{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:02:44Z","timestamp":1784772164367,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-026-05307-3","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T09:02:13Z","timestamp":1779872533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinformatics analysis and preliminary clinical validation of ITGA9 and NPTX2 as prognosis-related genes in acute myeloid leukemia"],"prefix":"10.1007","volume":"17","author":[{"given":"Lili","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"5307_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cancergen.2024.06.002","volume":"286\u2013287","author":"D Sonkin","year":"2024","unstructured":"Sonkin D, Thomas A, Teicher BA. Cancer treatments: past, present, and future. Cancer Genet. 2024;286\u2013287:18\u201324.","journal-title":"Cancer Genet"},{"key":"5307_CR2","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/ajh.27625","volume":"100","author":"S Shimony","year":"2025","unstructured":"Shimony S, Stahl M, Stone RM. Acute myeloid leukemia: 2025 update on diagnosis, risk-stratification, and management. Am J Hematol. 2025;100:860\u201391.","journal-title":"Am J Hematol"},{"key":"5307_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3892\/or.2025.8887","volume":"53","author":"H Qiu","year":"2025","unstructured":"Qiu H, Zhang C, Ma X, Li Y. Molecular insights and treatment innovations: advancing outcomes in acute myeloid leukemia with myelodysplasia\u2013related changes (review). Oncol Rep. 2025;53:54.","journal-title":"Oncol Rep"},{"key":"5307_CR4","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","volume":"374","author":"E Papaemmanuil","year":"2016","unstructured":"Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374:2209\u201321.","journal-title":"N Engl J Med"},{"key":"5307_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2024.107452","volume":"137","author":"H Goulart","year":"2024","unstructured":"Goulart H, Sastow D, Moshier E, Martin L, Mascarenhas J, Tremblay D. Systematic review and meta-analysis evaluating clinical outcomes in adult acute myeloid leukemia patients with central nervous system involvement. Leuk Res. 2024;137:107452.","journal-title":"Leuk Res"},{"key":"5307_CR6","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","volume":"368","author":"TJ Ley","year":"2013","unstructured":"Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr., Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013;368:2059\u201374.","journal-title":"N Engl J Med"},{"key":"5307_CR7","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","volume":"562","author":"JW Tyner","year":"2018","unstructured":"Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, Long N, Schultz AR, Traer E, Abel M, Agarwal A, Blucher A, Borate U, Bryant J, Burke R, Carlos A, Carpenter R, Carroll J, Chang BH, Coblentz C, d\u2019Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Devine D, Dibb J, Edwards DKt, Eide CA, English I, Glover J, Henson R, Ho H, Jemal A, Johnson K, Johnson R, Junio B, Kaempf A, Leonard J, Lin C, Liu SQ, Lo P, Loriaux MM, Luty S, Macey T, MacManiman J, Martinez J, Mori M, Nelson D, Nichols C, Peters J, Ramsdill J, Rofelty A, Schuff R, Searles R, Segerdell E, Smith RL, Spurgeon SE, Sweeney T, Thapa A, Visser C, Wagner J, Watanabe-Smith K, Werth K, Wolf J, White L, Yates A, Zhang H, Cogle CR, Collins RH, Connolly DC, Deininger MW, Drusbosky L, Hourigan CS, Jordan CT, Kropf P, Lin TL, Martinez ME, Medeiros BC, Pallapati RR, Pollyea DA, Swords RT, Watts JM, Weir SJ, Wiest DL, Winters RM, Druker BJ. Functional genomic landscape of acute myeloid leukaemia. Nature. 2018;562:526\u201331.","journal-title":"Nature"},{"key":"5307_CR8","doi-asserted-by":"publisher","first-page":"5243","DOI":"10.2147\/OTT.S147717","volume":"10","author":"R Huang","year":"2017","unstructured":"Huang R, Liao X, Li Q. Identification and validation of potential prognostic gene biomarkers for predicting survival in patients with acute myeloid leukemia. Onco Targets Ther. 2017;10:5243\u201354.","journal-title":"Onco Targets Ther"},{"key":"5307_CR9","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1007\/s00262-019-02408-7","volume":"68","author":"H Yan","year":"2019","unstructured":"Yan H, Qu J, Cao W, Liu Y, Zheng G, Zhang E, Cai Z. Identification of prognostic genes in the acute myeloid leukemia immune microenvironment based on TCGA data analysis. Cancer Immunol Immunother. 2019;68:1971\u20138.","journal-title":"Cancer Immunol Immunother"},{"key":"5307_CR10","doi-asserted-by":"publisher","first-page":"6170","DOI":"10.3390\/ijms24076170","volume":"24","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Zhang S, Chen J, Xie Z. The interplay between integrins and immune cells as a regulator in cancer immunology. Int J Mol Sci. 2023;24:6170.","journal-title":"Int J Mol Sci"},{"key":"5307_CR11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adf0141","volume":"15","author":"J Zhou","year":"2023","unstructured":"Zhou J, Wade SD, Graykowski D, Xiao MF, Zhao B, Giannini LAA, Hanson JE, van Swieten JC, Sheng M, Worley PF, Dejanovic B. The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration. Sci Transl Med. 2023;15: eadf0141.","journal-title":"Sci Transl Med"},{"key":"5307_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01757","volume":"11","author":"Z Wang","year":"2020","unstructured":"Wang Z, Wang X, Zou H, Dai Z, Feng S, Zhang M, et al. The basic characteristics of the pentraxin family and their functions in tumor progression. Front Immunol. 2020;11:1757.","journal-title":"Front Immunol"},{"key":"5307_CR13","doi-asserted-by":"publisher","first-page":"395","DOI":"10.4161\/cam.5.5.17949","volume":"5","author":"LA Mostovich","year":"2011","unstructured":"Mostovich LA, Prudnikova TY, Kondratov AG, Loginova D, Vavilov PV, Rykova VI, Sidorov SV, Pavlova TV, Kashuba VI, Zabarovsky ER, Grigorieva EV. Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. Cell Adh Migr. 2011;5:395\u2013401.","journal-title":"Cell Adh Migr"},{"key":"5307_CR14","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1007\/s00018-022-04557-y","volume":"79","author":"N Navarro","year":"2022","unstructured":"Navarro N, Molist C, Sansa-Girona J, Zarzosa P, Gallo-Oller G, Pons G, Magdaleno A, Guill\u00e9n G, Hladun R, Garrido M, Segura MF, Hontecillas-Prieto L, de \u00c1lava E, Ponsati B, Fern\u00e1ndez-Carneado J, Almaz\u00e1n-Moga A, Vall\u00e8s-Miret M, Farrera-Sinfreu J, de Toledo JS, Moreno L, Gallego S, Roma J. Integrin alpha9 emerges as a key therapeutic target to reduce metastasis in rhabdomyosarcoma and neuroblastoma. Cell Mol Life Sci. 2022;79:546.","journal-title":"Cell Mol Life Sci"},{"key":"5307_CR15","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41419-019-1467-7","volume":"10","author":"C Xu","year":"2019","unstructured":"Xu C, Tian G, Jiang C, Xue H, Kuerbanjiang M, Sun L, Gu L, Zhou H, Liu Y, Zhang Z, Xu Q. NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt\/\u03b2-catenin pathway via FZD6. Cell Death Dis. 2019;10:217.","journal-title":"Cell Death Dis"},{"key":"5307_CR16","doi-asserted-by":"publisher","first-page":"6563","DOI":"10.1158\/0008-5472.CAN-13-0298","volume":"73","author":"S Shukla","year":"2013","unstructured":"Shukla S, Pia Patric IR, Thinagararjan S, Srinivasan S, Mondal B, Hegde AS, Chandramouli BA, Santosh V, Arivazhagan A, Somasundaram K. A DNA methylation prognostic signature of glioblastoma: identification of NPTX2-PTEN-NF-\u03baB nexus. Cancer Res. 2013;73:6563\u201373.","journal-title":"Cancer Res"},{"key":"5307_CR17","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1038\/s41375-022-01696-w","volume":"36","author":"M Li","year":"2022","unstructured":"Li M, Ye J, Xia Y, Li M, Li G, Hu X, Su X, Wang D, Zhao X, Lu F, Li J, Ma D, Sun T, Ji C. METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4. Leukemia. 2022;36:2586\u201395.","journal-title":"Leukemia"},{"key":"5307_CR18","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.21037\/tcr-24-810","volume":"13","author":"C Zhou","year":"2024","unstructured":"Zhou C, Yang L, Zhao K, Jiang L. ITGAM sustains MAPK signaling and serves as an adverse prognostic factor and therapeutic target in acute myeloid leukemia. Transl Cancer Res. 2024;13:3062\u201374.","journal-title":"Transl Cancer Res"},{"key":"5307_CR19","doi-asserted-by":"publisher","first-page":"148761","DOI":"10.1016\/j.gene.2024.148761","volume":"928","author":"A Niibori-Nambu","year":"2024","unstructured":"Niibori-Nambu A, Wang CQ, Chin DWL, Chooi JY, Hosoi H, Sonoki T, Tham CY, Nah GSS, Cirovic B, Tan DQ, Takizawa H, Sashida G, Goh Y, Tng J, Fam WN, Fullwood MJ, Suda T, Yang H, Tergaonkar V, Taniuchi I, Li S, Chng WJ, Osato M. Integrin-\u03b19 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia. Gene. 2024;928:148761.","journal-title":"Gene"},{"key":"5307_CR20","doi-asserted-by":"publisher","first-page":"101286","DOI":"10.1016\/j.drup.2025.101286","volume":"83","author":"F Song","year":"2025","unstructured":"Song F, Lin S, Xu T, Yang C, Sharavyn B, Naranmandura H, Zhang Y, Huang P. Targeted therapy in acute myeloid leukemia: Resistance and overcoming strategy. Drug Resist Updat. 2025;83:101286.","journal-title":"Drug Resist Updat"},{"key":"5307_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41408-021-00425-3","volume":"11","author":"H Kantarjian","year":"2021","unstructured":"Kantarjian H, Kadia T, DiNardo C, Daver N, Borthakur G, Jabbour E, Garcia-Manero G, Konopleva M, Ravandi F. Acute myeloid leukemia: current progress and future directions. Blood Cancer J. 2021;11:41.","journal-title":"Blood Cancer J"},{"key":"5307_CR22","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.2174\/1381612828666220501165644","volume":"28","author":"Y Wu","year":"2022","unstructured":"Wu Y, Chen J, Tan F, Wang B, Xu W, Yuan C. ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors. Curr Pharm Des. 2022;28:1412\u20138.","journal-title":"Curr Pharm Des"},{"key":"5307_CR23","doi-asserted-by":"publisher","first-page":"4602570","DOI":"10.1155\/2018\/4602570","volume":"2018","author":"YL Zhang","year":"2018","unstructured":"Zhang YL, Xing X, Cai LB, Zhu L, Yang XM, Wang YH, Yang Q, Nie HZ, Zhang ZG, Li J, Zhang XL. Integrin \u03b19 suppresses hepatocellular carcinoma metastasis by rho GTPase signaling. J Immunol Res. 2018;2018:4602570.","journal-title":"J Immunol Res"},{"key":"5307_CR24","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.ccell.2019.01.007","volume":"35","author":"J Cooper","year":"2019","unstructured":"Cooper J, Giancotti FG. Integrin signaling in cancer: mechanotransduction, stemness, epithelial plasticity, and therapeutic resistance. Cancer Cell. 2019;35:347\u201367.","journal-title":"Cancer Cell"},{"key":"5307_CR25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.archoralbio.2019.03.007","volume":"101","author":"QC Fan","year":"2019","unstructured":"Fan QC, Tian H, Wang Y, Liu XB. Integrin-\u03b15 promoted the progression of oral squamous cell carcinoma and modulated PI3K\/AKT signaling pathway. Arch Oral Biol. 2019;101:85\u201391.","journal-title":"Arch Oral Biol"},{"key":"5307_CR26","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1002\/ijc.32359","volume":"145","author":"Z Wang","year":"2019","unstructured":"Wang Z, Li Y, Xiao Y, Lin HP, Yang P, Humphries B, Gao T, Yang C. Integrin \u03b19 depletion promotes \u03b2-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis. Int J Cancer. 2019;145:2767\u201380.","journal-title":"Int J Cancer"},{"key":"5307_CR27","doi-asserted-by":"publisher","first-page":"4796","DOI":"10.1158\/0008-5472.CAN-14-0210","volume":"74","author":"CA von Roemeling","year":"2014","unstructured":"von Roemeling CA, Radisky DC, Marlow LA, Cooper SJ, Grebe SK, Anastasiadis PZ, Tun HW, Copland JA. Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4. Cancer Res. 2014;74:4796\u2013810.","journal-title":"Cancer Res"},{"key":"5307_CR28","doi-asserted-by":"publisher","first-page":"5696","DOI":"10.1002\/cam4.4117","volume":"10","author":"H Yang","year":"2021","unstructured":"Yang H, Zhao L, Zhang Y, Li FF. A comprehensive analysis of immune infiltration in the tumor microenvironment of osteosarcoma. Cancer Med. 2021;10:5696\u2013711.","journal-title":"Cancer Med"},{"key":"5307_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.643986","volume":"11","author":"X Han","year":"2021","unstructured":"Han X, Lu Y, Li X, Xia L, Wen H, Feng Z, et al. Overexpression of NPTX2 promotes malignant phenotype of epithelial ovarian carcinoma via IL6-JAK2\/STAT3 signaling pathway under hypoxia. Front Oncol. 2021;11:643986.","journal-title":"Front Oncol"},{"key":"5307_CR30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.7150\/jca.100922","volume":"16","author":"H Liu","year":"2025","unstructured":"Liu H, Li Y, Karsidag M, Tu T, Wang P. Technical and biological biases in bulk transcriptomic data mining for cancer research. J Cancer. 2025;16:34\u201343.","journal-title":"J Cancer"},{"key":"5307_CR31","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.3390\/cancers17223720","volume":"17","author":"H Liu","year":"2025","unstructured":"Liu H, Karsidag I, Golin R, Wu G. Bridging discovery and treatment: cancer biomarker. Cancers (Basel). 2025;17:3720.","journal-title":"Cancers (Basel)"},{"key":"5307_CR32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cancergen.2024.12.006","volume":"292\u2013293","author":"FS Shafiei","year":"2025","unstructured":"Shafiei FS, Abroun S, Vahdat S, Rafiee M. Omics approaches: role in acute myeloid leukemia biomarker discovery and therapy. Cancer Genet. 2025;292\u2013293:14\u201326.","journal-title":"Cancer Genet"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-026-05307-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-05307-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-05307-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:42:48Z","timestamp":1784770968000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-026-05307-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5307"],"URL":"https:\/\/doi.org\/10.1007\/s12672-026-05307-3","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"25 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The research protocol received approval from the institutional ethics committee of The Affiliated Suqian Hospital of Xuzhou Medical University (No. 2025-042-01). The study was carried out following the ethical guidelines outlined in the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was waived due to the retrospective observational nature of the study.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1063"}}