{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:34:58Z","timestamp":1789601698779,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501193"],"award-info":[{"award-number":["81501193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701180"],"award-info":[{"award-number":["81701180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["No. 200805Q"],"award-info":[{"award-number":["No. 200805Q"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Foundation of New Medicine of University of Science and Technology of China","award":["WK9110000084"],"award-info":[{"award-number":["WK9110000084"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s12975-020-00840-x","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T03:39:50Z","timestamp":1598758790000},"page":"643-659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":192,"title":["TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage"],"prefix":"10.1007","volume":"12","author":[{"given":"Pengfei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaonan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"issue":"5","key":"840_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1001\/jamaneurol.2019.0006","volume":"76","author":"N Etminan","year":"2019","unstructured":"Etminan N, Chang HS, Hackenberg K, de Rooij NK, Vergouwen MDI, Rinkel GJE, et al. Worldwide incidence of aneurysmal subarachnoid hemorrhage according to region, time period, blood pressure, and smoking prevalence in the population: a systematic review and meta-analysis. JAMA Neurol. 2019;76(5):588\u201397. https:\/\/doi.org\/10.1001\/jamaneurol.2019.0006.","journal-title":"JAMA Neurol"},{"issue":"5","key":"840_CR2","first-page":"1082","volume":"56","author":"GF Prunell","year":"2005","unstructured":"Prunell GF, Niels-Aage S, Kanar A, Tiit M. Inflammation in the brain after experimental subarachnoid hemorrhage. Neurosurgery. 2005;56(5):1082\u201392.","journal-title":"Neurosurgery."},{"issue":"4","key":"840_CR3","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3390\/ijms17040497","volume":"17","author":"BP Lucke-Wold","year":"2016","unstructured":"Lucke-Wold BP, Logsdon AF, Manoranjan B, Turner RC, McConnell E, Vates GE, et al. Aneurysmal subarachnoid hemorrhage and neuroinflammation: a comprehensive review. Int J Mol Sci. 2016;17(4):497. https:\/\/doi.org\/10.3390\/ijms17040497.","journal-title":"Int J Mol Sci"},{"key":"840_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jocn.2017.02.001","volume":"42","author":"VZ Zheng","year":"2017","unstructured":"Zheng VZ, Wong GKC. Neuroinflammation responses after subarachnoid hemorrhage: a review. J Clin Neurosci. 2017;42:7\u201311. https:\/\/doi.org\/10.1016\/j.jocn.2017.02.001.","journal-title":"J Clin Neurosci"},{"issue":"7","key":"840_CR5","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1212\/WNL.0000000000001259","volume":"84","author":"B Neeraj","year":"2015","unstructured":"Neeraj B, Aimee M, Amanda C, Jacqueline Z, J Michael S, Jan C, et al. Inflammation, negative nitrogen balance, and outcome after aneurysmal subarachnoid hemorrhage. Neurology. 2015;84(7):680\u20137.","journal-title":"Neurology."},{"issue":"3","key":"840_CR6","first-page":"1","volume":"26","author":"C Tao","year":"2016","unstructured":"Tao C, Wang J, Hu X, Ma J, Li H, You C. Clinical value of neutrophil to lymphocyte and platelet to lymphocyte ratio after aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2016;26(3):1\u20139.","journal-title":"Neurocrit Care"},{"issue":"9","key":"840_CR7","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.imbio.2008.07.008","volume":"213","author":"O Sharif","year":"2008","unstructured":"Sharif O, Knapp S. From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology. 2008;213(9):701\u201313.","journal-title":"Immunobiology."},{"issue":"2","key":"840_CR8","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.imlet.2007.11.021","volume":"116","author":"AS Tessarz","year":"2008","unstructured":"Tessarz AS, Adelheid C. The TREM-1\/DAP12 pathway. Immunol Lett. 2008;116(2):111\u20136.","journal-title":"Immunol Lett"},{"key":"840_CR9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jocn.2016.09.005","volume":"35","author":"XG Sun","year":"2017","unstructured":"Sun XG, Ma Q, Jing G, Wang GQ, Hao XD, Wang L. Increased levels of soluble triggering receptor expressed on myeloid cells-1 in cerebrospinal fluid of subarachnoid hemorrhage patients. J Clin Neurosci. 2017;35:139\u201343. https:\/\/doi.org\/10.1016\/j.jocn.2016.09.005.","journal-title":"J Clin Neurosci"},{"issue":"11","key":"840_CR10","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1161\/CIRCRESAHA.116.305628","volume":"116","author":"B Amir","year":"2015","unstructured":"Amir B, J\u00e9r\u00e9mie L, Tabassome S, Marc D, Youcef B, Nguyen T, et al. TREM-1 mediates inflammatory injury and cardiac remodeling following myocardial infarction. Circ Res. 2015;116(11):1772\u201382.","journal-title":"Circ Res"},{"issue":"10","key":"840_CR11","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1172\/JCI30602","volume":"117","author":"S Mirjam","year":"2007","unstructured":"Mirjam S, Axel B, Frank S, Christoph M. TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Investig. 2007;117(10):3097\u2013106.","journal-title":"J Clin Investig"},{"issue":"6832","key":"840_CR12","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1038\/35074114","volume":"410","author":"A Bouchon","year":"2001","unstructured":"Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature. 2001;410(6832):1103\u20137. https:\/\/doi.org\/10.1038\/35074114.","journal-title":"Nature."},{"issue":"5","key":"840_CR13","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Dixit V. Mechanisms and functions of Inflammasomes. Cell. 2014;157(5):1013\u201322.","journal-title":"Cell."},{"issue":"15","key":"840_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/9743280","volume":"2017","author":"Z Qiu","year":"2017","unstructured":"Qiu Z, Lei S, Zhao B, Wu Y, Su W, Liu M, et al. NLRP3 inflammasome activation-mediated pyroptosis aggravates myocardial ischemia\/reperfusion injury in diabetic rats. Oxidative Med Cell Longev. 2017;2017(15):1\u201317.","journal-title":"Oxidative Med Cell Longev"},{"key":"840_CR15","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.intimp.2018.12.019","volume":"67","author":"S Wang","year":"2019","unstructured":"Wang S, Yuan YH, Chen NH, Wang HB. The mechanisms of NLRP3 inflammasome\/pyroptosis activation and their role in Parkinson's disease. Int Immunopharmacol. 2019;67:458\u201364. https:\/\/doi.org\/10.1016\/j.intimp.2018.12.019.","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"840_CR16","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41419-019-1777-9","volume":"10","author":"P Xu","year":"2019","unstructured":"Xu P, Zhang X, Liu Q, Xie Y, Shi X, Chen J, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019;10(8):555.","journal-title":"Cell Death Dis"},{"issue":"6","key":"840_CR17","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1161\/01.STR.26.6.1086","volume":"26","author":"JB Bederson","year":"1995","unstructured":"Bederson JB, Germano IM, Guarino L. Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat. Stroke. 1995;26(6):1086\u201391 discussion 91-92.","journal-title":"Stroke."},{"issue":"2","key":"840_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","volume":"167","author":"T Sugawara","year":"2008","unstructured":"Sugawara T, Ayer R, Jadhav V, Zhang JH. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 2008;167(2):327\u201334. https:\/\/doi.org\/10.1016\/j.jneumeth.2007.08.004.","journal-title":"J Neurosci Methods"},{"issue":"3","key":"840_CR19","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s13311-011-0051-3","volume":"8","author":"R Ye","year":"2011","unstructured":"Ye R, Kong X, Yang Q, Zhang Y, Han J, Li P, et al. Ginsenoside rd in experimental stroke: superior neuroprotective efficacy with a wide therapeutic window. Neurotherapeutics. 2011;8(3):515\u201325. https:\/\/doi.org\/10.1007\/s13311-011-0051-3.","journal-title":"Neurotherapeutics."},{"key":"840_CR20","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.bbi.2016.11.004","volume":"60","author":"Y Xie","year":"2017","unstructured":"Xie Y, Guo H, Wang L, Xu L, Zhang X, Yu L, et al. Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle\/Syk signaling in subarachnoid hemorrhage. Brain Behav Immun. 2017;60:346\u201360. https:\/\/doi.org\/10.1016\/j.bbi.2016.11.004.","journal-title":"Brain Behav Immun"},{"issue":"1","key":"840_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12974-018-1118-4","volume":"15","author":"Y Lu","year":"2018","unstructured":"Lu Y, Zhang XS, Zhang ZH, Zhou XM, Gao YY, Liu GJ, et al. Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage. J Neuroinflammation. 2018;15(1):87. https:\/\/doi.org\/10.1186\/s12974-018-1118-4.","journal-title":"J Neuroinflammation"},{"issue":"11","key":"840_CR22","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1084\/jem.20040708","volume":"200","author":"S Gibot","year":"2004","unstructured":"Gibot S, Kolopp-Sarda MN, Bene MC, Bollaert PE, Lozniewski A, Mory F, et al. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med. 2004;200(11):1419\u201326. https:\/\/doi.org\/10.1084\/jem.20040708.","journal-title":"J Exp Med"},{"issue":"11","key":"840_CR23","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1084\/jem.20171419","volume":"214","author":"H Jiang","year":"2017","unstructured":"Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017;214(11):3219\u201338. https:\/\/doi.org\/10.1084\/jem.20171419.","journal-title":"J Exp Med"},{"key":"840_CR24","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.redox.2018.06.012","volume":"18","author":"P Xu","year":"2018","unstructured":"Xu P, Liu Q, Xie Y, Shi X, Li Y, Peng M, et al. Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia\/reperfusion injury through NRF2-mediated antioxidant pathway. Redox Biol. 2018;18:158\u201372. https:\/\/doi.org\/10.1016\/j.redox.2018.06.012.","journal-title":"Redox Biol"},{"issue":"10","key":"840_CR25","doi-asserted-by":"publisher","first-page":"e440","DOI":"10.1097\/ccm.0000000000001193","volume":"43","author":"Y Xie","year":"2015","unstructured":"Xie Y, Liu W, Zhang X, Wang L, Xu L, Xiong Y, et al. Human albumin improves long-term behavioral sequelae after subarachnoid hemorrhage through neurovascular remodeling. Crit Care Med. 2015;43(10):e440\u20139. https:\/\/doi.org\/10.1097\/ccm.0000000000001193.","journal-title":"Crit Care Med"},{"issue":"4","key":"840_CR26","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","volume":"26","author":"JH Garcia","year":"1995","unstructured":"Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995;26(4):627\u201334.","journal-title":"Stroke"},{"key":"840_CR27","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.redox.2018.09.022","volume":"20","author":"J Mo","year":"2019","unstructured":"Mo J, Enkhjargal B, Travis ZD, Zhou K, Wu P, Zhang G, et al. AVE 0991 attenuates oxidative stress and neuronal apoptosis via mas\/PKA\/CREB\/UCP-2 pathway after subarachnoid hemorrhage in rats. Redox Biol. 2019;20:75\u201386. https:\/\/doi.org\/10.1016\/j.redox.2018.09.022.","journal-title":"Redox Biol"},{"issue":"6","key":"840_CR28","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/s12975-018-0665-4","volume":"9","author":"J Pang","year":"2018","unstructured":"Pang J, Peng J, Matei N, Yang P, Kuai L, Wu Y, et al. Apolipoprotein E exerts a whole-brain protective property by promoting M1? Microglia quiescence after experimental subarachnoid hemorrhage in mice. Transl Stroke Res. 2018;9(6):654\u201368. https:\/\/doi.org\/10.1007\/s12975-018-0665-4.","journal-title":"Transl Stroke Res"},{"issue":"4","key":"840_CR29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi J, Gao W, Shao F. Pyroptosis: Gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245\u201354. https:\/\/doi.org\/10.1016\/j.tibs.2016.10.004.","journal-title":"Trends Biochem Sci"},{"issue":"1","key":"840_CR30","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12974-018-1211-8","volume":"15","author":"Q Zhu","year":"2018","unstructured":"Zhu Q, Enkhjargal B, Huang L, Zhang T, Sun C, Xie Z, et al. Aggf1 attenuates neuroinflammation and BBB disruption via PI3K\/Akt\/NF-kappaB pathway after subarachnoid hemorrhage in rats. J Neuroinflammation. 2018;15(1):178. https:\/\/doi.org\/10.1186\/s12974-018-1211-8.","journal-title":"J Neuroinflammation"},{"issue":"8","key":"840_CR31","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1161\/strokeaha.115.010088","volume":"46","author":"Y He","year":"2015","unstructured":"He Y, Xu L, Li B, Guo ZN, Hu Q, Guo Z, et al. Macrophage-inducible C-type lectin\/spleen tyrosine kinase signaling pathway contributes to neuroinflammation after subarachnoid hemorrhage in rats. Stroke. 2015;46(8):2277\u201386. https:\/\/doi.org\/10.1161\/strokeaha.115.010088.","journal-title":"Stroke."},{"issue":"4","key":"840_CR32","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.jmb.2004.07.089","volume":"342","author":"MS Kelker","year":"2004","unstructured":"Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, et al. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. J Mol Biol. 2004;342(4):1237\u201348. https:\/\/doi.org\/10.1016\/j.jmb.2004.07.089.","journal-title":"J Mol Biol"},{"issue":"10","key":"840_CR33","doi-asserted-by":"publisher","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","volume":"164","author":"A Bouchon","year":"2000","unstructured":"Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol (Baltimore, Md : 1950). 2000;164(10):4991\u20135.","journal-title":"J Immunol (Baltimore, Md : 1950)"},{"issue":"3","key":"840_CR34","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s10753-016-0351-1","volume":"39","author":"Y Du","year":"2016","unstructured":"Du Y, Wu T, Zhou XJ, Davis LS, Mohan C. Blockade of CD354 (TREM-1) ameliorates anti-GBM-induced nephritis. Inflammation. 2016;39(3):1169\u201376. https:\/\/doi.org\/10.1007\/s10753-016-0351-1.","journal-title":"Inflammation."},{"key":"840_CR35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.neuroscience.2019.03.032","volume":"406","author":"XG Sun","year":"2019","unstructured":"Sun XG, Duan H, Jing G, Wang G, Hou Y, Zhang M. Inhibition of TREM-1 attenuates early brain injury after subarachnoid hemorrhage via downregulation of p38MAPK\/MMP-9 and preservation of ZO-1. Neuroscience. 2019;406:369\u201375. https:\/\/doi.org\/10.1016\/j.neuroscience.2019.03.032.","journal-title":"Neuroscience."},{"issue":"12","key":"840_CR36","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","volume":"25","author":"WT He","year":"2015","unstructured":"He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion. Cell Res. 2015;25(12):1285\u201398. https:\/\/doi.org\/10.1038\/cr.2015.139.","journal-title":"Cell Res"},{"issue":"16","key":"840_CR37","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.15252\/embj.201694696","volume":"35","author":"L Sborgi","year":"2016","unstructured":"Sborgi L, Ruhl S, Mulvihill E, Pipercevic J, Heilig R, Stahlberg H, et al. GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J. 2016;35(16):1766\u201378. https:\/\/doi.org\/10.15252\/embj.201694696.","journal-title":"EMBO J"},{"issue":"2","key":"840_CR38","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","volume":"10","author":"Y Yang","year":"2019","unstructured":"Yang Y, Wang H, Kouadir M, Song H, Shi F. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis. 2019;10(2):128. https:\/\/doi.org\/10.1038\/s41419-019-1413-8.","journal-title":"Cell Death Dis"},{"issue":"8","key":"840_CR39","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","volume":"17","author":"MSJ Mangan","year":"2018","unstructured":"Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov. 2018;17(8):588\u2013606. https:\/\/doi.org\/10.1038\/nrd.2018.97.","journal-title":"Nat Rev Drug Discov"},{"issue":"7245","key":"840_CR40","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature07965","volume":"459","author":"O Gross","year":"2009","unstructured":"Gross O, Poeck H, Bscheider M, Dostert C, Hannesschlager N, Endres S, et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature. 2009;459(7245):433\u20136. https:\/\/doi.org\/10.1038\/nature07965.","journal-title":"Nature."},{"key":"840_CR41","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.1038\/ncomms4755","volume":"5","author":"S Yasukawa","year":"2014","unstructured":"Yasukawa S, Miyazaki Y, Yoshii C, Nakaya M, Ozaki N, Toda S, et al. An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat Commun. 2014;5:3755. https:\/\/doi.org\/10.1038\/ncomms4755.","journal-title":"Nat Commun"},{"issue":"1","key":"840_CR42","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.coi.2009.01.009","volume":"21","author":"JW Ford","year":"2009","unstructured":"Ford JW, McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol. 2009;21(1):38\u201346. https:\/\/doi.org\/10.1016\/j.coi.2009.01.009.","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"840_CR43","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.imlet.2007.04.011","volume":"111","author":"R El Mezayen","year":"2007","unstructured":"El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007;111(1):36\u201344. https:\/\/doi.org\/10.1016\/j.imlet.2007.04.011.","journal-title":"Immunol Lett"},{"key":"840_CR44","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1742-2094-11-106","volume":"11","author":"Q Sun","year":"2014","unstructured":"Sun Q, Wu W, Hu YC, Li H, Zhang D, Li S, et al. Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro. J Neuroinflammation. 2014;11:106. https:\/\/doi.org\/10.1186\/1742-2094-11-106.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"840_CR45","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3171\/jns.1996.85.1.0138","volume":"85","author":"PG Matz","year":"1996","unstructured":"Matz PG, Sundaresan S, Sharp FR, Weinstein PR. Induction of HSP70 in rat brain following subarachnoid hemorrhage produced by endovascular perforation. J Neurosurg. 1996;85(1):138\u201345. https:\/\/doi.org\/10.3171\/jns.1996.85.1.0138.","journal-title":"J Neurosurg"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-020-00840-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-020-00840-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-020-00840-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T23:10:39Z","timestamp":1630278639000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-020-00840-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,30]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["840"],"URL":"https:\/\/doi.org\/10.1007\/s12975-020-00840-x","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,30]]},"assertion":[{"value":"9 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All experimental procedures were implemented according to the National Institute of Health Guide for the Care and Use of Laboratory Animals (NIH Publication No. 80-23, revised 1996) and approved by the Experimental Animal Ethical Committee of The First Affiliated Hospital of University of Science and Technology of China.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}