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This study utilized publicly available single-cell RNA sequencing datasets (GSE50772, GSE33630, GSE81622 and GSE29265 ) from the Gene Expression Omnibus (GEO) database. No human participants, human tissue, or live animals were involved in this research. This study utilized pre-existing, anonymized data from public repositories. No prospective participant recruitment or direct human interaction occurred.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This manuscript contains no individual-level data, clinical images, or identifiable personal information. All presented data are aggregated and derived from public sources. All the authors were aware of the content of the submission and unanimously agreed to publish it.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1322"}}