{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:43:52Z","timestamp":1794008632537,"version":"4.8.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K10825"],"award-info":[{"award-number":["JP17K10825"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K09346"],"award-info":[{"award-number":["JP20K09346"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s12975-020-00886-x","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T20:08:02Z","timestamp":1610222882000},"page":"808-816","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Higher Plasma Osteopontin Concentrations Associated with Subsequent Development of Chronic Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.1007","volume":"12","author":[{"given":"Reona","family":"Asada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Nakatsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kanamaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Shiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Toma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-5448","authenticated-orcid":false,"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"pSEED group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"key":"886_CR1","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.wneu.2017.06.119","volume":"106","author":"Z Xie","year":"2017","unstructured":"Xie Z, Hu X, Zan X, Lin S, Li H, You C. Predictors of shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage? A systematic review and meta-analysis. World Neurosurg. 2017;106:844\u201360.","journal-title":"World Neurosurg"},{"key":"886_CR2","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1007\/s12975-019-00697-9","volume":"10","author":"SM Adil","year":"2019","unstructured":"Adil SM, Liu B, Charalambous LT, Kiyani M, Gramer R, Swisher CB, et al. Healthcare economics of hydrocephalus after aneurysmal subarachnoid hemorrhage in the United States. Transl Stroke Res. 2019;10:650\u201363.","journal-title":"Transl Stroke Res"},{"key":"886_CR3","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1007\/s00415-006-0184-1","volume":"253","author":"H Suzuki","year":"2006","unstructured":"Suzuki H, Muramatsu M, Tanaka K, Fujiwara H, Kojima T, Taki W. Cerebrospinal fluid ferritin in chronic hydrocephalus after aneurysmal subarachnoid hemorrhage. J Neurol. 2006;253:1170\u20136.","journal-title":"J Neurol"},{"key":"886_CR4","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3171\/2016.5.JNS152907","volume":"127","author":"Y Nakatsuka","year":"2017","unstructured":"Nakatsuka Y, Kawakita F, Yasuda R, Umeda Y, Toma N, Sakaida H, et al. Preventive effects of cilostazol against the development of shunt-dependent hydrocephalus after subarachnoid hemorrhage. J Neurosurg. 2017;127:319\u201326.","journal-title":"J Neurosurg"},{"key":"886_CR5","doi-asserted-by":"publisher","first-page":"8584753","DOI":"10.1155\/2017\/8584753","volume":"2017","author":"S Chen","year":"2017","unstructured":"Chen S, Luo J, Reis C, Manaenko A, Zhang J. Hydrocephalus after subarachnoid hemorrhage: pathophysiology, diagnosis, and treatment. Biomed Res Int. 2017;2017:8584753. https:\/\/doi.org\/10.1155\/2017\/8584753.","journal-title":"Biomed Res Int"},{"key":"886_CR6","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1161\/STROKEAHA.107.505735","volume":"39","author":"H Suzuki","year":"2008","unstructured":"Suzuki H, Kinoshita N, Imanaka-Yoshida K, Yoshida T, Taki W. Cerebrospinal fluid tenascin-C increases preceding the development of chronic shunt-dependent hydrocephalus after subarachnoid hemorrhage. Stroke. 2008;39:1610\u20132.","journal-title":"Stroke."},{"key":"886_CR7","doi-asserted-by":"publisher","first-page":"8918","DOI":"10.1111\/jcmm.15641","volume":"24","author":"Y Zhou","year":"2020","unstructured":"Zhou Y, Yao Y, Sheng L, Zhang J, Zhang JH, Shao A. Osteopontin as a candidate of therapeutic application for the acute brain injury. J Cell Mol Med. 2020;24:8918\u201329.","journal-title":"J Cell Mol Med"},{"key":"886_CR8","doi-asserted-by":"publisher","first-page":"113057","DOI":"10.1016\/j.expneurol.2019.113057","volume":"322","author":"F Kawakita","year":"2019","unstructured":"Kawakita F, Kanamaru H, Asada R, Suzuki H. Potential roles of matricellular proteins in stroke. Exp Neurol. 2019;322:113057. https:\/\/doi.org\/10.1016\/j.expneurol.2019.113057.","journal-title":"Exp Neurol"},{"key":"886_CR9","doi-asserted-by":"publisher","first-page":"e198","DOI":"10.1111\/j.1755-5922.2011.00276.x","volume":"30","author":"H Okamoto","year":"2012","unstructured":"Okamoto H, Imanaka-Yoshida K. Matricellular proteins: new molecular targets to prevent heart failure. Cardiovasc Ther. 2012;30:e198\u2013209.","journal-title":"Cardiovasc Ther"},{"key":"886_CR10","doi-asserted-by":"publisher","first-page":"6841","DOI":"10.1007\/s12035-018-0893-3","volume":"55","author":"Y Nakatsuka","year":"2018","unstructured":"Nakatsuka Y, Shiba M, Nishikawa H, Terashima M, Kawakita F, Fujimoto M, et al. Acute-phase plasma osteopontin as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage. Mol Neurobiol. 2018;55:6841\u20139.","journal-title":"Mol Neurobiol"},{"key":"886_CR11","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3390\/cells8070695","volume":"8","author":"MG Abate","year":"2019","unstructured":"Abate MG, Moretto L, Licari I, Esposito T, Capuano L, Olivieri C, et al. Osteopontin in the cerebrospinal fluid of patients with severe aneurysmal subarachnoid hemorrhage. Cells. 2019;8:695. https:\/\/doi.org\/10.3390\/cells8070695.","journal-title":"Cells."},{"key":"886_CR12","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.4103\/1673-5374.235022","volume":"13","author":"H Suzuki","year":"2018","unstructured":"Suzuki H, Nishikawa H, Kawakita F. Matricellular proteins as possible biomarkers for early brain injury after aneurysmal subarachnoid hemorrhage. Neural Regen Res. 2018;13:1175\u20138.","journal-title":"Neural Regen Res"},{"key":"886_CR13","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.ajpath.2013.06.005","volume":"183","author":"T Tsukui","year":"2013","unstructured":"Tsukui T, Ueha S, Abe J, Hashimoto SI, Shichino S, Shimaoka T, et al. Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis. Am J Pathol. 2013;183:758\u201373.","journal-title":"Am J Pathol"},{"key":"886_CR14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12989-017-0198-0","volume":"14","author":"J Dong","year":"2017","unstructured":"Dong J, Ma Q. Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-\u03b21 activation and myofibroblast differentiation. Part Fibre Toxicol. 2017;14:18. https:\/\/doi.org\/10.1186\/s12989-017-0198-0.","journal-title":"Part Fibre Toxicol"},{"key":"886_CR15","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s12975-019-00713-y","volume":"10","author":"H Suzuki","year":"2019","unstructured":"Suzuki H. Inflammation: a good research target to improve outcomes of poor-grade subarachnoid hemorrhage. Transl Stroke Res. 2019;10:597\u2013600.","journal-title":"Transl Stroke Res"},{"key":"886_CR16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1227\/01.NEU.0000218821.34014.1B","volume":"59","author":"JA Frontera","year":"2006","unstructured":"Frontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, Connolly ES, et al. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified Fisher scale. Neurosurgery. 2006;59:21\u20136.","journal-title":"Neurosurgery."},{"key":"886_CR17","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1161\/STROKEAHA.110.589275","volume":"41","author":"MDI Vergouwen","year":"2010","unstructured":"Vergouwen MDI, Vermeulen M, van Gijn J, Rinkel GJE, Wijdicks EF, Muizelaar JP, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41:2391\u20135.","journal-title":"Stroke."},{"key":"886_CR18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.nec.2009.10.013","volume":"21","author":"AV Germanwala","year":"2010","unstructured":"Germanwala AV, Huang J, Tamargo RJ. Hydrocephalus after aneurysmal subarachnoid hemorrhage. Neurosurg Clin N Am. 2010;21:263\u201370.","journal-title":"Neurosurg Clin N Am"},{"key":"886_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.7461\/jcen.2014.16.2.78","volume":"16","author":"IS Bae","year":"2014","unstructured":"Bae IS, Yi HJ, Choi KS, Chun HJ. Comparison of incidence and risk factors for shunt-dependent hydrocephalus in aneurysmal subarachnoid hemorrhage patients. J Cerebrovasc Endovasc Neurosurg. 2014;16:78\u201384.","journal-title":"J Cerebrovasc Endovasc Neurosurg"},{"key":"886_CR20","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3171\/2015.11.JNS152094","volume":"126","author":"CD Wilson","year":"2017","unstructured":"Wilson CD, Safavi-Abbasi S, Sun H, Kalani MYS, Zhao YD, Levitt MR, et al. Meta-analysis and systematic review of risk factors for shunt dependency after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2017;126:586\u201395.","journal-title":"J Neurosurg"},{"key":"886_CR21","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1007\/s00701-014-2200-z","volume":"156","author":"HO Erixon","year":"2014","unstructured":"Erixon HO, Sorteberg A, Sorteberg W, Eide PK. Predictors of shunt dependency after aneurysmal subarachnoid hemorrhage: results of a single-center clinical trial. Acta Neurochir. 2014;156:2059\u201369.","journal-title":"Acta Neurochir"},{"key":"886_CR22","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3171\/jns.1999.91.1.0080","volume":"91","author":"EM Massicotte","year":"1999","unstructured":"Massicotte EM, Del Bigio MR. Human arachnoid villi response to subarachnoid hemorrhage: possible relationship to chronic hydrocephalus. J Neurosurg. 1999;91:80\u20134.","journal-title":"J Neurosurg"},{"key":"886_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/BF01411441","volume":"136","author":"O Motohashi","year":"1995","unstructured":"Motohashi O, Suzuki M, Shida N, Umezawa K, Ohtoh T, Sakurai Y, et al. Subarachnoid haemorrhage induced proliferation of leptomeningeal cells and deposition of extracellular matrices in the arachnoid granulations and subarachnoid space: immunohistochemical study. Acta Neurochir. 1995;136:88\u201391.","journal-title":"Acta Neurochir"},{"key":"886_CR24","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1097\/00006123-199911000-00021","volume":"45","author":"JP Sheehan","year":"1999","unstructured":"Sheehan JP, Polin RS, Sheehan JM, Baskaya MK, Kassell NF. Factors associated with hydrocephalus after aneurysmal subarachnoid hemorrhage. Neurosurgery. 1999;45:1120\u20138.","journal-title":"Neurosurgery."},{"key":"886_CR25","first-page":"R263","volume":"277","author":"CE Johanson","year":"1999","unstructured":"Johanson CE, Szmydynger-Chodobska J, Chodobski A, Baird A, McMillan P, Stopa EG. Altered formation and bulk absorption of cerebrospinal fluid in FGF-2-induced hydrocephalus. Am J Phys. 1999;277:R263\u201371.","journal-title":"Am J Phys"},{"key":"886_CR26","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1161\/01.STR.25.7.1400","volume":"25","author":"K Kitazawa","year":"1994","unstructured":"Kitazawa K, Tada T. Elevation of transforming growth factor-beta1 level in cerebrospinal fluid of patients with communicating hydrocephalus after subarachnoid hemorrhage. Stroke. 1994;25:1400\u20134.","journal-title":"Stroke."},{"key":"886_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0304-3940(95)11513-V","volume":"190","author":"O Motohashi","year":"1995","unstructured":"Motohashi O, Suzuki M, Yanai N, Umezawa K, Shida N, Yoshimoto T. Thrombin and TGF-beta promote human leptomeningeal cell proliferation in vitro. Neurosci Lett. 1995;190:105\u20138.","journal-title":"Neurosci Lett"},{"key":"886_CR28","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0165-5728(94)90041-8","volume":"50","author":"T Tada","year":"1994","unstructured":"Tada T, Kanaji M, Kobayashi S. Induction of communicating hydrocephalus in mice by intrathecal injection of human recombinant transforming growth factor-beta1. J Neuroimmunol. 1994;50:153\u20138.","journal-title":"J Neuroimmunol"},{"key":"886_CR29","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10555-010-9221-8","volume":"29","author":"C Chiodoni","year":"2010","unstructured":"Chiodoni C, Colombo MP, Sangaletti S. Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis. Cancer Metastasis Rev. 2010;29:295\u2013307.","journal-title":"Cancer Metastasis Rev"},{"key":"886_CR30","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1172\/JCI12980","volume":"107","author":"DT Denhardt","year":"2001","unstructured":"Denhardt DT, Noda M, O\u2019Regan AW, Pavlin D, Berman JS. Matricellular proteins osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest. 2001;107:1055\u201361.","journal-title":"J Clin Invest"},{"key":"886_CR31","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/ana.22102","volume":"68","author":"H Suzuki","year":"2010","unstructured":"Suzuki H, Hasegawa Y, Chen W, Kanamaru K, Zhang JH. Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage. Ann Neurol. 2010;68:650\u201360.","journal-title":"Ann Neurol"},{"key":"886_CR32","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1161\/STROKEAHA.115.011552","volume":"47","author":"J Wu","year":"2016","unstructured":"Wu J, Zhang Y, Yang P, Enkhjargal B, Manaenko A, Tang J, et al. Recombinant osteopontin stabilizes smooth muscle cell phenotype via integrin receptor\/integrin-linked kinase\/Rac-1 pathway after subarachnoid hemorrhage in rats. Stroke. 2016;47:1319\u201327.","journal-title":"Stroke."},{"key":"886_CR33","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1177\/0271678X16671147","volume":"37","author":"B Enkhjargal","year":"2017","unstructured":"Enkhjargal B, McBride DW, Manaenko A, Reis C, Sakai Y, Tang J, et al. Intranasal administration of vitamin D attenuates blood\u2013brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44\/P-gp glycosylation signaling after subarachnoid hemorrhage in rats. J Cereb Blood Flow Metab. 2017;37:2555\u201366.","journal-title":"J Cereb Blood Flow Metab"},{"key":"886_CR34","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1161\/STROKEAHA.110.586537","volume":"41","author":"H Suzuki","year":"2010","unstructured":"Suzuki H, Hasegawa Y, Kanamaru K, Zhang JH. Mechanisms of osteopontin-induced stabilization of blood-brain barrier disruption after subarachnoid hemorrhage in rats. Stroke. 2010;41:1783\u201390.","journal-title":"Stroke."},{"key":"886_CR35","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/cns.13199","volume":"25","author":"CM Sun","year":"2019","unstructured":"Sun CM, Enkhjargal B, Reis C, Zhou KR, Xie ZY, Wu LY, et al. Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats. CNS Neurosci Ther. 2019;25:1162\u201372.","journal-title":"CNS Neurosci Ther"},{"key":"886_CR36","first-page":"74","volume":"2015","author":"J He","year":"1611","unstructured":"He J, Liu M, Liu Z, Luo L. Recombinant osteopontin attenuates experimental cerebral vasospasm following subarachnoid hemorrhage in rats through an anti-apoptotic mechanism. Brain Res. 1611;2015:74\u201383.","journal-title":"Brain Res"},{"key":"886_CR37","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3390\/cells8090980","volume":"8","author":"C Sun","year":"2019","unstructured":"Sun C, Enkhjargal B, Reis C, Zhang T, Zhu Q, Zhou K, et al. Osteopontin-enhanced autophagy attenuates early brain injury via FAK\u2013ERK pathway and improves long-term outcome after subarachnoid hemorrhage in rats. Cells. 2019;8:980. https:\/\/doi.org\/10.3390\/cells8090980.","journal-title":"Cells."},{"key":"886_CR38","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.3390\/cells8121558","volume":"8","author":"I Abdelaziz Mohamed","year":"2019","unstructured":"Abdelaziz Mohamed I, Gadeau AP, Hasan A, Abdulrahman N, Mraiche F. Osteopontin: a promising therapeutic target in cardiac fibrosis. Cells. 2019;8:1558. https:\/\/doi.org\/10.3390\/cells8121558.","journal-title":"Cells."},{"key":"886_CR39","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s12079-009-0068-0","volume":"3","author":"SA Lund","year":"2009","unstructured":"Lund SA, Giachelli CM, Scatena M. The role of osteopontin in inflammatory processes. J Cell Commun Signal. 2009;3:311\u201322.","journal-title":"J Cell Commun Signal"},{"key":"886_CR40","doi-asserted-by":"publisher","first-page":"117328","DOI":"10.1016\/j.lfs.2020.117328","volume":"245","author":"R Lin","year":"2020","unstructured":"Lin R, Wu S, Zhu D, Qin M, Liu X. Osteopontin induces atrial fibrosis by activating Akt\/GSK-3\u03b2\/\u03b2-catenin pathway and suppressing autophagy. Life Sci. 2020;245:117328. https:\/\/doi.org\/10.1016\/j.lfs.2020.117328.","journal-title":"Life Sci"},{"key":"886_CR41","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ana.23529","volume":"71","author":"M Gliem","year":"2012","unstructured":"Gliem M, Mausberg AK, Lee JI, Simiantonakis I, van Rooijen N, Hartung HP, et al. Macrophages prevent hemorrhagic infarct transformation in murine stroke models. Ann Neurol. 2012;71:743\u201352.","journal-title":"Ann Neurol"},{"key":"886_CR42","doi-asserted-by":"publisher","first-page":"12870","DOI":"10.1523\/JNEUROSCI.2121-13.2013","volume":"33","author":"IB Wanner","year":"2013","unstructured":"Wanner IB, Anderson MA, Song B, Levine J, Fernandez A, Gray-Thompson Z, et al. Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J Neurosci. 2013;33:12870\u201386.","journal-title":"J Neurosci"},{"key":"886_CR43","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1002\/glia.22885","volume":"63","author":"M Gliem","year":"2015","unstructured":"Gliem M, Krammes K, Liaw L, van Rooijen N, Hartung HP, Jander S. Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke. Glia. 2015;63:2198\u2013207.","journal-title":"Glia."},{"key":"886_CR44","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/neup.12262","volume":"36","author":"M Ueno","year":"2016","unstructured":"Ueno M, Chiba Y, Matsumoto K, Murakami R, Fujihara R, Kawauchi M, et al. Blood-brain barrier damage in vascular dementia. Neuropathology. 2016;36:115\u201324.","journal-title":"Neuropathology."}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-020-00886-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-020-00886-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-020-00886-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T09:56:35Z","timestamp":1630922195000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-020-00886-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,9]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["886"],"URL":"https:\/\/doi.org\/10.1007\/s12975-020-00886-x","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,9]]},"assertion":[{"value":"5 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the ethical committee of Mie University Hospital (Ethics approval number: 2544 and H2018-031).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The ethical committee waived the need for informed consent with opt-out.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}