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Stroke Res."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to study the distribution of Circle of Willis (CoW) morphology and its association with intracerebral hemorrhage (ICH) etiology and cerebral small vessel disease (CSVD) burden. Patients with primary ICH who had brain MRIs were consecutively enrolled between March 2012 and January 2021. CoW morphology, CSVD features and the combined CSVD burden (including global CSVD burden, total hypertensive arteriopathy [HA] burden, and total cerebral amyloid angiopathy [CAA] burden) were assessed. CoW morphology included poor CoW (defined as CoW score 0\u20132), incomplete CoW, and complete fetal-variant of the posterior communicating artery (CFPcoA). Among 296 patients enrolled, 215 were included in the analysis. There was no significant difference among HA-, CAA-, and mixed-ICH in each CoW morphology. Exploratory subgroup analyses suggested that poor CoW was associated with a greater incidence of HA-ICH and low incidence of mixed ICH in patients aged &lt; 60 years, while mixed ICH occurred more frequently in patients with CFPcoA, especially in those without hypertension history (all <jats:italic>p<\/jats:italic> &lt; 0.050). Additionally, incomplete CoW was correlated with a larger incidence of lacunes (adjusted <jats:italic>OR<\/jats:italic> [adOR] 2.114, 95% <jats:italic>CI<\/jats:italic> 1.062\u20134.207), microbleeds \u2265 5 (adOR 2.437, 95% <jats:italic>CI<\/jats:italic> 1.187\u20135.002), and therefore the combined CSVD burden (adOR 1.194, 95% <jats:italic>CI<\/jats:italic> 1.004\u20131.419 for global CSVD burden, adOR 1.343, 95% <jats:italic>CI<\/jats:italic> 1.056\u20131.707 for total CAA burden), independent of modifiable vascular risk factors, but not age and sex. The CoW might therefore have a potential impact on ICH etiology and is associated with a greater CSVD burden. Our findings are novel, and need to be verified in future studies.<\/jats:p>","DOI":"10.1007\/s12975-022-00997-7","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T20:02:41Z","timestamp":1645300961000},"page":"736-744","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circle of Willis Morphology in Primary Intracerebral Hemorrhage"],"prefix":"10.1007","volume":"13","author":[{"given":"Mangmang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deren","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-9965","authenticated-orcid":false,"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,19]]},"reference":[{"key":"997_CR1","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","volume":"344","author":"AI Qureshi","year":"2001","unstructured":"Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. 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