{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:05:43Z","timestamp":1776668743603,"version":"3.51.2"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Medical Science and Technology Project of Zhejiang Province","award":["2022KY375"],"award-info":[{"award-number":["2022KY375"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-026-04814-7","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:48:29Z","timestamp":1773233309000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor-intrinsic KLRC1 exerts tumor-suppressive functions in colorectal cancer"],"prefix":"10.1007","volume":"17","author":[{"given":"Chao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"1","key":"4814_CR1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/jso.23806","volume":"111","author":"DO Herzig","year":"2015","unstructured":"Herzig DO, Tsikitis VL. Molecular markers for colon diagnosis, prognosis and targeted therapy. J Surg Oncol. 2015;111(1):96\u2013102.","journal-title":"J Surg Oncol"},{"issue":"1","key":"4814_CR2","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/clinchem\/hvad202","volume":"70","author":"SM Schwartz","year":"2024","unstructured":"Schwartz SM. Epidemiology of Cancer. Clin Chem. 2024;70(1):140\u20139.","journal-title":"Clin Chem"},{"issue":"4","key":"4814_CR3","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/DCR.0000000000000562","volume":"59","author":"JI Young","year":"2016","unstructured":"Young JI, Mongoue-Tchokote S, Wieghard N, Mori M, Vaccaro GM, Sheppard BC, et al. Treatment and Survival of Small-bowel Adenocarcinoma in the United States: a Comparison With Colon Cancer. Dis Colon Rectum. 2016;59(4):306\u201315.","journal-title":"Dis Colon Rectum"},{"key":"4814_CR4","doi-asserted-by":"publisher","first-page":"153303382311954","DOI":"10.1177\/15330338231195494","volume":"22","author":"C Kong","year":"2023","unstructured":"Kong C, Zheng L, Fang S, Chen M, Lin G, Qiu R, et al. Predictive Models for Colon Adenocarcinoma Diagnosis, Prognosis, and Immune Microenvironment Based on 2 Hypoxia-Related Genes: KDM3A and ENO3. Technol Cancer Res Treat. 2023;22:15330338231195494.","journal-title":"Technol Cancer Res Treat"},{"issue":"2","key":"4814_CR5","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1590\/s0004-2803.202000000-32","volume":"57","author":"S Aguiar Junior","year":"2020","unstructured":"Aguiar Junior S, Oliveira MM, Silva D, Mello C, Calsavara VF, Curado MP. Survival of patients with colorectal cancer in a cancer center. Arq Gastroenterol. 2020;57(2):172\u20137.","journal-title":"Arq Gastroenterol"},{"key":"4814_CR6","doi-asserted-by":"publisher","first-page":"960852","DOI":"10.3389\/fimmu.2022.960852","volume":"13","author":"X Wang","year":"2022","unstructured":"Wang X, Xiong H, Ning Z. Implications of NKG2A in immunity and immune-mediated diseases. Front Immunol. 2022;13:960852.","journal-title":"Front Immunol"},{"issue":"2","key":"4814_CR7","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ccell.2023.01.001","volume":"41","author":"X Liu","year":"2023","unstructured":"Liu X, Song J, Zhang H, Liu X, Zuo F, Zhao Y, et al. Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance. Cancer Cell. 2023;41(2):272\u2013. \u2013\u200987.e9.","journal-title":"Cancer Cell"},{"issue":"W1","key":"4814_CR8","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98\u2013102.","journal-title":"Nucleic Acids Res"},{"key":"4814_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1755-8794-2-18","volume":"2","author":"H Mizuno","year":"2009","unstructured":"Mizuno H, Kitada K, Nakai K, Sarai A. PrognoScan: a new database for meta-analysis of the prognostic value of genes. BMC Med Genomics. 2009;2:18.","journal-title":"BMC Med Genomics"},{"issue":"21","key":"4814_CR10","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","volume":"77","author":"T Li","year":"2017","unstructured":"Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, et al. TIMER: a Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells. Cancer Res. 2017;77(21):e108\u2013108110. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-0307.","journal-title":"Cancer Res"},{"issue":"1","key":"4814_CR11","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","volume":"18","author":"D Aran","year":"2017","unstructured":"Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18(1):220.","journal-title":"Genome Biol"},{"issue":"D1","key":"4814_CR12","doi-asserted-by":"publisher","first-page":"D1425","DOI":"10.1093\/nar\/gkac959","volume":"51","author":"Y Han","year":"2023","unstructured":"Han Y, Wang Y, Dong X, et al. TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment. Nucleic Acids Res. 2023;51(D1):D1425\u201331.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"4814_CR13","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1158\/2159-8290.CD-21-0316","volume":"12","author":"Y Wu","year":"2022","unstructured":"Wu Y, Yang S, Ma J, et al. Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level. Cancer Discov. 2022;12(1):134\u201353.","journal-title":"Cancer Discov"},{"issue":"1","key":"4814_CR14","doi-asserted-by":"publisher","first-page":"2046931","DOI":"10.1080\/2162402X.2022.2046931","volume":"11","author":"K Ducoin","year":"2022","unstructured":"Ducoin K, Oger R, Mutala LB, et al. Targeting NKG2A to boost anti-tumor CD8 T-cell responses in human colorectal cancer. Oncoimmunology. 2022;11(1):2046931.","journal-title":"Oncoimmunology"},{"issue":"1","key":"4814_CR15","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s40425-019-0553-9","volume":"7","author":"T Courau","year":"2019","unstructured":"Courau T, Bonnereau J, Chicoteau J, et al. Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA\/B and NKG2A targeting for cancer treatment. J Immunother Cancer. 2019;7(1):74.","journal-title":"J Immunother Cancer"},{"issue":"8","key":"4814_CR16","doi-asserted-by":"publisher","first-page":"100293","DOI":"10.1016\/j.patter.2021.100293","volume":"2","author":"\u00d3 Lapuente-Santana","year":"2021","unstructured":"Lapuente-Santana \u00d3, van Genderen M, Hilbers PAJ, Finotello F, Eduati F. Interpretable systems biomarkers predict response to immune-checkpoint inhibitors. Patterns (N Y). 2021;2(8):100293.","journal-title":"Patterns (N Y)"},{"key":"4814_CR17","doi-asserted-by":"publisher","first-page":"799497","DOI":"10.3389\/fmolb.2021.799497","volume":"8","author":"Y Yuan","year":"2021","unstructured":"Yuan Y, Jiang X, Tang L, Wang J, Duan L. Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer. Front Mol Biosci. 2021;8:799497.","journal-title":"Front Mol Biosci"},{"key":"4814_CR18","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3389\/fimmu.2020.00369","volume":"11","author":"E Picard","year":"2020","unstructured":"Picard E, Verschoor CP, Ma GW, Pawelec G. Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer. Front Immunol. 2020;11:369.","journal-title":"Front Immunol"},{"key":"4814_CR19","doi-asserted-by":"publisher","first-page":"e730","DOI":"10.1002\/ctm2.730","volume":"12","author":"H Jiang","year":"2022","unstructured":"Jiang H, Yu D, Yang P, Guo R, Kong M, Gao Y, Yu X, Lu X, Fan X. Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA Sequencing. Clin Transl Med. 2022;12:e730.","journal-title":"Clin Transl Med"},{"key":"4814_CR20","doi-asserted-by":"publisher","first-page":"1231916","DOI":"10.3389\/fimmu.2023.1231916","volume":"14","author":"AM Donald","year":"2023","unstructured":"Donald AM, Guipouy D, Lemieux W, Harvey M, Bordeleau L, Guay D, Rom\u00e9ro H, Li Y, Dion R, B\u00e9land K, et al. KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors. Front Immunol. 2023;14:1231916.","journal-title":"Front Immunol"},{"key":"4814_CR21","doi-asserted-by":"publisher","first-page":"8439","DOI":"10.1038\/s41467-024-52388-1","volume":"15","author":"T Bexte","year":"2024","unstructured":"Bexte T, Albinger N, Ajami AA, Wendel P, Buchinger L, Gessner A, Alzubi J, S\u00e4rchen V, Vogler M, Rasheed HM, et al. CRISPR\/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells. Nat Commun. 2024;15:8439.","journal-title":"Nat Commun"},{"key":"4814_CR22","doi-asserted-by":"publisher","first-page":"eadk8832","DOI":"10.1126\/scitranslmed.adk8832","volume":"16","author":"T Minowa","year":"2024","unstructured":"Minowa T, Murata K, Mizue Y, Murai A, Nakatsugawa M, Sasaki K, Tokita S, Kubo T, Kanaseki T, Tsukahara T, et al. Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment. Sci Transl Med. 2024;16:eadk8832.","journal-title":"Sci Transl Med"},{"key":"4814_CR23","doi-asserted-by":"publisher","first-page":"6211","DOI":"10.1038\/s41467-024-50474-y","volume":"15","author":"Q Ye","year":"2024","unstructured":"Ye Q, Zhu L, Liang J, Zhao D, Tian T, Fan Y, Ye S, Liu H, Huang X, Cao Z, et al. Orchestrating NK and T cells via tri-specific nano-antibodies for synergistic antitumor immunity. Nat Commun. 2024;15:6211.","journal-title":"Nat Commun"},{"key":"4814_CR24","doi-asserted-by":"crossref","unstructured":"Kotlyarov S. Immunology of atherosclerosis: problems and prospects of immunotherapy. Vessel Plus. 2025.","DOI":"10.20517\/2574-1209.2025.40"},{"key":"4814_CR25","doi-asserted-by":"crossref","unstructured":"Botros M, Fadah K, Mukherjee D. The role of inflammatory response in the development of atherosclerosis, myocardial infarction, and remodeling. Vessel Plus. 2024.","DOI":"10.20517\/2574-1209.2024.14"},{"key":"4814_CR26","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.3389\/fimmu.2019.03002","volume":"10","author":"Y Chen","year":"2019","unstructured":"Chen Y, Xin Z, Huang L, Zhao L, Wang S, Cheng J, Wu P, Chai Y. CD8(+) T Cells Form the Predominant Subset of NKG2A(+) Cells in Human Lung Cancer. Front Immunol. 2019;10:3002.","journal-title":"Front Immunol"},{"key":"4814_CR27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13578-022-00814-6","volume":"12","author":"L Yang","year":"2022","unstructured":"Yang L, Chen S, Xia J, Zhou Y, Peng L, Fan H, Han Y, Duan L, Cheng G, Yang H, et al. Histone deacetylase 3 facilitates TNF\u03b1-mediated NF-\u03baB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection. Cell Biosci. 2022;12:81.","journal-title":"Cell Biosci"},{"key":"4814_CR28","doi-asserted-by":"publisher","first-page":"101251","DOI":"10.1016\/j.gendis.2024.101251","volume":"12","author":"C Qiu","year":"2025","unstructured":"Qiu C, Cheng L, Di D, Xiang Z, Wang C, Li J, Xiong Y, Li M, Liu J, Zhou J, et al. TNF\u03b1-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis. Genes Dis. 2025;12:101251.","journal-title":"Genes Dis"},{"key":"4814_CR29","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1161\/CIRCULATIONAHA.121.058411","volume":"146","author":"R Dhingra","year":"2022","unstructured":"Dhingra R, Rabinovich-Nikitin I, Rothman S, Guberman M, Gang H, Margulets V, Jassal DS, Alagarsamy KN, Dhingra S, Ripoll CV, et al. Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy. Circulation. 2022;146:934\u201354.","journal-title":"Circulation"},{"key":"4814_CR30","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","volume":"16","author":"PEJ van der Meijden","year":"2019","unstructured":"van der Meijden PEJ, Heemskerk JWM. Platelet biology and functions: new concepts and clinical perspectives. Nat Rev Cardiol. 2019;16:166\u201379.","journal-title":"Nat Rev Cardiol"},{"key":"4814_CR31","first-page":"101484","volume":"35","author":"A Chatterjee","year":"2024","unstructured":"Chatterjee A, Tumarin J, Prabhakar S. Role of inflammation in the progression of diabetic kidney disease. Best Pract Res Clin Endocrinol Metab. 2024;35:101484.","journal-title":"Best Pract Res Clin Endocrinol Metab"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-026-04814-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04814-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04814-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:14:38Z","timestamp":1776665678000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-026-04814-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4814"],"URL":"https:\/\/doi.org\/10.1007\/s12672-026-04814-7","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"30 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Animal experiment protocol has been reviewed and approved Laboratory animal ethics committee of the Affiliated Hospital of Jiaxing University (Approval notice: JUMC2024-002). The maximal permitted tumor burden approved by the Institutional Animal Care and Use Committee of the Affiliated Hospital of Jiaxing University was a tumor volume not exceeding 1500 mm\n                      3\n                      (or a diameter\u2009\u2264\u200915\u00a0mm). Throughout the study, tumor volume was regularly measured and did not exceed this limit in any animal. In cases where tumor size approached the threshold, animals were euthanized promptly in accordance with the protocol to ensure adherence to ethical guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Animal experiments were conducted according to the Health Guide for the Care and comply with the ARRIVE guidelines. We confirm the maximal tumor size\/burden was not exceeded.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal experiment statement"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"592"}}