{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:14:47Z","timestamp":1778152487441,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Natural Science Foundation of Guangxi","award":["2023GXNSFDA026013"],"award-info":[{"award-number":["2023GXNSFDA026013"]}]},{"name":"the Natural Science Foundation of Guangxi","award":["2023GXNSFDA026013"],"award-info":[{"award-number":["2023GXNSFDA026013"]}]},{"name":"the Natural Science Foundation of Guangxi","award":["2023GXNSFDA026013"],"award-info":[{"award-number":["2023GXNSFDA026013"]}]},{"name":"the Natural Science Foundation of Guangxi","award":["2023GXNSFDA026013"],"award-info":[{"award-number":["2023GXNSFDA026013"]}]},{"name":"the First Affiliated Hospital of Guangxi Medical University Clinical Research Climbing Plan Young Science and Technology Rising Star Plan","award":["YYZS2020024"],"award-info":[{"award-number":["YYZS2020024"]}]},{"name":"the First Affiliated Hospital of Guangxi Medical University Clinical Research Climbing Plan Young Science and Technology Rising Star Plan","award":["YYZS2020024"],"award-info":[{"award-number":["YYZS2020024"]}]},{"name":"the First Affiliated Hospital of Guangxi Medical University Clinical Research Climbing Plan Young Science and Technology Rising Star Plan","award":["YYZS2020024"],"award-info":[{"award-number":["YYZS2020024"]}]},{"name":"the First Affiliated Hospital of Guangxi Medical University Clinical Research Climbing Plan Young Science and Technology Rising Star Plan","award":["YYZS2020024"],"award-info":[{"award-number":["YYZS2020024"]}]},{"name":"Nanning City Qingxiu District Science and Technology Plan","award":["2020045"],"award-info":[{"award-number":["2020045"]}]},{"name":"Nanning City Qingxiu District Science and Technology Plan","award":["2020045"],"award-info":[{"award-number":["2020045"]}]},{"name":"Nanning City Qingxiu District Science and Technology Plan","award":["2020045"],"award-info":[{"award-number":["2020045"]}]},{"name":"Nanning City Qingxiu District Science and Technology Plan","award":["2020045"],"award-info":[{"award-number":["2020045"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Olfactory neuroblastoma (ONB) is a rare malignant tumor arising from the nasal cavity and paranasal sinuses, often presenting diagnostic challenges due to its potential for recurrence and distant metastasis, particularly to uncommon sites such as the liver.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report the case of a 42-year-old female with a history of ONB who was admitted after a liver mass was detected during routine examinations at another hospital two months earlier. The lesion was initially misdiagnosed as primary hepatocellular carcinoma based on imaging findings from contrast-enhanced ultrasound, enhanced CT, and MRI, which revealed a focal lesion in liver segments S5\/6. Laboratory results showed slightly elevated AFP (8.91 ng\/ml) and CA19-9 (37.12 U\/ml), with no other significant abnormalities. The patient subsequently underwent open liver resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postoperative pathological examination revealed a malignant small round blue cell tumor. Histomorphological and immunohistochemical findings, in conjunction with the patient\u2019s clinical history, confirmed the diagnosis of hepatic metastasis from ONB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hepatic metastasis of ONB can closely mimic primary liver cancer on imaging, underscoring the necessity of integrating comprehensive clinical history, imaging assessment, and pathological confirmation to avoid misdiagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12672-026-04689-8","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T08:25:45Z","timestamp":1774772745000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic challenges in hepatic metastatic olfactory neuroblastoma: a case report and literature review"],"prefix":"10.1007","volume":"17","author":[{"given":"Ke","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyue","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinshu","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"4689_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s12105-022-01435-8","volume":"16","author":"O Mete","year":"2022","unstructured":"Mete O, Wenig BM. 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Orphanet J Rare Dis. 2021;16:400.","journal-title":"Orphanet J Rare Dis"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-026-04689-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04689-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04689-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:51:46Z","timestamp":1778151106000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-026-04689-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,29]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4689"],"URL":"https:\/\/doi.org\/10.1007\/s12672-026-04689-8","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,29]]},"assertion":[{"value":"17 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective case report was conducted using data collected for clinical purposes and was deemed exempt from formal Institutional Review Board approval by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University, as it involves a single-patient case report and does not constitute research involving human subjects. The study complies with the ethical standards of our institution and the 1964 Helsinki Declaration and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Informed consent to participate in the study was waived by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University due to the retrospective nature of this case report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"710"}}