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All animal experiments were conducted in strict compliance with institutional guidelines and relevant international standards, including the Basel Declaration. The maximal permitted tumor burden (\u2264\u20091.5\u00a0cm in any dimension) was not exceeded in any experimental animal. All procedures adhered to institutional animal welfare regulations. For human-related data, no new human participants or clinical samples were directly involved in this study. All analyses were performed using publicly available datasets (TCGA and GEO), for which ethical approval and informed consent had already been obtained by the original investigators. All methods were carried out in accordance with relevant guidelines and regulations. Not applicable. This study did not involve direct participation of human subjects. 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