{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:31:17Z","timestamp":1788388277145,"version":"build-2803163510"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"UTHSC Collaborative Research Network Award"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl. Stroke Res."],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12975-022-01001-y","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T01:02:43Z","timestamp":1646787763000},"page":"881-897","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Systematic Review of Inflammatory Cytokine Changes Following Aneurysmal Subarachnoid Hemorrhage in Animal Models and Humans"],"prefix":"10.1007","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0359-4620","authenticated-orcid":false,"given":"Patrick","family":"Devlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9869-1342","authenticated-orcid":false,"given":"Tauheed","family":"Ishrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-1130","authenticated-orcid":false,"given":"Ansley Grimes","family":"Stanfill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"issue":"3","key":"1001_CR1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/ANA.0000000000000130","volume":"27","author":"S D'Souza","year":"2015","unstructured":"D\u2019Souza S. Aneurysmal subarachnoid hemorrhage. J Neurosurg Anesthesiol. 2015;27(3):222\u201340.","journal-title":"J Neurosurg Anesthesiol"},{"issue":"1","key":"1001_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S1474-4422(03)00266-7","volume":"2","author":"VL Feigin","year":"2003","unstructured":"Feigin VL, Lawes CM, Bennett DA, Anderson CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol. 2003;2(1):43\u201353.","journal-title":"Lancet Neurol"},{"issue":"1","key":"1001_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s13054-015-1036-0","volume":"19","author":"H Lantigua","year":"2015","unstructured":"Lantigua H, Ortega-Gutierrez S, Schmidt JM, Lee K, Badjatia N, Agarwal S, Claassen J, Connolly ES, Mayer SA. Subarachnoid hemorrhage: who dies, and why? Crit Care. 2015;19(1):309.","journal-title":"Crit Care"},{"issue":"10","key":"1001_CR4","first-page":"1","volume":"16","author":"I Aisiku","year":"2014","unstructured":"Aisiku I, Edlow JA, Goldstein J, Thomas LE. An evidence-based approach to diagnosis and management of subarachnoid hemorrhage in the emergency department. Emerg Med Pract. 2014;16(10):1\u201329 (quiz 29\u201330).","journal-title":"Emerg Med Pract"},{"issue":"4","key":"1001_CR5","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s10143-017-0827-y","volume":"41","author":"JH van Lieshout","year":"2018","unstructured":"van Lieshout JH, Dibu\u00e9-Adjei M, Cornelius JF, Slotty PJ, Schneider T, Restin T, Boogaarts HD, Steiger HJ, Petridis AK, Kamp MA. An introduction to the pathophysiology of aneurysmal subarachnoid hemorrhage. Neurosurg Rev. 2018;41(4):917\u201330.","journal-title":"Neurosurg Rev"},{"key":"1001_CR6","doi-asserted-by":"crossref","unstructured":"Zeiler FA, Thelin EP, Czosnyka M, Hutchinson PJ, Menon DK, Helmy A: Cerebrospinal fluid and microdialysis cytokines in aneurysmal subarachnoid hemorrhage: a scoping systematic review. Frontiers in Neurology 2017, 8(379).","DOI":"10.3389\/fneur.2017.00379"},{"key":"1001_CR7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.cca.2018.08.011","volume":"486","author":"J Gong","year":"2018","unstructured":"Gong J, Zhu Y, Yu J, Jin J, Chen M, Liu W, Zhan R. Increased serum interleukin-33 concentrations predict worse prognosis of aneurysmal subarachnoid hemorrhage. Clin Chim Acta. 2018;486:214\u20138.","journal-title":"Clin Chim Acta"},{"issue":"4","key":"1001_CR8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s10571-014-0143-9","volume":"35","author":"LT Huang","year":"2015","unstructured":"Huang LT, Li H, Sun Q, Liu M, Li WD, Li S, Yu Z, Wei WT, Hang CH. IL-33 expression in the cerebral cortex following experimental subarachnoid hemorrhage in rats. Cell Mol Neurobiol. 2015;35(4):493\u2013501.","journal-title":"Cell Mol Neurobiol"},{"key":"1001_CR9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.cyto.2017.05.025","volume":"97","author":"SR Chaudhry","year":"2017","unstructured":"Chaudhry SR, G\u00fcresir E, Vatter H, Kinfe TM, Dietrich D, Lamprecht A, Muhammad S. Aneurysmal subarachnoid hemorrhage lead to systemic upregulation of IL-23\/IL-17 inflammatory axis. Cytokine. 2017;97:96\u2013103.","journal-title":"Cytokine"},{"key":"1001_CR10","doi-asserted-by":"crossref","unstructured":"Chaudhry SR, Kahlert UD, Kinfe TM, Lamprecht A, Niemel\u00e4 M, H\u00e4nggi D, Muhammad S: Elevated systemic IL-10 levels indicate immunodepression leading to nosocomial infections after aneurysmal subarachnoid hemorrhage (SAH) in Patients. Int J Mol Sci 2020, 21(5).","DOI":"10.3390\/ijms21051569"},{"key":"1001_CR11","doi-asserted-by":"crossref","unstructured":"Chaudhry SR, Stoffel-Wagner B, Kinfe TM, G\u00fcresir E, Vatter H, Dietrich D, Lamprecht A, Muhammad S: Elevated systemic IL-6 levels in patients with aneurysmal subarachnoid hemorrhage is an unspecific marker for post-SAH complications. Int J Mol Sci 2017, 18(12).","DOI":"10.3390\/ijms18122580"},{"issue":"1","key":"1001_CR12","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s12974-019-1578-1","volume":"16","author":"SH Ahn","year":"2019","unstructured":"Ahn SH, Savarraj JPJ, Parsha K, Hergenroeder GW, Chang TR, Kim DH, Kitagawa RS, Blackburn SL, Choi HA. Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage. J Neuroinflammation. 2019;16(1):213.","journal-title":"J Neuroinflammation"},{"issue":"2","key":"1001_CR13","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1378\/chest.118.2.503","volume":"118","author":"CA Dinarello","year":"2000","unstructured":"Dinarello CA. Proinflammatory cytokines. Chest. 2000;118(2):503\u20138.","journal-title":"Chest"},{"key":"1001_CR14","doi-asserted-by":"crossref","unstructured":"Kany S, Vollrath JT, Relja B: Cytokines in inflammatory disease. Int J Mol Sci 2019, 20(23).","DOI":"10.3390\/ijms20236008"},{"issue":"1","key":"1001_CR15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/imr.12671","volume":"285","author":"JM Cicchese","year":"2018","unstructured":"Cicchese JM, Evans S, Hult C, Joslyn LR, Wessler T, Millar JA, Marino S, Cilfone NA, Mattila JT, Linderman JJ, et al. Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology. Immunol Rev. 2018;285(1):147\u201367.","journal-title":"Immunol Rev"},{"key":"1001_CR16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.bbi.2017.01.021","volume":"62","author":"R Hou","year":"2017","unstructured":"Hou R, Garner M, Holmes C, Osmond C, Teeling J, Lau L, Baldwin DS. Peripheral inflammatory cytokines and immune balance in generalised anxiety disorder: case-controlled study. Brain Behav Immun. 2017;62:212\u20138.","journal-title":"Brain Behav Immun"},{"key":"1001_CR17","doi-asserted-by":"publisher","first-page":"1852517","DOI":"10.1155\/2017\/1852517","volume":"2017","author":"C Musolino","year":"2017","unstructured":"Musolino C, Allegra A, Innao V, Allegra AG, Pioggia G, Gangemi S. Inflammatory and anti-inflammatory equilibrium, proliferative and antiproliferative balance: the role of cytokines in multiple myeloma. Mediators Inflamm. 2017;2017:1852517.","journal-title":"Mediators Inflamm"},{"issue":"2","key":"1001_CR18","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/ane.13353","volume":"143","author":"S Bjerkne Wenneberg","year":"2021","unstructured":"Bjerkne Wenneberg S, Odenstedt Herg\u00e8s H, Svedin P, Mallard C, Karlsson T, Adiels M, Naredi S, Block L. Association between inflammatory response and outcome after subarachnoid haemorrhage. Acta Neurol Scand. 2021;143(2):195\u2013205.","journal-title":"Acta Neurol Scand"},{"key":"1001_CR19","doi-asserted-by":"publisher","first-page":"154778","DOI":"10.1016\/j.cyto.2019.154778","volume":"123","author":"YZ Al-Tamimi","year":"2019","unstructured":"Al-Tamimi YZ, Bhargava D, Orsi NM, Teraifi A, Cummings M, Ekbote UV, Quinn AC, Homer-Vanniasinkam S, Ross S. Compartmentalisation of the inflammatory response following aneurysmal subarachnoid haemorrhage. Cytokine. 2019;123:154778.","journal-title":"Cytokine"},{"key":"1001_CR20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.wneu.2016.11.131","volume":"99","author":"M Lenski","year":"2017","unstructured":"Lenski M, Huge V, Briegel J, Tonn JC, Schichor C, Thon N. Interleukin 6 in the cerebrospinal fluid as a biomarker for onset of vasospasm and ventriculitis after severe subarachnoid hemorrhage. World Neurosurg. 2017;99:132\u20139.","journal-title":"World Neurosurg"},{"issue":"1","key":"1001_CR21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41598-020-79586-3","volume":"11","author":"S Ridwan","year":"2021","unstructured":"Ridwan S, Grote A, Simon M. Interleukin 6 in cerebrospinal fluid is a biomarker for delayed cerebral ischemia (DCI) related infarctions after aneurysmal subarachnoid hemorrhage. Sci Rep. 2021;11(1):12.","journal-title":"Sci Rep"},{"issue":"7","key":"1001_CR22","doi-asserted-by":"publisher","first-page":"e0132115","DOI":"10.1371\/journal.pone.0132115","volume":"10","author":"HW Kao","year":"2015","unstructured":"Kao HW, Lee KW, Kuo CL, Huang CS, Tseng WM, Liu CS, Lin CP. Interleukin-6 as a prognostic biomarker in ruptured intracranial aneurysms. PLoS One. 2015;10(7):e0132115.","journal-title":"PLoS One"},{"key":"1001_CR23","doi-asserted-by":"publisher","first-page":"e362","DOI":"10.1016\/j.wneu.2017.12.076","volume":"111","author":"SY Lv","year":"2018","unstructured":"Lv SY, Wu Q, Liu JP, Shao J, Wen LL, Xue J, Zhang XS, Zhang QR, Zhang X. Levels of interleukin-1\u03b2, interleukin-18, and tumor necrosis factor-\u03b1 in cerebrospinal fluid of aneurysmal subarachnoid hemorrhage patients may be predictors of early brain injury and clinical prognosis. World Neurosurg. 2018;111:e362\u201373.","journal-title":"World Neurosurg"},{"issue":"1","key":"1001_CR24","doi-asserted-by":"publisher","first-page":"11809","DOI":"10.1038\/s41598-020-68861-y","volume":"10","author":"JA Roa","year":"2020","unstructured":"Roa JA, Sarkar D, Zanaty M, Ishii D, Lu Y, Karandikar NJ, Hasan DM, Ortega SB, Samaniego EA. Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. Sci Rep. 2020;10(1):11809.","journal-title":"Sci Rep"},{"issue":"5","key":"1001_CR25","doi-asserted-by":"publisher","first-page":"652","DOI":"10.2174\/1567202617666201214104623","volume":"17","author":"AM Gusdon","year":"2020","unstructured":"Gusdon AM, Savarraj J, Zhu L, Pandit PKT, Dor\u00e9 S, McBride DW, Choi HA, Blackburn SL. Haptoglobin genotype affects inflammation after aneurysmal subarachnoid hemorrhage. Curr Neurovasc Res. 2020;17(5):652\u20139.","journal-title":"Curr Neurovasc Res"},{"issue":"1","key":"1001_CR26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12974-016-0675-7","volume":"13","author":"A Niwa","year":"2016","unstructured":"Niwa A, Osuka K, Nakura T, Matsuo N, Watabe T, Takayasu M. Interleukin-6, MCP-1, IP-10, and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage. J Neuroinflammation. 2016;13(1):217.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"1001_CR27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s13054-015-0954-1","volume":"19","author":"A H\u00f6llig","year":"2015","unstructured":"H\u00f6llig A, Thiel M, Stoffel-Wagner B, Coburn M, Clusmann H. Neuroprotective properties of dehydroepiandrosterone-sulfate and its relationship to interleukin 6 after aneurysmal subarachnoid hemorrhage: a prospective cohort study. Crit Care. 2015;19(1):231.","journal-title":"Crit Care"},{"issue":"3","key":"1001_CR28","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s12975-018-0657-4","volume":"10","author":"S Marbacher","year":"2019","unstructured":"Marbacher S, Gr\u00fcter B, Sch\u00f6pf S, Croci D, Nevzati E, D\u2019Alonzo D, Lattmann J, Roth T, Bircher B, Wolfert C, et al. systematic review of in vivo animal models of subarachnoid hemorrhage: species, standard parameters, and outcomes. Transl Stroke Res. 2019;10(3):250\u20138.","journal-title":"Transl Stroke Res"},{"issue":"12","key":"1001_CR29","doi-asserted-by":"publisher","first-page":"e114946","DOI":"10.1371\/journal.pone.0114946","volume":"9","author":"MA Kamp","year":"2014","unstructured":"Kamp MA, Dibu\u00e9 M, Sommer C, Steiger HJ, Schneider T, H\u00e4nggi D. Evaluation of a murine single-blood-injection SAH model. PLoS One. 2014;9(12):e114946.","journal-title":"PLoS One"},{"issue":"5","key":"1001_CR30","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/s11064-017-2179-y","volume":"42","author":"N Wei","year":"2017","unstructured":"Wei N, Wei Y, Li B, Pang L. Baicalein promotes neuronal and behavioral recovery after intracerebral hemorrhage via suppressing apoptosis, oxidative stress and neuroinflammation. Neurochem Res. 2017;42(5):1345\u201353.","journal-title":"Neurochem Res"},{"key":"1001_CR31","doi-asserted-by":"crossref","unstructured":"Zhang XS, Li W, Wu Q, Wu LY, Ye ZN, Liu JP, Zhuang Z, Zhou ML, Zhang X, Hang CH: Resveratrol attenuates acute inflammatory injury in experimental subarachnoid hemorrhage in rats via inhibition of TLR4 pathway. Int J Mol Sci 2016, 17(8).","DOI":"10.3390\/ijms17081331"},{"issue":"8","key":"1001_CR32","first-page":"702","volume":"40","author":"L Tu","year":"2018","unstructured":"Tu L, Yang XL, Zhang Q, Wang Q, Tian T, Liu D, Qu X, Tian JY. Bexarotene attenuates early brain injury via inhibiting micoglia activation through PPAR\u03b3 after experimental subarachnoid hemorrhage. Neurol Res. 2018;40(8):702\u20138.","journal-title":"Neurol Res"},{"issue":"11","key":"1001_CR33","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1515\/hsz-2018-0269","volume":"399","author":"Z Li","year":"2018","unstructured":"Li Z, Han X. Resveratrol alleviates early brain injury following subarachnoid hemorrhage: possible involvement of the AMPK\/SIRT1\/autophagy signaling pathway. Biol Chem. 2018;399(11):1339\u201350.","journal-title":"Biol Chem"},{"issue":"6","key":"1001_CR34","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1007\/s11064-016-1863-7","volume":"41","author":"G Hao","year":"2016","unstructured":"Hao G, Dong Y, Huo R, Wen K, Zhang Y, Liang G. Rutin inhibits neuroinflammation and provides neuroprotection in an experimental rat model of subarachnoid hemorrhage, Possibly Through Suppressing the RAGE-NF-\u03baB Inflammatory Signaling Pathway. Neurochem Res. 2016;41(6):1496\u2013504.","journal-title":"Neurochem Res"},{"issue":"12","key":"1001_CR35","first-page":"5643","volume":"9","author":"X Gu","year":"2017","unstructured":"Gu X, Zheng C, Zheng Q, Chen S, Li W, Shang Z, Zhang H. Salvianolic acid A attenuates early brain injury after subarachnoid hemorrhage in rats by regulating ERK\/P38\/Nrf2 signaling. Am J Transl Res. 2017;9(12):5643\u201352.","journal-title":"Am J Transl Res"},{"issue":"4","key":"1001_CR36","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s11064-018-2480-4","volume":"43","author":"Y Peng","year":"2018","unstructured":"Peng Y, Jin J, Fan L, Xu H, He P, Li J, Chen T, Ruan W, Chen G. Rolipram attenuates early brain injury following experimental subarachnoid hemorrhage in rats: possibly via regulating the SIRT1\/NF-\u03baB pathway. Neurochem Res. 2018;43(4):785\u201395.","journal-title":"Neurochem Res"},{"issue":"12","key":"1001_CR37","first-page":"2887","volume":"21","author":"Q Huang","year":"2017","unstructured":"Huang Q, Wang G, Hu YL, Liu JX, Yang J, Wang S, Zhang HB. Study on the expression and mechanism of inflammatory factors in the brain of rats with cerebral vasospasm. Eur Rev Med Pharmacol Sci. 2017;21(12):2887\u201394.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"1001_CR38","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.cyto.2018.09.003","volume":"111","author":"JP Savarraj","year":"2018","unstructured":"Savarraj JP, McGuire MF, Parsha K, Hergenroeder G, Bajgur S, Ahn S, Zhu L, Espino E, Chang T, Blackburn S, et al. Disruption of thrombo-inflammatory response and activation of a distinct cytokine cluster after subarachnoid hemorrhage. Cytokine. 2018;111:334\u201341.","journal-title":"Cytokine"},{"key":"1001_CR39","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.neulet.2016.05.058","volume":"627","author":"Y Wu","year":"2016","unstructured":"Wu Y, Pang J, Peng J, Cao F, Vitek MP, Li F, Jiang Y, Sun X. An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage. Neurosci Lett. 2016;627:92\u20139.","journal-title":"Neurosci Lett"},{"issue":"3","key":"1001_CR40","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/jnc.14926","volume":"152","author":"Y Xie","year":"2020","unstructured":"Xie Y, Peng J, Pang J, Guo K, Zhang L, Yin S, Zhou J, Gu L, Tu T, Mu Q, et al. Biglycan regulates neuroinflammation by promoting M1 microglial activation in early brain injury after experimental subarachnoid hemorrhage. J Neurochem. 2020;152(3):368\u201380.","journal-title":"J Neurochem"},{"issue":"1","key":"1001_CR41","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1080\/13880209.2021.1876101","volume":"59","author":"G Xu","year":"2021","unstructured":"Xu G, Guo J, Sun C. Eucalyptol ameliorates early brain injury after subarachnoid haemorrhage via antioxidant and anti-inflammatory effects in a rat model. Pharm Biol. 2021;59(1):114\u201320.","journal-title":"Pharm Biol"},{"issue":"3","key":"1001_CR42","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12300","volume":"60","author":"Y Dong","year":"2016","unstructured":"Dong Y, Fan C, Hu W, Jiang S, Ma Z, Yan X, Deng C, Di S, Xin Z, Wu G, et al. Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling. J Pineal Res. 2016;60(3):253\u201362.","journal-title":"J Pineal Res"},{"key":"1001_CR43","doi-asserted-by":"publisher","first-page":"104043","DOI":"10.1016\/j.jff.2020.104043","volume":"72","author":"H Zeng","year":"2020","unstructured":"Zeng H, Shao B, Zhuang J, Peng Y, Chen H, Yu Q, Xu C, Fu X, Zhou H, Cao Y, et al. Naringenin reduces early brain injury in subarachnoid hemorrhage (SAH) mice: the role of the AMPK\/SIRT3 signaling pathway. Journal of Functional Foods. 2020;72:104043.","journal-title":"Journal of Functional Foods"},{"issue":"1","key":"1001_CR44","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12974-018-1118-4","volume":"15","author":"Y Lu","year":"2018","unstructured":"Lu Y, Zhang XS, Zhang ZH, Zhou XM, Gao YY, Liu GJ, Wang H, Wu LY, Li W, Hang CH. Peroxiredoxin 2 activates microglia by interacting with toll-like receptor 4 after subarachnoid hemorrhage. J Neuroinflammation. 2018;15(1):87.","journal-title":"J Neuroinflammation"},{"issue":"2","key":"1001_CR45","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1161\/HYPERTENSIONAHA.118.12595","volume":"75","author":"K Mitsui","year":"2020","unstructured":"Mitsui K, Ikedo T, Kamio Y, Furukawa H, Lawton MT, Hashimoto T. TLR4 (toll-like receptor 4) mediates the development of intracranial aneurysm rupture. Hypertension. 2020;75(2):468\u201376.","journal-title":"Hypertension"},{"issue":"1","key":"1001_CR46","doi-asserted-by":"publisher","first-page":"694","DOI":"10.18632\/aging.202178","volume":"13","author":"P Li","year":"2020","unstructured":"Li P, Li X, Deng P, Wang D, Bai X, Li Y, Luo C, Belguise K, Wang X, Wei X, et al. Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly rats. Aging (Albany NY). 2020;13(1):694\u2013713.","journal-title":"Aging (Albany NY)"},{"key":"1001_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/8302831","volume":"2021","author":"H Chen","year":"2021","unstructured":"Chen H, Yu X, Hu L, Peng Y, Yu Q, Zhou H, Xu C, Zeng H, Cao Y, Zhuang J, et al. Activation of nurr1 with amodiaquine protected neuron and alleviated neuroinflammation after subarachnoid hemorrhage in rats. Oxid Med Cell Longev. 2021;2021:1\u201315.","journal-title":"Oxid Med Cell Longev"},{"key":"1001_CR48","doi-asserted-by":"publisher","first-page":"1960106","DOI":"10.1155\/2018\/1960106","volume":"2018","author":"LY Wu","year":"2018","unstructured":"Wu LY, Ye ZN, Zhuang Z, Gao Y, Tang C, Zhou CH, Wang CX, Zhang XS, Xie GB, Liu JP, et al. Biochanin A reduces inflammatory injury and neuronal apoptosis following subarachnoid hemorrhage via suppression of the TLRs\/TIRAP\/MyD88\/NF-\u03baB pathway. Behav Neurol. 2018;2018:1960106.","journal-title":"Behav Neurol"},{"issue":"8","key":"1001_CR49","first-page":"14316","volume":"8","author":"A Wu","year":"2015","unstructured":"Wu A, Liu R, Dai W, Jie Y, Yu G, Fan X, Huang Q. Lycopene attenuates early brain injury and inflammation following subarachnoid hemorrhage in rats. Int J Clin Exp Med. 2015;8(8):14316\u201322.","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"1001_CR50","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10571-014-0106-1","volume":"35","author":"ZY Zhang","year":"2015","unstructured":"Zhang ZY, Sun BL, Yang MF, Li DW, Fang J, Zhang S. Carnosine attenuates early brain injury through its antioxidative and anti-apoptotic effects in a rat experimental subarachnoid hemorrhage model. Cell Mol Neurobiol. 2015;35(2):147\u201357.","journal-title":"Cell Mol Neurobiol"},{"issue":"6","key":"1001_CR51","first-page":"884","volume":"27","author":"HE Aydin","year":"2017","unstructured":"Aydin HE, Bektur NE, Ozbek Z, Oner S, Baycu C, Kilic FS. Comparison of the effects and mechanism of the curcumin with different drugs in experimental vasospasm after subarachnoid hemorrhage. Turk Neurosurg. 2017;27(6):884\u201393.","journal-title":"Turk Neurosurg"},{"issue":"6","key":"1001_CR52","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s00701-016-2795-3","volume":"158","author":"R Fang","year":"2016","unstructured":"Fang R, Zheng X, Zhang M. Ethyl pyruvate alleviates early brain injury following subarachnoid hemorrhage in rats. Acta Neurochir (Wien). 2016;158(6):1069\u201376.","journal-title":"Acta Neurochir (Wien)"},{"key":"1001_CR53","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.bbi.2017.04.020","volume":"65","author":"H Xu","year":"2017","unstructured":"Xu H, Li J, Wang Z, Feng M, Shen Y, Cao S, Li T, Peng Y, Fan L, Chen J, et al. Methylene blue attenuates neuroinflammation after subarachnoid hemorrhage in rats through the Akt\/GSK-3\u03b2\/MEF2D signaling pathway. Brain Behav Immun. 2017;65:125\u201339.","journal-title":"Brain Behav Immun"},{"issue":"6","key":"1001_CR54","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s12264-018-0232-8","volume":"34","author":"HM Hu","year":"2018","unstructured":"Hu HM, Li B, Wang XD, Guo YS, Hui H, Zhang HP, Wang B, Huang DG, Hao DJ. Fluoxetine is neuroprotective in early brain injury via its anti-inflammatory and anti-apoptotic effects in a rat experimental subarachnoid hemorrhage model. Neurosci Bull. 2018;34(6):951\u201362.","journal-title":"Neurosci Bull"},{"issue":"10","key":"1001_CR55","first-page":"1340","volume":"23","author":"C Du","year":"2020","unstructured":"Du C, Xi C, Wu C, Sha J, Zhang J, Li C. Ginkgo biloba extract protects early brain injury after subarachnoid hemorrhage via inhibiting thioredoxin interacting protein\/NLRP3 signaling pathway. Iran J Basic Med Sci. 2020;23(10):1340\u20135.","journal-title":"Iran J Basic Med Sci"},{"issue":"11","key":"1001_CR56","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1161\/STROKEAHA.120.029951","volume":"51","author":"Y Luo","year":"2020","unstructured":"Luo Y, Fang Y, Kang R, Lenahan C, Gamdzyk M, Zhang Z, Okada T, Tang J, Chen S, Zhang JH. Inhibition of EZH2 (enhancer of zeste homolog 2) attenuates neuroinflammation via H3k27me3\/SOCS3\/TRAF6\/NF-\u03baB (trimethylation of histone 3 lysine 27\/suppressor of cytokine signaling 3\/tumor necrosis factor receptor family 6\/nuclear factor-\u03baB) in a rat model of subarachnoid hemorrhage. Stroke. 2020;51(11):3320\u201331.","journal-title":"Stroke"},{"key":"1001_CR57","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.bbi.2020.09.016","volume":"91","author":"X Hu","year":"2021","unstructured":"Hu X, Yan J, Huang L, Araujo C, Peng J, Gao L, Liu S, Tang J, Zuo G, Zhang JH. INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5\/cAMP\/PKA signaling pathway after subarachnoid hemorrhage in rats. Brain Behav Immun. 2021;91:587\u2013600.","journal-title":"Brain Behav Immun"},{"issue":"2","key":"1001_CR58","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/STROKEAHA.115.011223","volume":"47","author":"Z Guo","year":"2016","unstructured":"Guo Z, Hu Q, Xu L, Guo ZN, Ou Y, He Y, Yin C, Sun X, Tang J, Zhang JH. Lipoxin A4 reduces inflammation through formyl peptide receptor 2\/p38 MAPK signaling pathway in subarachnoid hemorrhage rats. Stroke. 2016;47(2):490\u20137.","journal-title":"Stroke"},{"key":"1001_CR59","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neuroscience.2019.03.038","volume":"408","author":"L Liu","year":"2019","unstructured":"Liu L, Zhang P, Zhang Z, Hu Q, He J, Liu H, Zhao J, Liang Y, He Z, Li X, et al. LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats. Neuroscience. 2019;408:105\u201314.","journal-title":"Neuroscience"},{"issue":"11","key":"1001_CR60","first-page":"38","volume":"62","author":"X Liu","year":"2016","unstructured":"Liu X, Zhang X, Ma K, Zhang R, Hou P, Sun B, Yuan S, Wang Z, Liu Z. Matrine alleviates early brain injury after experimental subarachnoid hemorrhage in rats possible involvement of PI3K\/Akt-mediated NF-\u03baB inhibition and Keap1\/Nrf2-dependent HO-1 inductionn. Cell Mol Biol (Noisy-le-grand). 2016;62(11):38\u201344.","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"1001_CR61","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.freeradbiomed.2017.08.003","volume":"112","author":"LF Fan","year":"2017","unstructured":"Fan LF, He PY, Peng YC, Du QH, Ma YJ, Jin JX, Xu HZ, Li JR, Wang ZJ, Cao SL, et al. Mdivi-1 ameliorates early brain injury after subarachnoid hemorrhage via the suppression of inflammation-related blood-brain barrier disruption and endoplasmic reticulum stress-based apoptosis. Free Radic Biol Med. 2017;112:336\u201349.","journal-title":"Free Radic Biol Med"},{"key":"1001_CR62","doi-asserted-by":"publisher","first-page":"111048","DOI":"10.1016\/j.biopha.2020.111048","volume":"133","author":"M Han","year":"2021","unstructured":"Han M, Cao Y, Guo X, Chu X, Li T, Xue H, Xin D, Yuan L, Ke H, Li G, et al. Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK\/NF-\u03baB signaling pathway. Biomed Pharmacother. 2021;133:111048.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1001_CR63","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12974-019-1396-5","volume":"16","author":"W Liu","year":"2019","unstructured":"Liu W, Li R, Yin J, Guo S, Chen Y, Fan H, Li G, Li Z, Li X, Zhang X, et al. Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch. J Neuroinflammation. 2019;16(1):8.","journal-title":"J Neuroinflammation"},{"key":"1001_CR64","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.expneurol.2015.04.016","volume":"272","author":"F Liu","year":"2015","unstructured":"Liu F, Chen Y, Hu Q, Li B, Tang J, He Y, Guo Z, Feng H, Tang J, Zhang JH. MFGE8\/Integrin \u03b23 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats. Exp Neurol. 2015;272:120\u20137.","journal-title":"Exp Neurol"},{"issue":"6","key":"1001_CR65","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.4103\/1673-5374.250620","volume":"14","author":"Y Wang","year":"2019","unstructured":"Wang Y, Bao DJ, Xu B, Cheng CD, Dong YF, Wei XP, Niu CS. Neuroprotection mediated by the Wnt\/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage. Neural Regen Res. 2019;14(6):1013\u201324.","journal-title":"Neural Regen Res"},{"issue":"1","key":"1001_CR66","doi-asserted-by":"publisher","first-page":"11883","DOI":"10.1038\/s41598-017-12160-6","volume":"7","author":"Z Wang","year":"2017","unstructured":"Wang Z, Guo S, Wang J, Shen Y, Zhang J, Wu Q. Nrf2\/HO-1 mediates the neuroprotective effect of mangiferin on early brain injury after subarachnoid hemorrhage by attenuating mitochondria-related apoptosis and neuroinflammation. Sci Rep. 2017;7(1):11883.","journal-title":"Sci Rep"},{"key":"1001_CR67","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.brainres.2016.05.005","volume":"1644","author":"T Chen","year":"2016","unstructured":"Chen T, Wang W, Li JR, Xu HZ, Peng YC, Fan LF, Yan F, Gu C, Wang L, Chen G. PARP inhibition attenuates early brain injury through NF-\u03baB\/MMP-9 pathway in a rat model of subarachnoid hemorrhage. Brain Res. 2016;1644:32\u20138.","journal-title":"Brain Res"},{"issue":"4","key":"1001_CR68","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s11064-016-2129-0","volume":"42","author":"DY Xia","year":"2017","unstructured":"Xia DY, Zhang HS, Wu LY, Zhang XS, Zhou ML, Hang CH. Pentoxifylline alleviates early brain injury after experimental subarachnoid hemorrhage in rats: possibly via inhibiting TLR 4\/NF-\u03baB signaling pathway. Neurochem Res. 2017;42(4):963\u201374.","journal-title":"Neurochem Res"},{"issue":"3","key":"1001_CR69","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.3892\/etm.2016.3526","volume":"12","author":"YW Zhong","year":"2016","unstructured":"Zhong YW, Wu J, Hu HL, Li WX, Zhong Y. Protective effect 3,4-dihydroxyphenylethanol in subarachnoid hemorrhage provoked oxidative neuropathy. Exp Ther Med. 2016;12(3):1908\u201314.","journal-title":"Exp Ther Med"},{"issue":"6","key":"1001_CR70","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1142\/S0192415X18500647","volume":"46","author":"Y Peng","year":"2018","unstructured":"Peng Y, He P, Fan L, Xu H, Li J, Chen T, Ruan W, Dou Z, Chen G. Neuroprotective effects of magnesium lithospermate b against subarachnoid hemorrhage in rats. Am J Chin Med. 2018;46(6):1225\u201341.","journal-title":"Am J Chin Med"},{"issue":"8","key":"1001_CR71","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1177\/0271678X16675369","volume":"37","author":"T Miyamoto","year":"2017","unstructured":"Miyamoto T, Kung DK, Kitazato KT, Yagi K, Shimada K, Tada Y, Korai M, Kurashiki Y, Kinouchi T, Kanematsu Y, et al. Site-specific elevation of interleukin-1\u03b2 and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model. J Cereb Blood Flow Metab. 2017;37(8):2795\u2013805.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"1001_CR72","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.18632\/aging.202503","volume":"13","author":"YP Xu","year":"2021","unstructured":"Xu YP, Tao YN, Wu YP, Zhang J, Jiao W, Wang YH, Chen T. Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway. Aging (Albany NY). 2021;13(2):3101\u201311.","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"1001_CR73","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.4103\/1673-5374.313049","volume":"16","author":"Y Wang","year":"2021","unstructured":"Wang Y, Kong XQ, Wu F, Xu B, Bao DJ, Cheng CD, Wei XP, Dong YF, Niu CS. SOCS1\/JAK2\/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses. Neural Regen Res. 2021;16(12):2453\u201364.","journal-title":"Neural Regen Res"},{"issue":"11","key":"1001_CR74","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1177\/0963689719867285","volume":"28","author":"J Chen","year":"2019","unstructured":"Chen J, Jin H, Xu H, Peng Y, Jie L, Xu D, Chen L, Li T, Fan L, He P, et al. The neuroprotective effects of necrostatin-1 on subarachnoid hemorrhage in rats are possibly mediated by preventing blood-brain barrier disruption and RIP3-mediated necroptosis. Cell Transplant. 2019;28(11):1358\u201372.","journal-title":"Cell Transplant"},{"issue":"21","key":"1001_CR75","doi-asserted-by":"publisher","first-page":"21161","DOI":"10.18632\/aging.103796","volume":"12","author":"S Guo","year":"2020","unstructured":"Guo S, Li Y, Wei B, Liu W, Li R, Cheng W, Zhang X, He X, Li X, Duan C. Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2\/HMGB1 signaling pathway in rats. Aging (Albany NY). 2020;12(21):21161\u201385.","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"1001_CR76","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12974-015-0415-4","volume":"12","author":"C Zhou","year":"2015","unstructured":"Zhou C, Xie G, Wang C, Zhang Z, Chen Q, Zhang L, Wu L, Wei Y, Ding H, Hang C, et al. Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment. J Neuroinflammation. 2015;12(1):200.","journal-title":"J Neuroinflammation"},{"issue":"4","key":"1001_CR77","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s12031-015-0634-2","volume":"57","author":"SS Shi","year":"2015","unstructured":"Shi SS, Zhang HB, Wang CH, Yang WZ, Liang RS, Chen Y, Tu XK. Propofol attenuates early brain injury after subarachnoid hemorrhage in rats. J Mol Neurosci. 2015;57(4):538\u201345.","journal-title":"J Mol Neurosci"},{"issue":"12","key":"1001_CR78","doi-asserted-by":"publisher","first-page":"104375","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104375","volume":"28","author":"HB Zhang","year":"2019","unstructured":"Zhang HB, Tu XK, Chen Q, Shi SS. Propofol reduces inflammatory brain injury after subarachnoid hemorrhage: involvement of PI3K\/Akt pathway. J Stroke Cerebrovasc Dis. 2019;28(12):104375.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"1001_CR79","doi-asserted-by":"publisher","first-page":"110804","DOI":"10.1016\/j.fct.2019.110804","volume":"134","author":"X Shi","year":"2019","unstructured":"Shi X, Zhen L, Ding H, Chen J, Zhang S, Fu Y. Role of ATP-sensitive potassium channels and inflammatory response of basilar artery smooth muscle cells in subarachnoid hemorrhage of rabbit and immune-modulation by shikonin. Food Chem Toxicol. 2019;134:110804.","journal-title":"Food Chem Toxicol"},{"issue":"7","key":"1001_CR80","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1172\/JCI78443","volume":"125","author":"N Schallner","year":"2015","unstructured":"Schallner N, Pandit R, LeBlanc R 3rd, Thomas AJ, Ogilvy CS, Zuckerbraun BS, Gallo D, Otterbein LE, Hanafy KA. Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J Clin Invest. 2015;125(7):2609\u201325.","journal-title":"J Clin Invest"},{"issue":"42","key":"1001_CR81","doi-asserted-by":"publisher","first-page":"e17450","DOI":"10.1097\/MD.0000000000017450","volume":"98","author":"M Matas","year":"2019","unstructured":"Matas M, Soto\u0161ek V, Kozmar A, Liki\u0107 R, Sekuli\u0107 A. Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients: study protocol for a randomized clinical trial. Medicine (Baltimore). 2019;98(42):e17450.","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"1001_CR82","first-page":"346","volume":"27","author":"W Zhong","year":"2017","unstructured":"Zhong W, Zhang Z, Zhao P, Shen J, Li X, Wang D, Li G, Su W. the impact of initial systemic inflammatory response after aneurysmal subarachnoid hemorrhage. Turk Neurosurg. 2017;27(3):346\u201352.","journal-title":"Turk Neurosurg"},{"key":"1001_CR83","doi-asserted-by":"crossref","unstructured":"Duris K, Lipkova J, Splichal Z, Madaraszova T, Jurajda M: Early inflammatory response in the brain and anesthesia recovery time evaluation after experimental subarachnoid hemorrhage. Transl Stroke Res. 2019;10:308\u201318.","DOI":"10.1007\/s12975-018-0641-z"},{"issue":"2","key":"1001_CR84","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s12028-017-0471-y","volume":"28","author":"J Savarraj","year":"2018","unstructured":"Savarraj J, Parsha K, Hergenroeder G, Ahn S, Chang TR, Kim DH, Choi HA. Early brain injury associated with systemic inflammation after subarachnoid hemorrhage. Neurocrit Care. 2018;28(2):203\u201311.","journal-title":"Neurocrit Care"},{"issue":"1","key":"1001_CR85","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s12028-019-00871-9","volume":"33","author":"AP Coulibaly","year":"2020","unstructured":"Coulibaly AP, Gartman WT, Swank V, Gomes JA, Ruozhuo L, DeBacker J, Provencio JJ. RAR-related orphan receptor gamma T (RoR\u03b3t)-related cytokines play a role in neutrophil infiltration of the central nervous system after subarachnoid hemorrhage. Neurocrit Care. 2020;33(1):140\u201351.","journal-title":"Neurocrit Care"},{"key":"1001_CR86","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.wneu.2017.08.091","volume":"108","author":"Y Zhou","year":"2017","unstructured":"Zhou Y, Jiang Y, Peng Y, Zhang M. The quantitative and functional changes of postoperative peripheral blood immune cell subsets relate to prognosis of patients with subarachnoid hemorrhage: a preliminary study. World Neurosurg. 2017;108:206\u201315.","journal-title":"World Neurosurg"},{"issue":"1","key":"1001_CR87","doi-asserted-by":"publisher","first-page":"21","DOI":"10.5935\/0103-507X.20180003","volume":"30","author":"C Righy","year":"2018","unstructured":"Righy C, Turon R, Freitas G, Japiass\u00fa AM, Faria Neto HCC, Bozza M, Oliveira MF, Bozza FA. Hemoglobin metabolism by-products are associated with an inflammatory response in patients with hemorrhagic stroke. Rev Bras Ter Intensiva. 2018;30(1):21\u20137.","journal-title":"Rev Bras Ter Intensiva"},{"key":"1001_CR88","doi-asserted-by":"publisher","first-page":"135250","DOI":"10.1016\/j.neulet.2020.135250","volume":"736","author":"Y Wang","year":"2020","unstructured":"Wang Y, Zhou S, Han Z, Yin D, Luo Y, Tian Y, Wang Z, Zhang J. Fingolimod administration improves neurological functions of mice with subarachnoid hemorrhage. Neurosci Lett. 2020;736:135250.","journal-title":"Neurosci Lett"},{"issue":"6","key":"1001_CR89","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s12975-018-0614-2","volume":"9","author":"KG Blecharz-Lang","year":"2018","unstructured":"Blecharz-Lang KG, Wagner J, Fries A, Nieminen-Kelh\u00e4 M, R\u00f6sner J, Schneider UC, Vajkoczy P. Interleukin 6-mediated endothelial barrier disturbances can be attenuated by blockade of the IL6 receptor expressed in brain microvascular endothelial cells. Transl Stroke Res. 2018;9(6):631\u201342.","journal-title":"Transl Stroke Res"},{"key":"1001_CR90","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3389\/fnmol.2017.00398","volume":"10","author":"XP Huang","year":"2017","unstructured":"Huang XP, Peng JH, Pang JW, Tian XC, Li XS, Wu Y, Li Y, Jiang Y, Sun XC. Peli1 Contributions in microglial activation, neuroinflammatory responses and neurological deficits following experimental subarachnoid hemorrhage. Front Mol Neurosci. 2017;10:398.","journal-title":"Front Mol Neurosci"},{"issue":"6","key":"1001_CR91","first-page":"622","volume":"46","author":"X Zhao","year":"2016","unstructured":"Zhao X, Wu J, Zhang Y, Zhu L, Lu X. Alterations of intestinal labile zinc and cytokine production following subarachnoid hemorrhage in rats. Ann Clin Lab Sci. 2016;46(6):622\u20136.","journal-title":"Ann Clin Lab Sci"},{"issue":"4","key":"1001_CR92","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1007\/s12035-015-9318-8","volume":"53","author":"J Li","year":"2016","unstructured":"Li J, Chen J, Mo H, Chen J, Qian C, Yan F, Gu C, Hu Q, Wang L, Chen G. Minocycline protects against NLRP3 inflammasome-induced inflammation and P53-associated apoptosis in early brain injury after subarachnoid hemorrhage. Mol Neurobiol. 2016;53(4):2668\u201378.","journal-title":"Mol Neurobiol"},{"key":"1001_CR93","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fnins.2018.00096","volume":"12","author":"J Yin","year":"2018","unstructured":"Yin J, Li R, Liu W, Chen Y, Zhang X, Li X, He X, Duan C. Neuroprotective effect of protein phosphatase 2A\/tristetraprolin following subarachnoid hemorrhage in rats. Front Neurosci. 2018;12:96.","journal-title":"Front Neurosci"},{"key":"1001_CR94","first-page":"1268","volume":"26","author":"X Dang","year":"2017","unstructured":"Dang X, Ding D, Cheng S, Pei H. The neuroprotective effect of triptolide on experimental subarachnoid hemorrhage in rats. Chinese Journal of Emergency Medicine. 2017;26:1268\u201373.","journal-title":"Chinese Journal of Emergency Medicine"},{"issue":"9","key":"1001_CR95","doi-asserted-by":"publisher","first-page":"105054","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105054","volume":"29","author":"D Croci","year":"2020","unstructured":"Croci D, Nevzati E, Muroi C, Sch\u00f6pf S, Hornemann T, Widmer HR, Danura H, Fandino J, Marbacher S. Changes in the cerebrospinal fluid lipid profile following subarachnoid hemorrhage in a closed cranium model: correlations to cerebral vasospasm, neuronal cell death and Interleukin-6 synthesis. A pilot study. J Stroke Cerebrovasc Dis. 2020;29(9):105054.","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"3","key":"1001_CR96","doi-asserted-by":"publisher","first-page":"245","DOI":"10.23736\/S0390-5616.16.03876-5","volume":"63","author":"D Croci","year":"2019","unstructured":"Croci D, Nevzati E, Danura H, Sch\u00f6pf S, Fandino J, Marbacher S, Muroi C. The relationship between IL-6, ET-1 and cerebral vasospasm, in experimental rabbit subarachnoid hemorrhage. J Neurosurg Sci. 2019;63(3):245\u201350.","journal-title":"J Neurosurg Sci"},{"issue":"1","key":"1001_CR97","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13054-015-0809-9","volume":"19","author":"R Helbok","year":"2015","unstructured":"Helbok R, Schiefecker AJ, Beer R, Dietmann A, Antunes AP, Sohm F, Fischer M, Hackl WO, Rhomberg P, Lackner P, et al. Early brain injury after aneurysmal subarachnoid hemorrhage: a multimodal neuromonitoring study. Crit Care. 2015;19(1):75.","journal-title":"Crit Care"},{"issue":"5","key":"1001_CR98","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1007\/s12035-015-9268-1","volume":"53","author":"W Wu","year":"2016","unstructured":"Wu W, Guan Y, Zhao G, Fu XJ, Guo TZ, Liu YT, Ren XL, Wang W, Liu HR, Li YQ. Elevated IL-6 and TNF-\u03b1 levels in cerebrospinal fluid of subarachnoid hemorrhage patients. Mol Neurobiol. 2016;53(5):3277\u201385.","journal-title":"Mol Neurobiol"},{"issue":"1","key":"1001_CR99","first-page":"29","volume":"73","author":"A Matsumoto","year":"2019","unstructured":"Matsumoto A, Nakamura T, Shinomiya A, Kawakita K, Kawanishi M, Miyake K, Kuroda Y, Keep RF, Tamiya T. Histidine-rich glycoprotein could be an early predictor of vasospasm after aneurysmal subarachnoid hemorrhage. Acta Med Okayama. 2019;73(1):29\u201339.","journal-title":"Acta Med Okayama"},{"key":"1001_CR100","doi-asserted-by":"publisher","first-page":"e612","DOI":"10.1016\/j.wneu.2018.10.113","volume":"122","author":"P Vlachogiannis","year":"2019","unstructured":"Vlachogiannis P, Hillered L, Khalil F, Enblad P, Ronne-Engstr\u00f6m E. Interleukin-6 levels in cerebrospinal fluid and plasma in patients with severe spontaneous subarachnoid hemorrhage. World Neurosurg. 2019;122:e612\u20138.","journal-title":"World Neurosurg"},{"issue":"12","key":"1001_CR101","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.2174\/1389450117666160201111804","volume":"18","author":"AJ Schiefecker","year":"2017","unstructured":"Schiefecker AJ, Dietmann A, Beer R, Pfausler B, Lackner P, Kofler M, Fischer M, Broessner G, Sohm F, Mulino M, et al. Neuroinflammation is associated with brain extracellular TAU-protein release after spontaneous subarachnoid hemorrhage. Curr Drug Targets. 2017;18(12):1408\u201316.","journal-title":"Curr Drug Targets"},{"key":"1001_CR102","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cca.2017.08.018","volume":"473","author":"YH Chen","year":"2017","unstructured":"Chen YH, Cheng ZY, Shao LH, Shentu HS, Fu B. Macrophage migration inhibitory factor as a serum prognostic marker in patients with aneurysmal subarachnoid hemorrhage. Clin Chim Acta. 2017;473:60\u20134.","journal-title":"Clin Chim Acta"},{"issue":"16","key":"1001_CR103","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1212\/WNL.0000000000003842","volume":"88","author":"JPJ Savarraj","year":"2017","unstructured":"Savarraj JPJ, Parsha K, Hergenroeder GW, Zhu L, Bajgur SS, Ahn S, Lee K, Chang T, Kim DH, Liu Y, et al. Systematic model of peripheral inflammation after subarachnoid hemorrhage. Neurology. 2017;88(16):1535\u201345.","journal-title":"Neurology"},{"issue":"2","key":"1001_CR104","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s12640-019-00072-4","volume":"37","author":"X Yang","year":"2020","unstructured":"Yang X, Peng J, Pang J, Wan W, Zhong C, Peng T, Bao K, Jiang Y. The association between serum macrophage migration inhibitory factor and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Neurotox Res. 2020;37(2):397\u2013405.","journal-title":"Neurotox Res"},{"key":"1001_CR105","doi-asserted-by":"publisher","first-page":"577310","DOI":"10.1016\/j.jneuroim.2020.577310","volume":"346","author":"L Moraes","year":"2020","unstructured":"Moraes L, Trias N, Brugnini A, Grille P, Lens D, Biestro A, Grille S. TH17\/Treg imbalance and IL-17A increase after severe aneurysmal subarachnoid hemorrhage. Journal of Neuroimmunology. 2020;346:577310.","journal-title":"Journal of Neuroimmunology"},{"issue":"1","key":"1001_CR106","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s12028-020-01011-4","volume":"34","author":"LB Xu","year":"2021","unstructured":"Xu LB, Huang HD, Zhao M, Zhu GC, Xu Z. intranasal insulin treatment attenuates metabolic distress and early brain injury after subarachnoid hemorrhage in mice. Neurocrit Care. 2021;34(1):154\u201366.","journal-title":"Neurocrit Care"},{"issue":"8","key":"1001_CR107","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1161\/STROKEAHA.114.006365","volume":"46","author":"K Yagi","year":"2015","unstructured":"Yagi K, Lidington D, Wan H, Fares JC, Meissner A, Sumiyoshi M, Ai J, Foltz WD, Nedospasov SA, Offermanns S, et al. Therapeutically targeting tumor necrosis factor-\u03b1\/sphingosine-1-phosphate signaling corrects myogenic reactivity in subarachnoid hemorrhage. Stroke. 2015;46(8):2260\u201370.","journal-title":"Stroke"},{"issue":"6","key":"1001_CR108","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1007\/s11064-015-1572-7","volume":"40","author":"ZY Zhang","year":"2015","unstructured":"Zhang ZY, Sun BL, Liu JK, Yang MF, Li DW, Fang J, Zhang S, Yuan QL, Huang SL. Activation of mGluR5 attenuates microglial activation and neuronal apoptosis in early brain injury after experimental subarachnoid hemorrhage in rats. Neurochem Res. 2015;40(6):1121\u201332.","journal-title":"Neurochem Res"},{"issue":"9","key":"1001_CR109","doi-asserted-by":"publisher","first-page":"e00790","DOI":"10.1002\/brb3.790","volume":"7","author":"J Cai","year":"2017","unstructured":"Cai J, Xu D, Bai X, Pan R, Wang B, Sun S, Chen R, Sun J, Huang Y. Curcumin mitigates cerebral vasospasm and early brain injury following subarachnoid hemorrhage via inhibiting cerebral inflammation. Brain Behav. 2017;7(9):e00790.","journal-title":"Brain Behav"},{"issue":"1","key":"1001_CR110","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000505311","volume":"49","author":"H Chen","year":"2020","unstructured":"Chen H, Chen L, Xie D, Niu J. Protective effects of transforming growth factor-\u03b21 knockdown in human umbilical cord mesenchymal stem cells against subarachnoid hemorrhage in a rat model. Cerebrovasc Dis. 2020;49(1):79\u201387.","journal-title":"Cerebrovasc Dis"},{"key":"1001_CR111","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.3389\/fphar.2020.01073","volume":"11","author":"XH Zhang","year":"2020","unstructured":"Zhang XH, Peng L, Zhang J, Dong YP, Wang CJ, Liu C, Xia DY, Zhang XS. Berberine ameliorates subarachnoid hemorrhage injury via induction of sirtuin 1 and inhibiting HMGB1\/Nf-\u03baB pathway. Front Pharmacol. 2020;11:1073.","journal-title":"Front Pharmacol"}],"container-title":["Translational Stroke Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-022-01001-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12975-022-01001-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12975-022-01001-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T08:07:50Z","timestamp":1667117270000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12975-022-01001-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":111,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1001"],"URL":"https:\/\/doi.org\/10.1007\/s12975-022-01001-y","relation":{},"ISSN":["1868-4483","1868-601X"],"issn-type":[{"value":"1868-4483","type":"print"},{"value":"1868-601X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]},"assertion":[{"value":"1 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}