{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:10:50Z","timestamp":1785157850636,"version":"3.55.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s12975-016-0459-5","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T18:34:50Z","timestamp":1459103690000},"page":"209-219","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Hydrogen Sulfide Attenuates Tissue Plasminogen Activator-Induced Cerebral Hemorrhage Following Experimental Stroke"],"prefix":"10.1007","volume":"7","author":[{"given":"Hui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichun","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"issue":"13","key":"459_CR1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","volume":"359","author":"W Hacke","year":"2008","unstructured":"Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359(13):1317\u201329. doi: 10.1056\/NEJMoa0804656 .","journal-title":"N Engl J Med"},{"issue":"3","key":"459_CR2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12975-015-0391-0","volume":"6","author":"S Hafez","year":"2015","unstructured":"Hafez S, Hoda MN, Guo X, Johnson MH, Fagan SC, Ergul A. Comparative analysis of different methods of ischemia\/reperfusion in hyperglycemic stroke outcomes: interaction with tPA. Transl Stroke Res. 2015;6(3):171\u201380. doi: 10.1007\/s12975-015-0391-0 .","journal-title":"Transl Stroke Res"},{"issue":"6","key":"459_CR3","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1161\/01.STR.0000072513.72262.7E","volume":"34","author":"JM Wardlaw","year":"2003","unstructured":"Wardlaw JM, Sandercock PA, Berge E. Thrombolytic therapy with recombinant tissue plasminogen activator for acute ischemic stroke: where do we go from here? A cumulative meta-analysis. Stroke J Cereb Circ. 2003;34(6):1437\u201342. doi: 10.1161\/01.STR.0000072513.72262.7E .","journal-title":"Stroke J Cereb Circ"},{"issue":"5","key":"459_CR4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrn1106","volume":"4","author":"EH Lo","year":"2003","unstructured":"Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 2003;4(5):399\u2013415. doi: 10.1038\/nrn1106 .","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"459_CR5","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1161\/01.STR.0000023534.37670.F7","volume":"33","author":"RM Dijkhuizen","year":"2002","unstructured":"Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke J Cereb Circ. 2002;33(8):2100\u20134.","journal-title":"Stroke J Cereb Circ"},{"issue":"8","key":"459_CR6","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1161\/STROKEAHA.107.505420","volume":"39","author":"A Kastrup","year":"2008","unstructured":"Kastrup A, Groschel K, Ringer TM, Redecker C, Cordesmeyer R, Witte OW, et al. Early disruption of the blood\u2013brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke. Stroke J Cereb Circ. 2008;39(8):2385\u20137. doi: 10.1161\/STROKEAHA.107.505420 .","journal-title":"Stroke J Cereb Circ"},{"issue":"2","key":"459_CR7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ana.23762","volume":"73","author":"L Wang","year":"2013","unstructured":"Wang L, Fan W, Cai P, Fan M, Zhu X, Dai Y, et al. Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice. Ann Neurol. 2013;73(2):189\u201398. doi: 10.1002\/ana.23762 .","journal-title":"Ann Neurol"},{"issue":"1","key":"459_CR8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/jcbfm.2013.163","volume":"34","author":"S Won","year":"2014","unstructured":"Won S, Lee JH, Wali B, Stein DG, Sayeed I. Progesterone attenuates hemorrhagic transformation after delayed tPA treatment in an experimental model of stroke in rats: involvement of the VEGF-MMP pathway. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 2014;34(1):72\u201380. doi: 10.1038\/jcbfm.2013.163 .","journal-title":"J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab"},{"issue":"2","key":"459_CR9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00414-007-0172-8","volume":"122","author":"L Oesterhelweg","year":"2008","unstructured":"Oesterhelweg L, Puschel K. \u201cDeath may come on like a stroke of lightening\u201d: phenomenological and morphological aspects of fatalities caused by manure gas. Int J Legal Med. 2008;122(2):101\u20137. doi: 10.1007\/s00414-007-0172-8 .","journal-title":"Int J Legal Med"},{"issue":"5","key":"459_CR10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrd4433","volume":"14","author":"JL Wallace","year":"2015","unstructured":"Wallace JL, Wang R. Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat Rev Drug Discov. 2015;14(5):329\u201345. doi: 10.1038\/nrd4433 .","journal-title":"Nat Rev Drug Discov"},{"issue":"39","key":"459_CR11","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","volume":"104","author":"JW Elrod","year":"2007","unstructured":"Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, et al. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci U S A. 2007;104(39):15560\u20135. doi: 10.1073\/pnas.0705891104 .","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"459_CR12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1152\/japplphysiol.00096.2006","volume":"102","author":"YZ Zhu","year":"2007","unstructured":"Zhu YZ, Wang ZJ, Ho P, Loke YY, Zhu YC, Huang SH, et al. Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats. J Appl Physiol. 2007;102(1):261\u20138. doi: 10.1152\/japplphysiol.00096.2006 .","journal-title":"J Appl Physiol"},{"issue":"4","key":"459_CR13","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/ATVBAHA.112.300484","volume":"33","author":"CK Nicholson","year":"2013","unstructured":"Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW. Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. Arterioscler Thromb Vasc Biol. 2013;33(4):744\u201351. doi: 10.1161\/ATVBAHA.112.300484 .","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"459_CR14","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2012030268","volume":"24","author":"EM Bos","year":"2013","unstructured":"Bos EM, Wang R, Snijder PM, Boersema M, Damman J, Fu M, et al. Cystathionine gamma-Lyase protects against renal ischemia\/reperfusion by modulating oxidative stress. J Am Soc Nephrol. 2013;24(5):759\u201370. doi: 10.1681\/ASN.2012030268 .","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"459_CR15","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/bjs.8956","volume":"99","author":"JP Hunter","year":"2012","unstructured":"Hunter JP, Hosgood SA, Patel M, Rose R, Read K, Nicholson ML. Effects of hydrogen sulphide in an experimental model of renal ischaemia-reperfusion injury. Br J Surg. 2012;99(12):1665\u201371. doi: 10.1002\/bjs.8956 .","journal-title":"Br J Surg"},{"issue":"33","key":"459_CR16","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1073\/pnas.1105121108","volume":"108","author":"K Suzuki","year":"2011","unstructured":"Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gero D, et al. Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function. Proc Natl Acad Sci U S A. 2011;108(33):13829\u201334. doi: 10.1073\/pnas.1105121108 .","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"459_CR17","volume":"8","author":"YD Wen","year":"2013","unstructured":"Wen YD, Wang H, Kho SH, Rinkiko S, Sheng X, Shen HM, et al. Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress. PLoS One. 2013;8(2), e53147. doi: 10.1371\/journal.pone.0053147 .","journal-title":"PLoS One"},{"key":"459_CR18","author":"Y Cui","year":"2015","unstructured":"Cui Y, Duan X, Li H, Dang B, Yin J, Wang Y, et al. Hydrogen sulfide ameliorates early brain injury following subarachnoid hemorrhage in rats. Mol Neurobiol. 2015. doi: 10.1007\/s12035-015-9304-1 .","journal-title":"Mol Neurobiol"},{"issue":"5","key":"459_CR19","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jnc.12695","volume":"129","author":"Y Wang","year":"2014","unstructured":"Wang Y, Jia J, Ao G, Hu L, Liu H, Xiao Y, et al. Hydrogen sulfide protects blood\u2013brain barrier integrity following cerebral ischemia. J Neurochem. 2014;129(5):827\u201338. doi: 10.1111\/jnc.12695 .","journal-title":"J Neurochem"},{"issue":"1","key":"459_CR20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s12975-014-0373-7","volume":"6","author":"W Zhu","year":"2015","unstructured":"Zhu W, Casper A, Libal NL, Murphy SJ, Bodhankar S, Offner H, et al. Preclinical evaluation of recombinant T cell receptor ligand RTL1000 as a therapeutic agent in ischemic stroke. Transl Stroke Res. 2015;6(1):60\u20138. doi: 10.1007\/s12975-014-0373-7 .","journal-title":"Transl Stroke Res"},{"key":"459_CR21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.expneurol.2015.03.021","volume":"272","author":"J Suenaga","year":"2015","unstructured":"Suenaga J, Hu X, Pu H, Shi Y, Hassan SH, Xu M, et al. White matter injury and microglia\/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke. Exp Neurol. 2015;272:109\u201319. doi: 10.1016\/j.expneurol.2015.03.021 .","journal-title":"Exp Neurol"},{"key":"459_CR22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.expneurol.2015.04.005","volume":"272","author":"W Dong","year":"2015","unstructured":"Dong W, Qi Z, Liang J, Shi W, Zhao Y, Luo Y, et al. Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model. Exp Neurol. 2015;272:181\u20139. doi: 10.1016\/j.expneurol.2015.04.005 .","journal-title":"Exp Neurol"},{"issue":"7","key":"459_CR23","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm1787","volume":"14","author":"EJ Su","year":"2008","unstructured":"Su EJ, Fredriksson L, Geyer M, Folestad E, Cale J, Andrae J, et al. Activation of PDGF-CC by tissue plasminogen activator impairs blood\u2013brain barrier integrity during ischemic stroke. Nat Med. 2008;14(7):731\u20137. doi: 10.1038\/nm1787 .","journal-title":"Nat Med"},{"issue":"4","key":"459_CR24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/ana.22538","volume":"70","author":"SJ Won","year":"2011","unstructured":"Won SJ, Tang XN, Suh SW, Yenari MA, Swanson RA. Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by increasing superoxide production. Ann Neurol. 2011;70(4):583\u201390. doi: 10.1002\/ana.22538 .","journal-title":"Ann Neurol"},{"issue":"4","key":"459_CR25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2337\/dc08-1754","volume":"32","author":"AY Poppe","year":"2009","unstructured":"Poppe AY, Majumdar SR, Jeerakathil T, Ghali W, Buchan AM, Hill MD, et al. Admission hyperglycemia predicts a worse outcome in stroke patients treated with intravenous thrombolysis. Diabetes Care. 2009;32(4):617\u201322. doi: 10.2337\/dc08-1754 .","journal-title":"Diabetes Care"},{"key":"459_CR26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbi.2014.03.003","volume":"40","author":"Q Jin","year":"2014","unstructured":"Jin Q, Cheng J, Liu Y, Wu J, Wang X, Wei S, et al. Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia\/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav Immun. 2014;40:131\u201342. doi: 10.1016\/j.bbi.2014.03.003 .","journal-title":"Brain Behav Immun"},{"key":"459_CR27","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neuroscience.2012.11.050","volume":"231","author":"L Mao","year":"2013","unstructured":"Mao L, Jia J, Zhou X, Xiao Y, Wang Y, Mao X, et al. Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke. Neuroscience. 2013;231:272\u201381. doi: 10.1016\/j.neuroscience.2012.11.050 .","journal-title":"Neuroscience"},{"issue":"5","key":"459_CR28","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s12975-014-0348-8","volume":"5","author":"W Zhu","year":"2014","unstructured":"Zhu W, Libal NL, Casper A, Bodhankar S, Offner H, Alkayed NJ. Recombinant T cell receptor ligand treatment improves neurological outcome in the presence of tissue plasminogen activator in experimental ischemic stroke. Transl Stroke Res. 2014;5(5):612\u20137. doi: 10.1007\/s12975-014-0348-8 .","journal-title":"Transl Stroke Res"},{"issue":"8","key":"459_CR29","first-page":"1185","volume":"20","author":"E Kilic","year":"2006","unstructured":"Kilic E, Kilic U, Wang Y, Bassetti CL, Marti HH, Hermann DM. The phosphatidylinositol-3 kinase\/Akt pathway mediates VEGF\u2019s neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J Off Publ Fed Am Soc Exp Biol. 2006;20(8):1185\u20137. doi: 10.1096\/fj.05-4829fje .","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"issue":"3","key":"459_CR30","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/jcbfm.2014.223","volume":"35","author":"Y Geng","year":"2015","unstructured":"Geng Y, Li E, Mu Q, Zhang Y, Wei X, Li H, et al. Hydrogen sulfide inhalation decreases early blood\u2013brain barrier permeability and brain edema induced by cardiac arrest and resuscitation. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 2015;35(3):494\u2013500. doi: 10.1038\/jcbfm.2014.223 .","journal-title":"J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab"},{"key":"459_CR31","author":"PK Kamat","year":"2015","unstructured":"Kamat PK, Kyles P, Kalani A, Tyagi N. Hydrogen sulfide ameliorates homocysteine-induced Alzheimer\u2019s disease-like pathology, blood\u2013brain barrier disruption, and synaptic disorder. Mol Neurobiol. 2015. doi: 10.1007\/s12035-015-9212-4 .","journal-title":"Mol Neurobiol"},{"issue":"1","key":"459_CR32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1586\/ecp.10.129","volume":"4","author":"X Gu","year":"2011","unstructured":"Gu X, Zhu YZ. Therapeutic applications of organosulfur compounds as novel hydrogen sulfide donors and\/or mediators. Expert Rev Clin Pharmacol. 2011;4(1):123\u201333. doi: 10.1586\/ecp.10.129 .","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"1","key":"459_CR33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/ecp.10.134","volume":"4","author":"M Whiteman","year":"2011","unstructured":"Whiteman M, Winyard PG. Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising. Expert Rev Clin Pharmacol. 2011;4(1):13\u201332. doi: 10.1586\/ecp.10.134 .","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"18","key":"459_CR34","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","volume":"117","author":"L Li","year":"2008","unstructured":"Li L, Whiteman M, Guan YY, Neo KL, Cheng Y, Lee SW, et al. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide. Circulation. 2008;117(18):2351\u201360. doi: 10.1161\/CIRCULATIONAHA.107.753467 .","journal-title":"Circulation"},{"issue":"38","key":"459_CR35","doi-asserted-by":"crossref","first-page":"32124","DOI":"10.1074\/jbc.M112.374124","volume":"287","author":"E Marutani","year":"2012","unstructured":"Marutani E, Kosugi S, Tokuda K, Khatri A, Nguyen R, Atochin DN, et al. A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. J Biol Chem. 2012;287(38):32124\u201335. doi: 10.1074\/jbc.M112.374124 .","journal-title":"J Biol Chem"},{"issue":"23","key":"459_CR36","doi-asserted-by":"crossref","first-page":"17318","DOI":"10.1074\/jbc.M110.115261","volume":"285","author":"M Lee","year":"2010","unstructured":"Lee M, Tazzari V, Giustarini D, Rossi R, Sparatore A, Del Soldato P, et al. Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease. J Biol Chem. 2010;285(23):17318\u201328. doi: 10.1074\/jbc.M110.115261 .","journal-title":"J Biol Chem"},{"issue":"2","key":"459_CR37","first-page":"206","volume":"271","author":"Y Ukai","year":"1984","unstructured":"Ukai Y, Taniguchi N, Takeshita K, Kimura K, Enomoto H. Chronic anethole trithione treatment enhances the salivary secretion and increases the muscarinic acetylcholine receptors in the rat submaxillary gland. Arch Int Pharmacodyn Ther. 1984;271(2):206\u201312.","journal-title":"Arch Int Pharmacodyn Ther"},{"issue":"3","key":"459_CR38","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbrc.2015.02.017","volume":"458","author":"H Xie","year":"2015","unstructured":"Xie H, Xu Q, Jia J, Ao G, Sun Y, Hu L, et al. Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux. Biochem Biophys Res Commun. 2015;458(3):632\u20138. doi: 10.1016\/j.bbrc.2015.02.017 .","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"459_CR39","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1182\/blood-2008-02-141630","volume":"112","author":"J An","year":"2008","unstructured":"An J, Zhang C, Polavarapu R, Zhang X, Zhang X, Yepes M. Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain. Blood. 2008;112(7):2787\u201394. doi: 10.1182\/blood-2008-02-141630 .","journal-title":"Blood"},{"issue":"4","key":"459_CR40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00004647-200204000-00002","volume":"22","author":"ZG Zhang","year":"2002","unstructured":"Zhang ZG, Zhang L, Tsang W, Soltanian-Zadeh H, Morris D, Zhang R, et al. Correlation of VEGF and angiopoietin expression with disruption of blood\u2013brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab. 2002;22(4):379\u201392. doi: 10.1097\/00004647-200204000-00002 .","journal-title":"J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab"},{"issue":"9131","key":"459_CR41","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","volume":"352","author":"UK Prospective Diabetes Study (UKPDS) Group","year":"1998","unstructured":"UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352(9131):854\u201365.","journal-title":"Lancet"},{"issue":"3","key":"459_CR42","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1161\/01.STR.0000204184.34946.41","volume":"37","author":"K Qu","year":"2006","unstructured":"Qu K, Chen CP, Halliwell B, Moore PK, Wong PT. Hydrogen sulfide is a mediator of cerebral ischemic damage. Stroke J Cereb Circ. 2006;37(3):889\u201393. doi: 10.1161\/01.STR.0000204184.34946.41 .","journal-title":"Stroke J Cereb Circ"},{"issue":"2","key":"459_CR43","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/ars.2010.3517","volume":"15","author":"LF Hu","year":"2011","unstructured":"Hu LF, Lu M, Hon Wong PT, Bian JS. Hydrogen sulfide: neurophysiology and neuropathology. Antioxid Redox Signal. 2011;15(2):405\u201319. doi: 10.1089\/ars.2010.3517 .","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"459_CR44","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1089\/ars.2012.4565","volume":"19","author":"BB Tao","year":"2013","unstructured":"Tao BB, Liu SY, Zhang CC, Fu W, Cai WJ, Wang Y, et al. VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells. Antioxid Redox Signal. 2013;19(5):448\u201364. doi: 10.1089\/ars.2012.4565 .","journal-title":"Antioxid Redox Signal"},{"issue":"7","key":"459_CR45","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1172\/JCI60842","volume":"122","author":"AT Argaw","year":"2012","unstructured":"Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, et al. Astrocyte-derived VEGF-A drives blood\u2013brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012;122(7):2454\u201368. doi: 10.1172\/JCI60842 .","journal-title":"J Clin Invest"},{"issue":"7","key":"459_CR46","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI9369","volume":"106","author":"ZG Zhang","year":"2000","unstructured":"Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, Powers C, et al. VEGF enhances angiogenesis and promotes blood\u2013brain barrier leakage in the ischemic brain. J Clin Invest. 2000;106(7):829\u201338. doi: 10.1172\/JCI9369 .","journal-title":"J Clin Invest"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-016-0459-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12975-016-0459-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-016-0459-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T10:31:07Z","timestamp":1559471467000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12975-016-0459-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,28]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["459"],"URL":"https:\/\/doi.org\/10.1007\/s12975-016-0459-5","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,28]]}}}