{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:20:49Z","timestamp":1787728849702,"version":"build-2784847793"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Natural Science Foundation of Dongying, China","award":["2025ZRWS064, and 2025ZDJH11"],"award-info":[{"award-number":["2025ZRWS064, and 2025ZDJH11"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Onc"],"DOI":"10.1007\/s12672-026-05459-2","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:04:43Z","timestamp":1784905483000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive pan-cancer analysis of MEX3A in human tumors"],"prefix":"10.1007","volume":"17","author":[{"given":"Xuezhong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"5459_CR1","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s40001-024-01869-6","volume":"29","author":"Y Chen","year":"2024","unstructured":"Chen Y, Li D, Sha K, Zhang X, Liu T. Human pan-cancer analysis of the predictive biomarker for the CDKN3. Eur J Med Res. 2024;29:272.","journal-title":"Eur J Med Res"},{"key":"5459_CR2","doi-asserted-by":"publisher","first-page":"17875","DOI":"10.1038\/s41598-024-68784-y","volume":"14","author":"X Zhang","year":"2024","unstructured":"Zhang X, Zhang X, Liu T, Sha K. Comprehensive analysis of the prognostic and immunological signature of TNFAIP8 family genes in human glioma. Sci Rep. 2024;14:17875.","journal-title":"Sci Rep"},{"key":"5459_CR3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s12672-025-01795-x","volume":"16","author":"X Zhang","year":"2025","unstructured":"Zhang X, Zhang X, Liu T, Sha K. A comprehensive pan-cancer analysis of RNF187 in human tumors. Discov Oncol. 2025;16:37.","journal-title":"Discov Oncol"},{"key":"5459_CR4","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s12672-025-02040-1","volume":"16","author":"X Zhang","year":"2025","unstructured":"Zhang X, Zhou L, Wei S, Zhang X. Comprehensive analysis of TMEM9 in human tumors. Discov Oncol. 2025;16:276.","journal-title":"Discov Oncol"},{"key":"5459_CR5","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s12672-025-02070-9","volume":"16","author":"X Zhang","year":"2025","unstructured":"Zhang X, Xue H, Lv Y, Zhou Y, Sha K, Liu T. Pan-cancer bioinformatics analysis of TIPRL in human tumors. Discov Oncol. 2025;16:320.","journal-title":"Discov Oncol"},{"key":"5459_CR6","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s12672-025-01965-x","volume":"16","author":"X Zhang","year":"2025","unstructured":"Zhang X, Li N, Chu T, Zhao H, Liu T. Comprehensive pan-cancer analysis of ENOPH1 in human tumors. Discov Oncol. 2025;16:190.","journal-title":"Discov Oncol"},{"key":"5459_CR7","doi-asserted-by":"crossref","unstructured":"Chu T, Lei C, Zhang X, Wang Y, Gao M. A pan-cancer analysis of TMEM132A in human tumors. Discov Oncol. 2026.","DOI":"10.1007\/s12672-026-05075-0"},{"key":"5459_CR8","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1093\/nar\/gkm016","volume":"35","author":"K Buchet-Poyau","year":"2007","unstructured":"Buchet-Poyau K, Courchet J, Le Hir H, S\u00e9raphin B, Scoazec JY, Duret L, et al. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Res. 2007;35:1289\u2013300.","journal-title":"Nucleic Acids Res"},{"key":"5459_CR9","doi-asserted-by":"crossref","unstructured":"Jasinski-Bergner S, Steven A, Seliger B. The Role of the RNA-Binding Protein Family MEX-3 in Tumorigenesis. Int J Mol Sci. 2020;21.","DOI":"10.3390\/ijms21155209"},{"key":"5459_CR10","doi-asserted-by":"publisher","first-page":"1654036","DOI":"10.3389\/fimmu.2025.1654036","volume":"16","author":"X Zhang","year":"2025","unstructured":"Zhang X, Shang H, Chu T, Sha K. Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma. Front Immunol. 2025;16:1654036.","journal-title":"Front Immunol"},{"key":"5459_CR11","doi-asserted-by":"crossref","unstructured":"Lederer M, M\u00fcller S, Gla\u00df M, Bley N, Ihling C, Sinz A, Biology et al. (Basel). 2021;10.","DOI":"10.3390\/biology10050415"},{"key":"5459_CR12","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s10549-023-07028-5","volume":"201","author":"W Chen","year":"2023","unstructured":"Chen W, Hu L, Lu X, Wang X, Zhao C, Guo C, et al. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4. Breast Cancer Res Treat. 2023;201:353\u201366.","journal-title":"Breast Cancer Res Treat"},{"key":"5459_CR13","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s41392-024-01787-3","volume":"9","author":"RX Chen","year":"2024","unstructured":"Chen RX, Xu SD, Deng MH, Hao SH, Chen JW, Ma XD, et al. Mex-3 RNA binding family member A (MEX3A)\/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy. Signal Transduct Target Ther. 2024;9:80.","journal-title":"Signal Transduct Target Ther"},{"key":"5459_CR14","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1007\/s12072-023-10565-2","volume":"17","author":"S Fang","year":"2023","unstructured":"Fang S, Zheng L, Chen X, Guo X, Ding Y, Ma J, et al. MEX3A determines in vivo hepatocellular carcinoma progression and induces resistance to sorafenib in a Hippo-dependent way. Hepatol Int. 2023;17:1500\u201318.","journal-title":"Hepatol Int"},{"key":"5459_CR15","doi-asserted-by":"publisher","first-page":"16971","DOI":"10.1038\/s41598-025-02057-0","volume":"15","author":"X Zhang","year":"2025","unstructured":"Zhang X, Sun P, Chu T, Feng Y, Zhang X. Comprehensive bioinformatics analysis of MEX3 family genes in hepatocellular carcinoma. Sci Rep. 2025;15:16971.","journal-title":"Sci Rep"},{"key":"5459_CR16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/s41419-020-02858-3","volume":"11","author":"J Liang","year":"2020","unstructured":"Liang J, Li H, Han J, Jiang J, Wang J, Li Y, et al. Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K\/AKT pathway. Cell Death Dis. 2020;11:614.","journal-title":"Cell Death Dis"},{"key":"5459_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1158\/0008-5472.CAN-22-1159","volume":"83","author":"CK Wang","year":"2023","unstructured":"Wang CK, Chen TJ, Tan GYT, Chang FP, Sridharan S, Yu CA, et al. MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis. Cancer Res. 2023;83:251\u201363.","journal-title":"Cancer Res"},{"key":"5459_CR18","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1002\/cbin.12076","volume":"47","author":"G Feng","year":"2023","unstructured":"Feng G, Wang P, Zhang H, Cheng S, Xing Y, Wang Y. MEX3A induces the development of thyroid cancer via targeting CREB1. Cell Biol Int. 2023;47:1843\u201353.","journal-title":"Cell Biol Int"},{"key":"5459_CR19","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","volume":"38","author":"MJ Goldman","year":"2020","unstructured":"Goldman MJ, Craft B, Hastie M, Repe\u010dka K, McDade F, Kamath A, et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 2020;38:675\u20138.","journal-title":"Nat Biotechnol"},{"key":"5459_CR20","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Z Tang","year":"2019","unstructured":"Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47:W556\u201360.","journal-title":"Nucleic Acids Res"},{"key":"5459_CR21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","volume":"25","author":"DS Chandrashekar","year":"2022","unstructured":"Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, et al. UALCAN: An update to the integrated cancer data analysis platform. Neoplasia. 2022;25:18\u201327.","journal-title":"Neoplasia"},{"key":"5459_CR22","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6:pl1.","journal-title":"Sci Signal"},{"key":"5459_CR23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 2013;14:7.","journal-title":"BMC Bioinformatics"},{"key":"5459_CR24","unstructured":"Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH et al. The Immune Landscape of Cancer. Immunity. 2018;48:812\u2009\u2013\u200930.e14."},{"key":"5459_CR25","doi-asserted-by":"publisher","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","volume":"48","author":"T Li","year":"2020","unstructured":"Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, et al. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 2020;48:W509\u201314.","journal-title":"Nucleic Acids Res"},{"key":"5459_CR26","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/nature08822","volume":"463","author":"R Beroukhim","year":"2010","unstructured":"Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, et al. The landscape of somatic copy-number alteration across human cancers. Nature. 2010;463:899\u2013905.","journal-title":"Nature"},{"key":"5459_CR27","doi-asserted-by":"crossref","unstructured":"Bonneville R, Krook MA, Kautto EA, Miya J, Wing MR, Chen HZ et al. Landscape of Microsatellite Instability Across 39 Cancer Types. JCO Precis Oncol. 2017;2017.","DOI":"10.1200\/PO.17.00073"},{"key":"5459_CR28","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51:D638\u201346.","journal-title":"Nucleic Acids Res"},{"key":"5459_CR29","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa M, Furumichi M, Sato Y, Kawashima M, Ishiguro-Watanabe M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 2023;51:D587\u201392.","journal-title":"Nucleic Acids Res"},{"key":"5459_CR30","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16:284\u20137.","journal-title":"Omics"},{"key":"5459_CR31","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12943-023-01879-8","volume":"22","author":"M Han","year":"2023","unstructured":"Han M, Sun H, Zhou Q, Liu J, Hu J, Yuan W, et al. Effects of RNA methylation on Tumor angiogenesis and cancer progression. Mol Cancer. 2023;22:198.","journal-title":"Mol Cancer"},{"key":"5459_CR32","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/s41568-020-0253-2","volume":"20","author":"I Barbieri","year":"2020","unstructured":"Barbieri I, Kouzarides T. Role of RNA modifications in cancer. Nat Rev Cancer. 2020;20:303\u201322.","journal-title":"Nat Rev Cancer"},{"key":"5459_CR33","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","volume":"79","author":"DC Hinshaw","year":"2019","unstructured":"Hinshaw DC, Shevde LA. The Tumor Microenvironment Innately Modulates Cancer Progression. Cancer Res. 2019;79:4557\u201366.","journal-title":"Cancer Res"},{"key":"5459_CR34","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13045-020-00927-w","volume":"13","author":"H Qin","year":"2020","unstructured":"Qin H, Ni H, Liu Y, Yuan Y, Xi T, Li X, et al. RNA-binding proteins in tumor progression. J Hematol Oncol. 2020;13:90.","journal-title":"J Hematol Oncol"},{"key":"5459_CR35","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41392-024-01734-2","volume":"9","author":"Y Tao","year":"2024","unstructured":"Tao Y, Zhang Q, Wang H, Yang X, Mu H. Alternative splicing and related RNA binding proteins in human health and disease. Signal Transduct Target Ther. 2024;9:26.","journal-title":"Signal Transduct Target Ther"},{"key":"5459_CR36","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.semcancer.2022.01.010","volume":"86","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Mir C, Garcia-Mayea Y, Paciucci R, Kondoh H, ME LL. RNA-binding proteins: Underestimated contributors in tumorigenesis. Semin Cancer Biol. 2022;86:431\u201344.","journal-title":"Semin Cancer Biol"},{"key":"5459_CR37","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/s41419-022-05000-7","volume":"13","author":"F Li","year":"2022","unstructured":"Li F, Zhao C, Diao Y, Wang Z, Peng J, Yang N, et al. MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS. Cell Death Dis. 2022;13:553.","journal-title":"Cell Death Dis"},{"key":"5459_CR38","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00432-024-05845-9","volume":"150","author":"J Xu","year":"2024","unstructured":"Xu J, Chen S, Hao T, Liu G, Zhang K, Zhang C, et al. MEX3A promotes colorectal cancer migration, invasion and EMT via regulating the Wnt\/\u03b2-catenin signaling pathway. J Cancer Res Clin Oncol. 2024;150:319.","journal-title":"J Cancer Res Clin Oncol"},{"key":"5459_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10930-017-9696-z","volume":"36","author":"V Singh","year":"2017","unstructured":"Singh V, Ram M, Kumar R, Prasad R, Roy BK, Singh KK. Phosphorylation: Implications in Cancer. Protein J. 2017;36:1\u20136.","journal-title":"Protein J"},{"key":"5459_CR40","first-page":"100452","volume":"4","author":"Y Kong","year":"2023","unstructured":"Kong Y, Yu J, Ge S, Fan X. Novel insight into RNA modifications in tumor immunity: Promising targets to prevent tumor immune escape. Innov (Camb). 2023;4:100452.","journal-title":"Innov (Camb)"},{"key":"5459_CR41","doi-asserted-by":"crossref","unstructured":"Arneth B. Tumor Microenvironment. Medicina (Kaunas). 2019;56.","DOI":"10.3390\/medicina56010015"},{"key":"5459_CR42","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1152\/physrev.00048.2019","volume":"101","author":"G Biffi","year":"2021","unstructured":"Biffi G, Tuveson DA. Diversity and Biology of Cancer-Associated Fibroblasts. Physiol Rev. 2021;101:147\u201376.","journal-title":"Physiol Rev"},{"key":"5459_CR43","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s12943-021-01463-y","volume":"20","author":"C Li","year":"2021","unstructured":"Li C, Teixeira AF, Zhu HJ, Ten Dijke P. Cancer associated-fibroblast-derived exosomes in cancer progression. Mol Cancer. 2021;20:154.","journal-title":"Mol Cancer"},{"key":"5459_CR44","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.7150\/thno.53649","volume":"11","author":"J Hu","year":"2021","unstructured":"Hu J, Yu A, Othmane B, Qiu D, Li H, Li C, et al. Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer. Theranostics. 2021;11:3089\u2013108.","journal-title":"Theranostics"},{"key":"5459_CR45","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrc.2016.36","volume":"16","author":"SL Topalian","year":"2016","unstructured":"Topalian SL, Taube JM, Anders RA, Pardoll DM. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 2016;16:275\u201387.","journal-title":"Nat Rev Cancer"},{"key":"5459_CR46","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ccell.2020.10.001","volume":"39","author":"DL Jardim","year":"2021","unstructured":"Jardim DL, Goodman A, de Melo Gagliato D, Kurzrock R. The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker. Cancer Cell. 2021;39:154\u201373.","journal-title":"Cancer Cell"},{"key":"5459_CR47","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1111\/cas.16160","volume":"115","author":"H Yamamoto","year":"2024","unstructured":"Yamamoto H, Watanabe Y, Arai H, Umemoto K, Tateishi K, Sunakawa Y. Microsatellite instability: A 2024 update. Cancer Sci. 2024;115:1738\u201348.","journal-title":"Cancer Sci"},{"key":"5459_CR48","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1158\/0008-5472.CAN-20-3209","volume":"82","author":"L Krau\u00df","year":"2022","unstructured":"Krau\u00df L, Urban BC, Hastreiter S, Schneider C, Wenzel P, Hassan Z, et al. HDAC2 Facilitates Pancreatic Cancer Metastasis. Cancer Res. 2022;82:695\u2013707.","journal-title":"Cancer Res"},{"key":"5459_CR49","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.semcancer.2019.08.027","volume":"67","author":"CS Moreno","year":"2020","unstructured":"Moreno CS. SOX4: The unappreciated oncogene. Semin Cancer Biol. 2020;67:57\u201364.","journal-title":"Semin Cancer Biol"},{"key":"5459_CR50","doi-asserted-by":"publisher","first-page":"1513979","DOI":"10.3389\/fonc.2024.1513979","volume":"14","author":"T Sun","year":"2024","unstructured":"Sun T, Li X, Zhang Y, Zou B, Zhang Y. ILF2: a multifaceted regulator in malignant tumors and its prospects as a biomarker and therapeutic target. Front Oncol. 2024;14:1513979.","journal-title":"Front Oncol"}],"container-title":["Discover Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12672-026-05459-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-05459-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12672-026-05459-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:17:39Z","timestamp":1787725059000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12672-026-05459-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5459"],"URL":"https:\/\/doi.org\/10.1007\/s12672-026-05459-2","relation":{},"ISSN":["2730-6011"],"issn-type":[{"value":"2730-6011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"11 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1249"}}