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A. was supported by the Coordination Fund from the Japanese Ministry for Education, Culture, Sports, Science and Technology (MEXT) and Astellas Pharma Inc. to Kyoto University until 31th\/March\/2017 and S.N. is supported by a same grant. S.N. is a scientific advisor to Astellas Pharma. H. K., H. M., S. S., N.O., K. M., K. S., K. Y., K. N., and H. K. declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. And this study was approved by the Institutional Animal Care and Use Committee of Kyoto University Graduate School of Medicine and also of National Cerebral and Cardiovascular Center. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Institutional Review Board of Shimizu Hospital (Kyoto, Japan, Approval No. 203). Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}