{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:02:25Z","timestamp":1779685345382,"version":"3.53.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-026-04844-1","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T09:35:59Z","timestamp":1775381759000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological and molecular characteristics of small cell carcinoma of the ovary, hypercalcemic type: three case reports"],"prefix":"10.1007","volume":"17","author":[{"given":"Weiyang","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"4844_CR1","first-page":"15","volume":"15","author":"FSPL Wens","year":"2023","unstructured":"Wens FSPL, Hulsker CCC, Fiocco M, Mavinkurve-Groothuis AMC, et al. Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Patient Characteristics, Treatment, and Outcome-A Systematic Review. Cancers. 2023;15:15.","journal-title":"Syst Rev Cancers"},{"issue":"11","key":"4844_CR2","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1097\/00000478-199411000-00004","volume":"18","author":"RH Young","year":"1994","unstructured":"Young RH, Oliva E, Scully RE. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. Am J SurgPathol. 1994;18(11):1102\u201316.","journal-title":"Am J SurgPathol"},{"issue":"4","key":"4844_CR3","doi-asserted-by":"publisher","first-page":"238","DOI":"10.5114\/pjp.2013.39331","volume":"64","author":"J Kupryjanczyk","year":"2013","unstructured":"Kupryjanczyk J, Dansonka-Mieszkowska A, Moes-Sosnowska J, Spiewankiewicz B, et al. Ovarian small cell carcinoma of hypercalcemic type - evidence of germline origin and SMARCA4 gene inactivation. a pilot study. Pol J Pathol. 2013;64(4):238\u201346.","journal-title":"Pol J Pathol"},{"issue":"5","key":"4844_CR4","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/ng.2922","volume":"46","author":"P Jelinic","year":"2014","unstructured":"Jelinic P, Mueller JJ, Olvera N, Levine DA, et al. Recurrent SMARCA4 mutations in small cell carcinoma of the ovary. Nat Genet. 2014;46(5):424\u20136.","journal-title":"Nat Genet"},{"issue":"1","key":"4844_CR5","doi-asserted-by":"publisher","first-page":"e967148","DOI":"10.4161\/2167549X.2014.967148","volume":"2","author":"P Ramos","year":"2014","unstructured":"Ramos P, Karnezis AN, Hendricks WP, Trent JM, et al. Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Rare Dis. 2014;2(1):e967148.","journal-title":"Rare Dis"},{"issue":"5","key":"4844_CR6","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/ng.2928","volume":"46","author":"P Ramos","year":"2014","unstructured":"Ramos P, Karnezis AN, Craig DW, Trent JM, et al. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nat Genet. 2014;46(5):427\u20139.","journal-title":"Nat Genet"},{"issue":"5","key":"4844_CR7","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/ng.2931","volume":"46","author":"L Witkowski","year":"2014","unstructured":"Witkowski L, Carrot-Zhang J, Albrecht, Foulkes WD, et al. Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type. Nat Genet. 2014;46(5):438\u201343.","journal-title":"Nat Genet"},{"key":"4844_CR8","unstructured":"Scully RE. Tumors of the ovary and maldeveloped gonads. Atlas of Tumor Pathology, Second series, Fascicle. 16. Washington DC: Armed Forces Institute of Pathology; 1979."},{"issue":"1","key":"4844_CR9","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/1097-0142(19820101)49:1<188::AID-CNCR2820490137>3.0.CO;2-D","volume":"49","author":"GR Dickersin","year":"1982","unstructured":"Dickersin GR, Kline IW, Scully RE. Small cell carcinoma of the ovary with hypercalcemia: a report of eleven cases. Cancer. 1982;49(1):188\u201397.","journal-title":"Cancer"},{"issue":"7","key":"4844_CR10","first-page":"1878","volume":"73","author":"X Matias-Guiu","year":"1994","unstructured":"Matias-Guiu X, Prat J, Young RH, Scully RE, et al. Human parathyroid hormone-related protein in ovarian small cell carcinoma. An immunohistochemical study. Cancer. 1994;73(7):1878\u201381.","journal-title":"immunohistochemical study Cancer"},{"issue":"4","key":"4844_CR11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.5858\/2005-129-531-SCCOTO","volume":"129","author":"L Chen","year":"2005","unstructured":"Chen L, Dinh TA, Haque A. Small cell carcinoma of the ovary with hypercalcemia and ectopic parathyroid hormone production. Arch Pathol Lab Med. 2005;129(4):531\u20133.","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"4844_CR12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.7150\/jca.26978","volume":"10","author":"B Lu","year":"2019","unstructured":"Lu B, Shi H. An in-depth look at small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): clinical implications from recent molecular findings. J Cancer. 2019;10(1):223\u201337.","journal-title":"J Cancer"},{"issue":"3","key":"4844_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3109\/01913129809033472","volume":"22","author":"GR Dickersin","year":"1998","unstructured":"Dickersin GR, Scully RE. Ovarian small cell tumors: an electron microscopic review. Ultrastruct Pathol. 1998;22(3):199\u2013226.","journal-title":"Ultrastruct Pathol"},{"key":"4844_CR14","doi-asserted-by":"publisher","first-page":"e59073","DOI":"10.7554\/eLife.59073","volume":"9","author":"KA Orlando","year":"2020","unstructured":"Orlando KA, Douglas AK, Abudu A, Weissman BE, et al. Re-expression of SMARCA4\/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism. Elife. 2020;9:e59073.","journal-title":"Elife"},{"issue":"2","key":"4844_CR15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0046-8177(87)80336-2","volume":"18","author":"TM Ulbright","year":"1987","unstructured":"Ulbright TM, Roth LM, Stehman FB, Senekjian EK, et al. Poorly differentiated (small cell) carcinoma of the ovary in young women: evidence supporting a germ cell origin. Hum Pathol. 1987;18(2):175\u201384.","journal-title":"Hum Pathol"},{"key":"4844_CR16","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/his.13177","volume":"70","author":"WG McCluggage","year":"2017","unstructured":"McCluggage WG, Witkowski L, Clarke BA, et al. Clinical, morphological and immunohistochemical evidence that small-cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be aprimitive germ-cell neoplasm. Histopathology. 2017;70:1147\u201354.","journal-title":"Histopathology"},{"key":"4844_CR17","volume-title":"WHO Classification of Tumours. Female Genital Tumours","author":"The WHO Classification of Tumours Editorial Board","year":"2020","unstructured":"The WHO Classification of Tumours Editorial Board. WHO Classification of Tumours. Female Genital Tumours. 5th ed. Lyon, France: IARC; 2020.","edition":"5"},{"issue":"3","key":"4844_CR18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/path.4633","volume":"238","author":"AN Karnezis","year":"2016","unstructured":"Karnezis AN, Wang Y, Ramos P, Huntsman DG, et al. Dual loss of the SWI\/SNF complex ATPases SMARCA4\/BRG1 and SMARCA2\/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type. J Pathol. 2016;238(3):389\u2013400.","journal-title":"J Pathol"},{"key":"4844_CR19","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.3390\/cells9061496","volume":"9","author":"A Auguste","year":"2020","unstructured":"Auguste A, Blanc-Durand F, Deloger M, Leary A, et al. Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) beyond SMARCA4 mutations: a comprehensive genomic analysis. Cells. 2020;9:1496.","journal-title":"Cells"},{"issue":"2","key":"4844_CR20","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/curroncol29020037","volume":"29","author":"MFE da Sim\u00f5es","year":"2022","unstructured":"Sim\u00f5es MFE, da Costa AABA, Silva TN, De Brot L, et al. Case Report of Small Cell Carcinoma of the Ovary, Hypercalcemic Type (Ovarian Rhabdoid Tumor) with SMARCB1 Mutation: A Literature Review of a Rare and Aggressive Condition. Curr Oncol. 2022;29(2):411\u201322.","journal-title":"Curr Oncol"},{"issue":"4","key":"4844_CR21","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/s41416-019-0687-z","volume":"122","author":"C Genestie","year":"2020","unstructured":"Genestie C, Blanc-Durand F, Auguste A, Leary A, et al. Clinical utility of SMARCA4 testing by immunohistochemistry in rare ovarian tumours. Brit J Cancer. 2020;122(4):564\u20138.","journal-title":"Brit J Cancer"},{"issue":"15","key":"4844_CR22","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1158\/1078-0432.CCR-19-3797","volume":"26","author":"M Tischkowitz","year":"2020","unstructured":"Tischkowitz M, Huang S, Banerjee S, et al. Small-cell carcinoma of the ovary, hypercalcemic type-genetics, new treatment targets, and current management guidelines. Clin Cancer Res. 2020;26(15):3908\u201317.","journal-title":"Clin Cancer Res"},{"issue":"5","key":"4844_CR23","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1177\/10935266211021213","volume":"24","author":"D Atwi","year":"2021","unstructured":"Atwi D, Quinton MR, Kiser RM, Yu Z, et al. Small Cell Carcinoma of the Ovary, Hypercalcemic Type, in a 12-Month-Old Girl. Padiatr Devel Pathol. 2021;24(5):493\u20137.","journal-title":"Padiatr Devel Pathol"},{"issue":"3","key":"4844_CR24","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.ygyno.2016.03.013","volume":"141","author":"L Witkowski","year":"2016","unstructured":"Witkowski L, Goudie C, Ramos P, Foulkes WD, et al. The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. Gynecol Oncol. 2016;141(3):454\u201360.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"4844_CR25","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2350\/15-04-1624-CR.1","volume":"19","author":"PM Lavrut","year":"2016","unstructured":"Lavrut PM, Le Loarer F, Normand C, Collardeau-Frachon S, et al. Small Cell Carcinoma of the Ovary, Hypercalcemic Type, Report of a Bilateral Case in a Teenager Associated with SMARCA4 Germline Mutation. Pediatr Devel Pathol. 2016;19(1):56\u201360.","journal-title":"Pediatr Devel Pathol"},{"issue":"3","key":"4844_CR26","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s10689-016-9957-6","volume":"16","author":"L Witkowski","year":"2017","unstructured":"Witkowski L, Donini N, Byler-Dann R, Foulkes WD, et al. The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type, two new familial cases. Fam Cancer. 2017;16(3):395\u20139.","journal-title":"Fam Cancer"},{"issue":"4","key":"4844_CR27","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/01.pgp.0000139644.38835.9d","volume":"23","author":"WG McCluggage","year":"2004","unstructured":"McCluggage WG, Oliva E, Connolly LE, McBride HA, Young RH. An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type. Int J Gynecol Pathol. 2004;23(4):330\u20136.","journal-title":"Int J Gynecol Pathol"},{"issue":"3","key":"4844_CR28","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1177\/1066896920947788","volume":"29","author":"P Gupta","year":"2021","unstructured":"Gupta P, Kapatia G, Gupta N, Srinivasan R, et al. Small Cell Carcinoma of the Ovary: Clinicopathologic and Immunohistochemical Analysis of 7 New Cases of a Rare Malignancy. Int J Surg Pathol. 2021;29(3):236\u201345.","journal-title":"Int J Surg Pathol"},{"key":"4844_CR29","unstructured":"Zhao J, Luo RK, Chen TT, Ning Y, et al. Small cell carcinoma of the ovary of hypercalcaemic type: a clinicopathological analysis of sixteen cases. Zhonghua Bing Li Xue Za Zhi.2024; 53 (12): 1210\u20136."},{"issue":"9","key":"4844_CR30","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1097\/PAS.0000000000000475","volume":"39","author":"M Karanian-Philippe","year":"2015","unstructured":"Karanian-Philippe M, Velasco V, Longy M, Croce S, et al. SMARCA4 (BRG1) loss of expression is a useful marker for the diagnosis of ovarian small cell carcinoma of the hypercalcemic type (ovarian rhabdoid tumor): a comprehensive analysis of 116 rare gynecologic tumors, 9 soft tissue tumors, and 9 melanomas. Am J Surg Pathol. 2015;39(9):1197\u2013205.","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"4844_CR31","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/his.12988","volume":"69","author":"BA Clarke","year":"2016","unstructured":"Clarke BA, Witkowski L, Ton Nu TN, McCluggage WG, et al. Loss of SMARCA4 (BRG1) protein expression as determined by immunohistochemistry in small-cell carcinoma of the ovary, hypercalcaemic type distinguishes these tumours from their mimics. Histopathology. 2016;69(5):727\u201338.","journal-title":"Histopathology"},{"issue":"3","key":"4844_CR32","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1097\/PAS.0000000000000558","volume":"40","author":"N Conlon","year":"2016","unstructured":"Conlon N, Silva A, Guerra E, Soslow RA, et al. Loss of SMARCA4 Expression is both sensitive and specific for the diagnosis of small cell carcinoma of ovary, hypercalcemic type. Am J Surg Pathol. 2016;40(3):395\u2013403.","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"4844_CR33","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1097\/PAS.0000000000002088","volume":"47","author":"J Mazibrada","year":"2023","unstructured":"Mazibrada J, Jayatunge N, Domecq C, et al. Unusual aspects of small cell carcinoma of the ovary of hypercalcaemic type: retained smarca4 immunohistochemical staining and positive staining with TLE1. Am J Surg Pathol. 2023;47(11):1261\u20136.","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"4844_CR34","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1097\/PAS.0000000000002296","volume":"48","author":"J Cyrta","year":"2024","unstructured":"Cyrta J, Brillet R, Laas E, Masliah-Planchon J, et al. Additional considerations on aberrant BRG1 (SMARCA4) expression in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Am J Surg Pathol. 2024;48(10):1335\u20138.","journal-title":"AM J SURG PATHOL"},{"issue":"10","key":"4844_CR35","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1097\/PAS.0000000000002295","volume":"48","author":"J Mazibrada","year":"2024","unstructured":"Mazibrada J, Croce S, Foulkes WD, McCluggage WG. Reply to Letter by Cyrta entitled Additional considerations on aberrant BRG1 (SMARCA4) expression in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Am J Sugr Pathol. 2024;48(10):1338\u201340.","journal-title":"Am J Sugr Pathol"},{"issue":"1","key":"4844_CR36","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/modpathol.2015.129","volume":"29","author":"P Jelinic","year":"2016","unstructured":"Jelinic P, Schlappe BA, Conlon N, Levine DA. Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type. Mod Pathol. 2016;29(1):60\u20136.","journal-title":"Mod Pathol"},{"issue":"4","key":"4844_CR37","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/s41588-019-0363-5","volume":"51","author":"J Pan","year":"2019","unstructured":"Pan J, McKenzie ZM, D\u2019Avino AR, Kadoch C, et al. The ATPase module of mammalian SWI\/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting. Nat Genet. 2019;51(4):618\u201326.","journal-title":"Nat Genet"},{"key":"4844_CR38","doi-asserted-by":"publisher","first-page":"217282","DOI":"10.1016\/j.canlet.2024.217282","volume":"605","author":"NR Field","year":"2024","unstructured":"Field NR, Dickson KA, Nassif NT, Marsh. DJ. SMARCA4 and SMARCA2 co-deficiency: An uncommon molecular signature defining a subset of rare, aggressive and undifferentiated malignancies associated with defective chromatin remodeling. Cancer Lett. 2024;605:217282.","journal-title":"Cancer Lett"},{"key":"4844_CR39","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00428-024-03854-0","volume":"3","author":"K N\u011bmejcov\u00e1","year":"2024","unstructured":"N\u011bmejcov\u00e1 K, \u0160afanda A, Kendall B\u00e1rt\u016f M, Dundr P, et al. An extensive immunohistochemical analysis of 290 ovarian adult granulosa cell tumors with 29 markers. Virchows Arch. 2024;3:427\u201337.","journal-title":"Virchows Arch"},{"issue":"3","key":"4844_CR40","doi-asserted-by":"publisher","first-page":"102201","DOI":"10.1016\/j.labinv.2024.102201","volume":"105","author":"R Mich\u00e1lkov\u00e1","year":"2025","unstructured":"Mich\u00e1lkov\u00e1 R, \u0160afanda A, H\u00e1jkov\u00e1 N, N\u011bmejcov\u00e1 K, et al. The molecular landscape of 227 adult granulosa cell tumors of the ovary: Insights into the progression from primary to recurrence. Lab Invest. 2025;105(3):102201.","journal-title":"Lab Invest"},{"issue":"1","key":"4844_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13000-025-01599-1","volume":"20","author":"A \u0160afanda","year":"2025","unstructured":"\u0160afanda A, H\u00e1jkov\u00e1 N, Kendall B\u00e1rt\u016f M, N\u011bmejcov\u00e1 K, et al. Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K\/AKT\/mTOR signaling pathway. Diagn Pathol. 2025;20(1):3.","journal-title":"Diagn Pathol"},{"issue":"8","key":"4844_CR42","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1177\/10668969231157776","volume":"31","author":"M Kamal","year":"2023","unstructured":"Kamal M, Atwi D, Pang H, Hassell L, et al. Dedifferentiated Ovarian Carcinoma with ARID1A and ARID1B Mutations: A Clinicopathological Report and Literature Review. Int J Surg Pathol. 2023;31(8):1526\u201331.","journal-title":"Int J Surg Pathol"},{"issue":"1","key":"4844_CR43","doi-asserted-by":"publisher","first-page":"100374","DOI":"10.1016\/j.modpat.2023.100374","volume":"37","author":"B Tessier-Cloutier","year":"2024","unstructured":"Tessier-Cloutier B, Kommoss FKF, Kolin DL, Lee CH, et al. Dedifferentiated and Undifferentiated Ovarian Carcinoma: An Aggressive and Molecularly Distinct Ovarian Tumor Characterized by Frequent SWI\/SNF Complex Inactivation. Mod Pathol. 2024;37(1):100374.","journal-title":"Mod Pathol"},{"key":"4844_CR44","doi-asserted-by":"crossref","unstructured":"Daniels E, Chapel DB, Rottmann DA, Huang T et al. A Case Report of Uterine Dedifferentiated Mesonephric-Like Adenocarcinoma With Comprehensive Molecular Profiling. Int J Gynecol Pathol. 2025-05\u20139.","DOI":"10.1097\/PGP.0000000000001117"},{"key":"4844_CR45","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.ygyno.2017.09.031","volume":"147","author":"DI Lin","year":"2017","unstructured":"Lin DI, Chudnovsky Y, Duggan B, Elvin JA, et al. Comprehensive genomic profiling reveals inactivating SMARCA4 mutations and low tumor mutational burden in small cell carcinoma of the ovary, hypercalcemic-type. Gynecol Oncol. 2017;147:626\u201333.","journal-title":"Gynecol Oncol"},{"issue":"4","key":"4844_CR46","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/pbc.25279","volume":"62","author":"S Bailey","year":"2015","unstructured":"Bailey S, Murray MJ, Witkowski L, Nicholson JC, et al. Biallelic somatic SMARCA4 mutations in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Pediatr Blood Cancer. 2015;62(4):728\u201330.","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"4844_CR47","first-page":"241","volume":"33","author":"A Ghazi","year":"2017","unstructured":"Ghazi A, Ayaz A, Hamid T, Islam N, etal.Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A rare case after in vitro fertilization (IVF).Pak J Med Sci. 2017;33(1):241\u20134.","journal-title":"Vitro Fertilization PAK J MED SCI"},{"issue":"5","key":"4844_CR48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.annpat.2019.02.005","volume":"39","author":"R Bourgoin","year":"2019","unstructured":"Bourgoin R, Cornelis F, Masliah-Planchon J, La\u00e9 M, et al. SCCOHT\/ovarian rhabdoid tumor: A case report. Ann Pathol. 2019;39(5):357\u201363.","journal-title":"ANN PATHOL"},{"issue":"2","key":"4844_CR49","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10689-018-0108-0","volume":"18","author":"S Fahiminiya","year":"2019","unstructured":"Fahiminiya S, Sabbaghian N, Albrecht S, Foulkes WD, et al. Ovarian small cell carcinoma in one of a pair of monozygous twins. Fam Cancer. 2019;18(2):161\u20133.","journal-title":"FAM CANCER"},{"issue":"3","key":"4844_CR50","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.ygyno.2020.06.160","volume":"158","author":"JG Pressey","year":"2020","unstructured":"Pressey JG, Dandoy CE, Pater LE, Szabo S. Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): Comprehensive management of a newly diagnosed young adult. Gynecol Oncol. 2020;158(3):538\u201346.","journal-title":"Gynecol Oncol"},{"key":"4844_CR51","doi-asserted-by":"publisher","first-page":"100576","DOI":"10.1016\/j.gore.2020.100576","volume":"32","author":"N Phoolcharoen","year":"2020","unstructured":"Phoolcharoen N, Woodard T, James D, Schmeler K, et al. Successful pregnancy following chemotherapy in a survivor of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): A case report and review of literature. Gynecol Oncol Rep. 2020;32:100576.","journal-title":"Gynecol Oncol Rep"},{"issue":"1","key":"4844_CR52","first-page":"261","volume":"1","author":"A Sahay","year":"2020","unstructured":"Sahay A, Kante K, Menon S, Deodhar KK, et al. Small Cell Carcinoma of Ovary, Hypercalcemic Type (Malignant Rhabdoid Tumor of Ovary) with Loss of SMARCA4 (BRG1) Expression: Report of Two Cases. Turk J Pathol. 2020;1(1):261\u20137.","journal-title":"TURK J PATHOL"},{"issue":"1","key":"4844_CR53","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jpag.2020.07.017","volume":"34","author":"D Aggarwal","year":"2021","unstructured":"Aggarwal D, Gupta P, Chhabra P, Kakkar N, et al. Small Cell Carcinoma of Ovary, Hypercalcemic Type: Cytologic, Histopathologic, and Immunohistochemical Landscapes of a Rare Case. J Pediatr Adol Gynec. 2021;34(1):98\u2013102.","journal-title":"J PEDIATR ADOL GYNEC"},{"issue":"4","key":"4844_CR54","first-page":"355","volume":"20","author":"A Pastorczak","year":"2021","unstructured":"Pastorczak A, Krajewska K, Urbanska Z, Trelinska J, et al. Ovarian carcinoma in children with constitutional mutation of SMARCA4: single\u2013family report and literature review. Fam Cancer. 2021;20(4):355\u201362.","journal-title":"AM CANCER"},{"key":"4844_CR55","doi-asserted-by":"publisher","first-page":"107337","DOI":"10.1016\/j.ijscr.2022.107337","volume":"96","author":"F Keikha","year":"2022","unstructured":"Keikha F, Hadizadeh A, Akhavan S, Ghaemi M, et al. Ovarian small cell carcinoma by ovarian torsion feature: A cytopathology challenging case. Int J Surg Case Rep. 2022;96:107337.","journal-title":"Int J Surg Case Rep"},{"issue":"2","key":"4844_CR56","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jpag.2022.10.004","volume":"36","author":"\u00c7\u00c7 Co\u015fkun","year":"2023","unstructured":"Co\u015fkun \u00c7 \u00c7, Kurucu N, Usubutun A, Kutluk T, et al. Small Cell Carcinoma of Ovary, Hypercalcemic Type: A RareCase Report. J Pediatr Adol Gynec. 2023;36(2):112\u20135.","journal-title":"J PEDIATR ADOL GYNEC"},{"issue":"32","key":"4844_CR57","doi-asserted-by":"publisher","first-page":"e39226","DOI":"10.1097\/MD.0000000000039226","volume":"103","author":"X Li","year":"2024","unstructured":"Li X, Liu Z, Chen J, Huang W, et al. MR imaging diagnosis of small-cell carcinoma of the ovary, hypercalcemic type A case report and literature review. Medicine (Baltimore). 2024;103(32):e39226.","journal-title":"(Baltimore)"},{"issue":"2","key":"4844_CR58","doi-asserted-by":"publisher","first-page":"rjae079","DOI":"10.1093\/jscr\/rjae079","volume":"2024","author":"I Boujida","year":"2024","unstructured":"Boujida I, Mahdi Y, Khmou M, El-Khannoussi B, et al. A rare case of small cell carcinoma of the ovary, hypercalcemic type. Surg Case Rep. 2024;2024(2):rjae079.","journal-title":"Surg Case Rep"},{"issue":"3","key":"4844_CR59","first-page":"e55696","volume":"16","author":"L Saylany","year":"2024","unstructured":"Saylany L, Ellepola H, Broom E. A Rare Case of Advanced-Stage Small Cell Carcinoma of the Ovary Identified During the Third Trimester of Pregnancy. Cureus. 2024;16(3):e55696.","journal-title":"Cureus"},{"issue":"5","key":"4844_CR60","first-page":"e60802","volume":"16","author":"Y Aoyagi","year":"2024","unstructured":"Aoyagi Y, Kai K, Nishida H, Kobayashi E, et al. Multiple Somatic Mutations of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type: A Case Report. Cureus. 2024;16(5):e60802.","journal-title":"Cureus"},{"key":"4844_CR61","doi-asserted-by":"publisher","first-page":"1648580","DOI":"10.3389\/fonc.2025.1648580","volume":"15","author":"M Tripepi","year":"2025","unstructured":"Tripepi M, da Costa AG, Albergaria D, Casanova J, et al. Case Report: Hypercalcemic small-cell carcinoma of the ovary during pregnancy: diagnostic and therapeutic challenges. Front Oncol. 2025;15:1648580.","journal-title":"Front Oncol"},{"key":"4844_CR62","doi-asserted-by":"publisher","first-page":"101932","DOI":"10.1016\/j.gore.2025.101932","volume":"61","author":"J Benichou","year":"2025","unstructured":"Benichou J, Varinot J, Bossi-Croci R, Darai E, et al. Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): About three case reports. Gynecol Oncol Rep. 2025;61:101932.","journal-title":"Gynecol Oncol Rep"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-026-04844-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04844-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-04844-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:08:01Z","timestamp":1779682081000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-026-04844-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,5]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4844"],"URL":"https:\/\/doi.org\/10.1007\/s12672-026-04844-1","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,5]]},"assertion":[{"value":"27 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Chongqing University Cancer Hospital (CZLL2025-225-001)","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to partcipate"}},{"value":"Written informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"757"}}