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This study aimed to investigate the clinical implications of radial compression protocols. Consecutive patients who underwent outpatient invasive catheter angiography before and after April 2018 were treated with traditional and new protocols, respectively. Using the same hemostasis band, in the conventional protocol, fixed amount of air was removed soon after the procedure, 2\u00a0h later, and 3\u00a0h later, whereas the air was removed as much as possible every 30\u00a0min in the new protocol. A total of 1842 patients (71\u2009\u00b1\u200910\u00a0years old, 77% male) were included. Compared with the traditional protocol group (<jats:italic>n<\/jats:italic>\u2009=\u20091001), the new protocol group (<jats:italic>n<\/jats:italic>\u2009=\u2009841) had a significantly lower rate of dual antiplatelet therapy (35% and 24% in the traditional and new groups, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The time required for complete hemostasis was approximately one-third with the new protocol (190\u2009\u00b1\u200916 and 66\u2009\u00b1\u200932\u00a0min, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with no clinically relevant bleeding. The incidence of radial artery occlusion (RAO) was 9.8% and 0.9% in the traditional and new protocol groups, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After adjusting for covariates, the new protocol was associated with a reduced risk of RAO (odds ratio 0.10, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and a shorter hemostasis time (odds ratio 0.01, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The new protocol for hemostasis after TRA was strongly associated with a shorter hemostasis time and a lower rate of RAO.<\/jats:p>","DOI":"10.1007\/s12928-022-00896-6","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T09:08:51Z","timestamp":1670404131000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of radial compression protocols on radial artery occlusion and hemostasis time in coronary angiography"],"prefix":"10.1007","volume":"38","author":[{"given":"Sachiko","family":"Takamatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-0049","authenticated-orcid":false,"given":"Nobuyuki","family":"Kagiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Sone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Tougi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichiro","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Yuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Ii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomaru","family":"Masutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hirohata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"issue":"10","key":"896_CR1","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.jcin.2010.07.013","volume":"3","author":"OF Bertrand","year":"2010","unstructured":"Bertrand OF, Rao SV, Pancholy S, Jolly SS, Rod\u00e9s-Cabau J, Larose E, et al. 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