{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:12:50Z","timestamp":1788876770653,"version":"build-2803163510"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":84,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-026-05427-w","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:33:51Z","timestamp":1781631231000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NAT10 promotes colon cancer progression by enhancing predicted N4-acetylcytidine modification of Notch2 mRNA"],"prefix":"10.1007","volume":"17","author":[{"given":"Wang","family":"Xiao-Jie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"issue":"2","key":"5427_CR1","doi-asserted-by":"publisher","first-page":"e70067","DOI":"10.3322\/caac.70067","volume":"76","author":"RL Siegel","year":"2026","unstructured":"Siegel RL, Wagle NS, Star J, et al. Colorectal cancer statistics, 2026. CA Cancer J Clin. 2026;76(2):e70067. https:\/\/doi.org\/10.3322\/caac.70067.","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"5427_CR2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000543921","volume":"106","author":"T Matsuda","year":"2025","unstructured":"Matsuda T, Fujimoto A, Igarashi Y. Colorectal Cancer: Epidemiology, Risk Factors, and Public Health Strategies. Digestion. 2025;106(2):91\u20139. https:\/\/doi.org\/10.1159\/000543921.","journal-title":"Digestion"},{"issue":"1","key":"5427_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ccell.2025.12.001","volume":"44","author":"X Deng","year":"2026","unstructured":"Deng X, Wu D, Zhao Y, et al. Epitranscriptomic control of cancer hallmarks: Functions, mechanisms, and therapeutics of RNA modifications. Cancer Cell. 2026;44(1):50\u201376. https:\/\/doi.org\/10.1016\/j.ccell.2025.12.001.","journal-title":"Cancer Cell"},{"issue":"1","key":"5427_CR4","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s12964-025-02254-4","volume":"23","author":"Y Han","year":"2025","unstructured":"Han Y, Sun J, Yao M, et al. Biological roles of enhancer RNA m6A modification and its implications in cancer. Cell Commun Signal. 2025;23(1):254. https:\/\/doi.org\/10.1186\/s12964-025-02254-4.","journal-title":"Cell Commun Signal"},{"issue":"6","key":"5427_CR5","doi-asserted-by":"publisher","first-page":"e23749","DOI":"10.1002\/jbt.23749","volume":"38","author":"Y Cui","year":"2024","unstructured":"Cui Y, Lv P, Zhang C. NSUN6 mediates 5-methylcytosine modification of METTL3 and promotes colon adenocarcinoma progression. J Biochem Mol Toxicol. 2024;38(6):e23749. https:\/\/doi.org\/10.1002\/jbt.23749.","journal-title":"J Biochem Mol Toxicol"},{"issue":"28","key":"5427_CR6","doi-asserted-by":"publisher","first-page":"e2309840","DOI":"10.1002\/advs.202309840","volume":"11","author":"B Chen","year":"2024","unstructured":"Chen B, Deng Y, Hong Y, et al. Metabolic Recoding of NSUN2-Mediated m5C Modification Promotes the Progression of Colorectal Cancer via the NSUN2\/YBX1\/m5C-ENO1 Positive Feedback Loop. Adv Sci (Weinh). 2024;11(28):e2309840. https:\/\/doi.org\/10.1002\/advs.202309840.","journal-title":"Adv Sci (Weinh)"},{"key":"5427_CR7","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.omtn.2023.03.023","volume":"32","author":"L Xie","year":"2023","unstructured":"Xie L, Zhong X, Cao W, et al. Mechanisms of NAT10 as ac4C writer in diseases. Mol Ther Nucleic Acids. 2023;32:359\u201368. https:\/\/doi.org\/10.1016\/j.omtn.2023.03.023.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"1","key":"5427_CR8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13578-025-01504-9","volume":"15","author":"Y Wang","year":"2025","unstructured":"Wang Y, Wang S, Liu M, et al. The function of NAT10-driven N4-acetylcytidine modification in cancer: novel insights and potential therapeutic targets. Cell Biosci. 2025;15(1):165. https:\/\/doi.org\/10.1186\/s13578-025-01504-9.","journal-title":"Cell Biosci"},{"issue":"12","key":"5427_CR9","doi-asserted-by":"publisher","first-page":"e70026","DOI":"10.1002\/mco2.70026","volume":"5","author":"Z Gu","year":"2020","unstructured":"Gu Z, Zou L, Pan X et al. The role and mechanism of NAT10-mediated ac4C modification in tumor development and progression. MedComm (2020). 2024;5(12):e70026. https:\/\/doi.org\/10.1002\/mco2.70026.","journal-title":"MedComm (2020)"},{"issue":"1","key":"5427_CR10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13027-025-00650-6","volume":"20","author":"Y Chen","year":"2025","unstructured":"Chen Y, Wang J, Xu J, et al. NAT10 promotes gastric cancer progression by enhancing the N4-acetylcytidine modification of TNC mRNA. Infect Agent Cancer. 2025;20(1):20. https:\/\/doi.org\/10.1186\/s13027-025-00650-6.","journal-title":"Infect Agent Cancer"},{"issue":"5","key":"5427_CR11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1615\/CritRevEukaryotGeneExpr.2025058741","volume":"35","author":"M Huang","year":"2025","unstructured":"Huang M, Zhang Z, Yan W, et al. NAT10-Mediated N4-Acetylcytidine Modification of GRB7 Promotes the Progression of Gastric Cancer. Crit Rev Eukaryot Gene Expr. 2025;35(5):59\u201368. https:\/\/doi.org\/10.1615\/CritRevEukaryotGeneExpr.2025058741.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"12","key":"5427_CR12","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1002\/cac2.12363","volume":"42","author":"X Zheng","year":"2022","unstructured":"Zheng X, Wang Q, Zhou Y, et al. N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA. Cancer Commun (Lond). 2022;42(12):1347\u201366. https:\/\/doi.org\/10.1002\/cac2.12363.","journal-title":"Cancer Commun (Lond)"},{"issue":"9","key":"5427_CR13","doi-asserted-by":"publisher","first-page":"e30330","DOI":"10.1016\/j.heliyon.2024.e30330","volume":"10","author":"LP Gao","year":"2024","unstructured":"Gao LP, Li TD, Yang SZ, et al. NAT10-mediated ac4C modification promotes stemness and chemoresistance of colon cancer by stabilizing NANOGP8. Heliyon. 2024;10(9):e30330. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e30330.","journal-title":"Heliyon"},{"issue":"1","key":"5427_CR14","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s13046-022-02551-7","volume":"41","author":"C Jin","year":"2022","unstructured":"Jin C, Wang T, Zhang D, et al. Acetyltransferase NAT10 regulates the Wnt\/\u03b2-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA. J Exp Clin Cancer Res. 2022;41(1):345. https:\/\/doi.org\/10.1186\/s13046-022-02551-7.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"5427_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s10020-024-00780-4","volume":"30","author":"G Qin","year":"2024","unstructured":"Qin G, Bai F, Hu H, et al. Targeting the NAT10\/NPM1 axis abrogates PD-L1 expression and improves the response to immune checkpoint blockade therapy. Mol Med. 2024;30(1):13. https:\/\/doi.org\/10.1186\/s10020-024-00780-4.","journal-title":"Mol Med"},{"issue":"1","key":"5427_CR16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-024-01828-x","volume":"9","author":"Q Shi","year":"2024","unstructured":"Shi Q, Xue C, Zeng Y, et al. Notch signaling pathway in cancer: from mechanistic insights to targeted therapies. Signal Transduct Target Ther. 2024;9(1):128. https:\/\/doi.org\/10.1038\/s41392-024-01828-x.","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"5427_CR17","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.3390\/ijms25063322","volume":"25","author":"Y Lv","year":"2024","unstructured":"Lv Y, Pang X, Cao Z, et al. Evolution and function of the notch signaling pathway: an invertebrate perspective. Int J Mol Sci. 2024;25(6):3322. https:\/\/doi.org\/10.3390\/ijms25063322.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"5427_CR18","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.ccell.2019.08.003","volume":"36","author":"R Jackstadt","year":"2019","unstructured":"Jackstadt R, van Hooff SR, Leach JD, et al. Epithelial NOTCH Signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell. 2019;36(3):319\u2013e3367. https:\/\/doi.org\/10.1016\/j.ccell.2019.08.003.","journal-title":"Cancer Cell"},{"issue":"3","key":"5427_CR19","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.ccell.2019.08.003","volume":"36","author":"R Jackstadt","year":"2019","unstructured":"Jackstadt R, van Hooff SR, Leach JD, et al. Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell. 2019;36(3):319\u2013e3367. https:\/\/doi.org\/10.1016\/j.ccell.2019.08.003.","journal-title":"Cancer Cell"},{"key":"5427_CR20","doi-asserted-by":"publisher","first-page":"217534","DOI":"10.1016\/j.canlet.2025.217534","volume":"614","author":"H Chen","year":"2025","unstructured":"Chen H, Lin L, Qiao Z, et al. YTHDF3 drives tumor growth and metastasis by recruiting eIF4B to promote Notch2 translation in breast cancer. Cancer Lett. 2025;614:217534. https:\/\/doi.org\/10.1016\/j.canlet.2025.217534.","journal-title":"Cancer Lett"},{"issue":"18","key":"5427_CR21","doi-asserted-by":"publisher","first-page":"10766","DOI":"10.3390\/ijms231810766","volume":"23","author":"M Li","year":"2022","unstructured":"Li M, Cheng W, Zhang L, et al. Novel Roles of RNA m6A methylation regulators in the occurrence of Alzheimer\u2019s disease and the subtype classification. Int J Mol Sci. 2022;23(18):10766. https:\/\/doi.org\/10.3390\/ijms231810766.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"5427_CR22","doi-asserted-by":"publisher","first-page":"e23284","DOI":"10.1096\/fj.202301306R","volume":"37","author":"D Shao","year":"2023","unstructured":"Shao D, Liu C, Wang Y, et al. DNMT1 determines osteosarcoma cell resistance to apoptosis by associatively modulating DNA and mRNA cytosine-5 methylation. FASEB J. 2023;37(12):e23284. https:\/\/doi.org\/10.1096\/fj.202301306R.","journal-title":"FASEB J"},{"issue":"3","key":"5427_CR23","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.clcc.2022.05.006","volume":"21","author":"JC Fabregas","year":"2022","unstructured":"Fabregas JC, Ramnaraign B, George TJ. Clinical Updates for Colon Cancer Care in 2022. Clin Colorectal Cancer. 2022;21(3):198\u2013203. https:\/\/doi.org\/10.1016\/j.clcc.2022.05.006.","journal-title":"Clin Colorectal Cancer"},{"issue":"15","key":"5427_CR24","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1016\/j.molcel.2022.05.016","volume":"82","author":"D Arango","year":"2022","unstructured":"Arango D, Sturgill D, Yang R, et al. Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol Cell. 2022;82(15):2797\u2013e281411. https:\/\/doi.org\/10.1016\/j.molcel.2022.05.016.","journal-title":"Mol Cell"},{"key":"5427_CR25","doi-asserted-by":"publisher","first-page":"1695495","DOI":"10.3389\/fimmu.2025.1695495","volume":"16","author":"C Li","year":"2025","unstructured":"Li C, Jiang X, Jia Y, et al. The critical role of NAT10-mediated N4-acetylcytidine modification in tumor immunity. Front Immunol. 2025;16:1695495. https:\/\/doi.org\/10.3389\/fimmu.2025.1695495.","journal-title":"Front Immunol"},{"issue":"3","key":"5427_CR26","doi-asserted-by":"publisher","first-page":"115080","DOI":"10.1016\/j.isci.2026.115080","volume":"29","author":"Y Shi","year":"2026","unstructured":"Shi Y, Sun J, Chen H, et al. RNA N4-acetylcytidine modification in human cancers: from molecular function to oncogenic mechanisms. iScience. 2026;29(3):115080. https:\/\/doi.org\/10.1016\/j.isci.2026.115080.","journal-title":"iScience"},{"key":"5427_CR27","doi-asserted-by":"publisher","first-page":"111227","DOI":"10.1016\/j.compbiomed.2025.111227","volume":"198","author":"Y Huang","year":"2025","unstructured":"Huang Y, Wei Y, Xing X, et al. NAT10-mediated ac4C-modified genes predict tumor prognosis and immune response in colon adenocarcinoma. Comput Biol Med. 2025;198:111227. https:\/\/doi.org\/10.1016\/j.compbiomed.2025.111227.","journal-title":"Comput Biol Med"},{"issue":"1","key":"5427_CR28","doi-asserted-by":"publisher","first-page":"2188667","DOI":"10.1080\/15592294.2023.2188667","volume":"18","author":"H Zhang","year":"2023","unstructured":"Zhang H, Shan W, Yang Z, et al. NAT10 mediated mRNA acetylation modification patterns associated with colon cancer progression and microsatellite status. Epigenetics. 2023;18(1):2188667. https:\/\/doi.org\/10.1080\/15592294.2023.2188667.","journal-title":"Epigenetics"},{"issue":"6","key":"5427_CR29","doi-asserted-by":"publisher","first-page":"gkaf217","DOI":"10.1093\/nar\/gkaf217","volume":"53","author":"S Thalalla Gamage","year":"2025","unstructured":"Thalalla Gamage S, Howpay Manage S, Sas-Chen A, et al. A sequence-specific RNA acetylation catalyst. Nucleic Acids Res. 2025;53(6):gkaf217. https:\/\/doi.org\/10.1093\/nar\/gkaf217.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"5427_CR30","doi-asserted-by":"publisher","first-page":"e7283","DOI":"10.1002\/cam4.7283","volume":"13","author":"Q Guo","year":"2024","unstructured":"Guo Q, Yu W, Tan J, et al. Remodelin delays non-small cell lung cancer progression by inhibiting NAT10 via the EMT pathway. Cancer Med. 2024;13(11):e7283. https:\/\/doi.org\/10.1002\/cam4.7283.","journal-title":"Cancer Med"},{"issue":"11","key":"5427_CR31","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41419-023-06245-6","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wang X, Liu Y, et al. N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK\/ERK signaling pathway. Cell Death Dis. 2023;14(11):712. https:\/\/doi.org\/10.1038\/s41419-023-06245-6.","journal-title":"Cell Death Dis"},{"issue":"11","key":"5427_CR32","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41419-023-06245-6","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wang X, Liu Y, Yang J, Mao W, Feng C, Wu X, Chen X, Chen L, Dong P. N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK\/ERK signaling pathway. Cell Death Dis. 2023;14(11):712. https:\/\/doi.org\/10.1038\/s41419-023-06245-6.","journal-title":"Cell Death Dis"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-026-05427-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-05427-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-05427-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:04:11Z","timestamp":1788876251000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-026-05427-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5427"],"URL":"https:\/\/doi.org\/10.1007\/s12672-026-05427-w","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]},"assertion":[{"value":"24 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was reviewed and approved by the Ethics Committee of LuoDian Hospital (Protocol ID: LDYY-KY-2024-12). All procedures performed in studies involving human participants were in accordance with the ethical standards of the national research committee and with the 1964 Helsinki Declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1311"}}