{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:16:55Z","timestamp":1780676215227,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Community Genet"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s12687-021-00516-5","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:02:15Z","timestamp":1617148935000},"page":"345-355","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Birth prevalence of congenital anomalies in Argentina, according to socioeconomic level"],"prefix":"10.1007","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8859-3060","authenticated-orcid":false,"given":"Ruben","family":"Bronberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Groisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paz","family":"Bidondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Barbero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Liascovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"issue":"1","key":"516_CR1","doi-asserted-by":"publisher","first-page":"010429","DOI":"10.7189\/jogh.09.010429","volume":"9","author":"AE Adegbosin","year":"2019","unstructured":"Adegbosin AE, Zhou H, Wang S, Stantic B, Sun J (2019) Systematic review and meta-analysis of the association between dimensions of inequality and a selection of indicators of Reproductive, Maternal, Newborn and Child Health (RMNCH). J Glob Health 9(1):010429","journal-title":"J Glob Health"},{"key":"516_CR2","first-page":"414","volume":"72","author":"HE Arce","year":"2012","unstructured":"Arce HE (2012) Organizaci\u00f3n y financiamiento del sistema de salud en la Argentina. Revista Medicina (Buenos Aires) 72:414\u2013418","journal-title":"Revista Medicina (Buenos Aires)"},{"issue":"7","key":"516_CR3","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/ajmg.a.37016","volume":"167","author":"RJ Baer","year":"2015","unstructured":"Baer RJ, Chambers CD, Jones KL, Shew SB, MacKenzie TC, Shaw GM, Jelliffe-Pawlowski LL (2015) Maternal factors associated with the occurrence of gastroschisis. Am J Med Genet A 167(7):1534\u20131541","journal-title":"Am J Med Genet A"},{"key":"516_CR4","first-page":"9(7)","volume":"2","author":"MK Bakker","year":"2019","unstructured":"Bakker MK, Bergman JEH, Krikov S, Amar E, Cocchi G, Cragan J, de Walle HEK, Gatt M, Groisman B, Liu S, Nembhard WN, Pierini A, Rissmann A, Chidambarathanu S, Sipek A Jr, Szabova E, Tagliabue G, Tucker D, Mastroiacovo P, Botto LD (2019) Prenatal diagnosis and prevalence of critical congenital heart defects: an international retrospective cohort study. BMJ Open 2:9(7)","journal-title":"BMJ Open"},{"issue":"3\u20134 Suppl 1","key":"516_CR5","first-page":"1","volume":"42","author":"S Baldacci","year":"2018","unstructured":"Baldacci S, Gorini F, Santoro M, Pierini A, Minichilli F, Bianchi F (2018) Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence. Epidemiol Prev 42(3\u20134 Suppl 1):1\u201334","journal-title":"Epidemiol Prev"},{"issue":"3","key":"516_CR6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s12687-019-00451-6","volume":"11","author":"MP Bidondo","year":"2020","unstructured":"Bidondo MP, Groisman B, Duarte S, Tardivo A, Liascovich R, Barbero P (2020) Prenatal detection of congenital anomalies and related factors in Argentina. J Community Genet 11(3):313\u2013320. https:\/\/doi.org\/10.1007\/s12687-019-00451-6","journal-title":"J Community Genet"},{"issue":"2","key":"516_CR7","first-page":"117","volume":"109","author":"R Bronberg","year":"2011","unstructured":"Bronberg R, Alfaro E, Chaves E, Andrade A, Dipierri J (2011) Mortalidad infantil por anencefalia en la Argentina: an\u00e1lisis espacial y temporal (1998\u20132007). Arch Argent Pediatr 109(2):117\u2013123","journal-title":"Arch Argent Pediatr"},{"issue":"3","key":"516_CR8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/ajhb.22802","volume":"28","author":"R Bronberg","year":"2016","unstructured":"Bronberg R, Gili J, Gimenez L, Dipierri J, Lopez Camelo J (2016) Biosocial correlates and spatial distribution of consanguinity in South America. Am J Hum Biol 28(3):405\u2013411","journal-title":"Am J Hum Biol"},{"key":"516_CR9","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s12687-019-00449-0","volume":"11","author":"R Bronberg","year":"2020","unstructured":"Bronberg R, Groisman B, Bidondo MP, Barbero P, Liascovich R (2020) Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level. J Community Genet 11:303\u2013311","journal-title":"J Community Genet"},{"issue":"11","key":"516_CR10","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1002\/bdra.20294","volume":"76","author":"MA Canfield","year":"2006","unstructured":"Canfield MA, Honein MA, Yuskiv N, Xing J, Mai CT, Collins JS, Devine O, Petrini J, Ramadhani TA, Hobbs CA, Kirby RS (2006) National estimates and race\/ethnic-specific variation of selected birth defects in the United States, 1999\u20132001. Birth Defects Research Part A, Clinical and Molecular Teratology 76(11):747\u2013756","journal-title":"Birth Defects Research Part A, Clinical and Molecular Teratology"},{"issue":"4","key":"516_CR11","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/rmv.655","volume":"20","author":"MJ Cannon","year":"2010","unstructured":"Cannon MJ, Schmid DS, Hyde TB (2010) Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 20(4):202\u2013213","journal-title":"Rev Med Virol"},{"issue":"3","key":"516_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/ajmg.c.30181","volume":"148C","author":"EE Castilla","year":"2008","unstructured":"Castilla EE, Mastroiacovo P, Orioli IM (2008) Gastroschisis: international epidemiology and public health perspectives. Am J Med Genet C: Semin Med Genet 148C(3):162\u2013179","journal-title":"Am J Med Genet C: Semin Med Genet"},{"key":"516_CR13","unstructured":"Direcci\u00f3n de Estad\u00edsticas e Informaci\u00f3n de Salud (DEIS)(2018) Ministerio de Salud y Desarrollo Social de la Naci\u00f3n. Estad\u00edsticas Vitales, Informaci\u00f3n B\u00e1sica. Available at http:\/\/www.deis.msal.gov.ar\/"},{"key":"516_CR14","unstructured":"Encuesta nacional de nutrici\u00f3n y salud (ENNyS) (2007) Available at http:\/\/www.msal.gob.ar\/images\/stories\/bes\/graficos\/0000000257cnt-a08-ennys-documento-de-resultados-2007.pdf"},{"key":"516_CR15","doi-asserted-by":"crossref","unstructured":"Feldkamp ML, Arnold KE, Krikov S, Reefhuis J, Almli LM, Moore CA, Botto LD (2019) Risk of gastroschisis with maternal genitourinary infections: the US National birth defects prevention study 1997-2011.BMJ Open. 9(3)","DOI":"10.1136\/bmjopen-2018-026297"},{"issue":"4","key":"516_CR16","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/tera.1420420408","volume":"42","author":"G Goldbaum","year":"1990","unstructured":"Goldbaum G, Daling J, Milham S (1990) Risk factors for gastroschisis. Teratology. 42(4):397\u2013403","journal-title":"Teratology."},{"issue":"1","key":"516_CR17","first-page":"1","volume":"8","author":"B Groisman","year":"2016","unstructured":"Groisman B, Gili JA, Gimenez LG, Poletta FA, Bidondo MP (2016) Geographic clusters of congenital anomalies in Argentina. Community Genetics 8(1):1\u20137","journal-title":"Community Genetics"},{"issue":"2(6)","key":"516_CR18","doi-asserted-by":"publisher","first-page":"e256","DOI":"10.1371\/journal.pntd.0000256","volume":"25","author":"PJ Hotez","year":"2008","unstructured":"Hotez PJ (2008) Neglected infections of poverty in the United States of America. PLoS Negl Trop Dis 25(2(6)):e256","journal-title":"PLoS Negl Trop Dis"},{"issue":"11","key":"516_CR19","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1002\/bdra.23282","volume":"100","author":"AT Hoyt","year":"2014","unstructured":"Hoyt AT, Canfield MA, Shaw GM (2014) Sociodemographic and hispanic acculturation factors and isolated anotia\/microtia. Birth Defects Res A Clin Mol Teratol 100(11):852\u2013862","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"7","key":"516_CR20","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/bdr2.1665","volume":"112","author":"AT Hoyt","year":"2020","unstructured":"Hoyt AT, Ramadhani T, Le MT, Shumate CJ, Canfield MA, Scheuerle AE (2020) National Birth Defects Prevention Study. Acculturation and selected birth defects among non-Hispanic Blacks in a population-based case-control study. Birth Defects Res 112(7):535\u2013554","journal-title":"Birth Defects Res"},{"key":"516_CR21","unstructured":"International Center for Health Equity (n.d.) Universidade Federal de Pelotas, Brasil. http:\/\/www.equidade.org\/"},{"issue":"12","key":"516_CR22","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.2105\/AJPH.2005.069377","volume":"96","author":"B Khoshnood","year":"2006","unstructured":"Khoshnood B, De Vigan C, Vodovar V, Br\u00e9art G, Goffinet F, Blondel B (2006) Advances in medical technology and creation of disparities: the case of Down syndrome. Am J Public Health 96(12):2139\u20132144","journal-title":"Am J Public Health"},{"issue":"9","key":"516_CR23","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1002\/bdra.20836","volume":"91","author":"DV Luquetti","year":"2011","unstructured":"Luquetti DV, Leoncini E, Mastroiacovo P (2011) Microtia-anotia: a global review of prevalence rates. Birth Defects Res A Clin Mol Teratol 91(9):813\u2013822. https:\/\/doi.org\/10.1002\/bdra.20836","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"1","key":"516_CR24","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s40615-018-0502-1","volume":"6","author":"DT Mage","year":"2019","unstructured":"Mage DT, Maria Donner E, Holmes L Jr (2019) risk differences in disease-specific infant mortality between black and White US children, 1968\u20132015: an epidemiologic investigation. J Racial Ethn Health Disparities 6(1):86\u201393","journal-title":"J Racial Ethn Health Disparities"},{"issue":"3","key":"516_CR25","first-page":"215","volume":"112","author":"MS Pawluk","year":"2014","unstructured":"Pawluk MS, Campa\u00f1a H, Gili JA, Comas B, Gim\u00e9nez LG, Villalba MI, Scala SC, Poletta FA, L\u00f3pez Camelo JS (2014) Adverse social determinants and risk for congenital anomalies.Arch. Argent Pediatr 112(3):215\u2013223","journal-title":"Argent Pediatr"},{"issue":"41","key":"516_CR26","first-page":"e110","volume":"19","author":"MS Pawluk","year":"2018","unstructured":"Pawluk MS, Campa\u00f1a H, Rittler M, Poletta FA, Cosentino VR, Gili JA, Gimenez LG, L\u00f3pez Camelo JS (2018) Individual deprivation, regional deprivation, and risk for oral clefts in Argentina. Rev Panam Salud Publica 19(41):e110","journal-title":"Rev Panam Salud Publica"},{"issue":"2","key":"516_CR27","first-page":"187","volume":"39","author":"MC Perego","year":"2005","unstructured":"Perego MC, Briozzo G, Durante C (2005) Estudio bioqu\u00edmiconutricional en la gestaci\u00f3n temprana en la Maternidad Sard\u00e1 de Buenos Aires. Acta Bioquim Clin Latinoam 39(2):187\u2013196","journal-title":"Acta Bioquim Clin Latinoam"},{"issue":"24","key":"516_CR28","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1002\/ajmg.a.32076","volume":"143A","author":"FA Poletta","year":"2007","unstructured":"Poletta FA, Castilla EE, Orioli IM, Lopez-Camelo JS (2007) Regional analysis on the occurrence of oral clefts in South America. Am J Med Genet A 143A(24):3216\u20133227","journal-title":"Am J Med Genet A"},{"issue":"3","key":"516_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/bdra.10012","volume":"67","author":"SA Rasmussen","year":"2003","unstructured":"Rasmussen SA, Olney RS, Holmes LB, Lin AE, Keppler-Noreuil KM, Moore CA, the National Birth Defects Prevention Study (2003) Guidelines for case classification for the National Birth Defects Prevention Study. Birth Defects Res A Clin Mol Teratol 67(3):193\u2013201","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"1","key":"516_CR30","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/1096-8628(20010722)102:1<36::AID-AJMG1394>3.0.CO;2-M","volume":"102","author":"M Rittler","year":"2001","unstructured":"Rittler M, Liascovich R, L\u00f3pez-Camelo J, Castilla EE (2001) Parental consanguinity in specific types of congenital anomalies. Am J Med Genet 102(1):36\u201343","journal-title":"Am J Med Genet"},{"key":"516_CR31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ijporl.2019.03.026","volume":"122","author":"MA Ryan","year":"2019","unstructured":"Ryan MA, Olshan AF, Canfield MA, Hoyt AT, Scheuerle AE, Carmichael SL, Shaw GM, Werler MM, Fisher SC, Desrosiers TA (2019) National Birth Defects Prevention Study. Sociodemographic, health behavioral, and clinical risk factors for anotia\/microtia in a population-based case-control study. Int J Pediatr Otorhinolaryngol 122:18\u201326","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"8","key":"516_CR32","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1177\/1055665619838381","volume":"56","author":"OB Saeed","year":"2019","unstructured":"Saeed OB, Moore MG, Zawahrah H, Tayem M, Kavoosi T, van Aalst JA (2019) the influence of consanguinity on familial clefting among Palestinians. Cleft Palate Craniofac J 56(8):1072\u20131079","journal-title":"Cleft Palate Craniofac J"},{"key":"516_CR33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.earlhumdev.2019.06.005","volume":"135","author":"CM Silva","year":"2019","unstructured":"Silva CM, Pereira MCM, Queiroz TB, Neves LTD (2019) Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft? Early Hum Dev 135:23\u201326","journal-title":"Early Hum Dev"},{"key":"516_CR34","unstructured":"Stevenson RE, Hall JH, Goodman RM (1993) Human malformation and related Anomalies. Oxford Monographs on Medical Genetics n. 27. New York: Oxford University Press"},{"issue":"3","key":"516_CR35","first-page":"110","volume":"33","author":"S Susacasa","year":"2014","unstructured":"Susacasa S (2014) An\u00e1lisis de factores sociodemogr\u00e1ficos como determinantes de la multiparidad extrema y su relaci\u00f3n con la morbimortalidad materna. Rev Hosp Mat Inf Ram\u00f3n Sard\u00e1 33(3):110\u2013118","journal-title":"Rev Hosp Mat Inf Ram\u00f3n Sard\u00e1"},{"key":"516_CR36","unstructured":"Tobar F, Olaviaga S, Solano R (2012) Complejidad y fragmentaci\u00f3n: las mayores enfermedades del sistema sanitario argentino. CIPPEC Documentos de Pol\u00edticas P\u00fablicas 108"},{"issue":"7","key":"516_CR37","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2471\/BLT.12.111732","volume":"91","author":"PR Torgerson","year":"2013","unstructured":"Torgerson PR, Mastroiacovo P (2013) The global burden of congenital toxoplasmosis: a systematic review. Bull World Health Organ 91(7):501\u2013508","journal-title":"Bull World Health Organ"},{"issue":"5","key":"516_CR38","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1136\/adc.82.5.349","volume":"82","author":"M Vrijheid","year":"2000","unstructured":"Vrijheid M, Dolk H, Stone D, Abramsky L, Alberman E, Scott JE (2000) Socioeconomic inequalities in risk of congenital anomaly. Arch Dis Child 82(5):349\u2013352","journal-title":"Arch Dis Child"},{"issue":"5\/6","key":"516_CR39","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1590\/S1020-49892002000500007","volume":"11","author":"A Wagstaff","year":"2002","unstructured":"Wagstaff A (2002) Poverty and health. Pan Am J Public Health 11(5\/6):316\u2013326","journal-title":"Pan Am J Public Health"},{"key":"516_CR40","doi-asserted-by":"crossref","unstructured":"Yu D, Feng Y, Yang L, Da M, Fan C, Wang S, Mo X (2014) Maternal socioeconomic status and the risk of congenital heart defects in offspring: a meta-analysis of 33 PLoS One 9(10)","DOI":"10.1371\/journal.pone.0111056"}],"container-title":["Journal of Community Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12687-021-00516-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12687-021-00516-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12687-021-00516-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T12:24:24Z","timestamp":1624969464000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12687-021-00516-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["516"],"URL":"https:\/\/doi.org\/10.1007\/s12687-021-00516-5","relation":{},"ISSN":["1868-310X","1868-6001"],"issn-type":[{"value":"1868-310X","type":"print"},{"value":"1868-6001","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,31]]},"assertion":[{"value":"7 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"In the present study, the data of the RENAC public health surveillance system was used. The data are anonymized. Therefore, the study is within the specific answers in Resolution 1480\/2011 of the Ministry of National Health in Argentina (Guide for Research with Human Beings), which states that \u201cthe sources of health systems, official health programs, or public health surveillance in which no possibility of individual identification are not subject to evaluation by an Ethics Committee.\u201d","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}