{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:08:39Z","timestamp":1783728519619,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005890","name":"Ministry of Health of the People's Republic of China","doi-asserted-by":"publisher","award":["WKJ-ZJ-1612"],"award-info":[{"award-number":["WKJ-ZJ-1612"]}],"id":[{"id":"10.13039\/501100005890","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Technology Department of Zhejiang Province","award":["2017C03011"],"award-info":[{"award-number":["2017C03011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s12975-020-00785-1","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T20:02:48Z","timestamp":1581364968000},"page":"890-899","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Low Hemoglobin Levels at Admission Are Independently Associated with Cognitive Impairment after Ischemic Stroke: a Multicenter, Population-Based Study"],"prefix":"10.1007","volume":"11","author":[{"given":"Fanxia","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunjie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiwu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benyan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"issue":"8","key":"785_CR1","first-page":"80","volume":"2","author":"J-H Sun","year":"2014","unstructured":"Sun J-H, Tan L, Yu J-T. Post-stroke cognitive impairment: epidemiology, mechanisms and management. Ann Transl Med. 2014;2(8):80.","journal-title":"Ann Transl Med"},{"issue":"9","key":"785_CR2","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S1474-4422(10)70164-2","volume":"9","author":"RF Gottesman","year":"2010","unstructured":"Gottesman RF, Hillis AE. Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke. Lancet Neurol. 2010;9(9):895\u2013905.","journal-title":"Lancet Neurol"},{"issue":"1","key":"785_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12916-017-0779-7","volume":"15","author":"MD Mijajlovic","year":"2017","unstructured":"Mijajlovic MD, Pavlovic A, Brainin M, Heiss WD, Quinn TJ, Ihle-Hansen HB, et al. Post-stroke dementia\u2014a comprehensive review. BMC Med. 2017;15(1):11.","journal-title":"BMC Med"},{"issue":"1","key":"785_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.tics.2018.10.004","volume":"23","author":"G Sala","year":"2019","unstructured":"Sala G, Gobet F. Cognitive training does not enhance general cognition. Trends Cogn Sci. 2019;23(1):9\u201320.","journal-title":"Trends Cogn Sci"},{"issue":"3","key":"785_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1212\/WNL.0b013e318225aaa9","volume":"77","author":"RC Shah","year":"2011","unstructured":"Shah RC, Buchman AS, Wilson RS, Leurgans SE, Bennett DA. Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis. Neurology. 2011;77(3):219\u201326.","journal-title":"Neurology"},{"key":"785_CR6","doi-asserted-by":"crossref","unstructured":"Winchester LM, Powell J, Lovestone S, et al. Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer\u2019s disease. Genome Med. 2018;10(1):51.","DOI":"10.1186\/s13073-018-0556-z"},{"issue":"9","key":"785_CR7","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1111\/ene.12175","volume":"20","author":"M Andro","year":"2013","unstructured":"Andro M, Le Squere P, Estivin S, Gentric A. Anaemia and cognitive performances in the elderly: a systematic review. Eur J Neurol. 2013;20(9):1234\u201340.","journal-title":"Eur J Neurol"},{"issue":"1","key":"785_CR8","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1159\/000338905","volume":"34","author":"ST Pendlebury","year":"2012","unstructured":"Pendlebury ST, Markwick A, de Jager CA, Zamboni G, Wilcock GK, Rothwell PM. Differences in cognitive profile between TIA, stroke and elderly memory research subjects: a comparison of the MMSE and MoCA. Cerebrovasc Dis. 2012;34(1):48\u201354.","journal-title":"Cerebrovasc Dis"},{"issue":"3","key":"785_CR9","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3233\/JAD-170313","volume":"60","author":"RJ Chander","year":"2017","unstructured":"Chander RJ, Lim L, Handa S, Hiu S, Choong A, Lin X, et al. Atrial fibrillation is independently associated with cognitive impairment after ischemic stroke. J Alzheimers Dis. 2017;60(3):867\u201375.","journal-title":"J Alzheimers Dis"},{"issue":"12","key":"785_CR10","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1136\/jnnp.2009.204008","volume":"81","author":"SJ Cano","year":"2010","unstructured":"Cano SJ, Posner HB, Moline ML, Hurt SW, Swartz J, Hsu T, et al. The ADAS-cog in Alzheimer\u2019s disease clinical trials: psychometric evaluation of the sum and its parts. J Neurol Neurosurg Psychiatry. 2010;81(12):1363\u20138.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"785_CR11","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.14336\/ad.2018.0125","volume":"9","author":"S-TC Calvin Pak-Wing Cheng","year":"2018","unstructured":"Calvin Pak-Wing Cheng S-TC, Tam CW-C, Chan W-C, Chu WC-W, Lam LC-W. Relationship between cortical thickness and neuropsychological performance in normal older adults and those with mild cognitive impairment. Aging Dis. 2018;9(6):1020\u201330. https:\/\/doi.org\/10.14336\/ad.2018.0125.","journal-title":"Aging Dis"},{"issue":"10","key":"785_CR12","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/gps.709","volume":"17","author":"J Diehl","year":"2002","unstructured":"Diehl J, Kurz A. Frontotemporal dementia: patient characteristics, cognition, and behaviour. Int J Geriatr Psychiatry. 2002;17(10):914\u20138. https:\/\/doi.org\/10.1002\/gps.709.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"4","key":"785_CR13","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1017\/S1041610201007852","volume":"13","author":"CJ Vas","year":"2001","unstructured":"Vas CJ, Pinto C, Panikker D, Noronha S, Deshpande N, Kulkarni L, et al. Prevalence of dementia in an urban Indian population. Int Psychogeriatr. 2001;13(4):439\u201350.","journal-title":"Int Psychogeriatr"},{"issue":"1","key":"785_CR14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/01.str.24.1.35","volume":"24","author":"HP Adams Jr","year":"1993","unstructured":"Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35\u201341. https:\/\/doi.org\/10.1161\/01.str.24.1.35.","journal-title":"Stroke"},{"issue":"10","key":"785_CR15","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/gerona\/glt286","volume":"69","author":"Y Taniguchi","year":"2014","unstructured":"Taniguchi Y, Shinkai S, Nishi M, Murayama H, Nofuji Y, Yoshida H, et al. Nutritional biomarkers and subsequent cognitive decline among community-dwelling older Japanese: a prospective study. J Gerontol A Biol Sci Med Sci. 2014;69(10):1276\u201383.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"785_CR16","unstructured":"Shan G, Na L, Pin M, Niu J, Yong\u2019an S, Yingda X, et al. Midterm blood pressure variability is associated with poststroke cognitive impairment: a prospective cohort study. Front Neurol. 8:365."},{"issue":"2","key":"785_CR17","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.neurobiolaging.2005.02.007","volume":"27","author":"AR Atti","year":"2006","unstructured":"Atti AR, Palmer K, Volpato S, Zuliani G, Winblad B, Fratiglioni L. Anaemia increases the risk of dementia in cognitively intact elderly. Neurobiol Aging. 2006;27(2):278\u201384. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2005.02.007.","journal-title":"Neurobiol Aging"},{"issue":"1","key":"785_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/BF03033574","volume":"14","author":"MBH Youdim","year":"2008","unstructured":"Youdim MBH. Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus. Neurotox Res. 2008;14(1):45\u201356.","journal-title":"Neurotox Res"},{"issue":"01","key":"785_CR19","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1017\/S1041610215000733","volume":"28","author":"SE Park","year":"2016","unstructured":"Park SE, Kim H, Lee J, Lee NK, Hwang JW, Yang J-J, et al. Decreased hemoglobin levels, cerebreal small-vessel disease, and cortical atrophy: among cognitively normal elderly women and men. Int Psychogeriatr. 2016;28(01):147\u201356.","journal-title":"Int Psychogeriatr"},{"issue":"10","key":"785_CR20","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1111\/j.1532-5415.2008.01950.x","volume":"56","author":"M Inzitari","year":"2008","unstructured":"Inzitari M, Studenski S, Rosano C, Zakai NA, Longstreth WT, Cushman M, et al. Anemia is associated with the progression of white matter disease in older adults with high blood pressure: the cardiovascular health study. J Am Geriatr Soc. 2008;56(10):1867\u201372.","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"785_CR21","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.expneurol.2009.07.033","volume":"223","author":"X Zhang","year":"2010","unstructured":"Zhang X, Le W. Pathological role of hypoxia in Alzheimer\u2019s disease. Exp Neurol. 2010;223(2):299\u2013303.","journal-title":"Exp Neurol"},{"issue":"2","key":"785_CR22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/ene.12626","volume":"22","author":"M Brainin","year":"2015","unstructured":"Brainin M, Tuomilehto J, Heiss WD, Bornstein NM, Bath PM, Teuschl Y, et al. Post-stroke cognitive decline: an update and perspectives for clinical research. Eur J Neurol. 2015;22(2):229\u201338, e13-6. https:\/\/doi.org\/10.1111\/ene.12626.","journal-title":"Eur J Neurol"},{"issue":"12","key":"785_CR23","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1007\/s00277-014-2155-4","volume":"93","author":"T Juarez-Cedillo","year":"2014","unstructured":"Juarez-Cedillo T, Basurto-Acevedo L, Vega-Garcia S, Manuel-Apolinar L, Cruz-Tesoro E, Rodriguez-Perez JM, et al. Prevalence of anemia and its impact on the state of frailty in elderly people living in the community: SADEM study. Ann Hematol. 2014;93(12):2057\u201362.","journal-title":"Ann Hematol"},{"issue":"17","key":"785_CR24","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1212\/WNL.0b013e3181bd80c1","volume":"73","author":"R Savica","year":"2009","unstructured":"Savica R, Grossardt BR, Carlin JM, Icen M, Bower JH, Ahlskog JE, et al. Anemia or low hemoglobin levels preceding Parkinson disease: a case-control study. Neurology. 2009;73(17):1381\u20137.","journal-title":"Neurology"},{"issue":"3","key":"785_CR25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3233\/JAD-2012-120952","volume":"32","author":"RC Shah","year":"2012","unstructured":"Shah RC, Schneider JA, Leurgans S, Bennett DA. Association of lower hemoglobin level and neuropathology in community-dwelling older persons. J Alzheimers Dis. 2012;32(3):579\u201386.","journal-title":"J Alzheimers Dis"},{"issue":"16","key":"785_CR26","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1182\/blood-2018-04-841247","volume":"132","author":"AL Ford","year":"2018","unstructured":"Ford AL, Ragan DK, Fellah S, Binkley MM, Fields ME, Guilliams KP, et al. Silent infarcts in sickle cell disease occur in the border zone region and are associated with low cerebral blood flow. Blood. 2018;132(16):1714\u201323.","journal-title":"Blood"},{"issue":"8","key":"785_CR27","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1161\/STROKEAHA.116.013077","volume":"47","author":"B Panwar","year":"2016","unstructured":"Panwar B, Judd SE, Warnock DG, McClellan WM, Booth JN, Muntner P, et al. Hemoglobin concentration and risk of incident stroke in community-living adults. Stroke. 2016;47(8):2017\u201324.","journal-title":"Stroke"},{"issue":"1","key":"785_CR28","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000353859","volume":"60","author":"J Kulmala","year":"2014","unstructured":"Kulmala J, Nykanen I, Manty M, Hartikainen S. Association between frailty and dementia: a population-based study. Gerontology. 2014;60(1):16\u201321.","journal-title":"Gerontology"},{"issue":"5","key":"785_CR29","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1159\/000328970","volume":"31","author":"J Wagle","year":"2011","unstructured":"Wagle J, Farner L, Flekk\u00f8y K, Bruun Wyller T, Sandvik L, Fure B, et al. Early post-stroke cognition in stroke rehabilitation patients predicts functional outcome at 13 months. Dement Geriatr Cogn Disord. 2011;31(5):379\u201387.","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"3","key":"785_CR30","doi-asserted-by":"publisher","first-page":"170","DOI":"10.14336\/AD.2014.0500170","volume":"5","author":"VK Khemka","year":"2014","unstructured":"Khemka VK, Ganguly A, Bagchi D, Ghosh A, Bir A, Biswas A, et al. Raised serum proinflammatory cytokines in Alzheimer\u2019s disease with depression. Aging Dis. 2014;5(3):170\u20136. https:\/\/doi.org\/10.14336\/AD.2014.0500170.","journal-title":"Aging Dis"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-020-00785-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12975-020-00785-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-020-00785-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T23:51:11Z","timestamp":1612914671000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12975-020-00785-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,10]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["785"],"URL":"https:\/\/doi.org\/10.1007\/s12975-020-00785-1","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,10]]},"assertion":[{"value":"9 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of the First Affiliated Hospital, College of Medicine, Zhejiang University, and was conducted in accordance with the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}