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Stroke Res."],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1\u03b1 with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62.1%; mean age, 68.2 \u00b1 11.4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] \u2264 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 \u00b1 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1\u03b1 were measured by ELISA at admission, 7 \u00b1 1 days, at 3 \u00b1 1 months, and 12 \u00b1 3 months. Except for BDNF, all GF and SDF-1\u03b1 serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). High serum levels at day 7 of VEGF (OR, 19.3), Ang-1 (OR, 14.7), G-CSF (OR, 9.6), and SDF-1\u03b1 (OR, 28.5) were independently associated with good outcome at 12 months (all\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). On the other hand, serum levels of VEGF (B, \u2212 21.4), G-CSF (B, \u2212 14.0), Ang-1 (B, \u2212 13.3), and SDF-1\u03b1 (B, \u2212 44.6) measured at day 7 were independently associated with lesion volume at 6 months (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1\u03b1 at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up.\n                  <\/jats:p>","DOI":"10.1007\/s12975-019-00747-2","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T18:02:17Z","timestamp":1574704937000},"page":"653-663","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke: a Multicenter Study"],"prefix":"10.1007","volume":"11","author":[{"given":"Tom\u00e1s","family":"Sobrino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rodr\u00edguez-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-9135","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Iglesias-Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia P\u00e9rez","family":"de la Ossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"D\u00e1valos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Delgado-Mederos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mart\u00ednez-Dome\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Mart\u00ed-F\u00e1bregas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Castellanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Serena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Lago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Exuperio","family":"D\u00edez-Tejedor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"747_CR1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000441105","volume":"45","author":"GA Mensah","year":"2015","unstructured":"Mensah GA, Sacco RL, Vickrey BG, et al. 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