{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:20:06Z","timestamp":1790644806693,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Interv and Ther"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s12928-014-0281-5","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T06:02:25Z","timestamp":1406613745000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Histopathology of vascular response to drug-eluting stents: an insight from human autopsy into daily practice"],"prefix":"10.1007","volume":"30","author":[{"given":"Masataka","family":"Nakano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"281_CR1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.99.1.44","volume":"99","author":"A Farb","year":"1999","unstructured":"Farb A, Sangiorgi G, Carter AJ, Walley VM, Edwards WD, Schwartz RS, Virmani R. Pathology of acute and chronic coronary stenting in humans. Circulation. 1999;99:44\u201352.","journal-title":"Circulation"},{"key":"281_CR2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0049-3848(99)00202-9","volume":"98","author":"M Naito","year":"2000","unstructured":"Naito M, Stirk CM, Smith EB, Thompson WD. Smooth muscle cell outgrowth stimulated by fibrin degradation products. The potential role of fibrin fragment e in restenosis and atherogenesis. Thromb Res. 2000;98:165\u201374.","journal-title":"Thromb Res"},{"key":"281_CR3","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1161\/01.CIR.0000019071.72887.BD","volume":"105","author":"A Farb","year":"2002","unstructured":"Farb A, Weber DK, Kolodgie FD, Burke AP, Virmani R. Morphological predictors of restenosis after coronary stenting in humans. Circulation. 2002;105:2974\u201380.","journal-title":"Circulation"},{"key":"281_CR4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"R Ross","year":"1999","unstructured":"Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999;340:115\u201326.","journal-title":"N Engl J Med"},{"key":"281_CR5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nm0402-403","volume":"8","author":"M Sata","year":"2002","unstructured":"Sata M, Saiura A, Kunisato A, Tojo A, Okada S, Tokuhisa T, Hirai H, Makuuchi M, Hirata Y, Nagai R. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med. 2002;8:403\u20139.","journal-title":"Nat Med"},{"key":"281_CR6","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1161\/01.CIR.0000139337.56084.30","volume":"110","author":"A Farb","year":"2004","unstructured":"Farb A, Kolodgie FD, Hwang JY, Burke AP, Tefera K, Weber DK, Wight TN, Virmani R. Extracellular matrix changes in stented human coronary arteries. Circulation. 2004;110:940\u20137.","journal-title":"Circulation"},{"key":"281_CR7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1056\/NEJM199602293340903","volume":"334","author":"T Kimura","year":"1996","unstructured":"Kimura T, Yokoi H, Nakagawa Y, Tamura T, Kaburagi S, Sawada Y, Sato Y, Hamasaki N, Nosaka H, et al. Three-year follow-up after implantation of metallic coronary-artery stents. N Engl J Med. 1996;334:561\u20136.","journal-title":"N Engl J Med"},{"key":"281_CR8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2006.03.042","volume":"48","author":"M Joner","year":"2006","unstructured":"Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, Kutys R, Skorija K, Gold HK, Virmani R. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol. 2006;48:193\u2013202.","journal-title":"J Am Coll Cardiol"},{"key":"281_CR9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.niox.2006.03.011","volume":"15","author":"C Napoli","year":"2006","unstructured":"Napoli C, de Nigris F, Williams-Ignarro S, Pignalosa O, Sica V, Ignarro LJ. Nitric oxide and atherosclerosis: an update. Nitric Oxide. 2006;15:265\u201379.","journal-title":"Nitric Oxide"},{"key":"281_CR10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0735-1097(92)90494-8","volume":"19","author":"PG Anderson","year":"1992","unstructured":"Anderson PG, Bajaj RK, Baxley WA, Roubin GS. Vascular pathology of balloon-expandable flexible coil stents in humans. J Am Coll Cardiol. 1992;19:372\u201381.","journal-title":"J Am Coll Cardiol"},{"key":"281_CR11","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1161\/CIRCULATIONAHA.107.693739","volume":"115","author":"AV Finn","year":"2007","unstructured":"Finn AV, Joner M, Nakazawa G, Kolodgie F, Newell J, John MC, Gold HK, Virmani R. Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization. Circulation. 2007;115:2435\u201341.","journal-title":"Circulation"},{"key":"281_CR12","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1161\/CIRCULATIONAHA.107.762047","volume":"118","author":"G Nakazawa","year":"2008","unstructured":"Nakazawa G, Finn AV, Joner M, Ladich E, Kutys R, Mont EK, Gold HK, Burke AP, Kolodgie FD, Virmani R. Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study. Circulation. 2008;118:1138\u201345.","journal-title":"Circulation"},{"key":"281_CR13","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/hc3101.092214","volume":"104","author":"CW Hwang","year":"2001","unstructured":"Hwang CW, Wu D, Edelman ER. Physiological transport forces govern drug distribution for stent-based delivery. Circulation. 2001;104:600\u20135.","journal-title":"Circulation"},{"key":"281_CR14","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1161\/01.CIR.0000148371.53174.05","volume":"110","author":"H Takebayashi","year":"2004","unstructured":"Takebayashi H, Mintz GS, Carlier SG, Kobayashi Y, Fujii K, Yasuda T, Costa RA, Moussa I, Dangas GD, Mehran R, Lansky AJ, Kreps E, Collins MB, Colombo A, Stone GW, Leon MB, Moses JW. Nonuniform strut distribution correlates with more neointimal hyperplasia after sirolimus-eluting stent implantation. Circulation. 2004;110:3430\u20134.","journal-title":"Circulation"},{"key":"281_CR15","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1093\/eurheartj\/eht241","volume":"34","author":"M Nakano","year":"2013","unstructured":"Nakano M, Otsuka F, Yahagi K, Sakakura K, Kutys R, Ladich ER, Finn AV, Kolodgie FD, Virmani R. Human autopsy study of drug-eluting stents restenosis: histomorphological predictors and neointimal characteristics. Eur Heart J. 2013;34:3304\u201313.","journal-title":"Eur Heart J"},{"key":"281_CR16","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jacc.2011.01.011","volume":"57","author":"G Nakazawa","year":"2011","unstructured":"Nakazawa G, Otsuka F, Nakano M, Vorpahl M, Yazdani SK, Ladich E, Kolodgie FD, Finn AV, Virmani R. The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stents. J Am Coll Cardiol. 2011;57:1314\u201322.","journal-title":"J Am Coll Cardiol"},{"key":"281_CR17","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nature00804","volume":"417","author":"K Skalen","year":"2002","unstructured":"Skalen K, Gustafsson M, Rydberg EK, Hulten LM, Wiklund O, Innerarity TL, Boren J. Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature. 2002;417:750\u20134.","journal-title":"Nature"},{"key":"281_CR18","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJMoa051175","volume":"353","author":"S Windecker","year":"2005","unstructured":"Windecker S, Remondino A, Eberli FR, Juni P, Raber L, Wenaweser P, Togni M, Billinger M, Tuller D, Seiler C, Roffi M, Corti R, Sutsch G, Maier W, Luscher T, Hess OM, Egger M, Meier B. Sirolimus-eluting and paclitaxel-eluting stents for coronary revascularization. N Engl J Med. 2005;353:653\u201362.","journal-title":"N Engl J Med"},{"key":"281_CR19","first-page":"336","volume":"23","author":"C Simsek","year":"2011","unstructured":"Simsek C, Magro M, Boersma E, Onuma Y, Nauta S, Daemen J, Gaspersz M, van Geuns RJ, van der Giessen W, van Domburg R, Serruys P. Comparison of six-year clinical outcome of sirolimus- and paclitaxel-eluting stents to bare-metal stents in patients with st-segment elevation myocardial infarction: an analysis of the research (rapamycin-eluting stent evaluated at Rotterdam cardiology hospital) and t-search (taxus stent evaluated at Rotterdam cardiology hospital) registries. J Invasive Cardiol. 2011;23:336\u201341.","journal-title":"J Invasive Cardiol"},{"key":"281_CR20","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jacc.2010.05.066","volume":"57","author":"G Nakazawa","year":"2011","unstructured":"Nakazawa G, Finn AV, Vorpahl M, Ladich ER, Kolodgie FD, Virmani R. Coronary responses and differential mechanisms of late stent thrombosis attributed to first-generation sirolimus- and paclitaxel-eluting stents. J Am Coll Cardiol. 2011;57:390\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"281_CR21","doi-asserted-by":"crossref","unstructured":"Nakano M, Yahagi K, Otsuka F, Sakakura K, Finn AV, Kutys R, Ladich E, Fowler DR, Joner M, Virmani R. Causes of early stent thrombosis in patients presenting with acute coronary syndrome: an ex vivo human autopsy study. J Am Coll Cardiol. 2014;63:2510\u201320.","DOI":"10.1016\/j.jacc.2014.02.607"},{"key":"281_CR22","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1161\/01.CIR.0000116202.41966.D4","volume":"109","author":"R Virmani","year":"2004","unstructured":"Virmani R, Guagliumi G, Farb A, Musumeci G, Grieco N, Motta T, Mihalcsik L, Tespili M, Valsecchi O, Kolodgie FD. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? Circulation. 2004;109:701\u20135.","journal-title":"Circulation"},{"key":"281_CR23","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/hc3001.092037","volume":"104","author":"A Farb","year":"2001","unstructured":"Farb A, Heller PF, Shroff S, Cheng L, Kolodgie FD, Carter AJ, Scott DS, Froehlich J, Virmani R. Pathological analysis of local delivery of paclitaxel via a polymer-coated stent. Circulation. 2001;104:473\u20139.","journal-title":"Circulation"},{"key":"281_CR24","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.jacc.2006.08.033","volume":"48","author":"DW Park","year":"2006","unstructured":"Park DW, Hong MK, Mintz GS, Lee CW, Song JM, Han KH, Kang DH, Cheong SS, Song JK, Kim JJ, Weissman NJ, Park SW, Park SJ. Two-year follow-up of the quantitative angiographic and volumetric intravascular ultrasound analysis after nonpolymeric paclitaxel-eluting stent implantation: late \u201ccatch-up\u201d phenomenon from aspect study. J Am Coll Cardiol. 2006;48:2432\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"281_CR25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.amjcard.2010.03.031","volume":"106","author":"Y Nakagawa","year":"2010","unstructured":"Nakagawa Y, Kimura T, Morimoto T, Nomura M, Saku K, Haruta S, Muramatsu T, Nobuyoshi M, Kadota K, Fujita H, Tatami R, Shiode N, Nishikawa H, Shibata Y, Miyazaki S, Murata Y, Honda T, Kawasaki T, Doi O, Hiasa Y, Hayashi Y, Matsuzaki M, Mitsudo K. Incidence and risk factors of late target lesion revascularization after sirolimus-eluting stent implantation (3-year follow-up of the j-cypher registry). Am J Cardiol. 2010;106:329\u201336.","journal-title":"Am J Cardiol"},{"key":"281_CR26","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.amjcard.2009.07.041","volume":"104","author":"A Chieffo","year":"2009","unstructured":"Chieffo A, Foglieni C, Nodari RL, Briguori C, Sangiorgi G, Latib A, Montorfano M, Airoldi F, Michev I, Carlino M, Colombo A, Maseri A. Histopathology of clinical coronary restenosis in drug-eluting versus bare metal stents. Am J Cardiol. 2009;104:1660\u20137.","journal-title":"Am J Cardiol"},{"key":"281_CR27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0021-9150(82)90111-3","volume":"44","author":"T Ishida","year":"1982","unstructured":"Ishida T, Tanaka K. Effects of fibrin and fibrinogen-degradation products on the growth of rabbit aortic smooth muscle cells in culture. Atherosclerosis. 1982;44:161\u201374.","journal-title":"Atherosclerosis"},{"key":"281_CR28","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMoa035071","volume":"349","author":"JW Moses","year":"2003","unstructured":"Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O\u2019Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, Jaeger JL, Kuntz RE. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 2003;349:1315\u201323.","journal-title":"N Engl J Med"},{"key":"281_CR29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa032441","volume":"350","author":"GW Stone","year":"2004","unstructured":"Stone GW, Ellis SG, Cox DA, Hermiller J, O\u2019Shaughnessy C, Mann JT, Turco M, Caputo R, Bergin P, Greenberg J, Popma JJ, Russell ME. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med. 2004;350:221\u201331.","journal-title":"N Engl J Med"},{"key":"281_CR30","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0140-6736(12)60324-9","volume":"379","author":"T Palmerini","year":"2012","unstructured":"Palmerini T, Biondi-Zoccai G, Della Riva D, Stettler C, Sangiorgi D, D\u2019Ascenzo F, Kimura T, Briguori C, Sabate M, Kim HS, De Waha A, Kedhi E, Smits PC, Kaiser C, Sardella G, Marullo A, Kirtane AJ, Leon MB, Stone GW. Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis. Lancet. 2012;379:1393\u2013402.","journal-title":"Lancet"},{"key":"281_CR31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/CIRCULATIONAHA.113.001790","volume":"129","author":"F Otsuka","year":"2014","unstructured":"Otsuka F, Vorpahl M, Nakano M, Foerst J, Newell JB, Sakakura K, Kutys R, Ladich E, Finn AV, Kolodgie FD, Virmani R. Pathology of second-generation everolimus-eluting stents versus first-generation sirolimus- and paclitaxel-eluting stents in humans. Circulation. 2014;129:211\u201323.","journal-title":"Circulation"},{"key":"281_CR32","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4244\/EIJV9I11A217","volume":"9","author":"PW Serruys","year":"2014","unstructured":"Serruys PW, Onuma Y, Garcia-Garcia HM, Muramatsu T, van Geuns RJ, de Bruyne B, Dudek D, Thuesen L, Smits PC, Chevalier B, McClean D, Koolen J, Windecker S, Whitbourn R, Meredith I, Dorange C, Veldhof S, Hebert KM, Rapoza R, Ormiston JA. Dynamics of vessel wall changes following the implantation of the absorb everolimus-eluting bioresorbable vascular scaffold: a multi-imaging modality study at 6, 12, 24 and 36\u00a0months. Eurointervention. 2014;9:1271\u201384.","journal-title":"Eurointervention"},{"key":"281_CR33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0140-6736(09)60325-1","volume":"373","author":"PW Serruys","year":"2009","unstructured":"Serruys PW, Ormiston JA, Onuma Y, Regar E, Gonzalo N, Garcia-Garcia HM, Nieman K, Bruining N, Dorange C, Miquel-Hebert K, Veldhof S, Webster M, Thuesen L, Dudek D. A bioabsorbable everolimus-eluting coronary stent system (absorb): 2-year outcomes and results from multiple imaging methods. Lancet. 2009;373:897\u2013910.","journal-title":"Lancet"},{"key":"281_CR34","doi-asserted-by":"crossref","unstructured":"Finn AV, Nakazawa G, Joner M, Kolodgie FD, Mont EK, Gold HK, Virmani R. Vascular responses to drug eluting stents: importance of delayed healing. Arterioscler Thromb Vasc Biol. 2007;27:1500\u201310.","DOI":"10.1161\/ATVBAHA.107.144220"}],"container-title":["Cardiovascular Intervention and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12928-014-0281-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12928-014-0281-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12928-014-0281-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T10:25:33Z","timestamp":1559471133000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12928-014-0281-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,30]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["281"],"URL":"https:\/\/doi.org\/10.1007\/s12928-014-0281-5","relation":{},"ISSN":["1868-4300","1868-4297"],"issn-type":[{"value":"1868-4300","type":"print"},{"value":"1868-4297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,30]]}}}