{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:39:00Z","timestamp":1788910740924,"version":"build-2803163510"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Community Genet"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s12687-021-00509-4","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T10:03:33Z","timestamp":1611655413000},"page":"377-386","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Geographic distribution of live births and infant mortality from congenital anomalies in Brazil, 2012\u20132017"],"prefix":"10.1007","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-4947","authenticated-orcid":false,"given":"Luzivan Costa","family":"Reis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-5281","authenticated-orcid":false,"given":"Wesley Luciano","family":"Kaizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6437-789X","authenticated-orcid":false,"given":"Juliano Andr\u00e9","family":"Boquett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"issue":"11","key":"509_CR1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001549","volume":"5","author":"H Ahmed","year":"2017","unstructured":"Ahmed H, Akbari H, Emami A, Akbari MR (2017) Genetic overview of syndactyly and polydactyly. PRS Global Open 5(11):e1549. https:\/\/doi.org\/10.1097\/GOX.0000000000001549","journal-title":"PRS Global Open"},{"key":"509_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.15585\/mmwr.mm6902a1","volume":"69","author":"LM Almli","year":"2020","unstructured":"Almli LM, Ely DM, Ailes EC, Abouk R, Grosse SD, Isenburg JL, Waldron DB, Reefhuis J (2020) Infant mortality attributable to birth defects - United States, 2003-2017. Morb Mortal Wkly Rep 69:25\u201329. https:\/\/doi.org\/10.15585\/mmwr.mm6902a1","journal-title":"Morb Mortal Wkly Rep"},{"issue":"3","key":"509_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5020\/18061230.2017.6309","volume":"30","author":"AM Andrade","year":"2017","unstructured":"Andrade AM, Ramalho AA et al (2017) Anomalias cong\u00eanitas em nascidos vivos. Rev Bras Promo\u00e7 Sa\u00fade 30(3):1\u201311. https:\/\/doi.org\/10.5020\/18061230.2017.6309","journal-title":"Rev Bras Promo\u00e7 Sa\u00fade"},{"issue":"1","key":"509_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-015-0138-y","volume":"22","author":"A Asim","year":"2015","unstructured":"Asim A, Kumar A, Muthuswamy S, Jain S, Agarwal S (2015) Down syndrome: an insight of the disease. J Biomed Sci 22(1):1\u20139. https:\/\/doi.org\/10.1186\/s12929-015-0138-y","journal-title":"J Biomed Sci"},{"issue":"3","key":"509_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s10654-004-6517-4","volume":"20","author":"B B\u00e9gaud","year":"2005","unstructured":"B\u00e9gaud B, Martin K et al (2005) Any easy-to-use method for approximate Poisson confidence limits. Eur J Epidemiol 20(3):213\u2013216. https:\/\/doi.org\/10.1007\/s10654-004-6517-4","journal-title":"Eur J Epidemiol"},{"issue":"9901","key":"509_CR6","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/s0140-6736(13)61503-2","volume":"382","author":"AH Bittles","year":"2013","unstructured":"Bittles AH (2013) Consanguineous marriages and congenital anomalies. The Lancet 382(9901):1316\u20131317. https:\/\/doi.org\/10.1016\/s0140-6736(13)61503-2","journal-title":"The Lancet"},{"issue":"3","key":"509_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002755","volume":"16","author":"OJ Brady","year":"2019","unstructured":"Brady OJ, Osgood-Zimmerman A, Kassebaum NJ, Ray SE, de Ara\u00fajo VEM, da N\u00f3brega AA, Frutuoso LCV, Lecca RCR, Stevens A, Zoca de Oliveira B, de Lima JM, Bogoch II, Mayaud P, Jaenisch T, Mokdad AH, Murray CJL, Hay SI, Reiner RC, Marinho F (2019) The association between Zika virus infection and microcephaly in Brazil 2015-2017: an observational analysis of over 4 million births. PLoS Med 16(3):e1002755. https:\/\/doi.org\/10.1371\/journal.pmed.1002755","journal-title":"PLoS Med"},{"issue":"3","key":"509_CR8","doi-asserted-by":"publisher","first-page":"171","DOI":"10.5546\/aap.2019.eng.171","volume":"117","author":"RA Bronberg","year":"2019","unstructured":"Bronberg RA, Dipierri JE (2019) Infant mortality due to congenital malformations in the Autonomous City of Buenos Aires (1998-2015): spatial, temporal analysis and relation to the socioeconomic status. Arch Argent Pediatr 117(3):171\u2013178. https:\/\/doi.org\/10.5546\/aap.2019.eng.171","journal-title":"Arch Argent Pediatr"},{"issue":"3","key":"509_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s12687-013-0170-0","volume":"5","author":"R Bronberg","year":"2014","unstructured":"Bronberg R, Schuler-Faccini L, Ramallo V, Alfaro E, Dipierri J (2014) Spatial and temporal analysis of infant mortality from congenital malformations in Brazil (1996-2010). J Community Genet 5(3):269\u2013282. https:\/\/doi.org\/10.1007\/s12687-013-0170-0","journal-title":"J Community Genet"},{"issue":"1","key":"509_CR10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s12687-015-0249-x","volume":"7","author":"R Bronberg","year":"2015","unstructured":"Bronberg R, Dipierri J, Alfaro E, Sanseverino MT, Sch\u00fcler-Faccini L (2015) Primary prevention of neural tube defects in Brazil: insights into anencephaly. J Community Genet 7(1):97\u2013105. https:\/\/doi.org\/10.1007\/s12687-015-0249-x","journal-title":"J Community Genet"},{"key":"509_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12687-019-00449-0","volume":"11","author":"R Bronberg","year":"2020","unstructured":"Bronberg R, Groisman B, Bidondo MP, Barbero P, Liascovich R (2020) Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level. J Community Genet 11:1\u20139. https:\/\/doi.org\/10.1007\/s12687-019-00449-0","journal-title":"J Community Genet"},{"issue":"8","key":"509_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201452","volume":"13","author":"MC Campos","year":"2018","unstructured":"Campos MC, Dombrowski JG, Phelan J, Marinho CRF, Hibberd M, Clark TG, Campino S (2018) Zika might not be acting alone: using an ecological study approach to investigate potential co-acting risk factors for an unusual pattern of microcephaly in Brazil. PLoS One 13(8):e0201452. https:\/\/doi.org\/10.1371\/journal.pone.0201452","journal-title":"PLoS One"},{"issue":"4","key":"509_CR13","doi-asserted-by":"publisher","DOI":"10.5123\/s1679-49742020000400003","volume":"29","author":"AC Cardoso-dos-Santos","year":"2020","unstructured":"Cardoso-dos-Santos AC, Magalh\u00e3es VS et al (2020) Redes internacionais de colabora\u00e7\u00e3o para a vigil\u00e2ncia das anomalias cong\u00eanitas: uma revis\u00e3o narrativa. Epidemiol Serv Sa\u00fade 29(4):e2020093. https:\/\/doi.org\/10.5123\/s1679-49742020000400003","journal-title":"Epidemiol Serv Sa\u00fade"},{"issue":"1","key":"509_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1590\/1984-0462\/;2017;35;1;00002","volume":"35","author":"HW Cosme","year":"2017","unstructured":"Cosme HW, Lima LSB et al (2017) Preval\u00eancia de anomalias cong\u00eanitas e fatores associados em rec\u00e9m-nascidos do munic\u00edpio de S\u00e3o Paulo no per\u00edodo de 2010 a 2014. Rev Paul Pediatr 35(1):33\u201338 https:\/\/doi.org\/10.1590\/1984-0462\/;2017;35;1;00002","journal-title":"Rev Paul Pediatr"},{"key":"509_CR15","unstructured":"DATASUS - Banco de Dados do Sistema \u00danico de Sa\u00fade (2020a) In: Minist\u00e9rio da Sa\u00fade. Accessed 5 October 2020. Available at: http:\/\/datasus1.saude.gov.br\/informacoes-de-saude\/tabnet\/estatisticas-vitais"},{"key":"509_CR16","unstructured":"DATASUS - Banco de Dados do Sistema \u00danico de Sa\u00fade (2020b) In: Minist\u00e9rio da Sa\u00fade. Accessed 14 October 2020. Available at: http:\/\/www2.datasus.gov.br\/DATASUS\/index.php?area=02"},{"key":"509_CR17","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1590\/0102-311X00196113","volume":"30","author":"PG de Frias","year":"2014","unstructured":"de Frias PG, Szwarcwald CL et al (2014) Avalia\u00e7\u00e3o dos sistemas de informa\u00e7\u00f5es sobre nascidos vivos e \u00f3bitos no Brasil na d\u00e9cada de 2000. Cad Saude Publica 30:2068\u20132280. https:\/\/doi.org\/10.1590\/0102-311X00196113","journal-title":"Cad Saude Publica"},{"key":"509_CR18","doi-asserted-by":"crossref","unstructured":"Dipierri JE, Schuler-Faccini L et al (2019) Microcephaly infant mortality in Brazil before Zika outbreak. Rev Fac Cien Med Univ Nac Cordoba 76(4):217\u2013221. https:\/\/doi.org\/10.31053\/1853.0605.v76.n4.25172","DOI":"10.31053\/1853.0605.v76.n4.25172"},{"key":"509_CR19","unstructured":"European Surveillance of Congenital Anomalies (EUROCAT) (2020a) Prevalence charts and tables. Accessed 24 September 2020. Available at: https:\/\/eu-rd-platform.jrc.ec.europa.eu\/eurocat\/eurocat-data\/prevalence_en"},{"key":"509_CR20","unstructured":"European Surveillance of Congenital Anomalies (EUROCAT) (2020b) Calculation of prevalence and their 95% confidence intervals. Accessed 25 September 2020. Available at: https:\/\/eu-rd-platform.jrc.ec.europa.eu\/sites\/default\/files\/Calculations%20of%20Prevalence%20and%20CIs.pdf"},{"issue":"Suppl.1","key":"509_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1590\/1980-5497201700050005","volume":"20","author":"EB Fran\u00e7a","year":"2017","unstructured":"Fran\u00e7a EB, Lansky S, Rego MAS, Malta DC, Fran\u00e7a JS, Teixeira R, Porto D, Almeida MF, Souza MFM, Szwarcwald CL, Mooney M, Naghavi M, Vasconcelos AMN (2017) Leading causes of child mortality in Brazil, in 1990 and 2015: estimates from the Global Burden of Disease study. Rev Bras Epidemiol 20(Suppl.1):46\u201360. https:\/\/doi.org\/10.1590\/1980-5497201700050005","journal-title":"Rev Bras Epidemiol"},{"issue":"4","key":"509_CR22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/bdra.23481","volume":"106","author":"JA Gili","year":"2016","unstructured":"Gili JA, Poletta FA, Gim\u00e9nez LG, Pawluk MS, Campa\u00f1a H, Castilla EE, L\u00f3pez-Camelo JS (2016) Descriptive analysis of high birth prevalence rate geographical clusters of congenital anomalies in South America. Birth Defects Res A Clin Mol Teratol 106(4):257\u2013266. https:\/\/doi.org\/10.1002\/bdra.23481","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"1","key":"509_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12687-016-0276-2","volume":"8","author":"B Groisman","year":"2017","unstructured":"Groisman B, Gili J, Gim\u00e9nez L, Poletta F, Bidondo MP, Barbero P, Liascovich R, L\u00f3pez-Camelo J (2017) Geographic clusters of congenital anomalies in Argentina. J Community Genet 8(1):1\u20137. https:\/\/doi.org\/10.1007\/s12687-016-0276-2","journal-title":"J Community Genet"},{"issue":"2","key":"509_CR24","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/OGX.0000000000000405","volume":"72","author":"BS Harris","year":"2017","unstructured":"Harris BS, Bishop KC, Kemeny HR, Walker JS, Rhee E, Kuller JA (2017) Risk factors for birth defects. Obstet Gynecol Surv 72(2):123\u2013135. https:\/\/doi.org\/10.1097\/OGX.0000000000000405","journal-title":"Obstet Gynecol Surv"},{"issue":"11","key":"509_CR25","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1002\/ajmg.a.36249","volume":"161","author":"RC Hennekam","year":"2013","unstructured":"Hennekam RC, Biesecker LG, Allanson JE, Hall JG, Opitz JM, Temple IK, Carey JC, Elements of Morphology Consortium (2013) Elements of morphology: general terms for congenital anomalies. Am J Med Genet A 161(11):2726\u20132733. https:\/\/doi.org\/10.1002\/ajmg.a.36249","journal-title":"Am J Med Genet A"},{"issue":"4","key":"509_CR26","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1590\/S0102-311X2005000400008","volume":"21","author":"DDG Horovitz","year":"2005","unstructured":"Horovitz DDG, Llerena JJC et al (2005) Aten\u00e7\u00e3o aos defeitos cong\u00eanitos no Brasil: panorama atual. Cad Sa\u00fade P\u00fablica 21(4):1055\u20131064. https:\/\/doi.org\/10.1590\/S0102-311X2005000400008","journal-title":"Cad Sa\u00fade P\u00fablica"},{"issue":"3","key":"509_CR27","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s12687-012-0096-y","volume":"4","author":"DD Horovitz","year":"2013","unstructured":"Horovitz DD, de Faria Ferraz VE et al (2013) Genetic services and testing in Brazil. J Community Genet 4(3):355\u2013375. https:\/\/doi.org\/10.1007\/s12687-012-0096-y","journal-title":"J Community Genet"},{"key":"509_CR28","unstructured":"IBGE \u2013 Instituto Brasileiro de Geografia e Estat\u00edstica (2020) Panorama Brasil. Accessed 17 October 2020. Available at: https:\/\/cidades.ibge.gov.br\/brasil\/panorama"},{"issue":"e026351","key":"509_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmjopen2018-026351","volume":"9","author":"AM Kurdi","year":"2019","unstructured":"Kurdi AM, Majeed-Saidan MA, Rakaf MSA et al (2019) Congenital anomalies and associated risk factors in a Saudi population: a cohort study from pregnancy to age 2 years. BMJ Open 9(e026351):1\u201314. https:\/\/doi.org\/10.1136\/bmjopen2018-026351","journal-title":"BMJ Open"},{"issue":"3","key":"509_CR30","doi-asserted-by":"publisher","first-page":"328","DOI":"10.7322\/jhdg.88972","volume":"24","author":"R Laurenti","year":"2014","unstructured":"Laurenti R, Siqueira AAF et al (2014) A Import\u00e2ncia das anomalias cong\u00eanitas ao nascer. J Hum Growth Dev 24(3):328\u2013338. https:\/\/doi.org\/10.7322\/jhdg.88972","journal-title":"J Hum Growth Dev"},{"issue":"10","key":"509_CR31","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1002\/ajmg.a.33479","volume":"152A","author":"JS L\u00f3pez-Camelo","year":"2010","unstructured":"L\u00f3pez-Camelo JS, Castilla EE, Orioli IM (2010) Folic acid flour fortification: impact on the frequencies of 52 congenital anomaly types in three South American countries. Am J Med Genet Part A 152A(10):2444\u20132458. https:\/\/doi.org\/10.1002\/ajmg.a.33479","journal-title":"Am J Med Genet Part A"},{"issue":"8","key":"509_CR32","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1590\/S0102-311X2009000800008","volume":"25","author":"DV Luquetti","year":"2009","unstructured":"Luquetti DV, Koifman RJ (2009) Quality of reporting on birth defects in birth certificates: case study from a Brazilian reference hospital. Cad Sa\u00fade P\u00fablica 25(8):1721\u20131731. https:\/\/doi.org\/10.1590\/S0102-311X2009000800008","journal-title":"Cad Sa\u00fade P\u00fablica"},{"issue":"2","key":"509_CR33","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1590\/1678-4685-gmb-2016-0179","volume":"40","author":"T Mazzu-Nascimento","year":"2017","unstructured":"Mazzu-Nascimento T, Melo DG, Morbioli GG, Carrilho E, Vianna FSL, Silva AA, Schuler-Faccini L (2017) Teratogens: a public health issue - a Brazilian overview. Genet Mol Biol 40(2):387\u2013397. https:\/\/doi.org\/10.1590\/1678-4685-gmb-2016-0179","journal-title":"Genet Mol Biol"},{"key":"509_CR34","unstructured":"Mirfazeli A, Kaviany N et al (2018) Birth defects in Northern Iran (2008-2013). Iran J Public Health 47(3):413-417. Accessed 29 April 2020. Available at: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5971179\/pdf\/IJPH-47-413.pdf"},{"issue":"10","key":"509_CR35","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1056\/NEJMoa1600651","volume":"374","author":"J Mlakar","year":"2016","unstructured":"Mlakar J, Korva M, Tul N, Popovi\u0107 M, Polj\u0161ak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodu\u0161ek V, Vizjak A, Pi\u017eem J, Petrovec M, Av\u0161i\u010d \u017dupanc T (2016) Zika virus associated with microcephaly. N Engl J Med 374(10):951\u2013958. https:\/\/doi.org\/10.1056\/NEJMoa1600651","journal-title":"N Engl J Med"},{"key":"509_CR36","unstructured":"Modell B, Darlison MW et al (2016) Epidemiological methods in community genetics and the Modell global database of congenital disorders (MGDb). Downloaded from UCL Discovery at: http:\/\/discovery.ucl.ac.uk\/1532179\/. Accessed 10 October 2020"},{"key":"509_CR37","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s12687-017-0335-3","volume":"9","author":"S Moorthie","year":"2017","unstructured":"Moorthie S, Blencowe HW et al (2017) An overview of concepts and approaches used in estimating the burden of congenital disorders globally. J Community Genet 9:347\u2013362. https:\/\/doi.org\/10.1007\/s12687-017-0335-3","journal-title":"J Community Genet"},{"key":"509_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12687-018-0384-2","volume":"9","author":"S Moorthie","year":"2018","unstructured":"Moorthie S, Blencowe H et al (2018) Estimating the birth prevalence and pregnancy outcomes of congenital malformations worldwide. J Community Genet 9:1\u201310. https:\/\/doi.org\/10.1007\/s12687-018-0384-2","journal-title":"J Community Genet"},{"issue":"7","key":"509_CR39","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1590\/S0102-311X2010000700017","volume":"26","author":"PDR Nicola","year":"2010","unstructured":"Nicola PDR, Cernach MCSP et al (2010) A utiliza\u00e7\u00e3o da Internet na notifica\u00e7\u00e3o dos defeitos cong\u00eanitos na Declara\u00e7\u00e3o de Nascido Vivo em quatro maternidades p\u00fablicas do Munic\u00edpio de S\u00e3o Paulo, Brasil. Cad Sa\u00fade P\u00fablica 26(7):1383\u20131390. https:\/\/doi.org\/10.1590\/S0102-311X2010000700017","journal-title":"Cad Sa\u00fade P\u00fablica"},{"key":"509_CR40","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/npmj.npmj_77_19","volume":"26","author":"RO Oluwafemi","year":"2019","unstructured":"Oluwafemi RO, Abiodun MT (2019) Incidence, spectrum and outcome of congenital anomalies seen in a neonatal intensive care unit in Southern Nigeria. Niger Postgrad Med J 26:239\u2013243. https:\/\/doi.org\/10.4103\/npmj.npmj_77_19","journal-title":"Niger Postgrad Med J"},{"issue":"1","key":"509_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2471\/blt.14.139790","volume":"93","author":"S Oza","year":"2014","unstructured":"Oza S, Lawn JE, Hogan DR, Mathers C, Cousens SN (2014) Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries: 2000-2013. Bull World Health Organ 93(1):19\u201328. https:\/\/doi.org\/10.2471\/blt.14.139790","journal-title":"Bull World Health Organ"},{"issue":"9","key":"509_CR42","doi-asserted-by":"publisher","first-page":"e0007721","DOI":"10.1371\/journal.pntd.0007721","volume":"13","author":"ES Paix\u00e3o","year":"2019","unstructured":"Paix\u00e3o ES, Rodrigues MS et al (2019) Impact evaluation of Zika epidemic on congenital anomalies registration in Brazil: an interrupted time series analysis. PLoS Negl Trop Dis 13(9):e0007721. 13(9): e0007721. https:\/\/doi.org\/10.1371\/journal.pntd.0007721","journal-title":"PLoS Negl Trop Dis"},{"key":"509_CR43","unstructured":"R Core Team (2010) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Accessed 31 April 2020. Available at: http:\/\/www.R-project.org\/"},{"issue":"suppl 7","key":"509_CR44","doi-asserted-by":"publisher","first-page":"S428","DOI":"10.1093\/cid\/ciu738","volume":"59","author":"SA Rasmussen","year":"2014","unstructured":"Rasmussen SA, Hernandez-Diaz S, Abdul-Rahman OA, Sahin L, Petrie CR, Keppler-Noreuil KM, Frey SE, Mason RM, Nesin M, Carey JC (2014) Assessment of congenital anomalies in infants born to pregnant women enrolled in clinical trials. Clin Infect Dis 59(suppl 7):S428\u2013S436. https:\/\/doi.org\/10.1093\/cid\/ciu738","journal-title":"Clin Infect Dis"},{"issue":"2","key":"509_CR45","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s12687-013-0165-x","volume":"5","author":"L Schuler-Faccini","year":"2013","unstructured":"Schuler-Faccini L, Sanseverino MT et al (2013) Health needs assessment for congenital anomalies in middle-income countries: examining the case for neural tube defects in Brazil. J Community Genet 5(2):147\u2013155. https:\/\/doi.org\/10.1007\/s12687-013-0165-x","journal-title":"J Community Genet"},{"key":"509_CR46","doi-asserted-by":"crossref","unstructured":"Schuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG, Cavalcanti DP, Pessoa A, Doriqui MJR, Neri JI, Neto JMP, Wanderley HYC, Cernach M, el-Husny AS, Pone MVS, Serao CLC, Sanseverino MTV, Brazilian Medical Genetics Society\u2013Zika Embryopathy Task Force (2016) Possible association between Zika virus infection and microcephaly- Brazil, 2015. Morb Mortal Wkly Rep 65(3):59\u201362. https:\/\/doi.org\/10.15585\/mmwr.mm6503e2","DOI":"10.15585\/mmwr.mm6503e2"},{"issue":"4","key":"509_CR47","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1177\/0033354918777256","volume":"133","author":"AI Souza","year":"2018","unstructured":"Souza AI, de Siqueira MT, Ferreira ALCG, de Freitas CU, Bezerra ACV, Ribeiro AG, Nardocci AC (2018) Geography of Microcephaly in the Zika Era: a Study of Newborn Distribution and Socio-environmental Indicators in Recife, Brazil, 2015-2016. Public Health Rep 133(4):461\u2013471. https:\/\/doi.org\/10.1177\/0033354918777256","journal-title":"Public Health Rep"},{"key":"509_CR48","unstructured":"United Nations Program for Development (2020) Ranking IDHM Federation Units 2010. https:\/\/www.br.undp.org\/content\/brazil\/pt\/home\/idh0\/rankings\/idhm-uf-2010.html. Accessed 19 October 2020"},{"issue":"9","key":"509_CR49","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1002\/pd.5520","volume":"39","author":"IBVD Veyver","year":"2019","unstructured":"Veyver IBVD (2019) Prenatally diagnosed developmental abnormalities of the central nervous system and genetic syndromes: a practical review. Prenat Diagn 39(9):666\u2013678. https:\/\/doi.org\/10.1002\/pd.5520","journal-title":"Prenat Diagn"},{"key":"509_CR50","unstructured":"World Health Organization (WHO) (2013) Prevention and control of birth defects in South-East Asia Region: strategic framework (2013-2017). Available at: https:\/\/apps.who.int\/iris\/handle\/10665\/205644"},{"key":"509_CR51","unstructured":"World Health Organization (WHO) (2016) Congenital anomalies. Geneva: World Health Organization; 2016. Accessed 12 October 2020. Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/congenital-anomalies"},{"key":"509_CR52","unstructured":"World Health Organization (WHO) (2019) ICD-10 online versions: 2019. Accessed 13 October 2020. Available at: https:\/\/icd.who.int\/browse10\/2019\/en#\/XVII"},{"key":"509_CR53","unstructured":"World Health Organization (WHO) (2019) Global health observatory data repository. Number of deaths: WORLD by cause. Accessed 21 October 2020. Available at: https:\/\/www.who.int\/gho\/mortality_burden_disease\/causes_death\/top_10\/en\/"},{"issue":"1","key":"509_CR54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147280","volume":"11","author":"D Xie","year":"2016","unstructured":"Xie D, Yang T, Liu Z, Wang H (2016) Epidemiology of birth defects based on a birth defect surveillance system from 2005 to 2014 in Hunan Province, China. PloS One 11(1):e0147280. https:\/\/doi.org\/10.1371\/journal.pone.0147280","journal-title":"PloS One"},{"issue":"7","key":"509_CR55","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3109\/14767058.2014.932767","volume":"28","author":"M Yang","year":"2014","unstructured":"Yang M, Zhang S, Du Y (2014) Epidemiology characteristics of birth defects in Shenzhen city during 2003 to 2009, China. J Maternal-Fetal N Med 28(7):799\u2013803. https:\/\/doi.org\/10.3109\/14767058.2014.932767","journal-title":"J Maternal-Fetal N Med"}],"updated-by":[{"DOI":"10.1007\/s12687-021-00512-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000}}],"container-title":["Journal of Community Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12687-021-00509-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12687-021-00509-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12687-021-00509-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T12:21:32Z","timestamp":1624969292000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12687-021-00509-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["509"],"URL":"https:\/\/doi.org\/10.1007\/s12687-021-00509-4","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12687-021-00512-9","asserted-by":"object"}]},"ISSN":["1868-310X","1868-6001"],"issn-type":[{"value":"1868-310X","type":"print"},{"value":"1868-6001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,26]]},"assertion":[{"value":"21 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12687-021-00512-9","URL":"https:\/\/doi.org\/10.1007\/s12687-021-00512-9","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not contain human or animal studies by any of the authors. The data included here refer to human births identified in the DATASUS system. All human individuals had anonymized registers on the website. Resolution 466\/12 of Brazilian legislation does not require approval by the Research Ethics Committee for data obtained from public databases of free access (National Health Council\u2014<i>Conselho Nacional de Sa\u00fade<\/i> 2012, in Portuguese), as is the case with DATASUS.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}