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The purpose of this study was to investigate the impact of pullback speed on evaluation of lipid core plaque using the latest generation NIRS-IVUS catheter. Patients with coronary artery disease who underwent coronary angiography or percutaneous coronary intervention with NIRS-IVUS examination at 2 different pullback speeds (0.5 and 2.0\u00a0mm\/sec) for the same vessel were enrolled. The values of lipid core burden index (LCBI) and maxLCBI4mm were compared between the images recorded with pullback speeds of 0.5 and 2.0\u00a0mm\/sec, and match or mismatch of the location where maxLCBI4mm was detected was investigated. In a total of 286 NIRS-IVUS image sets, the location of maxLCBI4mm measured at 0.5 and 2.0\u00a0mm\/sec was mismatched in 81 (28.3%) image sets. In comparison by vessel type, 20.8% were mismatched in LAD, 31.1% in LCx, and 37.8% in RCA (<jats:italic>p<\/jats:italic>\u2009=\u20090.023). In 205 image sets with matched maxLCBI4mm location, the maxLCBI4mm value at 2.0\u00a0mm\/sec was significantly greater compared with that at 0.5\u00a0mm\/sec (348.0 vs. 302.0 in median, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In a substantial proportion of patients, the location of maxLCBI4mm values measured at 0.5 and 2.0\u00a0mm\/sec was mismatched. In the image sets with matched maxLCBI4mm location, the maxLCBI4mm value at 2.0\u00a0mm\/sec was significantly greater compared with that at 0.5\u00a0mm\/sec. These results should be noted when applying the cut-off values of maxLCBI4mm recorded at 2.0\u00a0mm\/sec.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s12928-025-01124-7","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T08:37:25Z","timestamp":1743842245000},"page":"536-543","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of pullback speed on evaluation of lipid core plaque using near-infrared spectroscopy-intravascular ultrasound"],"prefix":"10.1007","volume":"40","author":[{"given":"Tetsuharu","family":"Kasahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-6160","authenticated-orcid":false,"given":"Hideki","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Takou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Iimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"issue":"3","key":"1124_CR1","first-page":"e18","volume":"145","author":"JS Lawton","year":"2022","unstructured":"Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, et al. 2021 ACC\/AHA\/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines. 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