{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:52:47Z","timestamp":1787313167392,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,4,28]],"date-time":"2012-04-28T00:00:00Z","timestamp":1335571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s12975-012-0158-9","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T09:53:28Z","timestamp":1335520408000},"page":"296-304","source":"Crossref","is-referenced-by-count":85,"title":["Hyperglycemia Alters Mitochondrial Fission and Fusion Proteins in Mice Subjected to Cerebral Ischemia and Reperfusion"],"prefix":"10.1007","volume":"3","author":[{"given":"Santosh","family":"Kumari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavita","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Farmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh L.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Andy","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,28]]},"reference":[{"key":"158_CR1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0304-3940(94)90045-0","volume":"177","author":"PA Li","year":"1994","unstructured":"Li PA, Shamloo M, Smith ML, Katsura K, Siesjo BK. The influence of plasma glucose concentrations on ischemic brain damage is a threshold function. Neurosci Lett. 1994;177:63\u20135.","journal-title":"Neurosci Lett"},{"key":"158_CR2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/nbdi.1995.0010","volume":"2","author":"PA Li","year":"1995","unstructured":"Li PA, Shamloo M, Katsura K, Smith ML, Siesjo BK. Critical values for plasma glucose in aggravating ischaemic brain damage: correlation to extracellular pH. Neurobiol Dis. 1995;2:97\u2013108.","journal-title":"Neurobiol Dis"},{"key":"158_CR3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0006-8993(98)00651-9","volume":"804","author":"PA Li","year":"1998","unstructured":"Li PA, Gisselsson L, Keuker J, Vogel J, Smith ML, Kuschinsky W, Siesjo BK. Hyperglycemia-exaggerated ischemic brain damage following 30\u00a0min of middle cerebral artery occlusion is not due to capillary obstruction. Brain Res. 1998;804:36\u201344.","journal-title":"Brain Res"},{"key":"158_CR4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1365-201X.1997.00264.x","volume":"161","author":"PA Li","year":"1997","unstructured":"Li PA, Siesjo BK. Role of hyperglycaemia-related acidosis in ischaemic brain damage. Acta Physiol Scand. 1997;161:567\u201380.","journal-title":"Acta Physiol Scand"},{"key":"158_CR5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/00004647-199903000-00007","volume":"19","author":"L Gisselsson","year":"1999","unstructured":"Gisselsson L, Smith ML, Siesjo BK. Hyperglycemia and focal brain ischemia. J Cereb Blood Flow Metab. 1999;19:288\u201397.","journal-title":"J Cereb Blood Flow Metab"},{"key":"158_CR6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.jcbfm.9600355","volume":"27","author":"SR Martini","year":"2007","unstructured":"Martini SR, Kent TA. Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cereb Blood Flow Metab. 2007;27:435\u201351.","journal-title":"J Cereb Blood Flow Metab"},{"key":"158_CR7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-3-7091-0693-8_9","volume":"111","author":"Y Xing","year":"2011","unstructured":"Xing Y, Jiang X, Yang Y, Xi G. Hemorrhagic transformation induced by acute hyperglycemia in a rat model of transient focal ischemia. Acta Neurochir Suppl. 2011;111:49\u201354.","journal-title":"Acta Neurochir Suppl"},{"key":"158_CR8","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jama.1987.03390070069025","volume":"257","author":"RD Abbott","year":"1987","unstructured":"Abbott RD, Donahue RP, MacMahon SW, Reed DM, Yano K. Diabetes and the risk of stroke. The Honolulu Heart Program. JAMA. 1987;257:949\u201352.","journal-title":"JAMA"},{"key":"158_CR9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2337\/diacare.25.6.951","volume":"25","author":"BL Rodriguez","year":"2002","unstructured":"Rodriguez BL, Abbott RD, Fujimoto W, Waitzfelder B, Chen R, Masaki K, Schatz I, Petrovitch H, Ross W, Yano K, Blanchette PL, Curb JD. The American Diabetes Association and World Health Organization classifications for diabetes: their impact on diabetes prevalence and total and cardiovascular disease mortality in elderly Japanese-American men. Diabetes Care. 2002;25:951\u20135.","journal-title":"Diabetes Care"},{"key":"158_CR10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/01.nrl.0000131800.77824.dd","volume":"10","author":"A Bruno","year":"2004","unstructured":"Bruno A, Williams LS, Kent TA. How important is hyperglycemia during acute brain infarction? Neurologist. 2004;10:195\u2013200.","journal-title":"Neurologist"},{"key":"158_CR11","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/hs1001.096194","volume":"32","author":"SE Capes","year":"2001","unstructured":"Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001;32:2426\u201332.","journal-title":"Stroke"},{"key":"158_CR12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000047756","volume":"13","author":"T Els","year":"2002","unstructured":"Els T, Klisch J, Orszagh M, Hetzel A, Schulte-Monting J, Schumacher M, Lucking CH. Hyperglycemia in patients with focal cerebral ischemia after intravenous thrombolysis: influence on clinical outcome and infarct size. Cerebrovasc Dis. 2002;13:89\u201394.","journal-title":"Cerebrovasc Dis"},{"key":"158_CR13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/01.STR.27.2.210","volume":"27","author":"J Tuomilehto","year":"1996","unstructured":"Tuomilehto J, Rastenyte D, Jousilahti P, Sarti C, Vartiainen E. Diabetes mellitus as a risk factor for death from stroke. Prospective study of the middle-aged Finnish population. Stroke. 1996;27:210\u20135.","journal-title":"Stroke"},{"key":"158_CR14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.expneurol.2004.04.013","volume":"188","author":"C Ding","year":"2004","unstructured":"Ding C, He Q, Li PA. Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals. Exp Neurol. 2004;188:421\u20139.","journal-title":"Exp Neurol"},{"key":"158_CR15","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/00004647-200105000-00011","volume":"21","author":"PA Li","year":"2001","unstructured":"Li PA, Rasquinha I, He QP, Siesj\u00f6 BK, Csisz\u00e1r K, Boyd CD, MacManus JP. Hyperglycemia enhances DNA fragmentation after transient cerebral ischemia. J Cereb Blood Flow Metab. 2001;21:568\u201376.","journal-title":"J Cereb Blood Flow Metab"},{"key":"158_CR16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2337\/diabetes.52.2.481","volume":"52","author":"M Muranyi","year":"2003","unstructured":"Muranyi M, Fujioka M, He Q, Han A, Yong G, Csiszar K, Li PA. Diabetes activates cell death pathway after transient focal cerebral ischemia. Diabetes. 2003;52:481\u20136.","journal-title":"Diabetes"},{"key":"158_CR17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2337\/diabetes.55.02.06.db05-0654","volume":"55","author":"M Muranyi","year":"2006","unstructured":"Muranyi M, Ding C, He Q, Lin Y, Li PA. Streptozotocin-induced diabetes causes astrocyte death after ischemia and reperfusion injury. Diabetes. 2006;55:349\u201355.","journal-title":"Diabetes"},{"key":"158_CR18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/3-211-32318-X_81","volume":"95","author":"RF Keep","year":"2005","unstructured":"Keep RF, Andjelkovic AV, Stamatovic SM, Shakui P, Ennis SR. Ischemia-induced endothelial cell dysfunction. Acta Neurochir Suppl. 2005;95:399\u2013402.","journal-title":"Acta Neurochir Suppl"},{"key":"158_CR19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/ar.1092410212","volume":"241","author":"X Yang","year":"1995","unstructured":"Yang X, Borg LA, Eriksson UJ. Altered mitochondrial morphology of rat embryos in diabetic pregnancy. Anat Rec. 1995;241:255\u201367.","journal-title":"Anat Rec"},{"key":"158_CR20","doi-asserted-by":"crossref","first-page":"pR169","DOI":"10.1093\/hmg\/ddp326","volume":"18","author":"H Chen","year":"2009","unstructured":"Chen H, Chan DC. Mitochondrial dynamics\u2014fusion, fission, movement, and mitophagy\u2014in neurodegenerative diseases. Hum Mol Genet. 2009;18:pR169\u201376.","journal-title":"Hum Mol Genet"},{"key":"158_CR21","doi-asserted-by":"crossref","first-page":"e21347","DOI":"10.1371\/journal.pone.0021347","volume":"6","author":"NJ Bergen Van","year":"2010","unstructured":"Van Bergen NJ, Crowston JG, Kearns LS, Staffieri SE, Hewitt AW, Cohn AC, Mackey DA, Trounce IA. Mitochondrial oxidative phosphorylation compensation may preserve vision in patients with Opa1-linked autosomal dominant optic atrophy. PLoS One. 2010;6:e21347.","journal-title":"PLoS One"},{"key":"158_CR22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ng1341","volume":"36","author":"S Z\u00fcchner","year":"2004","unstructured":"Z\u00fcchner S, Mersiyanova IV, Muglia M, Bissar-Tadmouri N, Rochelle J, Dadali EL, Zappia M, Nelis E, Patitucci A, Senderek J, Parman Y, Evgrafov O, Jonghe PD, Takahashi Y, Tsuji S, Pericak-Vance MA, Quattrone A, Battaloglu E, Polyakov AV, Timmerman V, Schr\u00f6der JM, Vance JM. Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot\u2013Marie\u2013Tooth neuropathy type 2A. Nat Genet. 2004;36:449\u201351.","journal-title":"Nat Genet"},{"key":"158_CR23","doi-asserted-by":"crossref","first-page":"e3257","DOI":"10.1371\/journal.pone.0003257","volume":"3","author":"PA Parone","year":"2008","unstructured":"Parone PA, Da Cruz S, Tondera D, Mattenberger Y, James DI, Maechler P, Barja F, Martinou JC. Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One. 2008;3:e3257.","journal-title":"PLoS One"},{"key":"158_CR24","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M503062200","volume":"280","author":"H Chen","year":"2005","unstructured":"Chen H, Chomyn A, Chan DC. Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem. 2005;280:26185\u201392.","journal-title":"J Biol Chem"},{"key":"158_CR25","doi-asserted-by":"crossref","first-page":"23788","DOI":"10.1074\/jbc.M703812200","volume":"282","author":"A Jahani-Asl","year":"2007","unstructured":"Jahani-Asl A, Cheung EC, Neuspiel M, MacLaurin JG, Fortin A, Park DS, McBride HM, Slack RS. Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. J Biol Chem. 2007;282:23788\u201398.","journal-title":"J Biol Chem"},{"key":"158_CR26","doi-asserted-by":"crossref","first-page":"36373","DOI":"10.1074\/jbc.M303758200","volume":"278","author":"DI James","year":"2003","unstructured":"James DI, Parone PA, Mattenberger Y, Martinou JC. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem. 2003;278:36373\u20139.","journal-title":"J Biol Chem"},{"key":"158_CR27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","volume":"27","author":"G Twig","year":"2008","unstructured":"Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008;27:433\u201346.","journal-title":"EMBO J"},{"key":"158_CR28","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","volume":"20","author":"M Manczak","year":"2011","unstructured":"Manczak M, Calkins MJ, Reddy PH. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer\u2019s disease: implications for neuronal damage. Hum Mol Genet. 2011;20:2495\u2013509.","journal-title":"Hum Mol Genet"},{"key":"158_CR29","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.bbabio.2008.05.442","volume":"1777","author":"LC Gomes","year":"2008","unstructured":"Gomes LC, Scorrano L. High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta. 2008;1777:860\u20136.","journal-title":"Biochim Biophys Acta"},{"key":"158_CR30","doi-asserted-by":"crossref","first-page":"614","DOI":"10.4161\/auto.4872","volume":"3","author":"PI Moreira","year":"2007","unstructured":"Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy. 2007;3:614\u20135.","journal-title":"Autophagy"},{"key":"158_CR31","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.STR.17.3.472","volume":"17","author":"JB Bederson","year":"1986","unstructured":"Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 1986;17:472\u20136.","journal-title":"Stroke"},{"key":"158_CR32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/01.WCB.0000127161.89708.A5","volume":"24","author":"H Zhao","year":"2004","unstructured":"Zhao H, Yenari MA, Cheng D, Barreto-Chang OL, Sapolsky RM, Steinberg GK. Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. J Cereb Blood Flow Metab. 2004;24:681\u201392.","journal-title":"J Cereb Blood Flow Metab"},{"key":"158_CR33","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1242\/jcs.01131","volume":"117","author":"Y Kabeya","year":"2004","unstructured":"Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y, Yoshimori T. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci. 2004;117:2805\u201312.","journal-title":"J Cell Sci"},{"key":"158_CR34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00401-010-0697-7","volume":"120","author":"AM Vincent","year":"2010","unstructured":"Vincent AM, Edwards JL, McLean LL, Hong Y, Cerri F, Lopez I, Quattrini A, Feldman EL. Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy. Acta Neuropathol. 2010;120:477\u201389.","journal-title":"Acta Neuropathol"},{"key":"158_CR35","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1007\/s00125-010-1770-4","volume":"53","author":"A Makino","year":"2010","unstructured":"Makino A, Scott BT, Dillmann WH. Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes. Diabetologia. 2010;53:1783\u201394.","journal-title":"Diabetologia"},{"key":"158_CR36","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1073\/pnas.0511154103","volume":"103","author":"T Yu","year":"2006","unstructured":"Yu T, Robotham JL, Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A. 2006;103:2653\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"158_CR37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/cvr\/cvn104","volume":"79","author":"T Yu","year":"2008","unstructured":"Yu T, Sheu SS, Robotham JL, Yoon Y. Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res. 2008;79:341\u201351.","journal-title":"Cardiovasc Res"},{"key":"158_CR38","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/brain\/awq288","volume":"134","author":"P Yu-Wai-Man","year":"2011","unstructured":"Yu-Wai-Man P, Trenell MI, Hollingsworth KG, Griffiths PG, Chinnery PF. OPA1 mutations impair mitochondrial function in both pure and complicated dominant optic atrophy. Brain. 2011;134:e164.","journal-title":"Brain"},{"key":"158_CR39","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/hs0302.104541","volume":"33","author":"NJ Solenski","year":"2002","unstructured":"Solenski NJ, diPierro CG, Trimmer PA, Kwan AL, Helm GA. Ultrastructural changes of neuronal mitochondria after transient and permanent cerebral ischemia. Stroke. 2002;33:816\u201324.","journal-title":"Stroke"},{"key":"158_CR40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.nbd.2006.01.017","volume":"23","author":"GM Leinninger","year":"2006","unstructured":"Leinninger GM, Backus C, Sastry AM, Yi YB, Wang CW, Feldman EL. Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1. Neurobiol Dis. 2006;23:11\u201322.","journal-title":"Neurobiol Dis"},{"key":"158_CR41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tem.2007.04.004","volume":"18","author":"I Manoli","year":"2007","unstructured":"Manoli I, Alesci S, Blackman MR, Su YA, Rennert OM, Chrousos GP. Mitochondria as key components of the stress response. Trends Endocrinol Metab. 2007;18:190\u20138.","journal-title":"Trends Endocrinol Metab"},{"key":"158_CR42","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1161\/STROKEAHA.108.520114","volume":"39","author":"W Yin","year":"2008","unstructured":"Yin W, Signore AP, Iwai M, Cao G, Gao Y, Chen J. Rapidly increased neuronal mitochondrial biogenesis after hypoxic\u2013ischemic brain injury. Stroke. 2008;39:3057\u201363.","journal-title":"Stroke"},{"key":"158_CR43","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1523\/JNEUROSCI.5654-07.2008","volume":"28","author":"DR Gutsaeva","year":"2008","unstructured":"Gutsaeva DR, Carraway MS, Suliman HB, Demchenko IT, Shitara H, Yonekawa H, Piantadosi CA. Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci. 2008;28:2015\u201324.","journal-title":"J Neurosci"},{"key":"158_CR44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev.pathmechdis.2.010506.091842","volume":"3","author":"M Kundu","year":"2008","unstructured":"Kundu M, Thompson CB. Autophagy: basic principles and relevance to disease. Ann Rev Pathol. 2008;3:427\u201355.","journal-title":"Ann Rev Pathol"},{"key":"158_CR45","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069\u201375.","journal-title":"Nature"},{"key":"158_CR46","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.nbd.2007.08.005","volume":"29","author":"A Rami","year":"2008","unstructured":"Rami A, Langhagen A, Steiger S. Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiol Dis. 2008;29:132\u201341.","journal-title":"Neurobiol Dis"},{"key":"158_CR47","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1471-4159.2010.06905.x","volume":"115","author":"C Liu","year":"2010","unstructured":"Liu C, Gao Y, Barrett J, Hu B. Autophagy and protein aggregation after brain ischemia. J Neurochem. 2010;115:68\u201378.","journal-title":"J Neurochem"},{"key":"158_CR48","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2990.2009.01034.x","volume":"35","author":"A Rami","year":"2009","unstructured":"Rami A. Review: autophagy in neurodegeneration: firefighter and\/or incendiarist? Neuropathol Appl Neurobiol. 2009;35:449\u201361.","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-012-0158-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12975-012-0158-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-012-0158-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T10:25:41Z","timestamp":1559471141000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12975-012-0158-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,28]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["158"],"URL":"https:\/\/doi.org\/10.1007\/s12975-012-0158-9","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,28]]}}}