{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:12:42Z","timestamp":1778735562552,"version":"3.51.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Identification of Prognostic Risk Factors for Biliary Tract Malignancies and Clinical Targeted Therapeutic Translation Based on Database Analysis","award":["220171557"],"award-info":[{"award-number":["220171557"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-026-04766-y","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:47:03Z","timestamp":1775231223000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated single-cell and bulk RNA sequencing analysis identifies a pyroptosis related prognostic model for predicting prognosis and therapeutic response in intrahepatic cholangiocarcinoma"],"prefix":"10.1007","volume":"17","author":[{"given":"Pei","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shikun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"issue":"1","key":"4766_CR1","first-page":"42","volume":"31","author":"MC Bragazzi","year":"2018","unstructured":"Bragazzi MC, Ridola L, Safarikia S, Matteo SD, Costantini D, Nevi L, et al. New insights into cholangiocarcinoma: multiple stems and related cell lineages of origin. Ann Gastroenterol. 2018;31(1):42\u201355.","journal-title":"Ann Gastroenterol"},{"issue":"3","key":"4766_CR2","first-page":"286","volume":"73","author":"V Wadhwa","year":"2023","unstructured":"Wadhwa V, Patel N, Grover D, Ali FS, Thosani N. Interventional gastroenterology in oncology. CA Cancer J Clin. 2023;73(3):286\u2013319.","journal-title":"CA Cancer J Clin"},{"key":"4766_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejca.2022.11.006","volume":"179","author":"GS Roth","year":"2023","unstructured":"Roth GS, Neuzillet C, Sarabi M, Edeline J, Malka D, Li\u00e8vre A. Cholangiocarcinoma: what are the options in all comers and how has the advent of molecular profiling opened the way to personalised medicine ? Eur J Cancer. 2023;179:1\u201314.","journal-title":"Eur J Cancer"},{"issue":"1","key":"4766_CR4","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1038\/s41467-022-30708-7","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Ma Z, Li C, Wang C, Jiang W, Chang J, et al. The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers. Nat Commun. 2022;13(1):3061.","journal-title":"Nat Commun"},{"issue":"5","key":"4766_CR5","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/hep.30493","volume":"69","author":"B Goeppert","year":"2019","unstructured":"Goeppert B, Toth R, Singer S, Albrecht T, Lipka DB, Lutsik P, et al. Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma. Hepatology. 2019;69(5):2091\u2013106.","journal-title":"Hepatology"},{"key":"4766_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.omto.2022.09.008","volume":"27","author":"W Yao","year":"2022","unstructured":"Yao W, Liu X, He Y, Tian M, Lu S, Wang Q, et al. ScRNA-seq and bulk RNA-seq reveal the characteristics of ferroptosis and establish a risk signature in cholangiocarcinoma. Mol Ther Oncolytics. 2022;27:48\u201360.","journal-title":"Mol Ther Oncolytics"},{"issue":"1","key":"4766_CR7","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1186\/s12885-022-09665-3","volume":"22","author":"H Zhu","year":"2022","unstructured":"Zhu H, Zhao H, Wang J, Zhao S, Ma C, Wang D, et al. Potential prognosis index for m(6)A-related mRNA in cholangiocarcinoma. BMC Cancer. 2022;22(1):620.","journal-title":"BMC Cancer"},{"issue":"3","key":"4766_CR8","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25(3):486\u2013541.","journal-title":"Cell Death Differ"},{"issue":"4","key":"4766_CR9","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi J, Gao W, Shao F, Pyroptosis. Gasdermin-Mediated Programmed Necrotic Cell Death. Trends Biochem Sci. 2017;42(4):245\u201354.","journal-title":"Trends Biochem Sci"},{"key":"4766_CR10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/cancers11091313","volume":"11","author":"M Wang","year":"2019","unstructured":"Wang M, Jiang S, Zhang Y, Li P, Wang K. The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer. Cancers (Basel). 2019;11:9.","journal-title":"Cancers (Basel)"},{"issue":"2","key":"4766_CR11","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41418-022-01095-9","volume":"30","author":"S Missiroli","year":"2023","unstructured":"Missiroli S, Perrone M, Gaf\u00e0 R, Nicoli F, Bonora M, Morciano G, et al. PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment. Cell Death Differ. 2023;30(2):429\u201341.","journal-title":"Cell Death Differ"},{"key":"4766_CR12","doi-asserted-by":"publisher","first-page":"993771","DOI":"10.3389\/fimmu.2022.993771","volume":"13","author":"C Lang","year":"2022","unstructured":"Lang C, Roy S, Wang Y, Graves D, Xu Y, Serezani CH, et al. Efferocytosis drives myeloid NLRP3 dependent inflammasome signaling secretion of IL-1\u03b2 to promote tumor growth. Front Immunol. 2022;13:993771.","journal-title":"Front Immunol"},{"issue":"33","key":"4766_CR13","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1038\/s41388-025-03514-w","volume":"44","author":"YF Xu","year":"2025","unstructured":"Xu YF, Liu ZL, Pan C, Yang XQ, Ning SL, Liu HD, et al. Correction: HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium. Oncogene. 2025;44(33):3037\u20139.","journal-title":"Oncogene"},{"issue":"11","key":"4766_CR14","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.3748\/wjg.v21.i11.3256","volume":"21","author":"YF Xu","year":"2015","unstructured":"Xu YF, Ge FJ, Han B, Yang XQ, Su H, Zhao AC, et al. High-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma. World J Gastroenterol. 2015;21(11):3256\u201365.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"4766_CR15","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ajpath.2016.10.010","volume":"187","author":"L Maroni","year":"2017","unstructured":"Maroni L, Agostinelli L, Saccomanno S, Pinto C, Giordano DM, Rychlicki C, et al. Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes. Am J Pathol. 2017;187(2):366\u201376.","journal-title":"Am J Pathol"},{"issue":"5","key":"4766_CR16","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1002\/hep.29652","volume":"67","author":"E Kaffe","year":"2018","unstructured":"Kaffe E, Fiorotto R, Pellegrino F, Mariotti V, Amenduni M, Cadamuro M, et al. \u03b2-Catenin and interleukin-1\u03b2-dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis. Hepatology. 2018;67(5):1903\u201319.","journal-title":"Hepatology"},{"issue":"2","key":"4766_CR17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1158\/2159-8290.CD-20-0805","volume":"11","author":"SR Rosenbaum","year":"2021","unstructured":"Rosenbaum SR, Wilski NA, Aplin AE. Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy. Cancer Discov. 2021;11(2):266\u201381.","journal-title":"Cancer Discov"},{"issue":"7","key":"4766_CR18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/s41551-020-0583-0","volume":"4","author":"Y Gao","year":"2020","unstructured":"Gao Y, Zhang H, Zhou N, Xu P, Wang J, Gao Y, et al. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 2020;4(7):743\u201353.","journal-title":"Nat Biomed Eng"},{"issue":"4","key":"4766_CR19","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nbt.2859","volume":"32","author":"C Trapnell","year":"2014","unstructured":"Trapnell C, Cacchiarelli D, Grimsby J, Pokharel P, Li S, Morse M, et al. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat Biotechnol. 2014;32(4):381\u20136.","journal-title":"Nat Biotechnol"},{"issue":"6","key":"4766_CR20","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.jhep.2021.06.028","volume":"75","author":"L Ma","year":"2021","unstructured":"Ma L, Wang L, Khatib SA, Chang CW, Heinrich S, Dominguez DA, et al. Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. J Hepatol. 2021;75(6):1397\u2013408.","journal-title":"J Hepatol"},{"issue":"4","key":"4766_CR21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.4174\/astr.2019.96.4.153","volume":"96","author":"KS Ahn","year":"2019","unstructured":"Ahn KS, Kang KJ, Kim YH, Kim TS, Song BI, Kim HW, et al. Genetic features associated with (18)F-FDG uptake in intrahepatic cholangiocarcinoma. Ann Surg Treat Res. 2019;96(4):153\u201361.","journal-title":"Ann Surg Treat Res"},{"key":"4766_CR22","doi-asserted-by":"crossref","unstructured":"Hao Y, Hao S, Andersen-Nissen E, Mauck WM 3rd, Zheng S, Butler A, et al. Integrated analysis of multimodal single-cell data. Cell. 2021;184(13):3573\u2013e8729.","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"4766_CR23","doi-asserted-by":"crossref","unstructured":"Safran M, Dalah I, Alexander J, Rosen N, Iny Stein T, Shmoish M et al. GeneCards Version 3: the human gene integrator. Database (Oxford). 2010; 2010: baq020.","DOI":"10.1093\/database\/baq020"},{"issue":"4","key":"4766_CR24","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","volume":"15","author":"M Efremova","year":"2020","unstructured":"Efremova M, Vento-Tormo M, Teichmann SA, Vento-Tormo R. CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes. Nat Protoc. 2020;15(4):1484\u2013506.","journal-title":"Nat Protoc"},{"issue":"4","key":"4766_CR25","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"G Bindea","year":"2013","unstructured":"Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782\u201395.","journal-title":"Immunity"},{"issue":"5","key":"4766_CR26","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","volume":"24","author":"M Binnewies","year":"2018","unstructured":"Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018;24(5):541\u201350.","journal-title":"Nat Med"},{"issue":"5","key":"4766_CR27","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ng0506-500","volume":"38","author":"M Reich","year":"2006","unstructured":"Reich M, Liefeld T, Gould J, Lerner J, Tamayo P, Mesirov JP. GenePattern 2.0. Nat Genet. 2006;38(5):500\u20131.","journal-title":"Nat Genet"},{"issue":"1","key":"4766_CR28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13073-020-0721-z","volume":"12","author":"J Fu","year":"2020","unstructured":"Fu J, Li K, Zhang W, Wan C, Zhang J, Jiang P, et al. Large-scale public data reuse to model immunotherapy response and resistance. Genome Med. 2020;12(1):21.","journal-title":"Genome Med"},{"issue":"Database issue","key":"4766_CR29","first-page":"D955","volume":"41","author":"W Yang","year":"2013","unstructured":"Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, et al. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 2013;41(Database issue):D955\u201361.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"4766_CR30","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jaci.2022.02.031","volume":"150","author":"Y Li","year":"2022","unstructured":"Li Y, Chang LH, Huang WQ, Bao HW, Li X, Chen XH, et al. IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP. J Allergy Clin Immunol. 2022;150(2):337\u201351.","journal-title":"J Allergy Clin Immunol"},{"issue":"14","key":"4766_CR31","doi-asserted-by":"publisher","first-page":"5873","DOI":"10.7314\/APJCP.2014.15.14.5873","volume":"15","author":"S Thongchot","year":"2014","unstructured":"Thongchot S, Yongvanit P, Loilome W, Seubwai W, Phunicom K, Tassaneeyakul W, et al. High expression of HIF-1\u03b1, BNIP3 and PI3KC3: hypoxia-induced autophagy predicts cholangiocarcinoma survival and metastasis. Asian Pac J Cancer Prev. 2014;15(14):5873\u20138.","journal-title":"Asian Pac J Cancer Prev"},{"issue":"4","key":"4766_CR32","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","volume":"152","author":"D Sia","year":"2017","unstructured":"Sia D, Villanueva A, Friedman SL, Llovet JM. Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis. Gastroenterology. 2017;152(4):745\u201361.","journal-title":"Gastroenterology"},{"issue":"1","key":"4766_CR33","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13046-021-01959-x","volume":"40","author":"Y Tan","year":"2021","unstructured":"Tan Y, Chen Q, Li X, Zeng Z, Xiong W, Li G, et al. Pyroptosis: a new paradigm of cell death for fighting against cancer. J experimental Clin cancer research: CR. 2021;40(1):153.","journal-title":"J experimental Clin cancer research: CR"},{"key":"4766_CR34","doi-asserted-by":"publisher","first-page":"109552","DOI":"10.1016\/j.cellsig.2020.109552","volume":"69","author":"M Krze\u015bniak","year":"2020","unstructured":"Krze\u015bniak M, Zajkowicz A, Gdowicz-K\u0142osok A, G\u0142owala-Kosi\u0144ska M, \u0141asut-Szyszka B, Rusin M. Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity. Cell Signal. 2020;69:109552.","journal-title":"Cell Signal"},{"issue":"1","key":"4766_CR35","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/imm.13490","volume":"167","author":"R Feldtmann","year":"2022","unstructured":"Feldtmann R, K\u00fcmmel A, Chamling B, Strohbach A, Lehnert K, Gross S, et al. Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy. Immunology. 2022;167(1):40\u201353.","journal-title":"Immunology"},{"issue":"31","key":"4766_CR36","doi-asserted-by":"publisher","first-page":"e2201376119","DOI":"10.1073\/pnas.2201376119","volume":"119","author":"LT Ong","year":"2022","unstructured":"Ong LT, Lee WC, Ma S, Oguz G, Niu Z, Bao Y, et al. IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2\u2009+\u2009breast cancer. Proc Natl Acad Sci U S A. 2022;119(31):e2201376119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4766_CR37","doi-asserted-by":"publisher","first-page":"713322","DOI":"10.3389\/fphar.2021.713322","volume":"12","author":"X Hou","year":"2021","unstructured":"Hou X, Xia J, Feng Y, Cui L, Yang Y, Yang P, et al. USP47-Mediated Deubiquitination and Stabilization of TCEA3 Attenuates Pyroptosis and Apoptosis of Colorectal Cancer Cells Induced by Chemotherapeutic Doxorubicin. Front Pharmacol. 2021;12:713322.","journal-title":"Front Pharmacol"},{"issue":"6","key":"4766_CR38","doi-asserted-by":"publisher","first-page":"e22362","DOI":"10.1096\/fj.202101993RR","volume":"36","author":"X Wang","year":"2022","unstructured":"Wang X, Yin Y, Qian W, Peng C, Shen S, Wang T, et al. Citric acid of ovarian cancer metabolite induces pyroptosis via the caspase-4\/TXNIP-NLRP3-GSDMD pathway in ovarian cancer. Faseb j. 2022;36(6):e22362.","journal-title":"Faseb j"},{"key":"4766_CR39","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.canlet.2018.10.030","volume":"442","author":"Q Deng","year":"2019","unstructured":"Deng Q, Geng Y, Zhao L, Li R, Zhang Z, Li K, et al. NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver. Cancer Lett. 2019;442:21\u201330.","journal-title":"Cancer Lett"},{"issue":"3","key":"4766_CR40","first-page":"973","volume":"53","author":"XF Yin","year":"2018","unstructured":"Yin XF, Zhang Q, Chen ZY, Wang HF, Li X, Wang HX, et al. NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN\/AKT signaling pathway. Int J Oncol. 2018;53(3):973\u201386.","journal-title":"Int J Oncol"},{"issue":"2","key":"4766_CR41","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.yexcr.2016.03.009","volume":"342","author":"H Wang","year":"2016","unstructured":"Wang H, Wang Y, Du Q, Lu P, Fan H, Lu J, et al. Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells. Exp Cell Res. 2016;342(2):184\u201392.","journal-title":"Exp Cell Res"},{"key":"4766_CR42","doi-asserted-by":"publisher","first-page":"6574","DOI":"10.1038\/ncomms7574","volume":"6","author":"G dos Santos","year":"2015","unstructured":"dos Santos G, Rogel MR, Baker MA, Troken JR, Urich D, Morales-Nebreda L, et al. Vimentin regulates activation of the NLRP3 inflammasome. Nat Commun. 2015;6:6574.","journal-title":"Nat Commun"},{"issue":"1","key":"4766_CR43","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1038\/s41467-019-09482-6","volume":"10","author":"P Zhang","year":"2019","unstructured":"Zhang P, Cao L, Zhou R, Yang X, Wu M. The lncRNA Neat1 promotes activation of inflammasomes in macrophages. Nat Commun. 2019;10(1):1495.","journal-title":"Nat Commun"},{"issue":"9","key":"4766_CR44","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1038\/s41418-018-0239-8","volume":"26","author":"I Schulien","year":"2019","unstructured":"Schulien I, Hockenjos B, Schmitt-Graeff A, Perdekamp MG, Follo M, Thimme R, et al. The transcription factor c-Jun\/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression. Cell Death Differ. 2019;26(9):1688\u201399.","journal-title":"Cell Death Differ"},{"issue":"1","key":"4766_CR45","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ygeno.2021.12.008","volume":"114","author":"K He","year":"2022","unstructured":"He K, Feng Y, An S, Liu F, Xiang G. Integrative epigenomic profiling reveal AP-1 is a key regulator in intrahepatich cholangiocarcinoma. Genomics. 2022;114(1):241\u201352.","journal-title":"Genomics"},{"issue":"28","key":"4766_CR46","doi-asserted-by":"publisher","first-page":"16492","DOI":"10.1073\/pnas.2002672117","volume":"117","author":"E Manieri","year":"2020","unstructured":"Manieri E, Folgueira C, Rodr\u00edguez ME, Leiva-Vega L, Esteban-Lafuente L, Chen C, et al. JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma. Proc Natl Acad Sci U S A. 2020;117(28):16492\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"4766_CR47","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1002\/hep4.1495","volume":"4","author":"FJ Cubero","year":"2020","unstructured":"Cubero FJ, Mohamed MR, Woitok MM, Zhao G, Hatting M, Nevzorova YA, et al. Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatol Commun. 2020;4(6):834\u201351.","journal-title":"Hepatol Commun"},{"issue":"11","key":"4766_CR48","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/s41419-022-05418-z","volume":"13","author":"YL He","year":"2022","unstructured":"He YL, Li J, Gong SH, Cheng X, Zhao M, Cao Y, et al. BNIP3 phosphorylation by JNK1\/2 promotes mitophagy via enhancing its stability under hypoxia. Cell Death Dis. 2022;13(11):966.","journal-title":"Cell Death Dis"},{"issue":"3","key":"4766_CR49","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.jhep.2022.11.005","volume":"78","author":"J Merters","year":"2023","unstructured":"Merters J, Lamarca A. Integrating cytotoxic, targeted and immune therapies for cholangiocarcinoma. J Hepatol. 2023;78(3):652\u20137.","journal-title":"J Hepatol"},{"issue":"12","key":"4766_CR50","doi-asserted-by":"publisher","first-page":"111384","DOI":"10.1016\/j.celrep.2022.111384","volume":"40","author":"BP Keenan","year":"2022","unstructured":"Keenan BP, McCarthy EE, Ilano A, Yang H, Zhang L, Allaire K, et al. Circulating monocytes associated with anti-PD-1 resistance in human biliary cancer induce T cell paralysis. Cell Rep. 2022;40(12):111384.","journal-title":"Cell Rep"},{"issue":"13","key":"4766_CR51","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.3390\/cancers17132082","volume":"17","author":"M Kinoshita","year":"2025","unstructured":"Kinoshita M, Sato Y, Kubo S, Shinkawa H, Kimura K, Nishio K, et al. Subclassification-specific tumor immune microenvironment in intrahepatic cholangiocarcinoma: implications for appropriate pharmacotherapy. Cancers (Basel). 2025;17(13):2082.","journal-title":"Cancers (Basel)"},{"issue":"20","key":"4766_CR52","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.3390\/cancers16203542","volume":"16","author":"AD Ricci","year":"2024","unstructured":"Ricci AD, Rizzo A, Schirizzi A, D\u2019Alessandro R, Frega G, Brandi G, et al. Tumor immune microenvironment in intrahepatic cholangiocarcinoma: regulatory mechanisms, functions, and therapeutic implications. Cancers (Basel). 2024;16(20):3542.","journal-title":"Cancers (Basel)"},{"issue":"45","key":"4766_CR53","doi-asserted-by":"publisher","first-page":"6381","DOI":"10.1038\/s41388-021-02024-9","volume":"40","author":"X Chen","year":"2021","unstructured":"Chen X, Chen H, Yao H, Zhao K, Zhang Y, He D, et al. Turning up the heat on non-immunoreactive tumors: pyroptosis influences the tumor immune microenvironment in bladder cancer. Oncogene. 2021;40(45):6381\u201393.","journal-title":"Oncogene"},{"issue":"1","key":"4766_CR54","doi-asserted-by":"publisher","first-page":"1987636","DOI":"10.1080\/2162402X.2021.1987636","volume":"10","author":"W Song","year":"2021","unstructured":"Song W, Ren J, Xiang R, Kong C, Fu T. Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer. Oncoimmunology. 2021;10(1):1987636.","journal-title":"Oncoimmunology"},{"key":"4766_CR55","doi-asserted-by":"publisher","first-page":"782982","DOI":"10.3389\/fimmu.2022.782982","volume":"13","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Tan Y, Zhang J, Shi Y, Qi J, Zou D, et al. Pyroptosis-Related Signature Predicts Prognosis and Immunotherapy Efficacy in Muscle-Invasive Bladder Cancer. Front Immunol. 2022;13:782982.","journal-title":"Front Immunol"},{"issue":"3","key":"4766_CR56","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.cell.2016.01.002","volume":"164","author":"S Dadi","year":"2016","unstructured":"Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, et al. Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell. 2016;164(3):365\u201377.","journal-title":"Cell"},{"issue":"6494","key":"4766_CR57","doi-asserted-by":"publisher","first-page":"eaaz7548","DOI":"10.1126\/science.aaz7548","volume":"368","author":"Z Zhou","year":"2020","unstructured":"Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science. 2020;368(6494):eaaz7548.","journal-title":"Science"},{"issue":"4","key":"4766_CR58","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1002\/hep.30666","volume":"70","author":"C Hage","year":"2019","unstructured":"Hage C, Hoves S, Strauss L, Bissinger S, Prinz Y, P\u00f6schinger T, et al. Sorafenib Induces Pyroptosis in Macrophages and Triggers Natural Killer Cell-Mediated Cytotoxicity Against Hepatocellular Carcinoma. Hepatology. 2019;70(4):1280\u201397.","journal-title":"Hepatology"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-026-04766-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04766-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04766-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:47:53Z","timestamp":1778734073000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-026-04766-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4766"],"URL":"https:\/\/doi.org\/10.1007\/s12672-026-04766-y","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]},"assertion":[{"value":"28 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study utilized exclusively publicly available, de-identified data from the TCGA and GEO databases. Therefore, ethical approval was not required for this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Board Statement"}}],"article-number":"735"}}