hu S. Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1\/Akt Axis. Mol Neurobiol. 2024;61(9):6556\u201371.","journal-title":"Mol Neurobiol"},{"key":"4687_CR196","doi-asserted-by":"publisher","first-page":"102291","DOI":"10.1016\/j.tice.2023.102291","volume":"86","author":"W Chen","year":"2024","unstructured":"Chen W, Zhang H. Elucidating the mechanism of IL-1\u03b2-Mediated Piezo1 expression regulation of chondrocyte autophagy and apoptosis via the PI3K\/AKT\/mTOR signaling Pathway. Tissue Cell. 2024;86:102291.","journal-title":"Tissue Cell"},{"issue":"1","key":"4687_CR197","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s13046-021-01942-6","volume":"40","author":"C Ding","year":"2021","unstructured":"Ding C, Yi X, Chen X, Wu Z, You H, Chen X, et al. Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma. J Experimental Clin Cancer Res. 2021;40(1):164.","journal-title":"J Experimental Clin Cancer Res"},{"issue":"7","key":"4687_CR198","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1089\/cbr.2019.3492","volume":"36","author":"C Han","year":"2020","unstructured":"Han C, Wang S, Wang H, Zhang J. Exosomal circ-HIPK3 Facilitates Tumor Progression and Temozolomide Resistance by Regulating miR-421\/ZIC5 Axis in Glioma. Cancer Biotherapy Radiopharmaceuticals. 2020;36(7):537\u201348.","journal-title":"Cancer Biotherapy Radiopharmaceuticals"},{"issue":"4","key":"4687_CR199","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1615\/CritRevEukaryotGeneExpr.2020028454","volume":"30","author":"B Ahmed","year":"2020","unstructured":"Ahmed B, Qadir MI, Ghafoor S. Malignant Melanoma: Skin Cancer-Diagnosis, Prevention, and Treatment. Crit Rev Eukaryot Gene Expr. 2020;30(4):291\u20137.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"3","key":"4687_CR200","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1615\/CritRevEukaryotGeneExpr.2021040319","volume":"32","author":"L Cong","year":"2022","unstructured":"Cong L, Yang H, Sun H, Hao M, Liu C, Zheng Y, et al. Role of Circular RNAs in the Pathogenesis of Malignant Melanoma. Crit Rev Eukaryot Gene Expr. 2022;32(3):21\u201330.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"4","key":"4687_CR201","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.ncrna.2024.05.010","volume":"9","author":"A Mafi","year":"2024","unstructured":"Mafi A, Hedayati N, Kahkesh S, Khoshayand S, Alimohammadi M, Farahani N, et al. The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways. Non-coding RNA Res. 2024;9(4):1178\u201389.","journal-title":"Non-coding RNA Res"},{"issue":"6","key":"4687_CR202","doi-asserted-by":"publisher","first-page":"e0287347","DOI":"10.1371\/journal.pone.0287347","volume":"18","author":"H Zhu","year":"2023","unstructured":"Zhu H, Zhang P, Shi J, Kou D, Bai X. Exosome-delivered circRPS5 inhibits the progression of melanoma via regulating the miR-151a\/NPTX1 axis. PLoS ONE. 2023;18(6):e0287347.","journal-title":"PLoS ONE"},{"issue":"7","key":"4687_CR203","doi-asserted-by":"publisher","first-page":"e366","DOI":"10.1038\/oncsis.2017.66","volume":"6","author":"I Daugaard","year":"2017","unstructured":"Daugaard I, Sanders KJ, Idica A, Vittayarukskul K, Hamdorf M, Krog JD, et al. miR-151a induces partial EMT by regulating E-cadherin in NSCLC cells. Oncogenesis. 2017;6(7):e366.","journal-title":"Oncogenesis"},{"issue":"12","key":"4687_CR204","first-page":"6779","volume":"24","author":"S Guo","year":"2020","unstructured":"Guo S, Zhang J, Zhao YY, Zhou LY, Xie Y, Wu XY, et al. The expressions of miR-151a-5p and miR-23b in lung cancer tissues and their effects on the biological functions of lung cancer A549 cells. Eur Rev Med Pharmacol Sci. 2020;24(12):6779\u201385.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"5","key":"4687_CR205","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3892\/ol.2022.13275","volume":"23","author":"J Wu","year":"2022","unstructured":"Wu J, Liu G, An K, Shi L. NPTX1 inhibits pancreatic cancer cell proliferation and migration and enhances chemotherapy sensitivity by targeting RBM10. Oncol Lett. 2022;23(5):154.","journal-title":"Oncol Lett"},{"key":"4687_CR206","unstructured":"Pelcovits A, Niroula R. Acute Myeloid Leukemia: A Review. Rhode Island medical journal (2013). 2020;103(3):38\u201340."},{"issue":"1","key":"4687_CR207","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1182\/blood-2015-07-604496","volume":"127","author":"D Grimwade","year":"2016","unstructured":"Grimwade D, Ivey A, Huntly BJ. Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance. Blood. 2016;127(1):29\u201341.","journal-title":"Blood"},{"key":"4687_CR208","doi-asserted-by":"crossref","unstructured":"Yeh SC, Cheong FJF, Tay Y. Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia. Int J Mol Sci. 2023;24(4):3215.","DOI":"10.3390\/ijms24043215"},{"issue":"1","key":"4687_CR209","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12943-021-01446-z","volume":"20","author":"V Singh","year":"2021","unstructured":"Singh V, Uddin MH, Zonder JA, Azmi AS, Balasubramanian SK. Circular RNAs in acute myeloid leukemia. Mol Cancer. 2021;20(1):149.","journal-title":"Mol Cancer"},{"key":"4687_CR210","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.3389\/fonc.2019.01108","volume":"9","author":"M Jamal","year":"2019","unstructured":"Jamal M, Song T, Chen B, Faisal M, Hong Z, Xie T, et al. Recent Progress on Circular RNA Research in Acute Myeloid Leukemia. Front Oncol. 2019;9:1108.","journal-title":"Front Oncol"},{"key":"4687_CR211","doi-asserted-by":"publisher","first-page":"1010579","DOI":"10.3389\/fphar.2022.1010579","volume":"13","author":"M Zhou","year":"2022","unstructured":"Zhou M, Gao X, Zheng X, Luo J. Functions and clinical significance of circular RNAs in acute myeloid leukemia. Front Pharmacol. 2022;13:1010579.","journal-title":"Front Pharmacol"},{"key":"4687_CR212","doi-asserted-by":"publisher","first-page":"1149187","DOI":"10.3389\/fonc.2023.1149187","volume":"13","author":"A Rahmati","year":"2023","unstructured":"Rahmati A, Mafi A, Soleymani F, Babaei Aghdam Z, Masihipour N, Ghezelbash B, et al. Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia. Front Oncol. 2023;13:1149187.","journal-title":"Front Oncol"},{"key":"4687_CR213","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bcmd.2018.12.006","volume":"75","author":"L Ping","year":"2019","unstructured":"Ping L, Jian-Jun C, Chu-Shu L, Guang-Hua L, Ming Z. Silencing of circ_0009910 inhibits acute myeloid leukemia cell growth through increasing miR-20a-5p. Blood Cells Mol Dis. 2019;75:41\u20137.","journal-title":"Blood Cells Mol Dis"},{"key":"4687_CR214","doi-asserted-by":"publisher","first-page":"117255","DOI":"10.1016\/j.lfs.2020.117255","volume":"243","author":"HX Cao","year":"2020","unstructured":"Cao HX, Miao CF, Sang LN, Huang YM, Zhang R, Sun L, et al. Circ_0009910 promotes imatinib resistance through ULK1-induced autophagy by sponging miR-34a-5p in chronic myeloid leukemia. Life Sci. 2020;243:117255.","journal-title":"Life Sci"},{"issue":"3","key":"4687_CR215","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/hon.2874","volume":"39","author":"D Wang","year":"2021","unstructured":"Wang D, Ming X, Xu J, Xiao Y. Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p\/GRB10 axis. Hematol Oncol. 2021;39(3):390\u2013400.","journal-title":"Hematol Oncol"},{"issue":"7","key":"4687_CR216","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1080\/15384047.2020.1743150","volume":"21","author":"Y Li","year":"2020","unstructured":"Li Y, Jiang A. ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6. Cancer Biol Ther. 2020;21(7):647\u201355.","journal-title":"Cancer Biol Ther"},{"issue":"7","key":"4687_CR217","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.3727\/096504016X14831120463349","volume":"25","author":"Z Jiang","year":"2017","unstructured":"Jiang Z, Zhang Y, Cao R, Li L, Zhong K, Chen Q, et al. miR-5195-3p Inhibits Proliferation and Invasion of Human Bladder Cancer Cells by Directly Targeting Oncogene KLF5. Oncol Res. 2017;25(7):1081\u20137.","journal-title":"Oncol Res"},{"issue":"4","key":"4687_CR218","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/leu.2014.283","volume":"29","author":"AL Illert","year":"2015","unstructured":"Illert AL, Albers C, Kreutmair S, Leischner H, Peschel C, Miething C, et al. Grb10 is involved in BCR-ABL-positive leukemia in mice. Leukemia. 2015;29(4):858\u201368.","journal-title":"Leukemia"},{"issue":"3","key":"4687_CR219","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.molonc.2012.11.003","volume":"7","author":"JU Kazi","year":"2013","unstructured":"Kazi JU, R\u00f6nnstrand L. FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia. Mol Oncol. 2013;7(3):402\u201318.","journal-title":"Mol Oncol"},{"issue":"1","key":"4687_CR220","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s41065-024-00330-2","volume":"161","author":"Y Yu","year":"2024","unstructured":"Yu Y, Shang Y, Shi S, He Y, Shi W, Wang M, et al. Combination of arsenic trioxide and apatinib synergistically inhibits small cell lung cancer by down-regulating VEGFR2\/mTOR and Akt\/c-Myc signaling pathway via GRB10. Hereditas. 2024;161(1):29.","journal-title":"Hereditas"},{"issue":"2","key":"4687_CR221","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/ijlh.13742","volume":"44","author":"Y Wu","year":"2022","unstructured":"Wu Y, Zhao B, Chen X, Geng X, Zhang Z. Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K\/AKT signaling pathway. Int J Lab Hematol. 2022;44(2):320\u201332.","journal-title":"Int J Lab Hematol"},{"issue":"6","key":"4687_CR222","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.euo.2021.09.006","volume":"4","author":"G Gandaglia","year":"2021","unstructured":"Gandaglia G, Leni R, Bray F, Fleshner N, Freedland SJ, Kibel A, et al. Epidemiology and Prevention of Prostate Cancer. Eur Urol Oncol. 2021;4(6):877\u201392.","journal-title":"Eur Urol Oncol"},{"issue":"3","key":"4687_CR223","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"Cancer J Clin"},{"key":"4687_CR224","doi-asserted-by":"crossref","unstructured":"Sekhoacha M, Riet K, Motloung P, Gumenku L, Adegoke A, Mashele S. Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches. Molecules. 2022;27(17):5730.","DOI":"10.3390\/molecules27175730"},{"issue":"1","key":"4687_CR225","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12943-021-01480-x","volume":"21","author":"YZ Yu","year":"2022","unstructured":"Yu YZ, Lv DJ, Wang C, Song XL, Xie T, Wang T, et al. Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p. Mol Cancer. 2022;21(1):12.","journal-title":"Mol Cancer"},{"issue":"12","key":"4687_CR226","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1002\/iub.2915","volume":"76","author":"A Lin","year":"2024","unstructured":"Lin A, Li J, He W. CircSLC4A7 in resistant-cells-derived exosomes promotes docetaxel resistance via the miR-1205\/MAPT axis in prostate cancer. IUBMB Life. 2024;76(12):1342\u201355.","journal-title":"IUBMB Life"},{"issue":"7","key":"4687_CR227","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/s41374-019-0197-x","volume":"99","author":"KH Strang","year":"2019","unstructured":"Strang KH, Golde TE, Giasson BI. MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Lab Invest. 2019;99(7):912\u201328.","journal-title":"Lab Invest"},{"issue":"11","key":"4687_CR228","doi-asserted-by":"publisher","first-page":"862","DOI":"10.3390\/brainsci10110862","volume":"10","author":"S Papin","year":"2020","unstructured":"Papin S, Paganetti P. Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer. Brain Sci. 2020;10(11):862.","journal-title":"Brain Sci"},{"issue":"1","key":"4687_CR229","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12957-021-02164-y","volume":"19","author":"R Liu","year":"2021","unstructured":"Liu R, Deng P, Zhang Y, Wang Y, Peng C. Circ_0082182 promotes oncogenesis and metastasis of colorectal cancer in vitro and in vivo by sponging miR-411 and miR-1205 to activate the Wnt\/\u03b2-catenin pathway. World J Surg Oncol. 2021;19(1):51.","journal-title":"World J Surg Oncol"},{"issue":"11","key":"4687_CR230","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1007\/s12033-023-00684-4","volume":"65","author":"X Zhou","year":"2023","unstructured":"Zhou X, Zhao Q, Xiao M. Hsa_circ_0137652 Regulates miR-1205\/CCNB1 Axis to Accelerate the Malignancy of Breast Cancer. Mol Biotechnol. 2023;65(11):1824\u201335.","journal-title":"Mol Biotechnol"},{"issue":"3","key":"4687_CR231","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s10549-022-06801-2","volume":"198","author":"AI Aljohani","year":"2023","unstructured":"Aljohani AI, Toss MS, Green AR, Rakha EA. The clinical significance of cyclin B1 (CCNB1) in invasive breast cancer with emphasis on its contribution to lymphovascular invasion development. Breast Cancer Res Treat. 2023;198(3):423\u201335.","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"4687_CR232","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1007\/s10528-021-10160-w","volume":"60","author":"Y Wu","year":"2022","unstructured":"Wu Y. Circ_0044516 Enriches the Level of SARM1 as a miR-330-5p Sponge to Regulate Cell Malignant Behaviors and Tumorigenesis of Prostate Cancer. Biochem Genet. 2022;60(4):1346\u201361.","journal-title":"Biochem Genet"},{"key":"4687_CR233","doi-asserted-by":"publisher","first-page":"673237","DOI":"10.3389\/fcell.2021.673237","volume":"9","author":"R Zang","year":"2021","unstructured":"Zang R, Qiu X, Song Y, Wang Y. Exosomes Mediated Transfer of Circ_0000337 Contributes to Cisplatin (CDDP) Resistance of Esophageal Cancer by Regulating JAK2 via miR-377-3p. Front Cell Dev Biol. 2021;9:673237.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"4687_CR234","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12943-019-0986-2","volume":"18","author":"H Bai","year":"2019","unstructured":"Bai H, Lei K, Huang F, Jiang Z, Zhou X. Exo-circRNAs: a new paradigm for anticancer therapy. Mol Cancer. 2019;18(1):56.","journal-title":"Mol Cancer"},{"key":"4687_CR235","doi-asserted-by":"crossref","unstructured":"Wang D, Li R, Jiang J, Qian H, Xu W. Exosomal circRNAs: Novel biomarkers and therapeutic targets for gastrointestinal tumors. Volume 157. Biomedicine & pharmacotherapy\u2009=\u2009Biomedecine & pharmacotherapie; 2023. p. 114053.","DOI":"10.1016\/j.biopha.2022.114053"},{"key":"4687_CR236","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.pharmthera.2018.01.010","volume":"187","author":"B Han","year":"2018","unstructured":"Han B, Chao J, Yao H. Circular RNA and its mechanisms in disease: From the bench to the clinic. Pharmacol Ther. 2018;187:31\u201344.","journal-title":"Pharmacol Ther"},{"issue":"16","key":"4687_CR237","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.2174\/0109298673259378231031061149","volume":"32","author":"N Hedayati","year":"2025","unstructured":"Hedayati N, Babaei Aghdam Z, Rezaee M, Mousavi Dehmordi R, Alimohammadi M, Mafi A. Recent Insights into the Angioregulatory Role of Long Non-coding RNAs and Circular RNAs in Gliomas: From Signaling Pathways to Clinical Aspects. Curr Med Chem. 2025;32(16):3169\u201392.","journal-title":"Curr Med Chem"},{"issue":"1","key":"4687_CR238","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13045-023-01452-2","volume":"16","author":"F Zhang","year":"2023","unstructured":"Zhang F, Jiang J, Qian H, Yan Y, Xu W. Exosomal circRNA: emerging insights into cancer progression and clinical application potential. J Hematol Oncol. 2023;16(1):67.","journal-title":"J Hematol Oncol"},{"key":"4687_CR239","doi-asserted-by":"publisher","first-page":"790589","DOI":"10.3389\/fonc.2021.790589","volume":"11","author":"X-Y Liu","year":"2022","unstructured":"Liu X-Y, Zhang Q, Guo J, Zhang P, Liu H, Tian Z-B, et al. The role of circular RNAs in the drug resistance of cancers. Front Oncol. 2022;11:790589.","journal-title":"Front Oncol"},{"issue":"5","key":"4687_CR240","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41419-021-03680-1","volume":"12","author":"S-j Yang","year":"2021","unstructured":"Yang S-j, Wang D-d, Zhong S-l, Chen W-q, Wang F-l, Zhang J, et al. Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637\/Akt1\/\u03b2-catenin (cyclin D1) axis. Cell Death Dis. 2021;12(5):420.","journal-title":"Cell Death Dis"},{"issue":"3","key":"4687_CR241","doi-asserted-by":"publisher","first-page":"918","DOI":"10.7150\/jca.50548","volume":"12","author":"S Liu","year":"2021","unstructured":"Liu S, Lin Z, Rao W, Zheng J, Xie Q, Lin Y, et al. Upregulated expression of serum exosomal hsa_circ_0026611 is associated with lymph node metastasis and poor prognosis of esophageal squamous cell carcinoma. J Cancer. 2021;12(3):918.","journal-title":"J Cancer"},{"key":"4687_CR242","doi-asserted-by":"publisher","first-page":"7739","DOI":"10.2147\/CMAR.S259424","volume":"12","author":"Y Li","year":"2020","unstructured":"Li Y, Zang H, Zhang X, Huang G. Exosomal Circ-ZNF652 Promotes Cell Proliferation, Migration, Invasion and Glycolysis in Hepatocellular Carcinoma via miR-29a-3p\/GUCD1 Axis. Cancer Manag Res. 2020;12:7739\u201351.","journal-title":"Cancer Manag Res"},{"issue":"5","key":"4687_CR243","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2217\/bmm-2020-0476","volume":"15","author":"L Lyu","year":"2021","unstructured":"Lyu L, Yang W, Yao J, Wang H, Zhu J, Jin A, et al. The Diagnostic Value of Plasma Exosomal HSA_CIRC_0070396 for Hepatocellular Carcinoma. Biomark Med. 2021;15(5):359\u201371.","journal-title":"Biomark Med"},{"key":"4687_CR244","doi-asserted-by":"crossref","unstructured":"Lin Y, Zheng Z-H, Wang J-X, Zhao Z, Peng T-Y. Tumor Cell-Derived Exosomal Circ-0072088 Suppresses Migration and Invasion of Hepatic Carcinoma Cells Through Regulating MMP-16. Front Cell Dev Biology. 2021;9:726323.","DOI":"10.3389\/fcell.2021.726323"},{"key":"4687_CR245","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.2147\/JHC.S317256","volume":"8","author":"C Huang","year":"2021","unstructured":"Huang C, Yu W, Wang Q, Huang T, Ding Y. CircANTXR1 Contributes to the Malignant Progression of Hepatocellular Carcinoma by Promoting Proliferation and Metastasis. J Hepatocell Carcinoma. 2021;8:1339\u201353.","journal-title":"J Hepatocell Carcinoma"},{"issue":"6","key":"4687_CR246","first-page":"6001","volume":"13","author":"S Guo","year":"2021","unstructured":"Guo S, Hu C, Zhai X, Sun D. Circular RNA 0006602 in plasma exosomes: a new potential diagnostic biomarker for hepatocellular carcinoma. Am J Transl Res. 2021;13(6):6001\u201315.","journal-title":"Am J Transl Res"},{"key":"4687_CR247","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.suronc.2020.04.021","volume":"33","author":"Y Luo","year":"2020","unstructured":"Luo Y, Liu F, Gui R. High expression of circulating exosomal circAKT3 is associated with higher recurrence in HCC patients undergoing surgical treatment. Surg Oncol. 2020;33:276\u201381.","journal-title":"Surg Oncol"},{"issue":"1","key":"4687_CR248","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12943-020-01222-5","volume":"19","author":"P-F Zhang","year":"2020","unstructured":"Zhang P-F, Gao C, Huang X-Y, Lu J-C, Guo X-J, Shi G-M, et al. Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma. Mol Cancer. 2020;19(1):110.","journal-title":"Mol Cancer"},{"issue":"14","key":"4687_CR249","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.7150\/jca.30360","volume":"11","author":"F He","year":"2020","unstructured":"He F, Zhong X, Lin Z, Lin J, Qiu M, Li X, et al. Plasma exo-hsa_circRNA_0056616: A potential biomarker for lymph node metastasis in lung adenocarcinoma. J Cancer. 2020;11(14):4037\u201346.","journal-title":"J Cancer"},{"issue":"1","key":"4687_CR250","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41419-020-2230-9","volume":"11","author":"J Wang","year":"2020","unstructured":"Wang J, Zhao X, Wang Y, Ren F, Sun D, Yan Y, et al. circRNA-002178 act as a ceRNA to promote PDL1\/PD1 expression in lung adenocarcinoma. Cell Death Dis. 2020;11(1):32.","journal-title":"Cell Death Dis"},{"issue":"5","key":"4687_CR251","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1080\/15384101.2021.2024997","volume":"21","author":"Y Liu","year":"2022","unstructured":"Liu Y, Li L, Song X. Exosomal circPVT1 derived from lung cancer promotes the progression of lung cancer by targeting miR-124-3p\/EZH2 axis and regulating macrophage polarization. Cell Cycle. 2022;21(5):514\u201330.","journal-title":"Cell Cycle"},{"key":"4687_CR252","doi-asserted-by":"crossref","unstructured":"Ding C, Xi G, Wang G, Cui D, Zhang B, Wang H et al. Exosomal Circ-MEMO1 Promotes the Progression and Aerobic Glycolysis of Non-small Cell Lung Cancer Through Targeting MiR-101-3p\/KRAS Axis. Front Genet. 2020;11:962.","DOI":"10.3389\/fgene.2020.00962"},{"key":"4687_CR253","doi-asserted-by":"publisher","first-page":"5293","DOI":"10.2147\/OTT.S243214","volume":"13","author":"J Ma","year":"2020","unstructured":"Ma J, Qi G, Li L. A Novel Serum Exosomes-Based Biomarker hsa_circ_0002130 Facilitates Osimertinib-Resistance in Non-Small Cell Lung Cancer by Sponging miR-498. Onco Targets Ther. 2020;13:5293\u2013307.","journal-title":"Onco Targets Ther"},{"key":"4687_CR254","doi-asserted-by":"crossref","unstructured":"Xian J, Su W, Liu L, Rao B, Lin M, Feng Y, et al. Identification of Three Circular RNA Cargoes in Serum Exosomes as Diagnostic Biomarkers of Non\u2013Small-Cell Lung Cancer in the Chinese Population. The Journal of Molecular Diagnostics. 2020;22(8):1096\u2009\u2013\u2009108.","DOI":"10.1016\/j.jmoldx.2020.05.011"},{"issue":"14","key":"4687_CR255","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1111\/febs.14132","volume":"284","author":"X Zhu","year":"2017","unstructured":"Zhu X, Wang X, Wei S, Chen Y, Chen Y, Fan X, et al. hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma. FEBS J. 2017;284(14):2170\u201382.","journal-title":"FEBS J"},{"key":"4687_CR256","doi-asserted-by":"publisher","first-page":"5510869","DOI":"10.1155\/2021\/5510869","volume":"2021","author":"YW Chen","year":"2021","unstructured":"Chen YW, Du QR, He YJ, Chen WS, Jiang WY, Gui Q, et al. Circ_0044516 Regulates miR-136\/MAT2A Pathway to Facilitate Lung Cancer Development. J Immunol Res. 2021;2021:5510869.","journal-title":"J Immunol Res"},{"issue":"1","key":"4687_CR257","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13046-020-01791-9","volume":"40","author":"J Cao","year":"2021","unstructured":"Cao J, Zhang X, Xu P, Wang H, Wang S, Zhang L, et al. Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2\/\u03b2-catenin pathway. J experimental Clin cancer research: CR. 2021;40(1):6.","journal-title":"J experimental Clin cancer research: CR"},{"issue":"1","key":"4687_CR258","doi-asserted-by":"publisher","first-page":"20220625","DOI":"10.1515\/med-2022-0625","volume":"18","author":"Z Kuang","year":"2023","unstructured":"Kuang Z, Yang H, Cheng S, Zhou X, Chen L, Zhang Y, et al. Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p\/HMGA1 axis. Open Med (Warsaw Poland). 2023;18(1):20220625.","journal-title":"Open Med (Warsaw Poland)"},{"issue":"23","key":"4687_CR259","first-page":"8248","volume":"22","author":"M Liu","year":"2018","unstructured":"Liu M, Liu KD, Zhang L, Cai J, Yao HW, Bai YK, et al. Circ_0009910 regulates growth and metastasis and is associated with poor prognosis in gastric cancer. Eur Rev Med Pharmacol Sci. 2018;22(23):8248\u201356.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"4687_CR260","doi-asserted-by":"publisher","first-page":"16497","DOI":"10.1038\/s41598-019-53063-y","volume":"9","author":"KW Hon","year":"2019","unstructured":"Hon KW, Ab-Mutalib NS, Abdullah NMA, Jamal R, Abu N. Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer. Sci Rep. 2019;9(1):16497.","journal-title":"Sci Rep"},{"key":"4687_CR261","doi-asserted-by":"crossref","unstructured":"Pan B, Qin J, Liu X, He B, Wang X, Pan Y et al. Identification of Serum Exosomal hsa-circ-0004771 as a Novel Diagnostic Biomarker of Colorectal Cancer. Front Genet. 2019;10:1096.","DOI":"10.3389\/fgene.2019.01096"},{"key":"4687_CR262","doi-asserted-by":"publisher","first-page":"7451","DOI":"10.2147\/OTT.S123220","volume":"9","author":"JN Guo","year":"2016","unstructured":"Guo JN, Li J, Zhu CL, Feng WT, Shao JX, Wan L, et al. Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer. Onco Targets Ther. 2016;9:7451\u20138.","journal-title":"Onco Targets Ther"},{"issue":"1","key":"4687_CR263","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12957-021-02378-0","volume":"19","author":"S Kadkhoda","year":"2021","unstructured":"Kadkhoda S, Taslimi R, Noorbakhsh F, Darbeheshti F, Bazzaz JT, Ghafouri-Fard S, et al. Importance of Circ0009910 in colorectal cancer pathogenesis as a possible regulator of miR-145 and PEAK1. World J Surg Oncol. 2021;19(1):265.","journal-title":"World J Surg Oncol"},{"issue":"1","key":"4687_CR264","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13578-022-00833-3","volume":"12","author":"Q Chen","year":"2022","unstructured":"Chen Q, Li J, Shen P, Yuan H, Yin J, Ge W, et al. Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star. Cell Bioscience. 2022;12(1):97.","journal-title":"Cell Bioscience"},{"issue":"1","key":"4687_CR265","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s13046-018-0822-3","volume":"37","author":"J Li","year":"2018","unstructured":"Li J, Li Z, Jiang P, Peng M, Zhang X, Chen K, et al. Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis. J Experimental Clin Cancer Res. 2018;37(1):177.","journal-title":"J Experimental Clin Cancer Res"},{"issue":"6","key":"4687_CR267","doi-asserted-by":"publisher","first-page":"e24447","DOI":"10.1002\/jcla.24447","volume":"36","author":"L Hong","year":"2022","unstructured":"Hong L, Xu L, Jin L, Xu K, Tang W, Zhu Y, et al. Exosomal circular RNA hsa_circ_0006220, and hsa_circ_0001666 as biomarkers in the diagnosis of pancreatic cancer. J Clin Lab Anal. 2022;36(6):e24447.","journal-title":"J Clin Lab Anal"},{"issue":"6","key":"4687_CR268","doi-asserted-by":"publisher","first-page":"e0305050","DOI":"10.1371\/journal.pone.0305050","volume":"19","author":"Y Tong","year":"2024","unstructured":"Tong Y, Jia L, Li M, Li H, Wang S. Identification of exosomal circSLC26A4 as a liquid biopsy marker for cervical cancer. PLoS ONE. 2024;19(6):e0305050.","journal-title":"PLoS ONE"},{"issue":"2","key":"4687_CR269","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3892\/ol.2024.14820","volume":"29","author":"BX Tolentino-Molina","year":"2025","unstructured":"Tolentino-Molina BX, Loaeza-Loaeza J, Ortega-Soto A, Castro-Coronel Y, Fern\u00e1ndez-Tilapa G, Hern\u00e1ndez-Sotelo D. Hsa_circ_0009910 knockdown in HeLa cells increases miR\u2013198 expression levels and decreases c\u2013Met expression levels and cell viability. Oncol Lett. 2025;29(2):74.","journal-title":"Oncol Lett"},{"key":"4687_CR270","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.2147\/CMAR.S290645","volume":"13","author":"S Huo","year":"2021","unstructured":"Huo S, Dou D. Circ_0056285 Regulates Proliferation, Apoptosis and Glycolysis of Osteosarcoma Cells via miR-1244\/TRIM44 Axis. Cancer Manag Res. 2021;13:1257\u201370.","journal-title":"Cancer Manag Res"},{"issue":"null","key":"4687_CR271","doi-asserted-by":"publisher","first-page":"11883","DOI":"10.2147\/OTT.S284192","volume":"13","author":"Q Lu","year":"2020","unstructured":"Lu Q, Wang X, Zhu J, Fei X, Chen H, Li C. Hypoxic Tumor-Derived Exosomal Circ0048117 Facilitates M2 Macrophage Polarization Acting as miR-140 Sponge in Esophageal Squamous Cell Carcinoma. OncoTargets Therapy. 2020;13(null):11883\u201397.","journal-title":"OncoTargets Therapy"},{"issue":"7","key":"4687_CR272","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/s41419-022-05056-5","volume":"13","author":"X Geng","year":"2022","unstructured":"Geng X, Zhang Y, Lin X, Zeng Z, Hu J, Hao L, et al. Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p\/MGMT axis in glioma. Cell Death Dis. 2022;13(7):596.","journal-title":"Cell Death Dis"},{"issue":"9","key":"4687_CR273","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1111\/cas.14984","volume":"112","author":"J Si","year":"2021","unstructured":"Si J, Li W, Li X, Cao L, Chen Z, Jiang Z. Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma. Cancer Sci. 2021;112(9):3491\u2013506.","journal-title":"Cancer Sci"},{"key":"4687_CR274","doi-asserted-by":"crossref","unstructured":"Xia D, Gu X. Plasmatic exosome-derived circRNAs panel act as fingerprint for glioblastoma. Aging. 2021;13(15):19575\u201386.","DOI":"10.18632\/aging.203368"},{"issue":"1","key":"4687_CR275","doi-asserted-by":"publisher","first-page":"63","DOI":"10.32604\/or.2022.028168","volume":"31","author":"G Wang","year":"2023","unstructured":"Wang G, Qian M, Jian W, Chu J, Huang Y. Has_circ_0000069 expression in breast cancer and its influences on prognosis and cellular activities. Oncol Res. 2023;31(1):63\u201370.","journal-title":"Oncol Res"},{"issue":"2","key":"4687_CR276","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.ncrna.2024.01.016","volume":"9","author":"M Abtin","year":"2024","unstructured":"Abtin M, Nafisi N, Hosseinzadeh A, Kadkhoda S, Omranipour R, Sahebi L, et al. Inhibition of breast cancer cell growth and migration through siRNA-mediated modulation of circ_0009910\/miR-145-5p\/MUC1 axis. Non-coding RNA Res. 2024;9(2):367\u201375.","journal-title":"Non-coding RNA Res"},{"key":"4687_CR278","doi-asserted-by":"publisher","first-page":"9031","DOI":"10.2147\/IJN.S528115","volume":"20","author":"Y Shi","year":"2025","unstructured":"Shi Y, Chen H, Li W, An S, Li L, Gao H. Harnessing EVs-ncRNA for Lung Cancer: From Oncogenic Pathways to Novel Diagnostic and Therapeutic Strategies. Int J Nanomed. 2025;20:9031\u201354.","journal-title":"Int J Nanomed"},{"key":"4687_CR279","doi-asserted-by":"publisher","first-page":"787551","DOI":"10.3389\/fbioe.2021.787551","volume":"9","author":"T Tesovnik","year":"2021","unstructured":"Tesovnik T, Jenko Bizjan B, \u0160ket R, Debeljak M, Battelino T, Kova\u010d J. Technological approaches in the analysis of extracellular vesicle nucleotide sequences. Front Bioeng Biotechnol. 2021;9:787551.","journal-title":"Front Bioeng Biotechnol"},{"issue":"12","key":"4687_CR280","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.3390\/biom14121599","volume":"14","author":"S Kumari","year":"2024","unstructured":"Kumari S, Lausted C, Scherler K, Ng AHC, Lu Y, Lee I, et al. Approaches and Challenges in Characterizing the Molecular Content of Extracellular Vesicles for Biomarker Discovery. Biomolecules. 2024;14(12):1599.","journal-title":"Biomolecules"},{"key":"4687_CR281","doi-asserted-by":"publisher","first-page":"725323","DOI":"10.3389\/fimmu.2021.725323","volume":"12","author":"L Ting\u00f6","year":"2021","unstructured":"Ting\u00f6 L, Ahlberg E, Johansson L, Pedersen SA, Chawla K, S\u00e6trom P, et al. Non-coding RNAs in human breast milk: a systematic review. Front Immunol. 2021;12:725323.","journal-title":"Front Immunol"},{"issue":"12","key":"4687_CR282","doi-asserted-by":"publisher","first-page":"e70005","DOI":"10.1002\/jev2.70005","volume":"13","author":"RT Miceli","year":"2024","unstructured":"Miceli RT, Chen TY, Nose Y, Tichkule S, Brown B, Fullard JF, et al. Extracellular vesicles, RNA sequencing, and bioinformatic analyses: Challenges, solutions, and recommendations. J Extracell Vesicles. 2024;13(12):e70005.","journal-title":"J Extracell Vesicles"},{"issue":"31","key":"4687_CR283","doi-asserted-by":"publisher","first-page":"28021","DOI":"10.1021\/acsnano.5c00706","volume":"19","author":"HL Tran","year":"2025","unstructured":"Tran HL, Zheng W, Issadore DA, Im H, Cho Y-K, Zhang Y, et al. Extracellular vesicles for clinical diagnostics: from bulk measurements to single-vesicle analysis. ACS Nano. 2025;19(31):28021\u2013109.","journal-title":"ACS Nano"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-026-04687-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04687-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04687-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:03:44Z","timestamp":1776236624000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-026-04687-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":273,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4687"],"URL":"https:\/\/doi.org\/10.1007\/s12672-026-04687-w","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"assertion":[{"value":"18 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not involve any animal or human experimental models. Hence, ethical approval is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"During the preparation of this work, the author(s) used ChatGPT to correct the grammatical and typographical errors in the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of Generative AI and AIassisted technologies in the writing process"}}],"article-number":"564"}}