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A significant point of access for this allele testing is through services provided by medical facilities in Japan, which advertise out-of-insurance APOE testing on their websites. There is a concern that website advertisements for <jats:italic>APOE<\/jats:italic> testing may influence the ability for individuals to adequately self-determine whether to undergo <jats:italic>APOE<\/jats:italic> testing. We conducted a cross-sectional survey on medical facility websites in Japan advertising <jats:italic>APOE<\/jats:italic> genetic testing. We predefined desirable features for advertisement descriptions based on legal regulations and guidelines published by relevant professional societies and evaluated each website according to these features. We identified 220 medical facilities that had posted advertisements on their websites for the provision of <jats:italic>APOE<\/jats:italic> genetic testing, of which 85% were small clinics. Contact information, details, and costs of testing were described in most of the websites. Meanwhile, features such as \u201cexplaining <jats:italic>APOE<\/jats:italic> as a risk gene,\u201d \u201cnotes on interpreting <jats:italic>APOE<\/jats:italic> results,\u201d or \u201cexplaining examination methods\u201d (e.g., blood sampling) were described to a variable degree depending on individual facilities. \u201cNotes on genetic testing\u201d or \u201creferring to genetic counseling\u201d were hardly referred to, and specialists with appropriate expertise were considered to participate in clinical practice in approximately one-third of these facilities providing <jats:italic>APOE<\/jats:italic> testing services. These website evaluation results showed moderate to substantial reliability between independent raters. These results suggest that self-determination of pursuing out-of-insurance <jats:italic>APOE<\/jats:italic> testing at some medical facilities in Japan may possibly be influenced in an inappropriate manner, at least in its entry route of taking the test.<\/jats:p>","DOI":"10.1007\/s12687-024-00697-9","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T03:01:52Z","timestamp":1705374112000},"page":"195-204","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Advertisement by medical facilities as an opportunity route of APOE genetic testing in Japan: a website analysis"],"prefix":"10.1007","volume":"15","author":[{"given":"Kenichiro","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ikeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwatsubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"issue":"3","key":"697_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1177\/0891988721993575","volume":"35","author":"J Alber","year":"2022","unstructured":"Alber J, Popescu D, Thompson LI, Tonini GM, Arthur E, Oh H, Correia S, Salloway SP, Lee AK (2022) Safety and tolerability of APOE genotyping and disclosure in cognitively normal volunteers from the Butler Alzheimer\u2019s Prevention Registry. 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Informed consent was not required because the data were publicly available.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}